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F02 | Function of mitochondria

GO:0005739
Function of mitochondria

Compound Dose Time Species Model Method Action Result Positive criterion Reference
Acetaminophen 1 g/kg 6 hours mice; C57Bl/6 in vivo GSH level measurement increase Positive p < 0.05 1
Acetaminophen 1 g/kg 12 hours mice; C57Bl/6 in vivo GSH level measurement increase Positive p < 0.05 1
Acetaminophen 1 g/kg 24 hours mice; C57Bl/6 in vivo GSH level measurement increase Positive p < 0.05 1
Oligomycin 8 nM bovine heart mitochondria Measurement of complex V activity decrease Positive IC50 3
aurovertin B 1.5 μM bovine heart mitochondria Measurement of complex V activity decrease Positive IC50 3
Amiodarone 50 μM bovine heart mitochondria Measurement of complex I activity decrease Positive p < 0.05 3
Amiodarone 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
Amiodarone 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
Amiodarone 50 μM bovine heart mitochondria Measurement of complex IV activity decrease Positive p < 0.05 3
Amiodarone 50 μM bovine heart mitochondria Measurement of complex V activity decrease Positive p < 0.001 3
Chlorpromazine 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
Chlorpromazine 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
Chlorpromazine 50 μM bovine heart mitochondria Measurement of complex V activity decrease Positive p < 0.001 3
Diclofenac 50 μM bovine heart mitochondria Measurement of complex V activity decrease Positive p < 0.01 3
gefitinib 50 μM bovine heart mitochondria Measurement of complex IV activity decrease Positive p < 0.05 3
gefitinib 50 μM bovine heart mitochondria Measurement of complex V activity decrease Positive p < 0.001 3
Nefazodone 50 μM bovine heart mitochondria Measurement of complex I activity decrease Positive p < 0.001 3
Nefazodone 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.01 3
Nefazodone 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.01 3
Nefazodone 50 μM bovine heart mitochondria Measurement of complex IV activity decrease Positive p < 0.001 3
Nefazodone 50 μM bovine heart mitochondria Measurement of complex V activity decrease Positive p < 0.001 3
paroxetine 50 μM bovine heart mitochondria Measurement of complex I activity decrease Positive p < 0.01 3
paroxetine 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
paroxetine 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
paroxetine 50 μM bovine heart mitochondria Measurement of complex V activity decrease Positive p < 0.001 3
Simvastatin 50 μM bovine heart mitochondria Measurement of complex I activity decrease Positive p < 0.01 3
Simvastatin 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
Simvastatin 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
Simvastatin 50 μM bovine heart mitochondria Measurement of complex IV activity decrease Positive p < 0.001 3
Simvastatin 50 μM bovine heart mitochondria Measurement of complex V activity decrease Positive p < 0.001 3
Tamoxifen 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
Tamoxifen 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
Tamoxifen 50 μM bovine heart mitochondria Measurement of complex IV activity decrease Positive p < 0.001 3
Tamoxifen 50 μM bovine heart mitochondria Measurement of complex V activity decrease Positive p < 0.001 3
Tamoxifen 15 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive IC50 3
Tamoxifen 15 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive IC50 3
Tamoxifen 26.6 μM bovine heart mitochondria Measurement of complex IV activity decrease Positive IC50 3
Tamoxifen 8.1 μM bovine heart mitochondria Measurement of complex V activity decrease Positive IC50 3
Tamoxifen 4 μM bovine heart mitochondria Measurement of complex I activity decrease Positive IC50 3
Tamoxifen 1.6 μM bovine heart mitochondria Measurement of complex V activity decrease Positive IC50 3
Tamoxifen 30 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive IC50 3
Tamoxifen 30 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive IC50 3
Tamoxifen 29 μM bovine heart mitochondria Measurement of complex V activity decrease Positive IC50 3
Tamoxifen 26 μM bovine heart mitochondria Measurement of complex V activity decrease Positive IC50 3
Amiodarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
Amiodarone 10 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
Amiodarone 20 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
Amiodarone 50 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
Amiodarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
benzarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
benzbromarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
benzbromarone 1 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
benzbromarone 10 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
benzbromarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
2‐Butylbenzofuran 50 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.05 4
2‐Butylbenzofuran 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
Amiodarone 10 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
Amiodarone 20 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
Amiodarone 50 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
Amiodarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
benzarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
benzarone 20 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
benzarone 50 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
benzarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
benzbromarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
benzbromarone 0.1 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
benzbromarone 1 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
benzbromarone 10 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
benzbromarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
2‐Butylbenzofuran 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 4
Amiodarone 20 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease Positive p < 0.01 4
Amiodarone 50 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease Positive p < 0.01 4
Amiodarone 80 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease Positive p < 0.01 4
Amiodarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease Positive p < 0.01 4
benzarone 20 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease Positive p < 0.01 4
benzarone 50 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease Positive p < 0.01 4
benzarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease Positive p < 0.01 4
benzbromarone 2 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease Positive p < 0.05 4
benzbromarone 5 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease Positive p < 0.01 4
benzbromarone 10 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease Positive p < 0.01 4
benzbromarone 50 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease Positive p < 0.01 4
2‐Butylbenzofuran 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease Positive p < 0.01 4
Amiodarone 34 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease Positive IC50 4
benzarone 34 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease Positive IC50 4
benzbromarone 2 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease Positive IC50 4
2‐Butylbenzofuran 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease Positive 28% inhibition 4
Amiodarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of acyl‐CoA dehydrogenase activity decrease Positive 28% inhibition 4
benzarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of acyl‐CoA dehydrogenase activity decrease Positive 33% inhibition 4
benzbromarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of acyl‐CoA dehydrogenase activity decrease Positive 34% inhibition 4
2‐Butylbenzofuran 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of acyl‐CoA dehydrogenase activity decrease Positive 22% inhibition 4
benzarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of β‐ketothiolase activity decrease Positive 11% inhibition 4
benzbromarone 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of β‐ketothiolase activity decrease Positive 25% inhibition 4
Diclofenac 50 μmol/L 2 minutes rat liver mitochondria Assessment of Mitochondrial Ca2+ Efflux; Energized with succinate decrease Positive not mentioned 6
Diclofenac 50 μmol/L 10 minutes rat liver mitochondria Measurement of Mitochondrial NADPH; incubated in the presence of Ca2+ increase Positive p < 0.01 6
Diclofenac 50 μmol/L 10 minutes rat liver mitochondria Assay of Mitochondrial Protein Thiol; Assay of Mitochondrial GSH; incubated in the presence of Ca2+ decrease Positive p < 0.01 6
Diclofenac 250 μmol/L 24 hours rat hepatocytes Assay of Cellular ATP contents; Assay of LDH leakage decrease Positive p < 0.01 6
Diclofenac 500 μmol/L 24 hours rat hepatocytes Assay of Cellular ATP contents; Assay of LDH leakage decrease Positive p < 0.01 6
Rotenone 263±43 nM 2 minutes human HepG2 Measurement of OCR decrease Positive EC50 7
Rotenone 371±58 nM 2 minutes human HepG2 Measurement of ECAR increase Positive EC50 7
Antimycin A 4±0.2 nM 2 minutes human HepG2 Measurement of OCR decrease Positive EC50 7
Antimycin A 100±20 nM 2 minutes human HepG2 Measurement of ECAR increase Positive EC50 7
Oligomycin 0.92± 0.18 μM 2 minutes human HepG2 Measurement of OCR decrease Positive EC50 7
Oligomycin 1.1±0.23 μM 2 minutes human HepG2 Measurement of ECAR increase Positive EC50 7
FCCP 54±7 nM 2 minutes human HepG2 Measurement of OCR increase Positive EC50 7
FCCP 141±20 nM 2 minutes human HepG2 Measurement of ECAR increase Positive EC50 7
2-Deoxy-D-glucose 150 mM 2 minutes human HepG2 Measurement of OCR increase Positive EC50 7
2-Deoxy-D-glucose 150 mM 2 minutes human HepG2 Measurement of ECAR decrease Positive EC50 7
Tolcapone 3.7 μM 2 minutes human HepG2 Measurement of OCR increase Positive EC50 7
Tolcapone 3.7 μM 2 minutes human HepG2 Measurement of ECAR increase Positive EC50 7
Entacapone 33 μM 2 minutes human HepG2 Measurement of OCR increase Positive EC50 7
Entacapone 100 μM 2 minutes human HepG2 Measurement of ECAR increase Positive EC50 7
Nilutamide 66 μM 2 minutes human HepG2 Measurement of OCR decrease Positive EC50 7
Nilutamide 79 μM 2 minutes human HepG2 Measurement of ECAR increase Positive EC50 7
Flutamide > 100 μM 2 minutes human HepG2 Measurement of OCR decrease Positive EC50 7
Flutamide > 100 μM 2 minutes human HepG2 Measurement of ECAR increase Positive EC50 7
Chlorpromazine > 300 μM 2 minutes human HepG2 Measurement of OCR increase Positive EC50 7
Chlorpromazine > 300 μM 2 minutes human HepG2 Measurement of ECAR increase Positive EC50 7
Diflunisal 15 μM 2 minutes human HepG2 Measurement of OCR increase Positive EC50 7
Diflunisal 30 μM 2 minutes human HepG2 Measurement of ECAR increase Positive EC50 7
Benoxaprofen 30 μM 2 minutes human HepG2 Measurement of ECAR decrease Positive EC50 7
