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Drug

D0444 | trazodone

Molecular Formula C19H22ClN5O
Molecular Weight 371.9
Structure
State solid
Protein binding 89-95% bound to plasma proteins in vitro
Half life Undergoes biphasic elimination with an initial phase t<sub>1/2 &alpha;</sub> of 3-6 hours and a terminal phase t<sub>1/2 &beta;</sub> of 5-9 hours.
Absorption Rapidly and almost completely absorbed following oral administration. Food may decrease the rate and extent of absorption.

N

N06AX05 Trazodone


[N06AX] Other antidepressants


[N06A] ANTIDEPRESSANTS


[N06] PSYCHOANALEPTICS


[N] Nervous system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTRON TRANSPORT CHAIN 50 μM bovine heart mitochondria Measurement of complex I activity Negative p < 0.05 3
ELECTRON TRANSPORT CHAIN 50 μM bovine heart mitochondria Measurement of complex II + III activity Negative p < 0.05 3
ELECTRON TRANSPORT CHAIN 50 μM bovine heart mitochondria Measurement of complex II + III activity Negative p < 0.05 3
ELECTRON TRANSPORT CHAIN 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
ELECTRON TRANSPORT CHAIN 50 μM bovine heart mitochondria Measurement of complex V activity Negative p < 0.05 3

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase 50 μM bovine heart mitochondria Measurement of complex I activity Negative p < 0.05 3
Succinate dehydrogenase 50 μM bovine heart mitochondria Measurement of complex II + III activity Negative p < 0.05 3
Quinol--cytochrome-c reductase 50 μM bovine heart mitochondria Measurement of complex II + III activity Negative p < 0.05 3
Cytochrome c oxidase 50 μM bovine heart mitochondria Measurement of complex IV activity Negative p < 0.05 3
ATP synthase 50 μM bovine heart mitochondria Measurement of complex V activity Negative p < 0.05 3

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 3 companies from 1 notifications to the ECHA C&L Inventory.


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P264, P270, P301+P312, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H351: Suspected of causing cancer [Warning Carcinogenicity]


 P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • 1,2,4-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)- 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]- 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one,2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-
    19794-93-5 2-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 2-(3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
    2-(3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one # 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,5-a]pyridin-3-one
    2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one; 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 794T935
    8-[3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl]-1,7,8-triazabicyclo[4.3.0]nona-2,4,6-trien-9-one hydrochloride AB00053648-14 AB00053648_15
    AB00053648_16 AC-6778 AKOS015896423
    API0000873 AX8215176 BCP07176
    BDBM50073444 BG0346 BPBio1_000248
    BRD-K70778732-003-05-1 BRD-K70778732-003-15-0 BRN 0628010
    BSPBio_000224 BSPBio_003040 Beneficat
    C07156 C19H22ClN5O CAS-25332-39-2
    CCG-205233 CHEBI:9654 CHEMBL621
    CTK4E2359 D08626 DB00656
    DTXSID5045043 Desirel DivK1c_000196
    EC 243-317-1 EINECS 243-317-1 FT-0658382
    GTPL213 HSDB 7048 IDI1_000196
    J10.767K KBio1_000196 KBio2_001904
    KBio2_004472 KBio2_007040 KBio3_002540
    KBioGR_001110 KBioSS_001904 L000771
    LS-156735 Lopac-T-6154 Lopac0_001159
    M979 MCULE-8110542411 NCGC00016035-01
    NCGC00016035-02 NCGC00016035-03 NCGC00016035-04
    NCGC00016035-05 NCGC00016035-06 NCGC00016035-07
    NCGC00016035-08 NCGC00016035-09 NCGC00016035-10
    NCGC00016035-12 NCGC00024405-03 NINDS_000196
    Oleptro Oprea1_185901 PHLBKPHSAVXXEF-UHFFFAOYSA-N
    Prestwick0_000292 Prestwick1_000292 Prestwick2_000292
    Prestwick3_000292 Q411457 SBI-0051126.P003
    SC-77266 SCHEMBL28167 SPBio_000867
    SPBio_002443 Sideril Spectrum2_000854
    Spectrum3_001560 Spectrum4_000755 Spectrum5_000974
    Spectrum_001424 Tradozone Trazalon
    Trazodil Trazodon Trazodona
    Trazodona [INN-Spanish] Trazodona [Spanish] Trazodone (INN)
    Trazodone [INN:BAN] Trazodonum Trazodonum [INN-Latin]
    Trazodonum [Latin] Trazonil Trittico (TN)
    UNII-YBK48BXK30 YBK48BXK30 ZINC538483
    s-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(m-chlorophenyl)-1-piperazinyl)propyl)- s5857 trazodone
    trazodone (Desyrel)

    DrugBank Name trazodone
    DrugBank DB00656
    CAS Number 19794-93-5, 25332-39-2
    PubChem Compound 5533
    KEGG Compound ID C07156
    KEGG Drug D08626
    ChEBI 9654
    PharmGKB PA451744