Compound
D0482 | retinoic acid
L
L01XX14 Tretinoin
[L01XX] Other antineoplastic agents
[L01X] OTHER ANTINEOPLASTIC AGENTS
[L01] ANTINEOPLASTIC AGENTS
[L] Antineoplastic and immunomodulating agents
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| BASAL RESPIRATION | 100 mM | zebrafish | XFe24 Extracellular Flux Analyzer | Negative | 88 | |||
| BASAL RESPIRATION | 100 mM | zebrafish | XFe24 Extracellular Flux Analyzer | Negative | 88 | |||
| ELECTRON TRANSPORT CHAIN | rat | isolated liver mitochondria | measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay | decrease | 53 | |||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Danger |
Aggregated GHS information provided by 41 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (97.56%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H360 (97.56%): May damage fertility or the unborn child [Danger Reproductive toxicity] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P201, P202, P261, P264, P271, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
 |
Danger |
Aggregated GHS information provided by 318 companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (16.67%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (84.59%): Causes skin irritation [Warning Skin corrosion/irritation] H360 (84.28%): May damage fertility or the unborn child [Danger Reproductive toxicity] H400 (76.1%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (76.1%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P201, P202, P264, P270, P273, P280, P281, P301+P312, P302+P352, P308+P313, P321, P330, P332+P313, P362, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Warning |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard] |
P264, P270, P273, P301+P312, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | intravenous | 75mg/kg (75mg/kg) | Drugs in Japan Vol. -, Pg. 886, 1995. | |
| mouse | LD50 | oral | 1100mg/kg (1100mg/kg) | American Journal of Clinical Nutrition. Vol. 52, Pg. 183, 1990. | |
| mouse | LD50 | intravenous | 92mg/kg (92mg/kg) | United States Patent Document. Vol. #3878202, | |
| rat | LD50 | subcutaneous | 53mg/kg (53mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3194, 1973. | |
| mouse | LD50 | intraperitoneal | 208mg/kg (208mg/kg) | Drugs in Japan Vol. -, Pg. 886, 1995. | |
| rat | LD50 | oral | 2gm/kg (2000mg/kg) | American Journal of Clinical Nutrition. Vol. 52, Pg. 183, 1990. | |
| rat | LD50 | intraperitoneal | 96mg/kg (96mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3194, 1973. | |
| mouse | LD50 | subcutaneous | 253mg/kg (253mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3194, 1973. | |
| (11Z)-retinoic acid | (2E,4E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraenoic acid | (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid |
| (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic acid | (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid | (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetr aenoic acid |
| (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid | (4E,6E,8E)-9-(2,6,6-Trimethyl-1-cyclohexenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid | (5E)-Retinoic acid |
| (9Z,13Z)-Retinoic acid | (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate | (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid |
| .beta.-Retinoic acid | .beta.-all-trans-Retinoic acid | 02T794 |
| 15-Apo-beta-caroten-15-oic acid | 1cbr | 1n4h |