Benoxaprofen > 100 μM 2 minutes human HepG2 Measurement of ECAR increase Positive EC50 7
Troglitazone > 100 μM 2 minutes human HepG2 Measurement of ECAR decrease Positive EC50 7
Troglitazone > 100 μM 2 minutes human HepG2 Measurement of ECAR increase Positive EC50 7
Ciglitazone > 100 μM 2 minutes human HepG2 Measurement of ECAR decrease Positive EC50 7
Ciglitazone > 100 μM 2 minutes human HepG2 Measurement of ECAR increase Positive EC50 7
Troglitazone 10 μM 2 minutes feline cardiomyocytes Measurement of OCR increase Positive EC50 7
Troglitazone 10 μM 2 minutes feline cardiomyocytes Measurement of ECAR increase Positive EC50 7
Ciglitazone > 100 μM 2 minutes feline cardiomyocytes Measurement of OCR decrease Positive EC50 7
Ciglitazone 10 μM 2 minutes feline cardiomyocytes Measurement of ECAR increase Positive EC50 7
Rosiglitazone > 100 μM 2 minutes feline cardiomyocytes Measurement of OCR increase Positive EC50 7
Rosiglitazone > 100 μM 2 minutes feline cardiomyocytes Measurement of ECAR increase Positive EC50 7
Metformin 5 mM 24 hours human MCF7 Meassurement of mitochondrial respiration decrease Positive p < 0.05 172
Metformin 0.5 mM 24 hours human MCF7 Meassurement of coupled respiration decrease Positive p < 0.05 172
Metformin 5 mM 24 hours human MCF7 Meassurement of coupled respiration decrease Positive p < 0.05 172
Metformin 0.5 mM 24 hours human MCF7 Meassurement of non-mitochondrial respiration increase Positive p < 0.05 172
Metformin 5 mM 24 hours human MCF7 Meassurement of non-mitochondrial respiration increase Positive p < 0.05 172
Metformin 0.5 mM 24 hours human MCF7 Meassurement of coupled respiration; Meassurement of uncoupled respiration; cells grown in glucose increase Positive p < 0.05 172
Metformin 0.5 mM 24 hours human MCF7 Meassurement of coupled respiration; Meassurement of uncoupled respiration; cells grown in galactose increase Positive p < 0.05 172
Metformin 0.5 mM 24 hours mouse NMuMG Meassurement of mitochondrial respiration decrease Positive p < 0.05 172
Metformin 0.5 mM 24 hours mouse NT2196 Meassurement of mitochondrial respiration decrease Positive p < 0.05 172
Metformin 0.5 mM 24 hours human MCF10A Meassurement of mitochondrial respiration decrease Positive p < 0.05 172
Metformin 0.5 mM 24 hours human MCF7 Meassurement of mitochondrial respiration decrease Positive p < 0.05 172
Metformin 0.5 mM 24 hours mouse NMuMG Meassurement of coupled respiration; Meassurement of uncoupled respiration increase Positive p < 0.05 172
Metformin 0.5 mM 24 hours human MCF10A Meassurement of coupled respiration; Meassurement of uncoupled respiration increase Positive p < 0.05 172
Metformin 5 mM 24 hours mouse NMuMG Meassurement of glucose concentration increase Positive p < 0.05 172
Metformin 5 mM 24 hours mouse NT2196 Meassurement of glucose concentration increase Positive p < 0.05 172
Metformin 5 mM 24 hours human MCF10A Meassurement of glucose concentration increase Positive p < 0.05 172
Metformin 5 mM 24 hours human MCF7 Meassurement of glucose concentration increase Positive p < 0.05 172
Metformin 5 mM 24 hours mouse NT2196 Meassurement of lactate concentration increase Positive p < 0.05 172
Metformin 5 mM 24 hours human MCF10A Meassurement of lactate concentration increase Positive p < 0.05 172
Metformin 5 mM 24 hours human MCF7 Meassurement of lactate concentration increase Positive p < 0.05 172
Metformin 5 mM 48 hours mouse NMuMG Meassurement of glucose concentration increase Positive p < 0.05 172
Metformin 5 mM 48 hours mouse NT2196 Meassurement of glucose concentration increase Positive p < 0.05 172
Metformin 5 mM 48 hours human MCF10A Meassurement of glucose concentration increase Positive p < 0.05 172
Metformin 5 mM 48 hours human MCF7 Meassurement of glucose concentration increase Positive p < 0.05 172
Metformin 5 mM 48 hours mouse NMuMG Meassurement of lactate concentration increase Positive p < 0.05 172
Metformin 5 mM 48 hours mouse NT2196 Meassurement of lactate concentration increase Positive p < 0.05 172
Metformin 5 mM 48 hours human MCF10A Meassurement of lactate concentration increase Positive p < 0.05 172
Metformin 5 mM 48 hours human MCF7 Meassurement of lactate concentration increase Positive p < 0.05 172
Metformin 0.5mM 24 hours human MCF7 Meassurement of lactate + pyruvate concentration; compared with MCF10A increase Positive p < 0.05 172
Metformin 5.0mM 24 hours human MCF7 Meassurement of lactate + pyruvate concentration; compared with MCF10A increase Positive p < 0.05 172
Metformin 0.5mM 24 hours human MCF10A Meassurement of citrate concentration; compared with MCF10A affect Positive p < 0.05 172
Metformin 0.5mM 24 hours human MCF7 Meassurement of citrate concentration; compared with MCF10A affect Positive p < 0.05 172
Metformin 0.5mM 24 hours human MCF10A Meassurement of isocitrate concentration; compared with MCF10A affect Positive p < 0.05 172
Metformin 0.5mM 24 hours human MCF7 Meassurement of isocitrate concentration; compared with MCF10A affect Positive p < 0.05 172
Metformin 0.5mM 24 hours human MCF10A Meassurement of alpha-ketoglutarate concentration; compared with MCF10A affect Positive p < 0.05 172
Metformin 0.5mM 24 hours human MCF7 Meassurement of alpha-ketoglutarate concentration; compared with MCF10A affect Positive p < 0.05 172
Metformin 2mM 30 minutes mouse; C57BL/6J isolated skeletal muscle mitochondria Measurement of Oxygen level; incubated in complex I substrate; added ADP (500 μM) decrease Positive p < 0.05 172
Metformin 2mM 30 minutes mouse; C57BL/6J isolated skeletal muscle mitochondria Measurement of Oxygen level; incubated in complex I substrate; added oligomycin (2.5 μg oligomycin/mg mitochondrial protein) decrease Positive p < 0.05 172
Metformin 2mM 30 minutes mouse; C57BL/6J isolated skeletal muscle mitochondria Measurement of Oxygen level; incubated in complex I substrate; added FCCP (1.5 μM) decrease Positive p < 0.05 172
Metformin 5mM 30 minutes mouse; C57BL/6J isolated skeletal muscle mitochondria Meassurement of lactate concentration increase Positive p < 0.05 172
Metformin 5mM 30 minutes mouse; C57BL/6J isolated skeletal muscle mitochondria Meassurement of citrate concentration; compared with MCF10A affect Positive p < 0.05 172
Metformin 5mM 30 minutes mouse; C57BL/6J isolated skeletal muscle mitochondria Meassurement of citrate concentration; compared with MCF10A affect Positive p < 0.05 172
Metformin 5mM 30 minutes mouse; C57BL/6J isolated skeletal muscle mitochondria Meassurement of alpha-ketoglutarate concentration; compared with MCF10A affect Positive p < 0.05 172
Metformin 5mM 30 minutes mouse; C57BL/6J isolated skeletal muscle mitochondria Meassurement of alpha-ketoglutarate concentration; compared with MCF10A affect Positive p < 0.05 172
Metformin 5mM 30 minutes mouse; C57BL/6J isolated skeletal muscle mitochondria Meassurement of succinate concentration decrease Positive p < 0.05 172
Metformin 5mM 30 minutes mouse; C57BL/6J isolated skeletal muscle mitochondria Meassurement of succinate concentration decrease Positive p < 0.05 172
Nimesulide 1 mM rat; Sprague-Dawley Crl:CD (SD) BR lung microsomes measurement of oxygen consumption increase Positive p < 0.05 11
Nimesulide 1 mM rat; Sprague-Dawley Crl:CD (SD) BR lung microsomes measurement of NADPH oxidation increase Positive p < 0.05 11
Nitrofurantoin 1 mM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake; used glutamate as substrate decrease Positive p < 0.05; 61% inhibition 13
Nitrofurantoin 50 μM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake; used glutamate as substrate decrease Positive p < 0.05; 72% inhibition 13
Nitrofurantoin 5 μM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake; used glutamate as substrate decrease Positive p < 0.05; 38% inhibition 13
Nitrofurantoin 1 mM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake; used β-hydroxybutyrate as substrate decrease Positive p < 0.05 13
Nitrofurantoin 50 μM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake; used β-hydroxybutyrate as substrate decrease Positive p < 0.05; 60% inhibition 13
Nitrofurantoin 5 μM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake; used β-hydroxybutyrate as substrate decrease Positive p < 0.05 13
Nitrofurantoin 1 mM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake; used α-ketoghttarate as substrate decrease Positive p < 0.05 13
Nitrofurantoin 50 μM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake; used α-ketoghttarate as substrate decrease Positive p < 0.05; 70% inhibition 13
Nitrofurantoin 5 μM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake; used α-ketoghttarate as substrate decrease Positive p < 0.05 13
nitrofurazone 1mM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.05; 64% inhibition 13
nitrofurazone 1mM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.05; 63% inhibition 13
Nitrofurantoin 1 mM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.05 13
Nitrofurantoin 0.005mM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.05 13
Nitrofurantoin 1 mM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.05 13
Nitrofurantoin 0.05mM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.05 13
Nitrofurantoin 1 mM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.05 13
Nitrofurantoin 0.05mM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.05 13
nitrofurazone 1mM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.05 13
nitrofurazone 1mM mouse; C57B/6J liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.05 13
nitrofurazone 5μM mouse; C57B/6J mitoplasts Measurement of oxygen uptake decrease Positive p < 0.05 13
nitrofurazone 5μM mouse; C57B/6J mitoplasts Measurement of oxygen uptake decrease Positive p < 0.05 13
buformin 62.5 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease Positive p < 0.001 15
buformin 62.5 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease Positive p < 0.001 15
Phenformin 62.5 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease Positive p < 0.001 15
Phenformin 62.5 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease Positive p < 0.001 15
Metformin 657 μM 24 hours human hepatocytes Assay of Cellular ATP Content decrease Positive IC50 15
buformin 26.1 μM 24 hours human hepatocytes Assay of Cellular ATP Content decrease Positive IC50 15
Phenformin 11.7 μM 24 hours human hepatocytes Assay of Cellular ATP Content decrease Positive IC50 15
Metformin 1430 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease Positive IC50 15
buformin 43.7 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease Positive IC50 15
Phenformin 12.9 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease Positive IC50 15
Metformin > 2000 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease Positive IC50 15
buformin > 500 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease Positive IC50 15
Phenformin > 500 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease Positive IC50 15
buformin 25 μM 24 hours human HepG2 cells Measurement of OCR decrease Positive p < 0.001 15
