MITOTOX

Compound

D0516 | stigmatellin

Molecular Formula	C30H42O7
Molecular Weight	514.6
Structure
Description	potent inhibitor of the quinol oxidation (Qo) site of the cytochrome bc1 complex in mitochondria and the cytochrome b6f complex of thylakoid membranes; Stigmatellin binds at the cytochrome b Qo site in the '(heme) bl distal' position, and associates with the Rieske iron-sulfur protein

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
ELECTRON TRANSPORT CHAIN						affect		53
ELECTRON TRANSPORT CHAIN	100 mM	incubated overnight	bovine	isolated heart mitochondria	Measurements of redox potentials of the ISP	affect		83
ELECTRON TRANSPORT CHAIN	100 nmol/mg		bovine	mitochondria	NADH–Q	decrease	IC50	99

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
NADH:ubiquinone reductase	100 nmol/mg		bovine	mitochondria	NADH–Q	inhibitor	IC50	99
quinol						antagonist		53
Cytochrome b								185
Qo site (Qp site or ubiquinol oxidation site)	100 mM	incubated overnight	bovine	isolated heart mitochondria	Measurements of redox potentials of the ISP	fixed conformation		83

Pictogram	Signal	Statements	Precautionary Statement Codes
	Danger	The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]	P264, P270, P301+P310, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Danger

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

P264, P270, P301+P310, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism	Test type	Route	Dose (normalized dose)	Effect	Source
mouse	LD50	oral	30mg/kg (30mg/kg)		Journal of Antibiotics. Vol. 37, Pg. 454, 1984.
mouse	LD50	subcutaneous	2mg/kg (2mg/kg)		Journal of Antibiotics. Vol. 37, Pg. 454, 1984.

2-((7E,9E,11E)-4,6-dimethoxy-3,5,11-trimethyltrideca-7,9,11-trienyl)-8-hydroxy-5,7-dimethoxy-3-methyl-4H-chromen-4-one;	91682-96-1	SCHEMBL14066517
stigmatellin