| 2,4, 6,8-Nonatetranoic acid, 3,7-dimethyl-9-(2,6, 6-trimethyl-1-cyclohexen-1-yl)-, (2E, 4E, 6E, 8E)- | 2,4,6,8-Nonatetraenoic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)- | 2,4,6,8-Nonatetraenoic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)--, (all trans)- |
| 2,4,6,8-Nonatetranoic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)- | 2,4,6,8-Nonatetranoic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all trans)- | 2,6,8-Nonatetraenoic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)- |
| 2,6,8-Nonatetranoic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)- | 3,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid | 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate |
| 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid | 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid-, (all trans)- | 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2E,4E,6E,8E,-nonatetraenoic acid |
| 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid (ECL) | 3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-all-trans-tetraenoic acid | 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid |
| 3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2E,4E,6E,8E-tetraenoic acid | 302-79-4 | 33998-EP2275420A1 |
| 33998-EP2295055A2 | 33998-EP2295416A2 | 33998-EP2295426A1 |
| 33998-EP2295427A1 | 33998-EP2298748A2 | 33998-EP2298764A1 |
| 33998-EP2298765A1 | 33998-EP2298768A1 | 33998-EP2301928A1 |
| 33998-EP2305642A2 | 33998-EP2308833A2 | 33998-EP2308861A1 |
| 33998-EP2311453A1 | 33998-EP2311808A1 | 33998-EP2311829A1 |
| 33998-EP2311840A1 | 4759-48-2 | 5688UTC01R |
| 5914-EP2275412A1 | 5914-EP2292576A2 | 6-s-trans-retinoic acid |
| 9-cis-RA | 9-cis-retinoic acid (9cRA) | 97950-17-9; |
| A-Acido (Argentina) | A-Vitaminsyre | A-Vitaminsyre [Denmark] |
| A10944 | AB00052318-15 | AB00052318-16 |
| AB00052318-17 | AB00052318_18 | AB00052318_19 |
| AB03039 | AB1009361 | AC-6824 |
| ACT00012 | AGN 100335 | AKOS000280845 |
| ARONIS25153 | AT-RA | ATRA |
| ATRA | Aberel | Aberela |
| Aberela [Norway] | Acid A Vit (Belgium, Netherlands) | Acide retinoique (French) (DSL) |
| Acnavit | Acnavit [Denmark] | Airol |
| Aknefug | Aknoten | All Trans Retinoic Acid |
| All-trans Retinoic Acid | All-trans Retinoic Acid (Tretinoin) | Alltrans-retinoic acid |
| Altreno (0.05% lotion) | Atragen | Atralin |
| Avita (0.025% gel) | Avita (TN) | Avita Gel |
| Avitoin | Avitoin [Norway] | BCP01405 |
| BCPP000036 | BDBM31883 | BDBM323588 |
| BIDD:GT0483 | BIDD:PXR0081 | BML2-E05 |
| BP-20401 | BPBio1_000082 | BR-73126 |
| BRD-K06926592-001-01-7 | BRD-K71879491-001-15-0 | BRD-K71879491-001-22-6 |
| BRN 2057223 | BSPBio_000074 | BSPBio_001500 |
| Betarretin | C00777 | CAS-302-79-4 |
| CCG-39912 | CCRIS 3294 | CHEBI:15367 |
| CHEMBL38 | CPD000058245 | CS-1269 |
| Certified Reference Material | Cordes VAS [Germany] | Cordes vas |
| D00094 | DB00755 | DSSTox_CID_1239 |
| DSSTox_GSID_21239 | DSSTox_RID_76031 | DTXSID7021239 |
| Dermairol | EINECS 206-129-0 | EU-0101061 |
| Effederm | Effederm [France] | Epi-aberel |
| Eudyna | GS-3578 | GTPL2644 |
| HMS1361K22 | HMS1568D16 | HMS1791K22 |
| HMS1921D14 | HMS1989K22 | HMS2089D20 |
| HMS2092N11 | HMS2095D16 | HMS2236N03 |
| HMS3259E11 | HMS3263E04 | HMS3402K22 |
| HMS3411B09 | HMS3675B09 | HMS3712D16 |
| HMS502N05 | HSDB 2169 | HY-14649 |
| IDI1_000903 | IDI1_033970 | Isotretinoin;(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid |
| J10054 | L000833 | LMPR01090019 |
| LP01061 | LS-1154 | Lopac0_001061 |
| MFCD00001551 | MLS000028588 | MLS001076515 |
| MLS002207234 | MLS002222211 | MLS002548861 |