Phenformin 25 μM 24 hours human HepG2 cells Measurement of OCR decrease Positive p < 0.001 15
buformin 25 μM 24 hours human HepG2 cells Measurement of ECAR increase Positive p < 0.001 15
Phenformin 25 μM 24 hours human HepG2 cells Measurement of ECAR increase Positive p < 0.001 15
buformin 100 nmol/mg mitochondrial protein rat; Sprague–Dawley liver mitochondria Meassurement of respiration decrease Positive 15
Phenformin 100 nmol/mg mitochondrial protein rat; Sprague–Dawley liver mitochondria Meassurement of respiration decrease Positive 15
Metformin 500 nmol/mg mitochondrial protein 40 minutes preincubation rat; Sprague–Dawley liver mitochondria Meassurement of respiration decrease Positive 15
buformin 100 nmol/mg mitochondrial protein 40 minutes preincubation rat; Sprague–Dawley liver mitochondria Meassurement of respiration decrease Positive 15
Phenformin 100 nmol/mg mitochondrial protein 40 minutes preincubation rat; Sprague–Dawley liver mitochondria Meassurement of respiration decrease Positive 15
buformin 100 nmol/mg mitochondrial protein rat; Sprague–Dawley liver mitochondria Meassurement of respiration decrease Positive 15
Phenformin 100 nmol/mg mitochondrial protein rat; Sprague–Dawley liver mitochondria Meassurement of respiration decrease Positive 15
Metformin 500 nmol/mg mitochondrial protein 40 min preincubation rat; Sprague–Dawley liver mitochondria Meassurement of respiration decrease Positive 15
buformin 100 nmol/mg mitochondrial protein 40 min preincubation rat; Sprague–Dawley liver mitochondria Meassurement of respiration decrease Positive 15
Phenformin 100 nmol/mg mitochondrial protein 40 min preincubation rat; Sprague–Dawley liver mitochondria Meassurement of respiration decrease Positive 15
Metformin 66 mM Bovine heart mitochondria Measurement of complex I activity decrease Positive IC50 15
buformin 11.3 mM Bovine heart mitochondria Measurement of complex I activity decrease Positive IC50 15
Phenformin 1.2 mM Bovine heart mitochondria Measurement of complex I activity decrease Positive IC50 15
Perhexiline 5 μM 72 hours rat; Sprague-Dawley Crl:CD-1 (ICR) BR hepatocytes Measurement of beta oxidation decrease Positive p < 0.05 193
Perhexiline 25 μM 24 hours rat; Sprague-Dawley Crl:CD-1 (ICR) BR hepatocytes Measurement of beta oxidation decrease Positive p < 0.05 193
Perhexiline 100 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake increase Positive p < 0.01 193
Perhexiline 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake increase Positive p < 0.01 193
Perhexiline 100 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake increase Positive p < 0.01 193
Perhexiline 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake increase Positive p < 0.01 193
Perhexiline 100 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 193
Perhexiline 200 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 193
Perhexiline 400 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 193
Perhexiline 100 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.05 193
Perhexiline 200 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 193
Perhexiline 400 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 193
Perhexiline 200 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake decrease Positive p < 0.01 193
Perhexiline 100 μM 5 minutes preincubation; 10 minutes mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of beta oxidation decrease Positive p < 0.01 193
Perhexiline 100 μM 5 minutes preincubation; 10 minutes mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of beta oxidation decrease Positive p < 0.01 193
Perhexiline 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease Positive p < 0.01 193
Perhexiline 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease Positive p < 0.01 193
Perhexiline 800 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease Positive p < 0.01 193
Perhexiline 1200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease Positive p < 0.01 193
Perhexiline 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease Positive p < 0.01 193
Perhexiline 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease Positive p < 0.01 193
Perhexiline 800 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease Positive p < 0.01 193
Perhexiline 1200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease Positive p < 0.01 193
Perhexiline 1600 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease Positive p < 0.01 193
Perhexiline 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease Positive p < 0.05 193
Perhexiline 800 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease Positive p < 0.01 193
Perhexiline 1200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease Positive p < 0.01 193
Perhexiline 1600 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease Positive p < 0.01 193
Perhexiline decrease Positive 16
Perhexiline decrease Positive 16
Perhexiline decrease Positive 16
Perhexiline decrease Positive 16
Perhexiline decrease Positive 17
Perhexiline decrease Positive 17
Trimetazidine decrease Positive 17
Trimetazidine increase Positive 17
ranolazine increase Positive 17
ranolazine decrease Positive 17
Pioglitazone Positive 21
Pioglitazone decrease Positive 22
Pioglitazone decrease Positive 22
promethazine increase Positive 22
promethazine increase Positive 22
clomipramine increase Positive 22
clomipramine decrease Positive 22
clomipramine increase Positive 22
imipramine increase Positive 22
imipramine increase Positive 22
Chlorpromazine increase Positive 22
Chlorpromazine decrease Positive 22
Chlorpromazine increase Positive 22
Chlorpromazine rat isolated liver mitochondria decrease Positive 23
Haloperidol rat isolated liver mitochondria decrease Positive 23
Risperidone rat isolated liver mitochondria decrease Positive 23
quetiapine rat isolated liver mitochondria decrease Positive 23
2,4-dinitrophenol increase Positive 24
2,4-dinitrophenol increase Positive 24
2,4-dinitrophenol increase Positive 24
2-Deoxy-D-glucose human SkBr3 breast cancer cells MTT assay decrease Positive 25
Antimycin A decrease Positive 26
FOX-988 decrease Positive 28
Sdz-51641 decrease Positive 28
Myxothiazol bovine heart mitochondria decrease Positive 29
Papaverine decrease Positive 30
Salicylic acid decrease Positive 32
Thenoyltrifluoroacetone decrease Positive 33
thiazolidinediones decrease Positive 34
Acetaminophen decrease Positive 35
Acetaminophen decrease Positive 35
Acetylsalicylic acid decrease Positive 35
Acetylsalicylic acid decrease Positive 35
Clotrimazole decrease Positive 35
Flutamide decrease Positive 35
Ketoconazole decrease Positive 35
mefloquine decrease Positive 35
Metformin decrease Positive 35
Nefazodone decrease Positive 35
Nitrofurantoin decrease Positive 35
Paraquat decrease Positive 35
paroxetine decrease Positive 35
paroxetine decrease Positive 35
paroxetine decrease Positive 35
paroxetine decrease Positive 35
Perhexiline decrease Positive 35
Phenformin decrease Positive 35
Pioglitazone decrease Positive 35
Pioglitazone decrease Positive 35
promethazine decrease Positive 35
Rosiglitazone decrease Positive 35
Rotenone decrease Positive 35
Tamoxifen decrease Positive 35
Tamoxifen decrease Positive 35
Tamoxifen decrease Positive 35
Tamoxifen decrease Positive 35
Troglitazone decrease Positive 35
2-Deoxy-D-glucose decrease Positive 35
Antimycin A decrease Positive 35
Etomoxir decrease Positive 35
Myxothiazol decrease Positive 35
Oligomycin decrease Positive 35
Salicylic acid decrease Positive 35
Thenoyltrifluoroacetone decrease Positive 35
thiazolidinediones decrease Positive 35
alpidem decrease Positive 36
Amiodarone decrease Positive 36
benzbromarone decrease Positive 37
Chlorpromazine decrease Positive 7
clomipramine decrease Positive 38
Diclofenac decrease Positive 39
Flutamide decrease Positive 41
Ketoconazole decrease Positive 36
lovastatin decrease Positive 36
Phenformin decrease Positive 43
Rosiglitazone decrease Positive 7
Simvastatin decrease Positive 7
sitaxsentan decrease Positive 44
Tamoxifen decrease Positive 46
Troglitazone decrease Positive 7
Doxorubicin decrease Positive 36
imipramine decrease Positive 36
sertraline decrease Positive 48
zoniporide decrease Positive 50
pentamidine decrease Positive 51
ritonavir decrease Positive 36
Tenofovir decrease Positive 52
Polymyxin B rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
beclomethasone rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
bicalutamide rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
danazol rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
ethynodiol diacetate rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
retinoic acid rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
aripiprazole rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
axitinib rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
clofilium rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
tenidap rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
darifenacin rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
pimozide rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
amineptine decrease Positive 54
Gemfibrozil isolated mitochondria decrease Positive 7
pirprofen decrease Positive 59
Amitriptyline pig brain mitochondria decrease Positive 60
Bupivacaine decrease Positive 61
citalopram pig brain mitochondria decrease Positive 62
citalopram pig brain mitochondria decrease Positive 62
citalopram pig brain mitochondria decrease Positive 62
Haloperidol decrease Positive 23
propranolol pig brain mitochondria decrease Positive 60
Indomethacin rat isolated liver mitochondria decrease Positive 65
ochratoxin a rat isolated liver mitochondria decrease Positive 66
tacrolimus rat isolated kidney mitochondria decrease Positive 68
Piericidin A affect Positive 53
rolliniastatin-2 affect Positive 53
Idebenone affect Positive 53
Rotenone affect Positive 53
piericidin a affect Positive 53
piericidin b affect Positive 53
aureothin affect Positive 53
amytal affect Positive 53
4-alkyl-acridones affect Positive 53
4′-alkyl-mpp+ analoguesc affect Positive 53
phenoxan affect Positive 53
quinol products affect Positive 53
reduced q-2b affect Positive 53
Myxothiazol affect Positive 53
stigmatellin affect Positive 53
TDS affect Positive 53
2M-TIO affect Positive 53
meperidine affect Positive 53
para-nonylphenol affect Positive 53
Diphenyleneiodonium chloride affect Positive 69
ethoxyformic anhydride affect Positive 70
ethoxyformic anhydride decrease Positive 70
ethoxyformic anhydride decrease Positive 70
flutolanil affect Positive 71
atpenin a5 affect Positive 71
Carboxin affect Positive 71
penthiopyrad affect Positive 71
boscalid affect Positive 71
fluopyram affect Positive 71
dinitrophenol-17 affect Positive 71
atpenin a5 affect Positive 72
thiophene carboxamides affect Positive 73
HQNO affect Positive 74
Polymyxin B 1.6 μg/ml Mycobacterium smegmatis membrane-bound dehydrogenases decrease Positive IC50 76
nanaomycin a 31 μg/ml Mycobacterium smegmatis membrane-bound dehydrogenases decrease Positive IC50 76
