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Drug

D1256 | Dequalinium Chloride

Molecular Formula C30H40Cl2N4
Molecular Weight 527.6
Structure
State solid
Absorption The degree of absorption is minimal in case of topical or vaginal administration thus systemic exposure is negligible. <0.1 % is absorbed systemically after oral administration.
Description quaternary ammonium cation and bolaamphiphile; antiseptic and disinfectant;

D

G

R

R02AA02 Dequalinium


[R02AA] Antiseptics


[R02A] THROAT PREPARATIONS


[R02] THROAT PREPARATIONS


[R] Respiratory system

G01AC05 Dequalinium


[G01AC] Quinoline derivatives


[G01A] ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS


[G01] GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS


[G] Genitourinary system and reproductive hormones

D08AH01 Dequalinium


[D08AH] Quinoline derivatives


[D08A] ANTISEPTICS AND DISINFECTANTS


[D08] ANTISEPTICS AND DISINFECTANTS


[D] Dermatological drugs

Toxicity Dose Time Species Model Method Action Positive criterion Reference
TRANSMEMBRANE POTENTIAL 1 hr Ishikawa and Caco-2 JC-10 fluorescent dye decrease 299
ELECTRON TRANSPORT CHAIN 11 μM NADH:O2 decrease IC50 120
ROS PRODUCTION 14.24 ± 0.59, 57.85 ± 3.59, 93.31 ± 3.21 and 179.2 ± 5.2 μM 24 hr Ishikawa, MDA-MB-231, PC-3 and Caco-2 Intracellular ROS (a) and mitochondrial superoxide were measured by fluorescence intensity of H2DCFDA and MitoSOX respectively. increase IC50 299
MITOCHONDRIAL DNA METABOLIC PROCESS 24 hr Caco-2 and Ishikawa cells Relative quantification of mtDNA copy number was measured using the QuantiTect SYBR Green PCR kit decrease 299
APOPTOSIS 24 hr Ishikawa and Caco-2 WB was performed to measure the BCL-XL and released cytochrome c proteins from mitochondria; Caspase-3/7 activity was measured using the Caspase-Glo 3/7 reagent from the ApoTox-Glo Triplex Assay kit induce 299

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase 11 μM NADH:O2 inhibitor IC50 120

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 67 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 1 of 67 companies. For more detailed information, please visit ECHA C&L website


Of the 5 notification(s) provided by 66 of 67 companies with hazard statement code(s):


H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • 1,1 inverted exclamation marka-Decamethylenebis(4-aminoquinaldinium) dichloride 1,1'-(1,10-Decanediyl)bis(4-amino-2-methylquinolinium) dichloride 1,1'-(decane-1,10-diyl)bis(4-amino-2-methylquinolinium) chloride
    1,1'-DECAMETHYLENEBIS(4-AMINOQUINALDINIUM CHLORIDE 1,1'-Decamethylenebis(4-aminoquinaldinium chloride) 1,1'-Decamethylenebis(4-aminoquinaldinium) dichloride
    1,1'-decane-1,10-diylbis(4-amino-2-methylquinolinium) dichloride 1,10-Decamethylene-bis(4-aminoquinaldinium chloride) 1-[10-(4-amino-2-methylquinolin-1-ium-1-yl)decyl]-2-methylquinolin-1-ium-4-amine;dichloride
    1-[10-(4-amino-2-methylquinolyl)decyl]-2-methyl-4-quinolylamine, chloride, chl oride 522-51-0 AB1003158
    AKOS015895242 API0014417 Angils
    BAQD 10 BAQD-10 BCP21273
    BN0180 C-23091 C30H40Cl2N4
    C30H40N4 CAS-522-51-0 CC-26341
    CCG-213734 CHEBI:31466 CHEMBL121663
    CS-2676 CTK8F9037 Certified Reference Material
    Chlorure de dequalinium Chlorure de dequalinium [INN-French] Cloruro de decalinio
    Cloruro de decalinio [INN-Spanish] D 3768 D01575
    DB-052103 DECA DSSTox_CID_25144
    DSSTox_GSID_45144 DSSTox_RID_80700 DTXSID3045144
    Danical Decabis Decamethylenebis(4-aminoquinaldinium chloride)
    Decamine Decamine (pharmaceutical) Decaminum
    Decosan Dekadin Dekamin
    Dekuarin Dequadin Dequafungan
    Dequalin chloride Dequalinii chloridum Dequalinii chloridum [INN-Latin]
    Dequalinio cloruro Dequalinio cloruro [DCIT] Dequalinium (Chloride)
    Dequalinium Dichloride Dequalinium chloride (JAN/INN) Dequalinium chloride [INN:BAN:JAN]
    Dequalinium chloride for performance test, European Pharmacopoeia (EP) Reference Standard Dequalinium chloride hydrate Dequalinium chloride, European Pharmacopoeia (EP) Reference Standard
    Dequalinium chloride, Pharmaceutical Secondary Standard Dequalinum Chloride Dequavagyn
    Dequavagyn Dequavet Dynexan-mhp
    EINECS 208-330-9 EU-0100338 Efisol
    Eriosept Erosept Evazol
    FT-0603110 Gorgine Grocreme
    HMS1569M17 HMS1922G11 HMS2096M17
    HMS3261C17 HMS3713M17 HMS502F14
    HY-B0567 Ivazil LP00338
    LS-139898 Labosept MCULE-5255183860
    NCGC00015339-02 NCGC00093777-01 NCGC00093777-02
    NCGC00093777-03 NCGC00261023-01 NSC 166454
    NSC 166454 NSC-166454 NSC-166454
    NSC166454 Nordman (TN) Optipect
    Oralgol Phylletten Polycidine
    Q5261117 Quinaldinium, 1,1'-decamethylenebis(4-amino)-, dichloride Quinaldinium, 1,1'-decamethylenebis(4-amino-, dichloride
    Quinolinium, 1,1'-(1,10-decanediyl)bis(4-amino-2-methyl-, dichloride Quinolinium, 1,1'-(1,10-decanediyl)bis(4-amino-2-methyl-, dichloride (9CI) Quinolinium, 1,1'-(1,10-decanediyl)bis[4-amino-2-methyl-, dichloride
    Rumilet SC-22665 SCHEMBL34043
    SPECTRUM1503127 SR-01000075814 SR-01000075814-1
    SR-01000075814-3 SR-01000075814-6 SR-01000075814-7
    ST50981059 Sanoral Sentril
    Sorot Tox21_110128 Tox21_500338
    UNII-XYS8INN1I6 Vaster W-105841
    XYS8INN1I6 dequalinium chloride quinolinium, 1,1'-(1,10-decanediyl)bis[4-amino-2-methyl-, chloride (1:2)
    s4066

    DrugBank Name Dequalinium
    DrugBank DB04209
    CAS Number 522-51-0
    PubChem Compound 10649
    KEGG Drug D01575
    ChEBI 31466
    ChemSpider 10201
    Wikipedia Dequalinium