MITOTOX

Drug

D0283 | Myxothiazol

Properties

Molecular Formula	C25H33N3O3S2
Molecular Weight	487.7
Structure
State	solid
Description	contain a beta-methoxyacrylate (MOA) group; referred to as the MOA inhibitors; they presumably block the ET from quinol to the ISP, accompanying a red-shift in the alpha and beta-bands of the reduced heme bL spectrum.; class Ia inhibitors of Complex III (Qo site inhibitor )

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Species	Model	Method	Action	Positive criterion	Reference
ELECTRON TRANSPORT CHAIN		bovine	heart mitochondria		decrease		29
ELECTRON TRANSPORT CHAIN					decrease		35
ELECTRON TRANSPORT CHAIN					affect		53
ELECTRON TRANSPORT CHAIN					affect		81
ELECTRON TRANSPORT CHAIN	20 nmol/mg	bovine	mitochondria	NADH–Q	decrease	IC50	99

Targets

Target	Dose	Species	Model	Method	Action	Positive criterion	Reference
NADH:ubiquinone reductase	20 nmol/mg	bovine	mitochondria	NADH–Q	inhibitor	IC50	99
quinol					antagonist		53
Quinol--cytochrome-c reductase					inhibitor		35
Cytochrome b		bovine	heart mitochondria				29
Qo site (Qp site or ubiquinol oxidation site)					mobile conformation		81

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Danger	Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P264, P270, P301+P310, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Danger

Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P264, P270, P301+P310, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

(2E,4R,5S,6E)-7-{2'-[(1S,2E,4E)-1,6-dimethylhepta-2,4-dien-1-yl]-2,4'-bi-1,3-thiazol-4-yl}-3,5-dimethoxy-4-methylhepta-2,6-dienamide	(2Z,6E)-7-{2'-[(2E,4E)-1,6-DIMETHYLHEPTA-2,4-DIENYL]-2,4'-BI-1,3-THIAZOL-4-YL}-3,5-DIMETHOXY-4-METHYLHEPTA-2,6-DIENAMIDE	1sqp
6VY98BQ7NB	7-[2'-(1,6-DIMETHYL-HEPTA-2,4-DIENYL)-[2,4']BITHIAZOLYL-4-YL]-3,5-DIMETHOXY-4-METHYL-HEPTA-2,6-DIENOIC ACID AMIDE	76706-55-3
C15674	CHEMBL454568	DB04741
MYXOTHIAZOL	Myxothiazol	Myxothiazol A
Q27463616	SCHEMBL447904	UNII-6VY98BQ7NB
ZINC12504487

External IDs

DrugBank Name	Myxothiazol
DrugBank	DB04741
CAS Number	76706-55-3
PubChem Compound	10972974
KEGG Compound ID	C15674
PubChem.Substance	46507900
ChEBI	25461
ChemSpider	9148180
Wikipedia	Myxothiazol
HET	MYX