Polymyxin B 1.6 μg/ml Mycobacterium smegmatis membrane-bound dehydrogenases affect Positive IC50 76
nanaomycin a 31 μg/ml Mycobacterium smegmatis membrane-bound dehydrogenases affect Positive IC50 76
siccanin P. aeruginosa PAO1 cells affect Positive 76
cyenopyrafen affect Positive 77
pyflubumide affect Positive 77
3-Nitropropionate affect Positive 78
Malonate affect Positive 79
oxaloacetate affect Positive 79
malate affect Positive 79
citrate affect Positive 79
fumarate affect Positive 79
british anti-lewisite affect Positive 80
Myxothiazol affect Positive 81
moas affect Positive 82
azoxystrobin affect Positive 83
oudemansin a affect Positive 84
strobilurin a affect Positive 84
cpmb-oxime affect Positive 84
azoxystrobin 100 mM incubated overnight bovine isolated heart mitochondria Measurements of redox potentials of the ISP affect Positive 83
famoxadone 100 mM incubated overnight bovine isolated heart mitochondria Measurements of redox potentials of the ISP affect Positive 83
stigmatellin 100 mM incubated overnight bovine isolated heart mitochondria Measurements of redox potentials of the ISP affect Positive 83
uhdbt 100 mM incubated overnight bovine isolated heart mitochondria Measurements of redox potentials of the ISP affect Positive 83
hhdbt uhnq 100 mM incubated overnight bovine isolated heart mitochondria Measurements of redox potentials of the ISP affect Positive 83
dibromothymoquinone 100 mM incubated overnight bovine isolated heart mitochondria Measurements of redox potentials of the ISP affect Positive 83
Antimycin A bovine isolated heart mitochondria cytochrome bc1 complex affect Positive 166
diuron affect Positive 83
NQNO bovine isolated heart mitochondria cytochrome bc1 complex affect Positive 166
NQNO bovine isolated heart mitochondria cytochrome bc1 complex affect Positive 166
Carbon Monoxide affect Positive 167
nitric oxide affect Positive 167
Cyanide affect Positive 167
azides affect Positive 167
sulfide affect Positive 167
formate affect Positive 167
ethylxanthate affect Positive 167
bisulfate affect Positive 167
semicarbazide affect Positive 167
salicyaldoxime affect Positive 167
ethylxanthate decrease Positive 167
bisulfate decrease Positive 167
semicarbazide decrease Positive 167
salicyaldoxime decrease Positive 167
adda 5 human U251 mitochondria CcO activity assay affect Positive 168
tetrathiomolybdate 30 μM 48 hour human ECC-1 affect Positive 169
tetrathiomolybdate 30 μM 48 hour human IGROV-1 affect Positive 169
Oligomycin 152 μg inhibitor/mg protein E. coli membrane vesicle, pH gradient formation affect Positive 170
Oligomycin 7.1 μg inhibitor/mg protein C. asciculate SMP-ATPase affect Positive IC50 170
Oligomycin 2.0-3.0 μg inhibitor/mg protein S. cerevisiae SMP-ATPase affect Positive IC50 170
Oligomycin 0.3 μM human NCI-60 cell lines F0F1-ATPase affect Positive IC50 170
Oligomycin 15 ng inhibitor/mg protein N. crassa SMP-ATPase affect Positive Ki 170
Oligomycin 0.21 μM bovine heart MF0F1-ATPase affect Positive Ki 170
Oligomycin 0.4 μg inhibitor/mg protein bovine heart SMP-ATPase affect Positive 95% inhibition 170
Oligomycin 0.5 μg/ml rat liver SMP-ATPase affect Positive 75% inhibition 170
ossamycin 46 μg of inhibitor/mg protein E. coli pH gradient formation by membrane vesicle affect Positive IC50 170
ossamycin 8 μM human NCI-60 cell lines F0F1-ATPase affect Positive IC50 170
ossamycin 1.3 μg of inhibitor/mg protein S. cerevisiae SMP-ATPase affect Positive IC50 170
venturicidin B affect Positive 170
Bedaquiline affect Positive 170
tributyltin chloride 200 nM E. coli and F0F1-ATPase affect Positive 170
tributyltin chloride 200 nM I. tartaricus F0F1-ATPase affect Positive 170
tributyltin chloride 1 μM C. thermoaceticum membrane-bound F0F1-ATPase affect Positive 47% inhibition 170
tributyltin chloride 5 μM C. thermoaceticum membrane-bound F0F1-ATPase affect Positive 87% inhibition 170
tributyltin chloride 1 μM TF0F1-ATPase affect Positive 80% inhibition 170
NCCD 0.65 nmol/mg protein bovine heart SMP-ATPase affect Positive IC50 170
NCCD 1 nmol NCCD/mg protein bovine heart SMP-ATPase affect Positive 85% inhibition 170
substrate analogs affect Positive 170
tentoxin ∼0.6 mol/mol spinach CF1-ATPase affect Positive IC50 170
tentoxin 50 nM spinach CF1(-ɛ)-ATPase affect Positive IC50 170
tentoxin 0.4-0.6 μM lettuce chloroplasts, photophosphorylation affect Positive IC50 170
tentoxin 10 nM spinach CF1(-ɛ)-ATPase affect Positive Ki 170
tentoxin 30-60 μM TF1-ATPase affect Positive Ki 170
tentoxin 8-10 nM spinach CF1(-ɛ)-ATPase affect Positive Kd 170
efrapeptins affect Positive 170
azide affect Positive 170
resveratrol affect Positive 170
N,N'-dicyclohexylcarbodiimide 0.2 μg of inhibitor/mg protein S. cerevisiae SMP-ATPase affect Positive IC50 170
N,N'-dicyclohexylcarbodiimide 1-5 μg of inhibitor/mg protein T. pyriformis SMP-ATPase affect Positive IC50 170
N,N'-dicyclohexylcarbodiimide 200 μMa in less than 5 min and at ∼40 μMa in 30 min R. rubrum F1-ATPase affect Positive 170
N,N'-dicyclohexylcarbodiimide 1.9 μg/mg protein C. fasciculata SMP-ATPase affect Positive IC50 170
N,N'-dicyclohexylcarbodiimide 1 mol DCCD/mol F1 EF1-ATPase affect Positive 95% inhibition 170
N,N'-dicyclohexylcarbodiimide 30 μM membrane-bound EF0F1-ATPase affect Positive maximal 70-80% inhibition 170
N,N'-dicyclohexylcarbodiimide 5 μM C. thermoaceticum membrane-bound F0F1-ATPase affect Positive 47% inhibition 170
N,N'-dicyclohexylcarbodiimide 2 mol inhibitor bound/mol F1 bovine heart MF1-ATPase affect Positive 97% inhibition 170
N,N'-dicyclohexylcarbodiimide 1 mol inhibitor/mol F0 bovine heart SMP-ATPase affect Positive maximal inhibition 170
N,N'-dicyclohexylcarbodiimide 2 mol inhibitor/mol F0 bovine heart H+-translocation affect Positive maximal inhibition 170
N,N'-dicyclohexylcarbodiimide 1 mol inhibitor/mol F0 E. coli membrane H+-translocation affect Positive maximal inhibition 170
N,N'-dicyclohexylcarbodiimide affect Positive 170
woodward's reagent k affect Positive 170
woodward's reagent k affect Positive 170
Melittin 5μM and 16μM bovine bovine heart MF1-ATPase Positive IC50 170
IF1 0.25 μM bovine bovine heart MF1-ATPase Positive IC50 170
IF1 1.2 μM bovine heart MF1-ATPase Positive IC50 170
IF1 0.84 μM bovine heart MF1-ATPase Positive IC50 170
IF1 300 μg/mg protein (T. pyriformis SMP-ATPase) ; Positive IC50 170
IF1 34 μg/mg protein C. asciculate SMP-ATPase Positive IC50 170
IF1 0.24 μM rat liver MF1-ATPase Positive Ki 170
Angiostatin Positive 170
Enterostatin Positive 170
ethyldimethylaminopropyl carbodiimide 13 mol of EDC/mol F1 (EF1-ATPase) Positive 95% inhibition 170
1,5-difluoro-2,4-dinitrobenzene Positive 170
NBD-Cl Positive 170
NBD-Cl Positive 170
N-ethylmaleimide 20 nmoles/mg protein bovine heart mitochondria and submitochondrial particles. Determination of the energized accumulation of Pi and the binding of ADP; Assay of energized translocation of calcium and Pi affect Positive 228
Hypoglycin A Positive 232
4-Pentenoic acid Positive 232
2-bromooctanoic acid Positive 232
2-tetradecylglycidic acid Positive 232
2-bromopalmitic acid Positive 232
Palmitoylcarnitine Positive 232
cyclophilin D affect Positive 171
triclosan 0.5 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 85
triclosan 0.5 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 85
triclosan 0.5 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 85
Benzo(A)Pyrene 100 µg/l zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 85
Benzo(A)Pyrene 1000 µg/l zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 85
phenanthrene 500 µg/l zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 85
phenanthrene 100 µg/l zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 85
phenanthrene 500 µg/l zebrafish XFe24 Extracellular Flux Analyzer increase Positive 85
fluoranthene 100 µg/l zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 85
fluoranthene 100 µg/l zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 85
fluoranthene 100 µg/l zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 85
fluoranthene 100 µg/l zebrafish XFe24 Extracellular Flux Analyzer increase Positive 85
Phenanthrenequinone 2 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 86
benz(a)anthracene-7,12-dione 5 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 86
9,10-anthraquinone 20 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 86
1,9-benz-10-anthrone 10 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 86
Phenanthrenequinone 2 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 86
xanthone 20 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 86
benz(a)anthracene-7,12-dione 5 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 86
1,9-benz-10-anthrone 10 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 86
9,10-anthraquinone 20 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 86
1,9-benz-10-anthrone 10 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 86
xanthone 20 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 86
triclosan 30 μM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 89
triclosan 30 μM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 89
triclosan 30 μM zebrafish XFe24 Extracellular Flux Analyzer increase Positive 89
2,4-dinitrophenol 0.5 μM / 6 hpf zebrafish XFe24 Extracellular Flux Analyzer increase Positive 90
2,4-dinitrophenol 0.5 μM / 48 hpf zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 90
2,4-dinitrophenol 0.5 μM / 24 hpf zebrafish XFe24 Extracellular Flux Analyzer affect Positive 90
2,4-dinitrophenol 0.5 μM / 48 hpf zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 90
2,4-dinitrophenol 0.5 μM / 24 hpf zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 90
2,4-dinitrophenol 0.5 μM / 24 hpf zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 90
2,4-dinitrophenol 0.5 μM / 24 hpf zebrafish XFe24 Extracellular Flux Analyzer increase Positive 90
quercetin 1 µg/l zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 91
quercetin 1 µg/l zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 91
quercetin 10 µg/l zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 91
diquat 100 μM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 92
diquat 100 μM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 92
Rotenone 0.07 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 94
Rotenone 0.04 nmol/mg bovine mitochondria NADH–O2 decrease Positive IC50 94
Deguelin 4.2 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 95
Piericidin A 0.06 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 94
Piericidin A 0.03 nmol/mg bovine mitochondria NADH:O2 decrease Positive IC50 94
Ubicidin-3 0.17 nmol/mg bovine mitochondria NADH:O2 decrease Positive IC50 96
Rolliniastatin-1 0.03 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 98
rolliniastatin-2 0.06 nmol/mg bovine mitochondria NADH–Q-1 decrease Positive IC50 98
Otivarin 0.2 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 98
phenoxan 0.04 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 94
