D0172 | Diethylstilbestrol
G
L
L02AA04 Fosfestrol
[L02AA] Estrogens
[L02A] HORMONES AND RELATED AGENTS
[L02] ENDOCRINE THERAPY
[L] Antineoplastic and immunomodulating agents
L02AA01 Diethylstilbestrol
[L02AA] Estrogens
[L02A] HORMONES AND RELATED AGENTS
[L02] ENDOCRINE THERAPY
[L] Antineoplastic and immunomodulating agents
G03CC05 Diethylstilbestrol
[G03CC] Estrogens, combinations with other drugs
[G03C] ESTROGENS
[G03] SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
[G] Genitourinary system and reproductive hormones
G03CB02 Diethylstilbestrol
[G03CB] Synthetic estrogens, plain
[G03C] ESTROGENS
[G03] SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
[G] Genitourinary system and reproductive hormones
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 9.76±6.25 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 5.62 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 6.31 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 42.80±10.35 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 25.19±21.68 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| ELECTRON TRANSPORT CHAIN | 10 μM | rat | liver MF0F1-ATPase | decrease | 143 | |||
| ELECTRON TRANSPORT CHAIN | 10-25 μM | rat | brain MF0F1-ATPase | decrease | 141 | |||
| GLUCOSE GALACTOSE IC50 RATIO | 1 | LUHMES (Lund human mesencephalic) cells | Glc–Gal–NeuriTox assay | Negative | EC25(NA) [Glc/Gal] | 326 | ||
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| ATP synthase | 10 μM | rat | liver MF0F1-ATPase | inhibitor | 143 | |||
| ATP synthase | 10-25 μM | rat | brain MF0F1-ATPase | inhibitor | 141 | |||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
   |
Danger |
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H350 (100%): May cause cancer [Danger Carcinogenicity] H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] |
P201, P202, P264, P273, P280, P281, P302+P352, P305+P351+P338, P308+P313, P321, P332+P313, P337+P313, P362, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 300mg/kg (300mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 666, 1968. | |
| mouse | LD50 | oral | > 3gm/kg (3000mg/kg) | Drugs of the Future. Vol. 8, Pg. 413, 1983. | |
| mouse | LDLo | subcutaneous | 500mg/kg (500mg/kg) | Klinische Wochenscrift. Vol. 18, Pg. 156, 1939. | |
| mouse | LD50 | intraperitoneal | 538mg/kg (538mg/kg) | Drugs of the Future. Vol. 8, Pg. 413, 1983. | |
| human | TDLo | skin | 60ug/kg/14D (0.06mg/kg) | skin and appendages (skin): breast: other | American Industrial Hygiene Association Journal. Vol. 20, Pg. 469, 1959. |
| women | TDLo | oral | 375ug/kg/30D- (0.375mg/kg) | American Journal of Psychiatry. Vol. 151, Pg. 1246, 1994. | |
| rat | LD50 | oral | > 3gm/kg (3000mg/kg) | Drugs of the Future. Vol. 8, Pg. 413, 1983. | |
| rat | LD50 | intraperitoneal | 34mg/kg (34mg/kg) | Toxicology and Applied Pharmacology. Vol. 24, Pg. 142, 1973. | |
| (Z)-4,4'-(hex-3-ene-3,4-diyl)diphenol | (Z,E)-Diethylstilbestrol | 22610-99-7 |
| 4,4'-(3-HEXENE-3,4-DIYL)DIPHENOL | 4,4'-(Hex-3-ene-3,4-diyl)diphenol | 4,4'-hex-3-ene-3,4-diyldiphenol |
| 4-[4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | 6898-97-1 | A23912 |
| AC-12170 | ACMC-209o5h | AI3-17297 |
| AK113608 | AKOS025401352 | ANW-35571 |
| C18H20O2 | CAS-6898-97-1 | CCRIS 9140 |
| CHEMBL2135534 | CTK3J1177 | CTK6C6263 |
| CTK8F8699 | DB-052931 | DB00255 |
| DSSTox_CID_20770 | DSSTox_GSID_40770 | DSSTox_RID_79594 |
| DTXSID3040770 | Diethylstilbestrol BP | Diethylstilbestrol,(S) |
| Diethylstilbestrol,mixture of cis and trans | DivK1c_000519 | FT-0603236 |
| FT-0624909 | FT-0666798 | HMS3655E18 |
| HMS3746G09 | KBio1_000519 | KBio2_001420 |
| KBio2_003988 | KBio2_006556 | KBio3_001421 |
| KBioGR_001083 | KBioSS_001420 | KS-00000G1O |
| KS-0000113R | KS-000046H0 | KSC491C7P |
| LS-176713 | MCULE-1184803692 | NCGC00090749-04 |
| NCGC00090749-11 | NCGC00090749-12 | NCGC00188969-02 |
| NINDS_000519 | Oprea1_042748 | Phenol, 4,4'-(1,2-diethyl-1,2-ethenediyl)bis- |
| Prestwick0_000756 | Prestwick1_000756 | Q27164556 |
| SPBio_000256 | SPBio_002711 | Spectrum2_000148 |
| Spectrum3_000391 | Spectrum4_000512 | Spectrum_000940 |
| Tox21_111005 | Tox21_111005_1 | Z2197067559 |
| cis-Diethyl Stilbestrol | cis-Diethylstilbestrol | cpd w/o stereochem designation |
| DrugBank Name | Diethylstilbestrol |
| DrugBank | DB00255 |
| CAS Number | 22610-99-7, 56-53-1, 6898-97-1 |
| PubChem Compound | 3054 |
| KEGG Compound ID | C07620 |
| KEGG Drug | D00577 |
| PubChem.Substance | 46507453 |
| ChEBI | 41922 |
| PharmGKB | PA449307 |
| ChemSpider | 395306 |
| BindingDB | 20625.0 |
| TTD | DAP001011 |
| Wikipedia | Diethylstilbestrol |
| HET | DES |
| DPD | 7384|7380 |