Compound

D0145 | Fenpyroximate

Molecular Formula C24H27N3O4
Molecular Weight 421.5
Structure
Description acaricide/insecticide; inhibits mitochondrial electron transport at the NADH-coenzyme Q oxidoreductase (complex I)

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTRON TRANSPORT CHAIN 4.6 nM NADH–Q-1 decrease IC50 108
ELECTRON TRANSPORT CHAIN 18 nM NADH–Q decrease IC50 103
GLUCOSE GALACTOSE IC50 RATIO 5600 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay EC25(NA) [Glc/Gal] 326

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase 4.6 nM NADH–Q-1 inhibitor IC50 108
NADH:ubiquinone reductase 18 nM NADH–Q inhibitor IC50 103
NADH:ubiquinone reductase 5600 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay EC25(NA) [Glc/Gal] 326

Pictogram Signal Statements Precautionary Statement Codes
Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]


H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H330: Fatal if inhaled [Danger Acute toxicity, inhalation]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P310, P302+P352, P304+P340, P310, P320, P321, P330, P333+P313, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

Aggregated GHS information provided by 210 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]


H317 (99.52%): May cause an allergic skin reaction [Warning Sensitization, Skin]


H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]


H373 (100%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P310, P302+P352, P304+P340, P310, P314, P320, P321, P330, P333+P313, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]


H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P261, P271, P273, P304+P312, P304+P340, P312, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P264, P270, P273, P301+P312, P330, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]


H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H330: Fatal if inhaled [Danger Acute toxicity, inhalation]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P310, P302+P352, P304+P340, P310, P320, P321, P330, P333+P313, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]


H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H320: Causes eye irritation [Warning Serious eye damage/eye irritation]


H330: Fatal if inhaled [Danger Acute toxicity, inhalation]


H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]


H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


P260, P261, P264, P270, P271, P272, P280, P284, P301+P310, P302+P352, P304+P340, P305+P351+P338, P307+P311, P310, P314, P320, P321, P330, P333+P313, P337+P313, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • (E)-Fenpyroximate (E)-Fenpyroximate 10 microg/mL in Acetonitrile (E)-Fenpyroximate 10 microg/mL in Cyclohexane
    (E)-Fenpyroximate 100 microg/mL in Cyclohexane (E)-Fenpyroximate 100 microg/mL in Methanol (Z)-Fenpyroximate
    (Z,E)-Fenpyroximate 098F616 111812-58-9
    134098-61-6 4-[[(E)-(1,3-dimethyl-5-phenoxy-4-pyrazolyl)methylideneamino]oxymethyl]benzoic acid tert-butyl ester 4-[[[(E)-[(1,3-Dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene]amino]oxy]methyl]benzoic Acid tert-Butyl Ester
    9W557V4RYA A806730 AKOS015895778
    Acari Assault Benzoic acid, 4-(((((1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene)amino)oxy)methyl)-, 1,1-dimethylethyl ester, (E)-
    Benzoic acid, 4-((((E)-((1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene)amino)oxy)methyl)-, 1,1-dimethylethyl ester Benzoic acid, 4-(1,3-dimethyl-5-phenoxy-1H-pyrazol-4- yl)methyleneaminooxymethyl-, 1,1-dimethylethyl ester Benzoic acid,4-[[[(E)-[(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene]amino]oxy]methyl]-, 1,1-dimethylethyl ester
    C11098 CAS-111812-58-9 CHEBI:5011
    CHEMBL365100 DL-Fenpyroximate DSSTox_CID_12550
    DSSTox_GSID_32550 DSSTox_RID_78979 DTXSID7032557
    Danitron F1195 FENPYROXYMATE
    Fenpyroximate Fenpyroximate (Z,E) Fenpyroximate [ISO]
    Fenpyroximate, DL Fenpyroximate, PESTANAL(R), analytical standard FujiMite
    HSDB 7943 InChI=1/C24H27N3O4/c1-17-21(22(27(5)26-17)30-20-9-7-6-8-10-20)15-25-29-16-18-11-13-19(14-12-18)23(28)31-24(2,3)4/h6-15H,16H2,1-5H3/b25-15+ K-4223
    KS-5364 Kendo LS-37235
    NCGC00163915-01 NCGC00163915-02 NCGC00163915-03
    NCGC00163915-04 NCGC00163915-05 NCGC00163915-06
    NCGC00254802-01 NNI 850 Naja
    Ortus Pesticide4_Fenpyroximate_C24H27N3O4_tert-Butyl 4-[({[(1E)-(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylidene]amino}oxy)methyl]benzoate Q27265074
    SC-12556 SCHEMBL74176 Tox21_300898
    UNII-9W557V4RYA YYJNOYZRYGDPNH-MFKUBSTISA- YYJNOYZRYGDPNH-MYYYXRDXSA-N
    ZINC25763821 fenperoximate t-Butyl (E)-alpha-(1,3-dimethyl-5-phenoxypyrazol-4-ylmethyleneaminooxy)-p-toluate (IUPAC)
    t-butyl (E)-alpha-(1,3-dimethyl-5-phenoxypyrazol-4-ylmethyleneaminooxy)-p-toluate tert-Butyl 4-({[(E)-1,3-dimethyl-5-phenoxypyrazol-4-yl]methyl}aminooxymethyl)benzoate tert-Butyl 4-[[[(E)-[(1,3-Dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene]amino]oxy]methyl]benzoate
    tert-butyl 4-[({[(1E)-(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene]amino}oxy)methyl]benzoate tert-butyl 4-[[(E)-(1,3-dimethyl-5-phenoxy-pyrazol-4-yl)methylideneamino]oxymethyl]benzoate tert-butyl 4-[[(E)-(1,3-dimethyl-5-phenoxypyrazol-4-yl)methylideneamino]oxymethyl]benzoate
    tert-butyl 4-[[[1,3-dimethyl-5-(phenoxy)pyrazol-4-yl]methylideneamino]oxymethyl]

    CAS Number 111812-58-9, 134098-61-6
    PubChem Compound 9576412
    KEGG Compound ID C11098
    ChEBI 5011
    ChemSpider 7850857
    Wikipedia Fenpyroximat