Drug

D0404 | Thenoyltrifluoroacetone

Molecular Formula C8H5F3O2S
Molecular Weight 222.19
Structure
State solid
Description Inhibits succinate dehydrogenase; chelating agent; an inhibitor of cellular respiration by blocking the respiratory chain at complex II.

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTRON TRANSPORT CHAIN decrease 33
ELECTRON TRANSPORT CHAIN decrease 35
ELECTRON TRANSPORT CHAIN bovine heart mitochondria affect 192

Target Dose Time Species Model Method Action Positive criterion Reference
Succinate dehydrogenase inhibitor 33
Succinate dehydrogenase inhibitor 35
Succinate dehydrogenase 25 μM rat liver mitochondria The reduction of ferricyanide by succinate cata-lyzed by SDH was monitored spectrophotometrically inhibitor 303
Quinone pocket bovine heart mitochondria inhibitor 192

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 205 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 1 of 205 companies. For more detailed information, please visit ECHA C&L website


Of the 8 notification(s) provided by 204 of 205 companies with hazard statement code(s):


H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335 (98.53%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • .alpha.-Thenoyltrifluoroacetone 1, 4,4,4-trifluoro-1-(2-thienyl)- 1,1,1-Trifluoro-3-(2-thenoyl)acetone
    1,1-Trifluoro-3-(2-thenoyl)acetone 1,3-Butanedione, 4,4,4-trifluoro-1-(2-thienyl)- 1,3-Butanedione, 4,4,4-trifluoro-1-(thienyl)-
    1-(2-Thenoyl)-3,3,3-trifluoroacetone 1-(2-thienyl)-4,4,4-trifluoro-1,3-butanedione 1-(Thenoyl-(2'))-3,3,3-trifluoroacetone
    1-THIENYL-4,4,4-TRIFLUORO-1,3-BUTANEDIONE 1-Thenoyl-3,3,3-trifluoroacetone 1-Thenoyl-3,3-trifluoroacetone
    2-Thenoyltrifluoroacetone 2-Thenoyltrifluoroacetone pound>>4,4,4-trifluoro-1-(thiophen-2-yl)butane-1,3-dione 2-Thenoyltrifluoroacetone, 99%
    2-Thenoyltrifluoroacetone, for spectrophotometric det. of metal ions, >=99.0% 2-Thenoyltrifluoroacetone, purum, >=97.0% (GC) 2-thenoyl trifluoro acetone
    2-thenoyl trifluoroacetone 26T910 29463-74-9
    326-91-0 4,4,4-TRIFLUORO-1-THIEN-2-YLBUTANE-1,3-DIONE 4,4,4-Trifluoro-1-(2-thienyl)-1,3-Butanedion
    4,4,4-Trifluoro-1-(2-thienyl)-1,3-butanedione 4,4,4-Trifluoro-1-(2-thienyl)butane-1,3-dione 4,4,4-trifluoro-1-(thiophen-2-yl)butane-1,3-dione
    4,4,4-trifluoro-1-thiophen-2-yl-butane-1,3-dione 4,4,4-trifluoro-1-thiophen-2-ylbutane-1,3-dione AC-4921
    ACMC-1CM3H AI3-31295 AK-46533
    AKOS000119762 AM20090477 ANW-27410
    ARONIS021027 BBL014250 BCP21685
    BDBM50248361 BR-46533 BRD-K00959089-001-01-4
    CCG-207997 CHEMBL1236433 CS-W020091
    CTK0I4649 DB-001234 DB04795
    DS-1137 DTXSID1059812 EINECS 206-316-7
    EU-0000019 F0346-3664 FT-0613433
    HMS3604B13 HSCI1_000376 InChI=1/C8H5F3O2S/c9-8(10,11)7(13)4-5(12)6-2-1-3-14-6/h1-3H,4H2
    KS-00000C17 KS-00004CLY LS-166686
    LS40311 M-5475 MCULE-7481288995
    MFCD00005445 MFCD00005445 (98%) MYQ9MNW7NI
    NSC 66544 NSC-66544 NSC66544
    P634 PS-6790 Perfluoroacetyl(2-thenoyl)methane
    Q-200324 Q5933755 RTR-013716
    SBB003341 SC11823 SCHEMBL195358
    SR-01000388942 SR-01000388942-1 ST2410209
    ST45034729 STK020843 SY004998
    THENOYLTRIFLUOROACETONE TR-013716 TRA0096222
    TTB TXBBUSUXYMIVOS-UHFFFAOYSA- TXBBUSUXYMIVOS-UHFFFAOYSA-N
    Thenoyltrifluoroacetone, 99% UNII-MYQ9MNW7NI Z57201518
    ZINC100004957 alpha-Thenoyltrifluoroacetone thenoyl trifluoroacetone

    DrugBank Name Thenoyltrifluoroacetone
    DrugBank DB04795
    CAS Number 29463-74-9, 326-91-0, 77611-51-9
    PubChem Compound 5601
    PubChem.Substance 46504456
    ChemSpider 5399
    Wikipedia Thenoyltrifluoroacetone
    HET TTF