| MLS006010222 | NC00481 | NCGC00017280-05 |
| NCGC00017280-06 | NCGC00017280-07 | NCGC00017280-08 |
| NCGC00017280-09 | NCGC00017280-10 | NCGC00017280-12 |
| NCGC00017280-15 | NCGC00017280-16 | NCGC00017280-17 |
| NCGC00017280-18 | NCGC00017280-19 | NCGC00017280-20 |
| NCGC00017280-23 | NCGC00021808-04 | NCGC00021808-05 |
| NCGC00021808-06 | NCGC00021808-07 | NCGC00021808-09 |
| NCGC00021808-11 | NCGC00021808-14 | NCGC00021808-15 |
| NCGC00254179-01 | NCGC00259879-01 | NCGC00261746-01 |
| NSC 122758 | NSC-122758 | NSC-759631 |
| NSC122758 | NSC759631 | Nexret |
| Opera_ID_1055 | PDT-002-002 | Pharmakon1600-01502016 |
| Prestwick2_000257 | Prestwick3_000257 | Prestwick_424 |
| PubChem16466 | Q-200610 | Q29417 |
| QCR-120 | R 2625 | R0064 |
| REA | RETINOIC ACID, ALL TRANS | Refissa |
| Renova | Renova (0.02% cream) | Renova (TN) |
| Retacnyl | Retin A | Retin A (TN) |
| Retin-A | Retin-A Micro | Retinoic acid |
| Retinoic acid all trans | Retinoic acid, >=98% (HPLC), powder | Retinoic acid, all-trans- |
| Retinoic acid, all-trans- (8CI) | Retinoic acid, cis- | Retinova |
| Retionic acid | Retisol-A | Ro 1-5488 |
| S-1635 | SAM002264647 | SBB065722 |
| SBI-0051031.P003 | SC-16932 | SCHEMBL19091395 |
| SCHEMBL3145 | SHGAZHPCJJPHSC-YCNIQYBTSA-N | SMR000058245 |
| SPECTRUM1502016 | SR-01000000239 | SR-01000000239-12 |
| SR-01000000239-13 | SR-01000000239-14 | SR-01000000239-15 |
| SR-01000000239-3 | SR-01000000239-4 | SR-01000000239-6 |
| SR-01000000239-7 | ST057075 | ST2407905 |
| SW203749-4 | Solage | Spectrum5_001746 |
| Spectrum5_001933 | Stieva-A | TNP00194 |
| TRETINON | Tox21_110812 | Tox21_110812_1 |
| Tox21_202330 | Tox21_300305 | Tox21_501061 |
| Tretin M | Tretinoin | Tretinoin (JAN/USP/INN) |
| Tretinoin (Retinoic acid) | Tretinoin (TN) | Tretinoin - Retinoic Acid |
| Tretinoin 0.1% cream or placebo | Tretinoin [USAN:INN:BAN] | Tretinoin [USAN:USP:INN:BAN] |
| Tretinoin(Aberela) | Tretinoin, European Pharmacopoeia (EP) Reference Standard | Tretinoin, Pharmaceutical Secondary Standard |
| Tretinoin, United States Pharmacopeia (USP) Reference Standard | Tretinoin, all-trans- | Tretinoin/All-Trans Retinoic Acid |
| Tretinoina | Tretinoina [INN-Spanish] | Tretinoine |
| Tretinoine (French) | Tretinoine [INN-French] | Tretinoino |
| Tretinoino [INN-Spanish] | Tretinoinum | Tretinoinum [INN-Latin] |
| UNII-5688UTC01R | UPCMLD-DP097 | US10188615, at-RA |
| Vesanoid | Vesanoid (TN) (Roche) | Vesnaroid |
| Vitamin A acid | Vitamin A acid | Vitamin A acid, all-trans- |
| Vitamin A1 acid, all-trans- | Vitamin a acid, trans- | Vitamin-A-sA currencyure |
| WLN: L6UTJ A1 B1U1Y1 & U2U1Y1 & U1VQ C1 C1 | WLN: L6UTJ A1 B1U1Y1&U2U1Y1&U1VQ C1 C1 | ZINC12358651 |
| [3H]RA | [3H]Retinoic acid | [3H]Vitamin A acid |
| [3H]tretinoin | [All-E]-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid | acide retinoique (French) |
| all trans-Retinoic acid | all-(E)-Retinoate | all-(E)-Retinoic acid |
| all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid | all-trans-Retinoic acid | all-trans-Retinoic acid |
| all-trans-Retinoic acid, 97% | all-trans-Tretinoin | all-trans-Vitamin A acid |
| all-trans-Vitamin A1 acid | all-trans-b-Retinoic acid | all-trans-beta-Retinoic acid |
| all-trans-retinoic acid (ATRA) | b-Retinoic acid | beta-Ra |
| beta-Retinoate | beta-Retinoic acid | bmse000562 |
| cid_444795 | cis-Retinoic acid | s1653 |
| trans-Retinoate | trans-Retinoic acid | trans-Retinoic acid|||Retinoid analogues |
| tretinoin | tretinoin liposome | tretinoine (French) (EINECS) |