Compound

D0163 | Cyanide

Molecular Formula CN-
Molecular Weight 26.017
Structure
Description Classical respiratory inhibitors

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTRON TRANSPORT CHAIN affect 167
GLUCOSE GALACTOSE IC50 RATIO 5.2 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay EC25(NA) [Glc/Gal] 326

Target Dose Time Species Model Method Action Positive criterion Reference
oxygen noncompetitive inhibitor 167

Organism Test type Route Dose (normalized dose) Effect Source
mouse LD50 oral 3700ug/kg (3.7mg/kg) Annales Pharmaceutiques Francaises. Vol. 19, Pg. 740, 1961.
rabbit LD50 intraperitoneal 1570ug/kg (1.57mg/kg) British Journal of Pharmacology and Chemotherapy. Vol. 23, Pg. 455, 1964.
man LDLo unreported 1471ug/kg (1.471mg/kg) "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
monkey LD50 intravenous 1300ug/kg (1.3mg/kg) National Technical Information Service. Vol. AD-A028-501,
rat LD50 intravenous 810ug/kg (0.81mg/kg) National Technical Information Service. Vol. AD-A028-501,
dog LDLo subcutaneous 1700ug/kg (1.7mg/kg) "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1340, 1935.
man TCLo inhalation 500mg/m3/3M-C (500mg/m3) Human Toxicology. Vol. 3, Pg. 57, 1984.
human LDLo subcutaneous 1mg/kg (1mg/kg) Science Journal. Vol. 3(4), Pg. 33, 1967.
mouse LC50 inhalation 323ppm/5M (323ppm) Toxicology and Applied Pharmacology. Vol. 42, Pg. 417, 1977.
guinea pig LDLo subcutaneous 100ug/kg (0.1mg/kg) "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1340, 1935.
frog LDLo subcutaneous 60mg/kg (60mg/kg) "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1340, 1935.
rabbit LD50 intravenous 660ug/kg (0.66mg/kg) National Technical Information Service. Vol. AD-A028-501,
duck LDLo oral 3280ug/kg (3.28mg/kg) "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
mouse LDLo subcutaneous 3mg/kg (3mg/kg) "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1340, 1935.
rabbit LDLo oral 4mg/kg (4mg/kg) "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1340, 1935.
dog LD50 intravenous 1340ug/kg (1.34mg/kg) National Technical Information Service. Vol. AD-A028-501,
man LCLo inhalation 400mg/m3/2M (400mg/m3) "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 75, 1982.
pigeon LDLo intramuscular 1500ug/kg (1.5mg/kg) "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
cat LDLo subcutaneous 1100ug/kg (1.1mg/kg) "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1340, 1935.
mouse LD50 intraperitoneal 2990ug/kg (2.99mg/kg) British Journal of Pharmacology and Chemotherapy. Vol. 23, Pg. 455, 1964.
pigeon LDLo subcutaneous 2150ug/kg (2.15mg/kg) "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rabbit LD50 ocular 1040ug/kg (1.04mg/kg) Journal of Toxicology, Cutaneous and Ocular Toxicology. Vol. 2, Pg. 119, 1983.
human LCLo inhalation 200mg/m3/10M (200mg/m3) World Health Organization, Technical Report Series. Vol. -, Pg. 30, 1970.
man TDLo intravenous 55ug/kg (0.055mg/kg) lungs, thorax, or respiration: respiratory stimulation National Technical Information Service. Vol. PB158-508,
rabbit LD50 intramuscular 486ug/kg (0.486mg/kg) Journal of the American College of Toxicology. Vol. 1(3), Pg. 120, 1982.
bird - domestic LDLo oral 600ug/kg (0.6mg/kg) "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
dog LDLo oral 4mg/kg (4mg/kg) "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1340, 1935.
human LDLo oral 570ug/kg (0.57mg/kg) Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 596, 1966.
rat LC50 inhalation 160ppm/30M (160ppm) Fundamental and Applied Toxicology. Vol. 9, Pg. 236, 1987.
cat LD50 intravenous 810ug/kg (0.81mg/kg) National Technical Information Service. Vol. AD-A028-501,
rabbit LC50 inhalation 208mg/m3/35M (208mg/m3) Toxic Substances Journal. Vol. 13, Pg. 263, 1994.
bird - wild LDLo subcutaneous 100ug/kg (0.1mg/kg) "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
guinea pig LD50 intravenous 1430ug/kg (1.43mg/kg) National Technical Information Service. Vol. AD-A028-501,
domestic animals - goat/sheep LD50 intravenous 660ug/kg (0.66mg/kg) National Technical Information Service. Vol. PB158-508,
mammal (species unspecified) LCLo inhalation 200ppm/5M (200ppm) Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 138, Pg. 65, 1928.
bird - domestic LDLo subcutaneous 100ug/kg (0.1mg/kg) "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1340, 1935.
pig LDLo oral 2mg/kg (2mg/kg) Archives of Environmental Health. Vol. 22, Pg. 496, 1971.
mammal (species unspecified) LCLo inhalation 36ppm/2H (36ppm) Tabulae Biologicae. Vol. 3, Pg. 231, 1933.
pigeon LDLo oral 14mg/kg (14mg/kg) "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
mouse LD50 intramuscular 2700ug/kg (2.7mg/kg) British Journal of Pharmacology and Chemotherapy. Vol. 23, Pg. 455, 1964.
mouse LD50 intravenous 990ug/kg (0.99mg/kg) National Technical Information Service. Vol. AD-A028-501,
bird - wild LDLo oral 7500ug/kg (7.5mg/kg) "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
human LCLo inhalation 120mg/m3/1H (120mg/m3) Journal of Industrial Hygiene and Toxicology. Vol. 24, Pg. 255, 1942.
rabbit LD50 subcutaneous 2500ug/kg (2.5mg/kg) British Journal of Pharmacology and Chemotherapy. Vol. 23, Pg. 455, 1964.


  • 57-12-5 BDBM26984 BRN 1900509
    C00177 CHEBI:17514 CHEMBL186374
    CN(-) CN(-1) CN-
    CTK1G9863 CYANIDE ION Carbon nitride ion (CN(sup 1-))
    Carbon nitride ion (CN1-) Cyanide (CN(sup 1-)) Cyanide (anion)
    Cyanide anion Cyanide ions Cyanide solutions, n.o.s.
    Cyanide solutions, n.o.s. [UN1935] [Poison, Keep away from food] Cyanide solutions, n.o.s. [UN1935] [Poison, Keep away from food] Cyanide with potassium salt
    Cyanide(1-) Cyanide(1-) ion Cyanide, free
    Cyanides (soluble salts and complexes) not otherwise specified Cyano Cyanure
    Cyanure [French] DTXSID6023991 Hydrocyanic acid, ion(1-)-
    Isocyanide LS-55777 NCGC00188964-01
    Nitrile anion OXN4E7L11K Prussiate
    Q185076 RCRA waste no. P030 RCRA waste number P030
    UN1935 UNII-OXN4E7L11K VZ36346
    XFXPMWWXUTWYJX-UHFFFAOYSA-N Zyanid cyanide
    iminomethanide isonitrile nitridocarbonate(1-)

    CAS Number 12539-57-0, 57-12-5, 74-90-8
    PubChem Compound 5975
    KEGG Compound ID C00177
    ChEBI 17514
    ChemSpider 5755

    1. Meyer et al. (2013)
    2. Zarazuela Zolkipli-Cunningham & Marni J.Falk. (2017)
    3. Wallace, 2008