Search References Drug Actions/Targets About Access data Feedback
Sign In
mitontu@gmail.com
2021 MitoTox | (CC BY-NC 4.0)
Drug

D1077 | quercetin

Molecular Formula C15H10O7
Molecular Weight 302.23
Structure
State solid
Description plant flavonol from the flavonoid group of polyphenols

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 2.69±2.26 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 3.16 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 15.14±6.79 rat hepatocytes MMP assay decrease IC50 163
BASAL RESPIRATION 1 µg/l zebrafish XFe24 Extracellular Flux Analyzer decrease 91
BASAL RESPIRATION 10 µg/l zebrafish XFe24 Extracellular Flux Analyzer decrease 91
MAXIMAL RESPIRATION 1 µg/l zebrafish XFe24 Extracellular Flux Analyzer decrease 91
ATP TURNOVER 10 µg/l zebrafish XFe24 Extracellular Flux Analyzer Negative 91
PROTON LEAK 10 µg/l zebrafish XFe24 Extracellular Flux Analyzer Negative 91
ELECTRON TRANSPORT CHAIN 5 kmol/mol bovine heart MF1-ATPase decrease IC50 147
ELECTRON TRANSPORT CHAIN 85 μM bovine heart MF1-ATPase decrease IC50 148
ELECTRON TRANSPORT CHAIN 180 μM bovine heart SMP-ATPase decrease IC50 148
ELECTRON TRANSPORT CHAIN 50 μM rat brain F0F1-ATPase decrease IC50 140
ELECTRON TRANSPORT CHAIN 3 μM rat liver F1-ATPase decrease IC50 141
ELECTRON TRANSPORT CHAIN 2 kmol/mola spinach CF1-ATPase decrease 147
ELECTRON TRANSPORT CHAIN 2.6 μg/mg protein C. asciculate SMP-ATPase decrease IC50 131
ELECTRON TRANSPORT CHAIN 0.2 mM pig heart MF1-ATPase decrease Ki 149
ELECTRON TRANSPORT CHAIN 27 μM bovine heart MF1-ATPase decrease Kd 147
ELECTRON TRANSPORT CHAIN 5 μM C. thermoaceticum membrane-bound F0F1-ATPase decrease 46% inhibition 150
TRANSPORT OF CALCIUM 21 μM mitochondrial Ca2+ uptake increase EC50 234
BIOGENESIS HepG 263
BIOGENESIS brain 265

Target Dose Time Species Model Method Action Positive criterion Reference
ATP synthase 5 kmol/mol bovine heart MF1-ATPase inhibitor IC50 147
ATP synthase 85 μM bovine heart MF1-ATPase inhibitor IC50 148
ATP synthase 180 μM bovine heart SMP-ATPase inhibitor IC50 148
ATP synthase 50 μM rat brain F0F1-ATPase inhibitor IC50 140
ATP synthase 3 μM rat liver F1-ATPase inhibitor IC50 141
ATP synthase 2 kmol/mola spinach CF1-ATPase inhibitor 147
ATP synthase 2.6 μg/mg protein C. asciculate SMP-ATPase inhibitor IC50 131
ATP synthase 0.2 mM pig heart MF1-ATPase inhibitor Ki 149
ATP synthase 27 μM bovine heart MF1-ATPase inhibitor Kd 147
ATP synthase 5 μM C. thermoaceticum membrane-bound F0F1-ATPase inhibitor 46% inhibition 150
mCU (mitochondrial calcium uniporter) 21 μM mitochondrial Ca2+ uptake activate EC50 234

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 323 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 3 of 323 companies. For more detailed information, please visit ECHA C&L website


Of the 2 notification(s) provided by 320 of 323 companies with hazard statement code(s):


H301 (50.94%): Toxic if swallowed [Danger Acute toxicity, oral]


H302 (49.06%): Harmful if swallowed [Warning Acute toxicity, oral]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P264, P270, P301+P310, P301+P312, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
mouse LD50 oral 159mg/kg (159mg/kg) Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951.


