T005 Source: Uniprot

Compound Dose Time Species Model Method Result Positive criterion Reference
Sodium Azide 11 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
Benoxaprofen 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
Bezafibrate 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
Chlorpromazine 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
Dantrolene 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
Zidovudine Positive 307
Acyclovir Positive 307
Ganciclovir Positive 307
Zalcitabine Positive 307
Diclofenac 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
Fluconazole 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
Carbon Monoxide Positive 254
gefitinib 50 μM bovine heart mitochondria Measurement of complex IV activity Positive p < 0.05 3
Linezolid 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
Ciprofloxacin Positive 307
Metformin 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
Nefazodone 50 μM bovine heart mitochondria Measurement of complex IV activity Positive p < 0.001 3
paroxetine 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
pravastatin 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
Primaquine 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
radicicol 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
sertraline Positive 307
Fluoxetine Positive 307
Rosiglitazone 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
ethylxanthate Positive 167
bisulfate Positive 167
semicarbazide Positive 167
Simvastatin 50 μM bovine heart mitochondria Measurement of complex IV activity Positive p < 0.001 3
salicyaldoxime Positive 167
Tamoxifen 50 μM bovine heart mitochondria Measurement of complex IV activity Positive p < 0.001 3
trazodone 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
Acetylsalicylic acid Positive 35
Trovafloxacin 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
Peroxynitrite 2mM rat heart mitochondria oxidation of reduced cytochrome c oxidase at 550nm Negative 298
Tamoxifen 8.1 μM bovine heart mitochondria Measurement of complex V activity Positive IC50 3
Tamoxifen Positive 35
Amiodarone 50 μM bovine heart mitochondria Measurement of complex IV activity Positive p < 0.05 3