Compound

D0221 | Deguelin

Molecular Formula C23H22O6
Molecular Weight 394.4
Structure
Description member of rotenoids; insecticide and piscicide; Complex I inhibitor; anticancer candidate drug

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTRON TRANSPORT CHAIN 4.2 nmol/mg bovine mitochondria NADH–Q decrease IC50 95
GLUCOSE GALACTOSE IC50 RATIO 450 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay EC25(NA) [Glc/Gal] 326

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase 4.2 nmol/mg bovine mitochondria NADH–Q inhibitor IC50 95
NADH:ubiquinone reductase 185
NADH:ubiquinone reductase 450 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay EC25(NA) [Glc/Gal] 326


  • (-)-Deguelin (-)-Deguelin, >98% (HPLC), powder (-)-Deguelin, Mundulea sericea
    (-)-cis-deguelin (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H,7aH-pyrano[2,3-c;6,5-f']dichromen-7-one (7as,13as)-13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-3h-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7ah)-one
    13,13aS-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-[1]benzopyrano[3,4-b]pyrano[2,3-h][1]benzopyran-7(7aS)-one 1702AH 3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
    3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS-cis)- 3H-[1]Benzopyrano[3,4-b]pyrano[2,3-h][1]benzopyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)- 4CN-1289
    522-17-8 ABP000411 ACN-053693
    AKOS024456769 AS-56004 BCP9000596
    BRD-K61401890-001-02-0 BRD-K61401890-001-03-8 BRD-K61401890-001-04-6
    BSPBio_002583 C10417 CCG-39856
    CCRIS 8104 CHEBI:4357 CHEMBL393417
    CS-1802 DEGUELIN(-) DTXSID10200231
    Deguelin Deguelin/ HMS1923A05
    HMS3268E12 HY-13425 K5Z93K66IE
    KBio2_001524 KBio2_004092 KBio2_006660
    KBio3_002083 KBioGR_002434 KBioSS_001524
    LMPK12060019 MFCD01740600 MLS006010295
    NCGC00025288-01 NCGC00025288-02 NCGC00025288-03
    ORDAZKGHSNRHTD-UXHICEINSA-N Q5251862 SCHEMBL73183
    SDCCGMLS-0066380.P001 SMR004701363 SPBio_000236
    SPECTRUM201138 SR-01000597503 SR-01000597503-1
    SR-01000597503-3 SR-01000597503-4 Spectrum2_000298
    Spectrum3_001122 Spectrum4_001965 Spectrum5_001852
    Spectrum_001044 Tocris-1770 UNII-K5Z93K66IE
    ZINC3978987 s8132

    CAS Number 522-17-8, 53308-83-1
    PubChem Compound 107935
    KEGG Compound ID C10417
    ChEBI 4357
    ChemSpider 97058
    Wikipedia Deguelin