D0781 | apigenin
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 1.61±0.00 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 3.55 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 28.93±9.26 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| ELECTRON TRANSPORT CHAIN | 105 μM | rat | brain MF0F1-ATPase | decrease | IC50 | 140 | ||
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| ATP synthase | 105 μM | rat | brain MF0F1-ATPase | inhibitor | IC50 | 140 | ||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Aggregated GHS information provided by 29 companies from 2 notifications to the ECHA C&L Inventory. Reported as not meeting GHS hazard criteria by 25 of 29 companies. For more detailed information, please visit ECHA C&L website Of the 1 notification(s) provided by 4 of 29 companies with hazard statement code(s): H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P273, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) | ||
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Warning |
Aggregated GHS information provided by 77 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 25 of 77 companies. For more detailed information, please visit ECHA C&L website Of the 6 notification(s) provided by 52 of 77 companies with hazard statement code(s): H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (98.08%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Warning |
Aggregated GHS information provided by 231 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H315 (28.57%): Causes skin irritation [Warning Skin corrosion/irritation] H412 (71.43%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P273, P280, P302+P352, P321, P332+P313, P362, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LCLo | inhalation | 24000ppm/4H (24000ppm) | National Technical Information Service. Vol. OTS0556683, | |
| rat | LD50 | oral | 3200mg/kg (3200mg/kg) | National Technical Information Service. Vol. OTS0556683, | |
| rabbit | LD50 | skin | > 5gm/kg (5000mg/kg) | Food and Cosmetics Toxicology. Vol. 12, Pg. 851, 1974. | |
| rat | LD50 | oral | 10gm/kg (10000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 615, 1969. | |
| 2-(p-Hydroxyphenyl)-5,7-dihydroxychromone | 20A365 | 3cf9 |
| 4 inverted exclamation mark ,5,7-trihydroxyflavone | 4 inverted exclamation marka,5,7-Trihydroxyflavone | 4′,5,7-Trihydroxyflavone |
| 4',5,7-Trihydroxyflavone | 4',5,7-Trihydroxyflavone | 4',5,7-Trihydroxyflavone, 97% |
| 4',5,7-trihydroxy-Flavone | 4',7-Trihydroxyflavone | 4,5, 7-Trihydroxyflavone |
| 4CN-0925 | 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)- | 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)- (9CI); |
| 4H-1-Benzopyran-4-one,7-dihydroxy-2-(4-hydroxyphenyl)- | 4der | 4dgm |
| 4hkk | 5,7,4'-Trihydroxyflavone | 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone |
| 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one | 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one # |
| 5,7-dihydroxy-2-(4-hydroxyphenyl)-chromen-4-one | 5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one | 5-18-04-00574 (Beilstein Handbook Reference) |
| 520-36-5 | 7V515PI7F6 | 8002-66-2 |
| A 3145 | AB0010536 | AB1011450 |
