Drug

D0502 | propranolol

Molecular Formula C16H21NO2
Molecular Weight 259.34
Structure
State solid
Volume of distribution * 4 L
Route of elimination Propranolol is extensively metabolized with most metabolites appearing in the urine.
Protein binding More than 90%
Half life 4 hours
Absorption Propranolol is almost completely absorbed from the GI tract; however, plasma concentrations attained are quite variable among individuals.
Trade names Inderal
Description beta blocker

C

C07FX01 Propranolol and other combinations


[C07FX] Beta blocking agents, other combinations


[C07F] BETA BLOCKING AGENTS, OTHER COMBINATIONS


[C07] BETA BLOCKING AGENTS


[C] Cardiovascular system


C07BA05 Propranolol and thiazides


[C07BA] Beta blocking agents, non-selective, and thiazides


[C07B] BETA BLOCKING AGENTS AND THIAZIDES


[C07] BETA BLOCKING AGENTS


[C] Cardiovascular system


C07AA05 Propranolol


[C07AA] Beta blocking agents, non-selective


[C07A] BETA BLOCKING AGENTS


[C07] BETA BLOCKING AGENTS


[C] Cardiovascular system


Toxicity Dose Time Species Model Method Action Positive criterion Reference
UNCOUPLING rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay Negative 53
ELECTROPHORETIC UNCOUPLING 278
ELECTRON TRANSPORT CHAIN pig brain mitochondria decrease 60
ELECTRON TRANSPORT CHAIN rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay Negative 53

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory.


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P264, P270, P301+P312, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
man LDLo oral 137mg/kg (137mg/kg) Journal of Forensic Sciences. Vol. 27, Pg. 213, 1982.
women LDLo oral 120mg/kg (120mg/kg) Acta Pharmacologica et Toxicologica. Vol. 41, Pg. 190, 1977.
human TDLo oral 2300ug/kg/D (2.3mg/kg) behavioral: "hallucinations, distorted perceptions" British Medical Journal. Vol. 1, Pg. 1182, 1978.
cat LD50 intravenous 23mg/kg (23mg/kg) Polish Journal of Pharmacology and Pharmacy. Vol. 32, Pg. 833, 1980.
mouse LD50 subcutaneous 150mg/kg (150mg/kg) Farmakologiya i Toksikologiya Vol. 44, Pg. 342, 1981.
man TDLo oral 8343mg/kg/4Y- (8343mg/kg) endocrine: evidence of thyroid hyperfunction Archives of Internal Medicine. Vol. 143, Pg. 2193, 1983.
women TDLo oral 708mg/kg/39W- (708mg/kg) Annals of Pharmacotherpy. Vol. 27, Pg. 512, 1993.
human LDLo intravenous 71ug/kg (0.071mg/kg) Lancet. Vol. 1, Pg. 165, 1967.
rat LD50 intravenous 2750ug/kg (2.75mg/kg) Polish Journal of Pharmacology and Pharmacy. Vol. 32, Pg. 823, 1980.
guinea pig LD50 intravenous 26mg/kg (26mg/kg) Dissertationes Pharmaceuticae et Pharmacologicae. Vol. 24, Pg. 103, 1972.
man TDLo oral 45714ug/kg (45.714mg/kg) Pediatric Emergency Care. Vol. 15, Pg. 262, 1999.
rat LD50 intravenous 23mg/kg (23mg/kg) Pharmazie. Vol. 31, Pg. 635, 1976.
child LDLo oral 800ug/kg/12H (0.8mg/kg) British Medical Journal. Vol. 2, Pg. 254, 1978.
mouse LD50 oral 289mg/kg (289mg/kg) autonomic nervous system: beta adrenergic blockage Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1831, 1980.
women TDLo oral 3200ug/kg/2D- (3.2mg/kg) endocrine: hypoglycemia Israel Journal of Medical Sciences. Vol. 18, Pg. 725, 1982.
rabbit LD50 intravenous 18500ug/kg (18.5mg/kg) Polish Journal of Pharmacology and Pharmacy. Vol. 32, Pg. 833, 1980.
man TDLo unreported 22857ug/kg/40 (22.857mg/kg) sense organs and special senses: change in acuity: ear British Medical Journal. Vol. 289, Pg. 1490, 1984.
dog LDLo oral 120mg/kg (120mg/kg) Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69(4), Pg. 262P, 1973.
child TDLo oral 400mg/kg (400mg/kg) Medical Journal of Australia. Vol. 1, Pg. 82, 1981.
mouse LD50 intravenous 24400ug/kg (24.4mg/kg) United States Patent Document. Vol. #4013663,
rat LD50 oral 660mg/kg (660mg/kg) Pharmazie. Vol. 31, Pg. 635, 1976.
mouse LD50 intraperitoneal 42mg/kg (42mg/kg) autonomic nervous system: beta adrenergic blockage Ain Shams Medical Journal. Vol. 30, Pg. 23, 1979.
dog LDLo intraperitoneal 40mg/kg (40mg/kg) behavioral: convulsions or effect on seizure threshold Pharmazie. Vol. 31, Pg. 635, 1976.


