D0462 | quetiapine

Molecular Formula C21H25N3O2S
Molecular Weight 383.5
State solid
Volume of distribution * 10±4 L/kg
Route of elimination Elimination of quetiapine is mainly via hepatic metabolism. Following a single oral dose of 14C-quetiapine, less than 1% of the administered dose was excreted as unchanged drug, indicating that quetiapine is highly metabolized. Approximately 73% and 20% of the dose was recovered in the urine and feces, respectively.
Protein binding 0.83
Half life 6 hours
Absorption Rapidly and well absorbed.


N05AH04 Quetiapine

[N05AH] Diazepines, oxazepines, thiazepines and oxepines



[N] Nervous system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTRON TRANSPORT CHAIN rat isolated liver mitochondria decrease 23

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase rat isolated liver mitochondria inhibitor 23

Pictogram Signal Statements Precautionary Statement Codes

Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H318 (50%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure

Respiratory tract irritation]

H400 (50%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H412 (50%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P261, P264, P270, P271, P273, P280, P301+P312, P304+P340, P305+P351+P338, P310, P312, P330, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H331: Toxic if inhaled [Danger Acute toxicity, inhalation]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]

H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P273, P280, P301+P310, P302+P352, P303+P361+P353, P304+P340, P307+P311, P311, P312, P321, P322, P330, P361, P363, P370+P378, P403+P233, P403+P235, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

  • (E)-2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethanol 11-[4-[2-(2-Hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine 111974-69-7
    2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethanol 2-(2-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethan-1-ol 2-(2-(4-Dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)ethanol
    2-(2-(4-dibenzo[b,f]-[1,4]thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol 2-(2-(4-dibenzo[b,f][1,4] thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol
    2-[2-(4-benzo[b][1,5]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethoxy]ethanol 2-[2-(4-{2-thia-9-azatricyclo[^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-10-yl}piperazin-1-yl)ethoxy]ethan-1-ol
    2-{2-[4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl]ethoxy}ethanol 2-{[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethyl]oxy}ethanol 4769-EP2272537A2
    4769-EP2272841A1 4769-EP2275420A1 4769-EP2298731A1
    4769-EP2301936A1 4769-EP2308867A2 4769-EP2308870A2
    74Q697 AB00640033-09 AB00640033-10
    AB00640033_11 AB00640033_12 AKOS003588973
    API0004010 AS-35258 BBL029071
    BCP23508 BDBM50095890 BGL0JSY5SI
    BIDD:GT0279 BRD-K68867920-001-05-2 C07397
    C21H25N3O2S CAS-111974-69-7 CCG-213347
    CHEBI:8707 CHEMBL716 CS-1171
    CTK8F1296 Co-Quetiapine D08456
    DB01224 DSSTox_CID_3546 DSSTox_GSID_23546
    DSSTox_RID_77073 DTXSID9023546 ETH065
    Ethanol, 2-(2-(4-dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)- Ethanol, 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]- FK949E
    FT-0658790 GTPL50 HMS2093K06
    HMS2231O11 HMS3372B05 HMS3744E21
    HSDB 7557 HY-14544 InChI=1/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2;
    L001200 LS-172170 M872
    MLS001165710 MLS001195658 MRF-0000010
    NCGC00095911-01 NCGC00095911-03 NCGC00095911-04
    NCGC00095911-06 NSC-758918 NSC758918
    Norsic (TN) Pharmakon1600-01505187 Q408535
    Quetiapin Quetiapine (INN) Quetiapine [INN:BAN]
    Quetiapine fumarate RT-015180 SBI-0206776.P001
    SC-19077 SCHEMBL7932 SMR000550491
    SPECTRUM1505187 SR-01000759335 SR-01000759335-5
    SR-01000759335-7 STL373578 Seroquel
    Seroquel (Fumarate) Tox21_111537 Tox21_111537_1
    W-5151 ZINC19632628 ZM-204636
    quetiapina quetiapine quetiapinum

    DrugBank Name quetiapine
    DrugBank DB01224
    CAS Number 1031703-35-1, 111974-69-7, 111974-72-2
    PubChem Compound 5002
    KEGG Compound ID C07397
    KEGG Drug D08456
    ChEBI 8707
    PharmGKB PA451201