Drug

D0293 | Papaverine

Molecular Formula C20H21NO4
Molecular Weight 339.4
Structure
State solid
Protein binding ~90%
Half life 0.5-2 hours

G

A

G04BE52 Papaverine, combinations


[G04BE] Drugs used in erectile dysfunction


[G04B] UROLOGICALS


[G04] UROLOGICALS


[G] Genitourinary system and reproductive hormones


G04BE02 Papaverine


[G04BE] Drugs used in erectile dysfunction


[G04B] UROLOGICALS


[G04] UROLOGICALS


[G] Genitourinary system and reproductive hormones


A03AD01 Papaverine


[A03AD] Papaverine and derivatives


[A03A] DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS


[A03] DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS


[A] Alimentary tract and metabolism


Toxicity Dose Time Species Model Method Action Positive criterion Reference
UNCOUPLING increase 35
ELECTRON TRANSPORT CHAIN decrease 30
ELECTRON TRANSPORT CHAIN 5 μM bovine mitochondria NADH–Q-1 decrease IC50 30

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase inhibitor 30
NADH:ubiquinone reductase 5 μM bovine mitochondria NADH–Q-1 inhibitor IC50 30

Pictogram Signal Statements Precautionary Statement Codes
Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]


P264, P270, P301+P312, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

Aggregated GHS information provided by 6 companies from 1 notifications to the ECHA C&L Inventory.


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P264, P270, P301+P312, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]


P264, P270, P301+P312, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

  • Abdominal pain

  • Acute myocardial infarction

  • Angina pectoris

  • Coronary artery occlusion

  • Muscle spasms

  • Peripheral vascular disorder

  • Pulmonary embolism

  • Vasospasm

  • 1-((3,4-Dimethoxyphenyl)methyl)-6,7-dimethoxyisoquinoline 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-isoquinoline 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline
    1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline # 1-[(3,4-Dimethoxyphenyl)methyl]6,7-dimethoxyisoquinoline 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline
    1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline 1-{[3,4-bis(methyloxy)phenyl]methyl}-6,7-bis(methyloxy)isoquinoline 2wey
    4-[(6,7-Dimethoxyisoquinolyl)methyl]-1,2-dimethoxybenzene 5-21-06-00182 (Beilstein Handbook Reference) 58-74-2
    6,7-DI-METHOXY-1-VERATRYLISOQUINOLINE 6,7-DIMETHOXY-1-(3.4-DIMETHOXYBENZYL)-ISOQUINOLINE 6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)isoquinoline
    6,7-Dimethoxy-1-veratrylisoquinoline 6,7-dimethoxy-1-veratryl-isoquinoline;hydrochloride AB00053515
    AB00053515_14 ACon1_000238 ACon1_002094
    AKOS000277460 ALBB-010475 API0003747
    BBL012345 BDBM14754 BPBio1_000470
    BRD-K15567136-001-01-1 BRD-K15567136-003-06-6 BRD-K15567136-003-18-1
    BRN 0312930 BSPBio_000426 BSPBio_002153
    C06533 CAS-61-25-6 CCG-202821
    CHEBI:28241 CHEMBL19224 CS-7800
    CTK7A7298 Ceraspan D07425
    DAA13NKG2Q DB-053252 DB01113
    DTXSID4023418 DivK1c_000321 EINECS 200-397-2
    EV1 FT-0631261 HMS3561N11
    HMS3746M21 HSDB 3147 HY-18077
    IDI1_000321 InChI=1/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-
    Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy- Isoquinoline, 6,7-dimethoxy-1-veratryl- Isoquinoline, 6,7-dimethoxy-1-veratryl- (8CI)
    Isoquinoline, 6,7-dimethoxy-1-veratryl-(8Cl) Isoquinoline,4-dimethoxyphenyl)methyl]-6,7-dimethoxy- Isoquinoline,7-dimethoxy-1-veratryl-
    KBio1_000321 KBio2_000471 KBio2_003039
    KBio2_005607 KBio3_001653 KBioGR_000914
    KBioSS_000471 KS-00002WWI KS-5336
    LS-85584 Lopac-P-3510 Lopac0_000957
    MCULE-9598291893 MEGxp0_001880 Mesotina (TN)
    NCGC00015810-01 NCGC00015810-02 NCGC00015810-03
    NCGC00015810-04 NCGC00015810-05 NCGC00015810-06
    NCGC00015810-07 NCGC00015810-08 NCGC00015810-09
    NCGC00015810-13 NCGC00024428-03 NCGC00024428-04
    NCI60_003183 NINDS_000321 NSC 136630
    NSC-136630 NSC136630 NSC35443
    Oprea1_387689 Oprea1_810508 Papanerin
    Papanerine Papaverin Papaverina
    Papaverina [Italian] Papaverine (BAN) Papaverine [BAN]
    Pavabid Pavacot Pavatym
    Prestwick0_000583 Prestwick1_000583 Prestwick2_000583
    Prestwick3_000583 Q410374 R1247
    RS 47 Robaxapap S-M-R
    SBI-0050931.P004 SCHEMBL34702 SDCCGMLS-0003037.P003
    SPBio_001015 SPBio_002645 SR-01000003098-10
    ST023301 STK039035 Spectrum2_000978
    Spectrum3_000537 Spectrum4_000467 Spectrum5_001188
    Spectrum_000071 TNP00305 UNII-DAA13NKG2Q
    WLN: T66 CNJ B1R CO1 DO1& HO1 IO1 XQYZDYMELSJDRZ-UHFFFAOYSA-N Y1354
    ZINC56555 papaverine

    DrugBank Name Papaverine
    DrugBank DB01113
    CAS Number 127060-78-0, 132-40-1, 58-74-2, 61-25-6
    PubChem Compound 4680
    KEGG Compound ID C06533
    KEGG Drug D07425
    PubChem.Substance 46508003
    ChEBI 28241
    PharmGKB PA164745550
    ChemSpider 4518
    BindingDB 14754.0
    TTD DAP000959
    Wikipedia Papaverine
    HET EV1
    DPD 6941|2957