Thiangazole 0.04 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 94
myxalamid pi 15 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 94
phenalamid a2 0.6 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 94
Aurachin a 8.0 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 94
Myxothiazol 20 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 99
stigmatellin 100 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 99
TDS 40 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 99
aureothin 0.3 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 94
Cochlioquinone b 83 nmol/mg bovine mitochondria NADH:O2 decrease Positive IC50 100
strobilurin a >100 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 99
pterulone 36 μM bovine mitochondria NADH:O2 decrease Positive IC50 101
Capsaicin 20–30 μM bovine mitochondria NADH–Q decrease Positive IC50 102
Capsaicin 20–30 μM bovine mitochondria NADH:O2 decrease Positive IC50 102
Rhein 30 μM bovine mitochondria NADH:O2 decrease Positive IC50 104
Papaverine 5 μM bovine mitochondria NADH–Q-1 decrease Positive IC50 30
Ubiquinone-2 2 μM bovine mitochondria NADH–Q-1 decrease Positive IC50 106
Ubiquinone-3 40 μM bovine mitochondria NADH–Q decrease Positive IC50 107
Idebenone 0.4 μM NADH–Q decrease Positive IC50 106
Pyridaben 2.4 nM NADH–Q-1 decrease Positive IC50 108
Fenpyroximate 4.6 nM NADH–Q-1 decrease Positive IC50 108
Fenpyroximate 18 nM NADH–Q decrease Positive IC50 103
Tebufenpyrad 6 nM NADH–Q-1 decrease Positive IC50 108
fenazaquin 20 nM NADH–Q-1 decrease Positive IC50 109
Benzimidazole 3 nM NADH–Q decrease Positive IC50 94
cyhalothrin 0.6 μM NADH–DQ decrease Positive IC50 110
6-chloro-benzothiadiazole 0.1 mM NADH:O2 decrease Positive IC50 111
2M-TIO 40 μM NADH–Q-1 decrease Positive IC50 112
amytal 0.2 mM NADH–Q-1 decrease Positive IC50 112
meperidine 0.1 mM NADH–Q-1 decrease Positive IC50 108
MPP+ 0.3 mM NADH:O2 decrease Positive IC50 114
MPP+ 2–4 mM NADH–Q decrease Positive IC50 115
4'-decyl-mpp+ 1.7 μM NADH:O2 decrease Positive IC50 115
MQ18 0.2 μM NADH–Q-1 decrease Positive IC50 116
2-methylharmine 0.18 mM NADH:O2 decrease Positive IC50 117
TIQ 2 mM NADH:O2 decrease Positive IC50 118
Haloperidol 3 μM NADH–Q-1 decrease Positive IC50 119
HPP+ 15 μM NADH–Q-1 decrease Positive IC50 119
Dequalinium Chloride 11 μM NADH:O2 decrease Positive IC50 120
Cinnarizine 5–10 μM NADH–Q-1 decrease Positive IC50 121
para-nonylphenol 20 μM NADH–Q decrease Positive IC50 108
Catechol 0.4 mM NADH–Q decrease Positive IC50 108
CCCP 85 μM NADH–Q-1 decrease Positive IC50 108
Erythrosin 5'-iodoacetamide 20 nM NADH–O2 decrease Positive IC50 126
Safranine 17 μM NADH–Q decrease Positive IC50 127
dioc5(3) 1.5 μM NADH–Q decrease Positive IC50 127
dioc6(3) 80 nM NADH–O2 decrease Positive IC50 126
Diphenyleneiodonium chloride 0.23 μM NADH–Q-1c decrease Positive IC50 128
N,N'-dicyclohexylcarbodiimide 0.1 mM NADH–Q-1 decrease Positive IC50 129
o-phenanthroline 0.25 mM NADH–Q decrease Positive IC50 130
Leucinostatin 11 μg/mg protein C. asciculate SMP-ATPase decrease Positive IC50 131
Leucinostatin 2 μg inhibitor/ml spinach chloroplast decrease Positive IC50 132
Leucinostatin 0.1-0.4 μg/mg protein rat isolated liver mitochondria decrease Positive 133
efrapeptins 0.56 mol/mol F1 bovine heart MF1-ATPase decrease Positive IC50 134
efrapeptins 70 ng/ml C. asciculate MF1-ATPase decrease Positive IC50 135
efrapeptins 0.3 μM human umbilical vein endothelial cell, nonmitochondrial ATP synthase decrease Positive IC50 136
efrapeptins 0.5 μg/ml R. rubrum chromatophores decrease Positive IC50 137
efrapeptins 0.05-0.5 μg of inhibitor/mg protein T. pyriformis SMP-ATPase decrease Positive IC50 138
efrapeptins 21.5 μM EF1-ATPase decrease Positive ki 139
efrapeptins 10 nM bovine heart MF1-ATPase decrease Positive kd 134
efrapeptins 2.4 mol inhibitor/mol enzyme bovine heart SMP-ATPase decrease Positive complete inhibition 134
resveratrol 27.7 μM rat brain SMP, ATP synthesis decrease Positive 140
resveratrol 14 μM rat liver MF1-ATPase decrease Positive 141
resveratrol 19 μM rat brain M F0F1-ATPase decrease Positive 140
resveratrol 6.4 μM bovine bovine heart MF1-ATPase decrease Positive 142
resveratrol 2 μM human human umbilical vein endothelial cell, nonmitochondrial ATP synthase, ATP synthesis decrease Positive 136
Diethylstilbestrol 10 μM rat liver MF0F1-ATPase decrease Positive 143
Diethylstilbestrol 10-25 μM rat brain MF0F1-ATPase decrease Positive 141
SITS ∼1.3 μM V. parahaemolyticus F0F1-ATPase decrease Positive 144
SITS 25 μM V. parahaemolyticus F1-ATPase decrease Positive 95% inhibition 145
DIDS 20.9 μM rat liver MF1ATPase decrease Positive 146
quercetin 5 kmol/mol bovine heart MF1-ATPase decrease Positive IC50 147
quercetin 85 μM bovine heart MF1-ATPase decrease Positive IC50 148
quercetin 180 μM bovine heart SMP-ATPase decrease Positive IC50 148
quercetin 50 μM rat brain F0F1-ATPase decrease Positive IC50 140
quercetin 3 μM rat liver F1-ATPase decrease Positive IC50 141
quercetin 2 kmol/mola spinach CF1-ATPase decrease Positive 147
quercetin 2.6 μg/mg protein C. asciculate SMP-ATPase decrease Positive IC50 131
quercetin 0.2 mM pig heart MF1-ATPase decrease Positive Ki 149
quercetin 27 μM bovine heart MF1-ATPase decrease Positive Kd 147
quercetin 5 μM C. thermoaceticum membrane-bound F0F1-ATPase decrease Positive 46% inhibition 150
kaempferol 55 μM rat brain MF0F1-ATPase decrease Positive IC50 140
morin 60 μM  rat brain MF0F1-ATPase decrease Positive IC50 140
apigenin 105 μM  rat brain MF0F1-ATPase decrease Positive IC50 140
genistein 55 μM rat brain MF0F1-ATPase decrease Positive IC50 140
genistein 50 μM rat liver F1-ATPase decrease Positive 10% inhibition 141
Biochanin A 65 μM  rat brain MF0F1-ATPase decrease Positive IC50 140
Daidzein 127 μM  rat brain MF0F1-ATPase decrease Positive IC50 151
Oligomycin 152 μg inhibitor/mg protein E. coli membrane vesicle decrease Positive IC50 152
Oligomycin 7.1 μg inhibitor/mg protein C. asciculate SMP-ATPase decrease Positive IC50 131
Oligomycin 2.0-3.0 μg inhibitor/mg protein S. cerevisiae SMP-ATPase decrease Positive IC50 153
Oligomycin 0.3 μM human NCI-60 cell lines, F0F1-ATPase decrease Positive IC50 154
Oligomycin 15 ng inhibitor/mg protein N. crassa SMP-ATPase decrease Positive Ki 155
Oligomycin 0.21 μM bovine heart MF0F1-ATPase decrease Positive Ki 156
Oligomycin 0.4 μg inhibitor/mg protein bovine heart SMP-ATPase decrease Positive 95% inhibition 157
Oligomycin 0.5 μg/ml rat liver SMP-ATPase decrease Positive 75% inhibition 158
peliomycin 4.5 μg inhibitor/mg protein S. cerevisiae SMP-ATPase decrease Positive IC50 153
venturicidin B 9 μg inhibitor/mg protein E. coli membrane vesicle decrease Positive IC50 152
venturicidin B 11 μg inhibitor/mg protein E. coli membrane-bound ATPase decrease Positive IC50 152
venturicidin B 0.13 μg inhibitor/mg protein decrease Positive IC50 153
venturicidin B 0.06-0.18 (A and B) and 11.0 (X) μg inhibitor/mg protein S. cerevisiae SMP-ATPase decrease Positive IC50 159
venturicidin B 5-11 μg inhibitor/mg protein T. pyriformis decrease Positive IC50 138
venturicidin B 3.0 μg/mg protein C. asciculate SMP-ATPase decrease Positive IC50 131
venturicidin B 0.5 μM spinach thylakoids decrease Positive IC50 160
venturicidin B 0.5 μM spinach thylakoids, ATPase decrease Positive IC50 160
ossamycin 1.3 μg of inhibitor/mg protein S. cerevisiae SMP-ATPase decrease Positive IC50 153
ossamycin 46 μg of inhibitor/mg protein E. coli membrane vesicle decrease Positive IC50 152
ossamycin 8 μM human NCI-60 cell lines, F0F1-ATPase decrease Positive IC50 154
apoptolidin 4-5 μM S. cerevisiae membrane-bound F0F1-ATPase decrease Positive Ki 161
apoptolidin 18 μM human NCI-60 cell lines, F0F1-ATPase decrease Positive IC50 154
cytovaricin 1 μM human NCI-60 cell lines, F0F1-ATPase decrease Positive IC50 154
cytovaricin 0.4 μM S. cerevisiae membrane-bound F0F1-ATPase decrease Positive Ki 161
ossamycin 0.8 μM 60 human cancer cell lines of the National Cancer Institute decrease Positive mean 184
1h-benzimidazol-5-amine-2-4-aminophenyl ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-(Dimethylamino)-1,3-benzothiazol-6-ol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)amino]phenol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
7,8-Dihydroxy-4-methylcoumarin ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-Amino-2-(5-ethyl-benzooxazol-2-yl)-phenol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(4-Methoxyphenyl)-[2-(p-anisidino)ethyl]amine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
3,3'-Diamino-4,4'-dihydroxydiphenyl Sulfone ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-(4-Hydroxy-1H-indol-3-yl)acetamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2,5-Bis(2-phenylacetamido)terephthalic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2,6-Dimethyl-5,12-dihydroindolo[3,2-d][1,3]benzodiazepine;hydrochloride ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(4-{[(4,6-Dimethyl-2-pyrimidinyl)amino]sulfonyl}phenyl)-2,4-dimethoxybenzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N'-(4-Methoxybenzyl)-N,N-dimethylbenzene-1,3-diamine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-(1,2,3,4-Tetrahydro-benzo[a]phenanthridin-5-yl)-benzene-1,2-diol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-Benzyl-4-methoxyaniline ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
Methyl 2-amino-4-ethyl-5-methylthiophene-3-carboxylate ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(4-(4-Methyl-1-piperazinyl)phenyl)-9-acridinamine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-Chloro-N-(2-hydroxyphenyl)benzenesulfonamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(4-Hydroxyphenyl)furan-2-carboxamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(Z)-2-Cyano-3-(3-ethoxy-4-hydroxyphenyl)prop-2-enamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(3-Bromo-4-hydroxyphenyl)[(4-chlorophenyl)sulfonyl]amine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Chloro-6-methylindolo[1,2-c]quinazolin-12-amine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-(2,3-Dihydro-1H-benzo[f]cyclopenta[c]quinolin-4-yl)benzene-1,2-diol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(5E)-5-(4-Hydroxybenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
8-Chloro-2,2-dimethyl-2,3-dihydro-1H-phenothiazin-4(10H)-one ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-[(3,4-Dimethylphenyl)sulfonyl]benzene-1,4-diol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-([4-(1H-Benzimidazol-2-yl)phenyl]amino)-4-oxobutanoic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
Ethyl 2-ethoxy-5-hydroxy-1H-indole-3-carboxylate ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-(1,2,3,4-Tetrahydrobenzo[a]phenanthridin-5-yl)benzene-1,3-diol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(Cyclohexylmethyl)-4-methoxyaniline ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(Furan-2-ylmethyl)-1,3-benzodioxol-5-amine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
5-Nitro-2-phenyl-1H-indole ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