| AC-8011 | ACN-034762 | ACN-S003241 |
| ACon1_002450 | AK-88794 | AKOS002140699 |
| AX8015784 | Apigenin | Apigenin, 13 |
| Apigenin, >=95.0% (HPLC) | Apigenin, >=97% (TLC), from citrus | Apigenin, >=97% (TLC), from parsley, powder |
| Apigenin, United States Pharmacopeia (USP) Reference Standard | Apigenin, analytical standard | Apigenin, primary pharmaceutical reference standard |
| Apigenine | Apigenol | BBL010499 |
| BCP28288 | BDBM7458 | BIDD:ER0135 |
| BIK9018 | BPBio1_000406 | BRD-K01493881-001-10-4 |
| BRD-K01493881-001-17-9 | BRN 0262620 | BS0030 |
| BSPBio_000368 | BSPBio_003384 | Bio1_000376 |
| Bio1_000865 | Bio1_001354 | Biochem Biophys Res Comm 212: 767 (1997) |
| BiomolKI2_000082 | BiomolKI_000078 | C-16977 |
| C.I. Natural Yellow 1 | C01477 | CAS-520-36-5 |
| CC-24158 | CCG-40061 | CCRIS 3789 |
| CHEBI:18388 | CHEMBL28 | CS-5432 |
| Chamomile | Chamomile Powder | D50A2D8A-6D8B-4708-B21E-2DE9580D033F |
| DB07352 | DSSTox_CID_2391 | DSSTox_GSID_22391 |
| DSSTox_RID_76568 | DTXSID6022391 | DivK1c_000798 |
| EBD2138579 | EINECS 208-292-3 | EU-0100065 |
| FLAVONE, 4',5,7-TRIHYDROXY- | FT-0622445 | FT-0623582 |
| GP1532 | GTPL4136 | HMS1569C10 |
| HMS1922P22 | HMS2096C10 | HMS2230D17 |
| HMS3260M11 | HMS3267D21 | HMS3373B18 |
| HMS3412A08 | HMS3561P09 | HMS3655D18 |
| HMS3676A08 | HMS502H20 | HSCI1_000221 |
| HSDB 7573 | HY-N1201 | IDI1_000798 |
| J10341 | K00045 | KBio1_000798 |
| KBio3_002887 | KBioGR_002565 | KZNIFHPLKGYRTM-UHFFFAOYSA-N |
| LMPK12110005 | LP00065 | LS-2209 |
| LY 080400 | Lopac-A-3145 | Lopac0_000065 |
| M-6923 | MCULE-6141069907 | MEGxp0_000176 |
| MFCD00006831 | MLS000697626 | MLS000859991 |
| MLS001074874 | MLS006011839 | N1828 |
| NCGC00015049-01 | NCGC00015049-02 | NCGC00015049-03 |
| NCGC00015049-04 | NCGC00015049-05 | NCGC00015049-06 |
| NCGC00015049-07 | NCGC00015049-08 | NCGC00015049-09 |
| NCGC00015049-10 | NCGC00015049-11 | NCGC00015049-12 |
| NCGC00015049-13 | NCGC00015049-14 | NCGC00015049-15 |
| NCGC00015049-16 | NCGC00015049-18 | NCGC00025057-01 |
| NCGC00025057-02 | NCGC00025057-03 | NCGC00025057-04 |
| NCGC00025057-05 | NCGC00025057-06 | NCGC00025057-07 |
| NCGC00025057-08 | NCGC00025057-09 | NCGC00169835-01 |
| NCGC00169835-02 | NCGC00169835-03 | NCGC00256419-01 |
| NCGC00259092-01 | NCGC00260750-01 | NCI60_041830 |
| ND-9076 | NINDS_000798 | NSC 83244 |
| NSC-83244 | NSC83244 | Naringenin, 18 |
| OR7265T | Oprea1_622293 | Pelargidenon 1449 |
| Prestwick0_000414 | Prestwick1_000414 | Prestwick2_000414 |
| Prestwick3_000414 | Prestwick_719 | PubChem9831 |
| Q-100586 | Q-200822 | Q424567 |
| SBB066087 | SC-05011 | SCHEMBL19428 |
| SCHEMBL222227 | SDCCGMLS-0066379.P001 | SMP2_000338 |
| SMR000326850 | SPBio_000416 | SPBio_002307 |
| SPECTRUM200846 | SR-01000075663 | SR-01000075663-1 |
| SR-01000075663-3 | SR-01000075663-7 | SR-01000075663-8 |
| ST056301 | ST2411642 | STK801630 |
| SW196866-2 | SY005957 | Spectrum2_000428 |
| Spectrum3_001882 | Spectrum4_001999 | Spigenin |
| TC-307820 | TR-018510 | TRA0067512 |
| TS-00897 | Tocris-1227 | Tox21_201542 |
| Tox21_302884 | Tox21_500065 | UCCF 031 |
| UNII-7V515PI7F6 | Versulin | ZINC3871576 |
| ZX-AFC000435 | ZX-AT019281 | apigenin |
| cid_5280443 | ghl.PD_Mitscher_leg0.1194 | s2262 |