MITOTOX

D0565 | NCCD

Properties

Molecular Formula	X
Molecular Weight	X
Structure
Description	lipid-soluble carbodiimides; inhibit ATP synthase; Carboxyl Group Modifiers; lipid-soluble spin-labeled inhibitor of ATP synthase

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
ELECTRON TRANSPORT CHAIN	0.65 nmol/mg protein		bovine	heart SMP-ATPase		affect	IC50	170
ELECTRON TRANSPORT CHAIN	1 nmol NCCD/mg protein		bovine	heart SMP-ATPase		affect	85% inhibition	170

Targets

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
Fo subunits	0.65 nmol/mg protein		bovine	heart SMP-ATPase		inhibitor	IC50	170
Fo subunits	1 nmol NCCD/mg protein		bovine	heart SMP-ATPase		inhibitor	85% inhibition	170

Indications Source: SIDER

Synonyms Source: PubChem

N-(2,2,6,6-tetramethylpeperidyl-1-oxyl)-N-(cyclohexyl)carbo-diimide

References