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D0568 | efrapeptins

Molecular Formula X
Molecular Weight X
Structure
Description peptides produced by fungi in the genus Tolypocladium that have antifungal, insecticidal, and mitochondrial ATPase inhibitory activities

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTRON TRANSPORT CHAIN affect 170
ELECTRON TRANSPORT CHAIN 0.56 mol/mol F1 bovine heart MF1-ATPase decrease IC50 134
ELECTRON TRANSPORT CHAIN 70 ng/ml C. asciculate MF1-ATPase decrease IC50 135
ELECTRON TRANSPORT CHAIN 0.3 μM human umbilical vein endothelial cell, nonmitochondrial ATP synthase decrease IC50 136
ELECTRON TRANSPORT CHAIN 0.5 μg/ml R. rubrum chromatophores decrease IC50 137
ELECTRON TRANSPORT CHAIN 0.05-0.5 μg of inhibitor/mg protein T. pyriformis SMP-ATPase decrease IC50 138
ELECTRON TRANSPORT CHAIN 21.5 μM EF1-ATPase decrease ki 139
ELECTRON TRANSPORT CHAIN 10 nM bovine heart MF1-ATPase decrease kd 134
ELECTRON TRANSPORT CHAIN 2.4 mol inhibitor/mol enzyme bovine heart SMP-ATPase decrease complete inhibition 134

Target Dose Time Species Model Method Action Positive criterion Reference
ATP synthase 0.56 mol/mol F1 bovine heart MF1-ATPase inhibitor IC50 134
ATP synthase 70 ng/ml C. asciculate MF1-ATPase inhibitor IC50 135
ATP synthase 0.3 μM human umbilical vein endothelial cell, nonmitochondrial ATP synthase inhibitor IC50 136
ATP synthase 0.5 μg/ml R. rubrum chromatophores inhibitor IC50 137
ATP synthase 0.05-0.5 μg of inhibitor/mg protein T. pyriformis SMP-ATPase inhibitor IC50 138
ATP synthase 21.5 μM EF1-ATPase inhibitor ki 139
ATP synthase 10 nM bovine heart MF1-ATPase inhibitor kd 134
ATP synthase 2.4 mol inhibitor/mol enzyme bovine heart SMP-ATPase inhibitor complete inhibition 134
F1 subunits inhibitor 170