8-Chloro-2,3-dihydro-1H-phenothiazin-4(10H)-one ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(4-Bromophenyl)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-[2-(2-Aminophenyl)vinyl]-5,7-dimethylquinolin-8-ol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4,6-Dimethyl-2-phenyl-2H-pyrazolo[3,4-b]pyridin-3-ol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-Methoxy-2-[(4-piperidylpiperidyl)methyl]phenol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(5-Isopropyl-1,3,4-thiadiazol-2-yl)-3-nitrobenzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Amino-6-ethyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(NE)-N-[[3-[[3-[(E)-hydroxyiminomethyl]-2,4,6-trimethylphenyl]methyl]-2,4,6-trimethylphenyl]methylidene]hydroxylamine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(3-Fluorophenyl)-2,4,6-tri(propan-2-yl)benzenesulfonamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-(4-Hydroxy-3-methoxybenzylidene)-1H-indene-1,3(2H)-dione ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Furancarboxamide, N-[[(4-methoxyphenyl)amino]thioxomethyl]- ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Amino-N-quinolin-8-yl-benzenesulfonamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(5Z)-5-[(4-Fluorophenyl)methylidene]-1-methyl-3-phenyl-1,3-diazinane-2,4,6-trione ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-[4-(1-Adamantyl)phenoxy]-N,N-diethylethanamine;hydrochloride ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(2Z)-2-(Acetylamino)-N-(4-hydroxyphenyl)-3-phenylprop-2-enamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(5E)-5-[(3-Bromo-4-methoxyphenyl)methylidene]-1-phenyl-2-sulfanylidene-1,3-diazinane-4,6-dione ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
[(3-{[(4-Bromophenyl)amino]carbonyl}phenyl)thio]acetic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-[(4-Chlorobenzyl)thio]-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
1-(5-Hydroxy-2-methyl-1-phenyl-1H-indol-3-yl)ethanone ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-[(4-Ethylpiperazin-1-yl)methyl]-4-methoxyphenol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-(4-Fluorophenyl)-1,3,5-trimethyl-2,6-diphenylpiperidin-4-ol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-[(E)-1-[5-(4-Bromophenyl)furan-2-yl]-3-[3-(dimethylamino)propylamino]-3-oxoprop-1-en-2-yl]-4-methylbenzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(2Z)-3-{N-[4-(4-Chlorophenyl)phenyl]carbamoyl}prop-2-enoic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-[(E)-3-(4-Ethylpiperazin-1-yl)prop-1-enyl]-N,N-dimethylaniline ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
1,5-Dihydro-4,5-diphenyl-2H-imidazol-2-one ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-[(E)-2-(4-Chlorophenyl)ethenyl]-1-methyl-1H-benzimidazole ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-[1-Azabicyclo[2.2.2]octan-3-ylidene-[4-(dimethylamino)phenyl]methyl]-N,N-dimethylaniline;hydrochloride ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-Oxo-4-((4-(styryl)phenyl)amino)but-2-enoic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2,5-Dianilinoterephthalic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-Methoxy-N-[4-(thiazol-2-ylsulfinamoyl)-phenyl]-benzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
3-[(3,4-Dimethylphenyl)sulfonyl]propanenitrile ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-[4-(1,3-Benzoxazol-2-yl)anilino]-4-oxobutanoic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
1-(3-Chlorophenyl)-2,3,4,5,6,7,8,8a-octahydro-1H-isoquinolin-4a-ol;hydrochloride ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
6-Methyl-2-(1,2,2,2-tetrafluoroethyl)-1H-benzimidazole ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
Ethyl 6-amino-5-cyano-2-methyl-4-(2-nitrophenyl)-4H-pyran-3-carboxylate ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(2,1,3-Benzoxadiazol-4-yl)-2,2,2-trifluoroacetamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-Tert-butyl-N-(4-methylphenyl)benzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Methoxy-4-(morpholin-4-ylmethyl)phenol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
Bis((1E)-2-phenylvinyl)phosphinic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
1-[2-(Allyloxy)benzyl]-4-benzylpiperidine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2,5-Diaminoterephthalic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(1-Adamantylcarbonyl)-N'-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)thiourea ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-(Isobutylthio)succinic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-{4-[Acetyl(methyl)amino]phenyl}-4-biphenylcarboxamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-[(E)-3-(2-Ethylpiperidin-1-yl)prop-1-enyl]-N,N-dimethylaniline ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
3-(2-Chloro-phenyl)-2-(4-(2-oxo-2H-chromen-3-YL)-thiazol-2-YL)-acrylonitrile ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
Ethyl (7Z)-2-amino-7-(hydroxyimino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Amino-4-(3,4-dichlorophenyl)thiazole ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
5-(2-Nitrobenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
3-(4-Bromo-2-thienyl)-2-cyano-2-propenethioamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
Benzyl [(6-amino-3,5-dicyano-4-ethylpyridin-2-yl)sulfanyl]acetate ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-{2-[(1,3-Diphenyl-1H-pyrazol-5-yl)amino]phenyl}benzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Butyl-5-methylisophthalic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Butylsulfanyl-6-methyl-9H-1,3,4,9-tetraaza-fluorene ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Phenyldipyrrolo[1,2-a:2',1'-c]pyrazine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
Fluoroacetate affect Positive 173
Rosiglitazone 1uM 24 and 48 hours Murine 3T3-L1 adipocytes differentiated 96-well BD Oxygen Biosensor System plates increase Positive 179
Rosiglitazone 1uM 24 and 48 hours Murine adipocytes Citrate Synthase Activity affect Positive 179
atorvastatin C2C12 myoblasts affect Positive 180
lovastatin C2C12 myoblasts affect Positive 180
Simvastatin C2C12 myoblasts affect Positive 180
Cerivastatin 100uM C2C12 myoblasts measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds decrease Positive 180
pitavastatin 100uM C2C12 myoblasts measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds decrease Positive 180
lovastatin 100uM C2C12 myoblasts measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds decrease Positive 180
Simvastatin 100uM C2C12 myoblasts Measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds. The lactone forms of the indicated statins were included in the assay medium at their cytotoxic EC50 concentration for measurement of their effect on the catalytic capacity. decrease Positive 180
Simvastatin 200uM bovine heart mitochondria Reduction of the CIII cytochromes c1 and b was determined spectrophotometrically in bovine heart mitochondria. affect Positive p < 0.01 180
Diazoxide EC50= 40mmol/L, saturation by 100mmol/L Primary Culture of Neonatal Rat Cardiac Ventricular Myocytes flow cytometry and quantitative image analysis of cells stained with fluorescent DC indicators. affect Positive 188
Pinacidil affect Positive 188
5-Hydroxydecanoate 500mmol/L Primary Culture of Neonatal Rat Cardiac Ventricular Myocytes flow cytometry and quantitative image analysis of cells stained with fluorescent DC indicators. affect Positive 188
Glibenclamide affect Positive 188
5-Hydroxydecanoate 100 μm decrease Positive 189
Glibenclamide K1/2 values 1-6 microM heart and liver mitochondria from rat affect Positive 190
5-Hydroxydecanoate K1/2 values 45-75 microM heart and liver mitochondria from rat decrease Positive 190
ionomycin rat liver mitochondria Oxygen consumption and medium pH were monitored simultaneously with a dual channel Gilson oxygraph equipped with a Clark electrode (Yellow Springs Instruments) and a combination pH electrode (Beckman No. 39030). increase Positive 202
Troglitazone human hepatocytes ATP bioluminescence assay decrease Positive 226
Troglitazone affect Positive 227
Valproic Acid affect Positive 227
Amiodarone affect Positive 227
Tamoxifen affect Positive 227
Tamoxifen affect Positive 227
Perhexiline affect Positive 227
Perhexiline rat hepatocytes affect Positive 238
Acetaminophen affect Positive 227
Salicylic acid affect Positive 227
Ibuprofen affect Positive 227
buprenorphine 100 μM rat liver mitochondria the mitochondrial membrane potential assessed by the fluorescence of safranine. affect Positive 235
Tianeptine 0.0625 mmol/kg i.p. mouse in vivo affect Positive 237
Tianeptine 0.5 mM mouse The activity of the tricarboxylic acid cycle, assessed as the in vitro formation of [14C]CO2 from [1-14C]acetylcoenzyme A in vitro. affect Positive 237
tetracyclines mouse liver mitochondria affect Positive 236
tetracyclines mouse liver mitochondria Tricarboxylic acid cycle activity was assessed by the in vitro formation of [14C]CO2 from [1-14C]acetylcoenzyme A by mouse liver mitochondria. affect Positive 236
Ibuprofen affect Positive 239
Perhexiline 77 μmol/L rat cardiac mitochondria CPT-1 activity was measured by the formation of palmitoyl-[3H]-carnitine from palmitoyl-CoA and [3H]-I- carnitine, affect Positive IC50 240
Perhexiline 148 μmol/L rat hepatic mitochondria CPT-1 activity was measured by the formation of palmitoyl-[3H]-carnitine from palmitoyl-CoA and [3H]-I- carnitine, affect Positive IC50 240
Amiodarone 228 μmol/L rat cardiac and hepatic mitochondria CPT-1 activity was measured by the formation of palmitoyl-[3H]-carnitine from palmitoyl-CoA and [3H]-I- carnitine, affect Positive IC50 240
Acetaminophen >400μM >400 mice Lean mice vs Ob/ob mice Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform Positive EC20 227
Carbamazepine >400μM 341 mice Lean mice vs Ob/ob mice Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform Positive EC20 227
Diclofenac 47μM 11* mice Lean mice vs Ob/ob mice Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform Positive EC20 227
Ibuprofen 287μM 80* mice Lean mice vs Ob/ob mice Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform Positive EC20 227
Irinotecan 6μM 10 mice Lean mice vs Ob/ob mice Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform Positive EC20 227
Methotrexate 44μM 42 mice Lean mice vs Ob/ob mice Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform Positive EC20 227
Salicylic acid >400μM >400 mice Lean mice vs Ob/ob mice Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform Positive EC20 227
Tamoxifen 4μM 11 mice Lean mice vs Ob/ob mice Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform Positive EC20 227
Zidovudine 79μM 83 mice Lean mice vs Ob/ob mice Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform Positive EC20 227
SB202190 10 μM intact and in permeabilized HeLa cells (MM5 cells expressing mitmutAEQ ) mitochondrial Ca2+ uptake increase Positive 233