  • (+)-3,3',4',5,7-Pentahydroxyflavone (+)-4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy- 117-39-5
    17Q395 2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-chromen-4-one 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
    2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one # 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one
    2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;hydrate 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one 3',4',5,7-Tetrahydroxyflavan-3-ol
    3',4',5,7-tetrahydroxyflavon-3-ol 3',5,7-Tetrahydroxyflavan-3-ol 3,3',4',5,7-Pentahydroxyflavone
    3,3',4',5,7-Pentahydroxyflavone 3,3',4,5,7-Pentahydroxyflavone 3,4',5,5',7-pentahydroxy-Flavone
    3,4',5,7-Pentahydroxyflavone 3,5,7,3',4'-Pentahydroxyflavon 3,5,7,3',4'-Pentahydroxyflavone
    3,5,7-Trihydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-on 3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one 3,7,3',4'-Pentahydroxyflavone
    3cf8 49643640-FD4C-4B93-BD28-0D7C2021CC52 4CN-0923
    4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy- 4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-, zirconium(2+) salt (1:1); 4dfu
    4mra 5-18-05-00494 (Beilstein Handbook Reference) 74893-81-5
    9IKM0I5T1E A-8821 AC-19596
    AC-29756 ACon1_000560 AI3-26018
    AK106169 AKOS000511724 ANW-73134
    AX8030401 BBL005513 BDBM7460
    BIDD:ER0315 BIDD:PXR0007 BPBio1_000477
    BRD-9794 BRD-K97399794-001-02-1 BRD-K97399794-001-07-0
    BRD-K97399794-001-09-6 BRD-K97399794-001-11-2 BRD-K97399794-335-03-1
    BRD9794 BRN 0317313 BS0155
    BSPBio_000433 BSPBio_001068 BSPBio_002243
    Bio1_000369 Bio1_000858 Bio1_001347
    Bio2_000374 Bio2_000854 BiomolKI2_000068
    BiomolKI_000062 C.I . natural yellow 10 C.I. 75670
    C.I. Natural Yellow 10 C.I. Natural red 1 C.I. Natural yellow 10 & 13
    C.I. natural yellow 13 C00389 CAS-117-39-5
    CCG-40054 CCRIS 1639 CHEBI:16243
    CHEMBL50 CI 75670 CI Natural Yellow 10
    CQ0011 CS-3981 CTK3J7142
    CU-01000012502-3 Cyanidelonon 1522 Cyanidenolon 1522
    DB04216 DS-3416 DSSTox_CID_1218
    DSSTox_GSID_21218 DSSTox_RID_76017 DTXSID4021218
    DivK1c_000485 EBD2197934 EINECS 204-187-1
    EU-0100999 Enicostemma Littorale Blume FT-0603318
    FT-0655108 Flavin meletin Flavone, 3,3',4',5,7-pentahydroxy-
    Flavone, 3,3',4',5,7-pentahydroxy-, (+)- Flavone, 3,4',5,5',7-pentahydroxy- Flavone,3',4',5,7-pentahydroxy-
    GP9232 GTPL5346 HMS1362F09
    HMS1792F09 HMS1923O19 HMS1990F09
    HMS3263G19 HMS3267M12 HMS3414J21
    HMS3649D04 HMS3656C15 HMS3678J19
    HMS501I07 HSDB 3529 HY-18085
    IDI1_000485 IDI1_002129 K00029
    KBio1_000485 KBio2_000408 KBio2_000584
    KBio2_002976 KBio2_003152 KBio2_005544
    KBio2_005720 KBio3_000775 KBio3_000776
    KBio3_001463 KBioGR_000408 KBioGR_001293
    KBioSS_000408 KBioSS_000584 KS-0000021G
    KSC-10-126 KSC-23-76 KSC497C4F
    KUC104418N KUC107684N Kvercetin
    Kvercetin [Czech] LDN 0052529 LDN-0052529
    LIM-5662 LK87600000 LMPK12110004
    LNS-5662 LP00999 LS-589
    LS-69030 Lopac-Q-0125 Lopac0_000999
    MCULE-2433372790 MEGxp0_000381 MFCD00006828
    MLS006011766 Maybridge1_008992 Meletin
    MixCom3_000183 N1841 NCGC00015870-01
    NCGC00015870-02 NCGC00015870-03 NCGC00015870-05
    NCGC00015870-06 NCGC00015870-07 NCGC00015870-08
    NCGC00015870-09 NCGC00015870-10 NCGC00015870-11
    NCGC00015870-12 NCGC00015870-13 NCGC00015870-14
    NCGC00015870-15 NCGC00015870-16 NCGC00015870-17
    NCGC00015870-18 NCGC00015870-19 NCGC00015870-21
    NCGC00015870-22 NCGC00015870-23 NCGC00015870-24
    NCGC00025016-01 NCGC00025016-02 NCGC00025016-03
    NCGC00025016-04 NCGC00025016-05 NCGC00025016-06
    NCGC00025016-07 NCGC00025016-08 NCGC00168962-01
    NCGC00168962-02 NCGC00168962-03 NCGC00168962-04
    NCGC00254218-01 NCGC00259857-01 NCGC00261684-01
    NCI-C60106 NCI60_042036 NCIOpen2_007628
    NCIOpen2_007882 NINDS_000485 NIOSH/LK8760000
    NSC 57655 NSC 9219 NSC-57655
    NSC-9219 NSC324608 NSC57655
    NSC58588 NSC9219 NUT0000107
    Natural Yellow 10 P0042 Prestwick0_000507
    Prestwick1_000507 Prestwick2_000507 Prestwick3_000507
    Q 0125 Q-200333 Q0025
    Q409478 QUE Quer
    Quercetin Quercetin (Sophoretin) Quercetin - Sophoretin
    Quercetin content Quercetin(Sophoretin) Quercetin, >=95% (HPLC), solid
    Quercetin, Sophoretin, Meletin, Quercetine Quercetin2H2O Quercetin_sathishkumar
    Quercetine Quercetol Quercitin
    Quertin Quertine REFJWTPEDVJJIY-UHFFFAOYSA-N
    RTX-012622 Ritacetin S00057
    S295 SBB012521 SC-25667
    SCHEMBL19723 SCHEMBL219729 SGCUT00001
    SMP1_000252 SMR000112559 SPBio_000217
    SPBio_002354 SPECTRUM1500672 SR-01000076098
    SR-01000076098-1 SR-01000076098-11 SR-01000076098-3
    SR-01000076098-7 SR-01000076098-8 ST024706
    ST057237 ST24039236 STK365650
    SW148203-4 SY057722 Sophoretin
    Spectrum2_000059 Spectrum3_000642 Spectrum4_000807
    Spectrum5_001389 Spectrum_000124 T-Gelb bzw. grun 1
    TNP00070 TNP00089 Tocris-1125
    Tox21_202308 Tox21_300285 Tox21_500999
    UNII-9IKM0I5T1E UPCMLD-DP081 UPCMLD-DP081:001
    WLN: T66 BO EVJ CR CQ DQ & DQ GQ IQ Xanthaurine ZINC3869685
    quercetin s2391 to_000078

    DrugBank DB04216
    CAS Number 117-39-5, 263711-79-1, 6151-25-3, 7255-55-2, 74893-81-5, 79124-76-8, 849061-97-8
    PubChem Compound 5280343
    KEGG Compound ID C00389
    ChEBI 16243