Compound

D1267 | cytovaricin

Molecular Formula C47H80O16
Molecular Weight 901.1
Structure
Description polyketide inhibitors of F0F1-ATPase,

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTRON TRANSPORT CHAIN 1 μM human NCI-60 cell lines, F0F1-ATPase decrease IC50 154
ELECTRON TRANSPORT CHAIN 0.4 μM S. cerevisiae membrane-bound F0F1-ATPase decrease Ki 161
APOPTOSIS 1 μM 60 human cancer cell lines of the National Cancer Institute mean 184

Target Dose Time Species Model Method Action Positive criterion Reference
ATP synthase 1 μM human NCI-60 cell lines, F0F1-ATPase inhibitor IC50 154
ATP synthase 0.4 μM S. cerevisiae membrane-bound F0F1-ATPase inhibitor Ki 161

Organism Test type Route Dose (normalized dose) Effect Source
mouse LDLo intraperitoneal 3130ug/kg (3.13mg/kg) Journal of Antibiotics. Vol. 34, Pg. 1073, 1981.


  • 79553-45-0 BRN 4226438 Cytovaricin
    H-230 LS-59152 NSC 349622

    CAS Number 79553-45-0
    PubChem Compound 6436235
    ChemSpider 4940885