kaempferol 1μM The HeLa cell clone MM5 expressing mitochondrially targeted mutated aequorin was used for [Ca2+]M measurements. [Ca2+]c measurements were carried out using HeLa cells transiently transfected with the plasmid for cytosolic aequorin. increase Positive 234
kaempferol 7μM The HeLa cell clone MM5 expressing mitochondrially targeted mutated aequorin was used for [Ca2+]M measurements. [Ca2+]c measurements were carried out using HeLa cells transiently transfected with the plasmid for cytosolic aequorin. increase Positive EC50 234
quercetin 21 μM mitochondrial Ca2+ uptake increase Positive EC50 234
genistein 37μM mitochondrial Ca2+ uptake increase Positive EC50 234
CGP37157 1 μmol/L periodically paced rat ventricular myocytes (VMs) under β-adrenergic stimulation mitochondrial Ca2+ monitored by mitochondrial-targeted Ca2+ biosensor mtRCamp1h. Positive 241
kaempferol 10 μmol/L periodically paced rat ventricular myocytes (VMs) under β-adrenergic stimulation mitochondrial Ca2+ monitored by mitochondrial-targeted Ca2+ biosensor mtRCamp1h. Positive 241
CGP37157 1 μmol/L Positive 241
Ru360 2 μmol/L Positive 241
atpenin a5 bovine heart mitochondria affect Positive 192
Carboxin bovine heart mitochondria affect Positive 192
Thenoyltrifluoroacetone bovine heart mitochondria affect Positive 192
HQNO bovine heart mitochondria affect Positive 192
Nimesulide Positive 197
lumiracoxib Positive 197
Chloramphenicol Positive 197
Cephaloglycin inhibit Positive 197
Imipenem inhibit Positive 197
Chlorpromazine inhibit Positive 197
Haloperidol inhibit Positive 197
Clozapine inhibit Positive 197
Amitriptyline Positive 197
Desipramine Positive 197
Nefazodone inhibit Positive 197
Metformin inhibit Positive 197
Phenformin inhibit Positive 197
Troglitazone inhibit Positive 197
Rosiglitazone inhibit Positive 197
Pioglitazone inhibit Positive 197
Doxorubicin Positive 197
Efavirenz Positive 197
Propofol Positive 197
Barbiturate decrease Positive 197
Chlorpyrifos 30–50 μM PC12 cell line we measured the concentration malondialdehyde (MDA) to indicate formation of lipid peroxides Positive 242
Paraquat 10 mg/kg/week intraperitoneal (i.p.) 3weeks C57BL/6 mice Positive 242
Rotenone 10–100 nmol SK-N-MC Neuroblastoma cells decrease Positive 242
Lead 1%,2%,4% in oral chow Wistar rats Positive 242
Aluminium 100 mg/kg in drinking water daily for six weeks Wistar rats Positive 242
Fluoroacetate Positive 251
2-Deoxy-D-glucose Positive 249
Lonidamine Positive 249
Lonidamine Positive 249
3-Bromopyruvate Positive 249
Imatinib Positive 249
Oxythiamine Positive 249
Yohimbine mouse neuron Oxygen consumption rate (OCR) or extracellular acidification rate (ECAR) measurements from permeabilized neurons and isolated brain mitochondria were performed using the XF96 Extracellular Flux analyzer (Seahorse Bioscience). increase Positive 269
Dyclonine mouse neuron Oxygen consumption rate (OCR) or extracellular acidification rate (ECAR) measurements from permeabilized neurons and isolated brain mitochondria were performed using the XF96 Extracellular Flux analyzer (Seahorse Bioscience). increase Positive 269
Dronedarone 10µM 24hr isolated rat liver mitochondria, and the human hepatoma cell line HepG2 inhibit Positive 271
Amiodarone 20µM 24hr isolated rat liver mitochondria, and the human hepatoma cell line HepG2 inhibit Positive 271
Trimetazidine 10-100µM rat isolated cardiac mitochondria increase Positive 274
Valproic Acid 0.5–2 mM 3min rat inverted submitochondrial vesicles (ISMV) from rat liver isolated mitochondria The rate of the radiolabeled substrate [1-14C]-pyruvate uptake by ISMV was measured in the presence or absence of an inwardly directed proton gradient. inhibitor Positive 279
alpha-Cyano-4-hydroxycinnamate 1mM 3min rat inverted submitochondrial vesicles (ISMV) from rat liver isolated mitochondria The rate of the radiolabeled substrate [1-14C]-pyruvate uptake by ISMV was measured in the presence or absence of an inwardly directed proton gradient. inhibitor Positive 279
alpha-Cyano-4-hydroxycinnamate 0.05mM inhibitor Positive >90% inhibition 280
Alpha-Cyanocinnamate 0.05mM inhibitor Positive >90% inhibition 280
ranolazine 25μM 24hr T47D cells quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion stimulate Positive Student’s two-tail t-test, where p < 0.05 273
Trimetazidine 100 μM 24hr T47D cells quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion stimulate Positive Student’s two-tail t-test, where p < 0.05 273
Etomoxir 0.1 to 50 μM 24hr MCF-7 and T47D cells quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion inhibition Positive Student’s two-tail t-test, where p < 0.05 273
Oxfenicine 1.5 to 4.5mM 24hr T47D cells quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion inhibition Positive Student’s two-tail t-test, where p < 0.05 273
Carnitine 0.5mM 24hr U-937, MCF-7, and T47D quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion stimulate Positive 273
AICAR 1mM 24hr U-937, MCF-7, and T47D quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion stimulate Positive 273
AICAR stimulate Positive 273
iodoacetate inhibition Positive 278
Dichloroacetate inhibition Positive 278
tacrolimus 50 µg/ml 12hr INS-1 cells XF24 Extracellular Flux Analyzer decrease Positive 322
tacrolimus 50 µg/ml 12hr INS-1 cells XF24 Extracellular Flux Analyzer decrease Positive 322
tacrolimus 50 µg/ml 12hr INS-1 cells XF24 Extracellular Flux Analyzer decrease Positive 322
tacrolimus 50 µg/ml 12hr INS-1 cells XF24 Extracellular Flux Analyzer decrease Positive 322
tacrolimus 1 μM rat isolated kidney mitochondria Oxygen consumption was measured with a Clark‐type electrode decrease Positive 10% 323
rapamycin 1 μM rat isolated kidney mitochondria Oxygen consumption was measured with a Clark‐type electrode decrease Positive 11% 323
tacrolimus 3.4E−11 M and 2.3E−8 M rat isolated kidney mitochondria Oxygen consumption was measured with a Clark‐type electrode decrease Positive EC50 ; maximal inhibitory effect was about 20% 323
rapamycin 4.4×10−10 M rat isolated kidney mitochondria Oxygen consumption was measured with a Clark‐type electrode decrease Positive EC50 ; maximal inhibitory effect was about14% 323
tacrolimus 1 μM rat isolated kidney mitochondria Oxygen consumption was measured with a Clark‐type electrode decrease Positive 323
rapamycin 1 μM rat isolated kidney mitochondria Oxygen consumption was measured with a Clark‐type electrode decrease Positive 323
MG-132 20 μM 24 hr rat PC12 cells The total glutathione (reduced form GSH + oxidized form GSSG) was determined using glutathione reductase deplete GSH Positive 289
3-morpholinosydnonimine 150 μM 24 hr rat PC12 cells The total glutathione (reduced form GSH + oxidized form GSSG) was determined using glutathione reductase restore GSH Positive 289
MG-132 20 μM 6 hr HeLa cells Total ubiquitin, Lysine 48-linked polyubiquitin and Lysine 63-linked polyubiquitin levels were assessed in whole cell extracts by western blotting. increase Positive 291
MG-132 20 μM 6 hr HeLa cells Mitochondrial respiration was calculated by measuring oxygen consumption rate (OCR) and proton flux under a series of conditions using a Seahorse Flux analyzer. inhibit Positive 291
Diazepam 70 μg/ml pig kidney embryo cells polarographic cell (1.2 ml) inhibit Positive 293
Diazepam 150μg/ml 2hr PE cells luciferin-luciferase method decrease Positive 293
Cadmium 50-500 μM 3hr rat PC12 cells Cell respiration was determined polarographically with the help of Clark oxygen electrode decrease Positive 300
Mercury 10-50 μM 3hr rat PC12 cells Cell respiration was determined polarographically with the help of Clark oxygen electrode decrease Positive 300
Copper 50 μM rat PC12 cells Cell respiration was determined polarographically with the help of Clark oxygen electrode decrease Positive 300
MCU-i4 5 μM HeLa cells transfected with mitochondria-targeted aequorin (mtAeq) after cellular stimulation with histamine Highigh-throughput screening assay based on aequorin. decrease Positive 301
MCU-i11 5 μM HeLa cells transfected with mitochondria-targeted aequorin (mtAeq) after cellular stimulation with histamine Highigh-throughput screening assay based on aequorin. decrease Positive 301
MCU-i4 10 μM mouse embryonic fibroblasts (MEFs), MDA-MB-231, and HEK293T cell lines Small-Scale Validation Assay (cytoplasmic- or mitochondria-targeted aequorin (cytAeq and mtAeq, respectively) decrease Positive 301
MCU-i11 10 μM mouse embryonic fibroblasts (MEFs), MDA-MB-231, and HEK293T cell lines Small-Scale Validation Assay (cytoplasmic- or mitochondria-targeted aequorin (cytAeq and mtAeq, respectively) decrease Positive 301
MCU-i4 8.4 μM(Micu1), 18 μM (Micu1-Micu2) Purified recombinant Micu1, Micu2 Purified recombinant Micu1, Micu2, and the dimeric Micu1-Micu2 proteins were immobilized on different channels of a SPR sensor chip surface. decrease Positive IC50 301
MCU-i11 2.9 μM(Micu1), 2.7 μM (Micu1-Micu2) Purified recombinant Micu1, Micu2 Purified recombinant Micu1, Micu2, and the dimeric Micu1-Micu2 proteins were immobilized on different channels of a SPR sensor chip surface. decrease Positive IC50 301
MCU-i4 10 μM Skeletal Muscle Fibers measured mitochondrial Ca2+ uptake in flexor digitorum brevis (FDB) myofibers freshly isolated from adult mice and previously transfected in vivo with the mitochondria-targeted Ca2+ probe 4mt-GCaMP6f decrease Positive 301
MCU-i11 10 μM Skeletal Muscle Fibers measured mitochondrial Ca2+ uptake in flexor digitorum brevis (FDB) myofibers freshly isolated from adult mice and previously transfected in vivo with the mitochondria-targeted Ca2+ probe 4mt-GCaMP6f decrease Positive 301
DS16570511 7 μM HEK293A cells HEK293A cell lines expressing the mitochondria-targeted Ca2+ indicator protein aequorin decrease Positive IC50 302
Ketoconazole I50=32, 74, 65, 75, 500μM for substrates Glutamate/Malate, Pyruvate/Malate, Ornithine/Malate, Arginine/Malate and Succinate repectively rat liver mitochondria Clark electrode inhibit Positive 303
Miconazole I50=100, 160, 160, 170, 150 μM for substrates Glutamate/Malate, Pyruvate/Malate, Ornithine/Malate, Arginine/Malate and Succinate repectively rat liver mitochondria Clark electrode inhibit Positive 303
amphotericin B 2.5mg/ml Aspergillus fumigatus the formation of MDAs by antifungal drug-derived ROS in A. fumigatus was determined using the thiobarbituric acid (TBA) assay. induce Positive 304
Terbinafine 4mg/ml Aspergillus fumigatus lipid peroxidation using the thiobarbituric acid assay induce Positive 304
itraconazole 4mg/ml Aspergillus fumigatus lipid peroxidation using the thiobarbituric acid assay induce Positive 304
amphotericin B 2.5mg/ml Aspergillus fumigatus mitochondrion-specific lipid peroxidation probe MitoPerOx induce Positive 304
Terbinafine 4mg/ml 3min, 5min, 15min Aspergillus fumigatus mitochondrion-specific lipid peroxidation probe MitoPerOx induce Positive 304
itraconazole 4mg/ml Aspergillus fumigatus mitochondrion-specific lipid peroxidation probe MitoPerOx induce Positive 304