  • (+-)-Propranolol (+/-)-Propranolol-D7 (ring-D7) solution, 100 mug/mL in methanol with 5% 1 M HCl, ampule of 1 mL, certified reference material; (.+/-.)-Propranolol
    (1)-1-(Isopropylamino)-3-(naphthyloxy)propan-2-ol (A+/-)-Propranolol hydrochloride .beta.-Propranolol
    1(-alpha-naphthoxy)-3-(iso-propylamino)-2-propanol 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol 1-((1-Methylethyl)amino)-3-(1-naphthyloxy)-2-propanol
    1-(1-Naphthyloxy)-2-hydroxy-3-(isopropylamino)propane 1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol 1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol
    1-(alpha-naphthoxy)-3-(iso-propylamino)-2-propanol 1-(alpha-naphthoxy)-3-(isopropylamino)-2-propanol 1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol
    1-(isopropylamino)-3-naphthalen-1-yloxy-propan-2-ol 1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol 1-Isopropylamino-3-(1-naphthyloxy)-2-propanol
    1-[(1-methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol 13013-17-7
    2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)- 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)- (9CI) 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)-
    2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)- (9CI) 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)- 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)-, (+-)-
    2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)- 3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol 3-[(methylethyl)amino]-1-naphthyloxypropan-2-ol
    525-66-6 525P666 AB00053537
    AB00053537-10 AB00053537_11 AB00053537_12
    AB0108847 AKOS000588816 AKOS016050338
    ALBB-023324 AQHHHDLHHXJYJD-UHFFFAOYSA-N ARONIS27011
    AY 20694 AY-20694 AY-64043-
    Anapriline Avlocardyl Avlocardyl (Salt/Mix)
    BBL023437 BCP26001 BDBM25761
    BPBio1_001040 BRD-A10070317-003-06-9 BRD-A10070317-003-17-6
    BSPBio_000944 BSPBio_002682 Bedranol
    Betadren Betalong Bio1_000367
    Bio1_000856 Bio1_001345 C07407
    CBDivE_006180 CCG-103643 CCRIS 3082
    CHEBI:8499 CHEMBL27 CS-0069968
    CTK8I6896 Corpendol D,L-Propranolol
    D08443 DB00571 DTXSID6023525
    DivK1c_000023 Dociton Dociton (Salt/Mix)
    EINECS 208-378-0 EINECS 235-867-6 EN300-40731
    Euprovasin F0001-3681 FE-0204
    FT-0700657 GTPL564 HMS2090L21
    HMS3428G03 HY-B0573B ICI 45520 (Salt/Mix)
    IDI1_000023 Inderal Inderal (Salt/Mix)
    Inderal hydrochloride Inderol KBio1_000023
    KBio2_002515 KBio2_005083 KBio2_007651
    KBio3_001766 KBio3_001902 KBio3_002993
    KBioGR_001347 KBioGR_001684 KBioGR_002515
    KBioSS_002523 KS-00002WT3 L000679
    LS-122410 LS-184129 Lopac0_000896
    MCULE-7804628650 NCGC00015798-04 NCGC00015798-05
    NCGC00015798-06 NCGC00015798-07 NCGC00015798-08
    NCGC00015798-09 NCGC00024690-02 NCGC00024690-03
    NINDS_000023 NSC 91523 (Salt/Mix) NSC91523
    Obsidan (Salt/Mix) Obzidan Oprea1_304193
    PDSP1_000767 PDSP1_001607 PDSP1_001608
    PDSP2_000755 PDSP2_001591 PDSP2_001592
    PROPANOLOL(-) PROPRANOLOL, d PROPRANOLOL,(+)
    PROPRANOLOL,(-) Pranolol Prestwick0_000952
    Prestwick1_000952 Prestwick2_000952 Prestwick3_000952
    Propanalol Propanix Propanolol
    Propanolol [INN-Spanish] Propanolol,(+/-) Propranalol
    Propranolol (INN) Propranolol (TN) Propranolol [INN:BAN]
    Propranololo [DCIT] Propranololum Propranololum [INN-Latin]
    Proprasylyt Q423364 Racemic propranolol
    Reducor SBI-0050871.P003 SCHEMBL12264958
    SCHEMBL3955 SPBio_001361 SPBio_001658
    SPBio_003093 ST024757 STK735510
    Sawatal Spectrum2_001301 Spectrum2_001699
    Spectrum3_000883 Spectrum3_001071 Spectrum4_000974
    Spectrum4_001222 Spectrum5_000751 Sumial
    T7896 W-109550 [2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine
    b-Propranolol beta-Propranolol cMAP_000071
    dl-propranolol hemangiol propranolol
    propranololo racemic-Propranolol

    DrugBank Name propranolol
    DrugBank DB00571
    CAS Number 13013-17-7, 13071-11-9, 318-98-9, 4199-10-4, 501-30-4, 5051-22-9, 525-66-6
    PubChem Compound 4946
    KEGG Compound ID C07407
    KEGG Drug D08443
    ChEBI 8499
    PharmGKB PA451145