neomycin 400 μM zebrafish zebrafish lateral line hair measrueing cytoplasmic oxidation (HyPer) and mitochondrial Ca2+ uptake (mitoRGECO) increase Positive 315
Gentamicin 300 μg/ml 1hr postnatal day 6 (P6±1d) FVB mice basal turn outer hair cells ( low-frequency processing OHCs) from intact cochlear (organ of Corti) explants scanning confocal microscope (NADH autofluorescence); T1 imaging buffer contained 5 mM glucose. T2 imaging buffer contained 10 mM glucose, 3 mM glutamate and 2 mM pyruvate. decrease Positive 312
Gentamicin 5mM 10min rat isolated rat liver (and kidney) mitochondria Oroboros O2K Oxygraph, complex II-based state 4 respiration increase Positive 316
Gentamicin 5mM 10min rat isolated rat liver (and kidney) mitochondria Oroboros O2K Oxygraph, complex II-based state 3u respiration decrease Positive 316
Gentamicin 5mM 10min rat isolated rat liver mitochondria Oroboros O2K Oxygraph, complex I-based state 4 respiration increase Positive 316
Gentamicin 5mM 10min rat isolated rat liver mitochondria Oroboros O2K Oxygraph, complex I-based state 3u respiration decrease Positive 316
Gentamicin 5mM 10min rat isolated rat liver (and kidney) mitochondria Oroboros O2K Oxygraph reduce Positive 316
Berberine 1-10 µM isolated rat muscle mitochondria Clark type oxygen electrode (Strathkelvin Instruments) decrease Positive 328
Berberine 25 μM 48, 72 hr K1735-M2 mouse melanoma cells An acid extraction procedure was used to evaluate the intracellular concentration of adenine nucleotides. Adenine nucleotides were separated by reverse-phase high-performance liquid chromatography. Quantification was achieved by employing ATP, ADP, and AMP standard curves. decrease Positive p< 0.05 vs. control for each time of incubation 327
Berberine 10 μM 24 hr K1735-M2 mouse melanoma cells An acid extraction procedure was used to evaluate the intracellular concentration of adenine nucleotides. Adenine nucleotides were separated by reverse-phase high-performance liquid chromatography. Quantification was achieved by employing ATP, ADP, and AMP standard curves. decrease Positive p< 0.05 vs. control for each time of incubation 327
Acetaminophen 348.5 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Acetylsalicylic acid > 800 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
alpidem 25.6 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Amantadine > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Ambroxol > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Amiodarone 45.92 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Amoxicillin 90.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. increase Positive EC20 36
Ampicillin > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Antipyrine > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Arsenic trioxide < 50 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Biotin 44.5 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
lumiracoxib > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
bisacodyl 50.9 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
estradiol acetate > 200 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Bupivacaine 60.6 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Busulfan 169.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Butein 29.6 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Caffeine > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Capsaicin 15 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Carbamazepine 53.4 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Cefixime 41.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Chlorambucil 138.7 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Ciprofloxacin 195.0 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. increase Positive EC20 36
Clodronate > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Clotrimazole 2.9 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
curcumin > 200 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Daunorubicin 12.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
dexamethasone valerate > 200 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Diazoxide 4.9 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Diclofenac 9.1 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Diflunisal 9.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Doxorubicin 15.9 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
erlotinib 328.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Fluconazole > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Flufenamic Acid 1.7 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
gefitinib 269.6 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
genistein 81.3 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Glimepiride 16.6 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Gossypol 30.3 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Ibuprofen 170.1 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
imipramine 75.5 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. increase Positive EC20 36
Indomethacin 25.2 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Isoniazid 59.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Ketoconazole > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Lamivudine 160.7 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Lidocaine > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Lonidamine 18.9 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
lovastatin 4.4 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
lumiracoxib 26.3 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Manganese > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Mefenamic acid 10.1 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Metformin > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Mitomycin 4.9 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Nicotine > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
nifuroxazide 61.5 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Nimesulide < 25 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Nitrofurantoin 232.3 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Perhexiline 88.4 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Piroxicam 224.5 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
pravastatin 5 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
propylparaben 63 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Pyrazinamide 107.5 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
resveratrol 7.7 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
riboflavin 264.6 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
rifampicin 124.1 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
ritonavir 35.5 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Salicylic acid 354.4 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Simvastatin 1.6 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
sorafenib 283.4 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Sulindac > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Tolfenamic Acid > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Troglitazone 3.9 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Valproic Acid > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Zidovudine > 800 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease Positive EC20 36
Acetaminophen > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Acetylsalicylic acid 149.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
alpidem 29.6 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Amantadine > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Ambroxol > 200 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Amoxicillin 188.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. increase Positive EC20 36
Ampicillin 161.2 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. increase Positive EC20 36
Antipyrine > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Arsenic trioxide 0.9 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
lumiracoxib > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
bisacodyl 52.5 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
estradiol acetate > 200 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Bupivacaine > 800 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Caffeine > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Capsaicin 15.7 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Carbamazepine 170.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. increase Positive EC20 36
Cefixime 216.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Chlorambucil 140.9 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Clodronate 227.2 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
curcumin > 200 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Daunorubicin 10.9 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
dexamethasone valerate > 200 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Diclofenac 29.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
erlotinib 17.4 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. increase Positive EC20 36
Fluconazole 186.6 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Ibuprofen 132.1 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
imipramine 18.3 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. increase Positive EC20 36
Ketoconazole 2.9 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Lamivudine 317.4 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Lidocaine 188.2 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. increase Positive EC20 36
lovastatin 6.2 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
lumiracoxib 12 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Manganese > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Metformin 351.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Nicotine 312 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
nifuroxazide 3.7 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Nitrofurantoin 8.7 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Perhexiline 87.7 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Piroxicam 6.6 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
propylparaben 28.4 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Pyrazinamide 190.9 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
riboflavin 182.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Salicylic acid 120.9 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Sulindac 35.6 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Tolfenamic Acid 238.7 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. increase Positive EC20 36
Troglitazone 6 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Valproic Acid 44.9 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease Positive EC20 36
Zidovudine 242.0 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. increase Positive EC20 36
Zidovudine Interfere Positive 307
Acyclovir Interfere Positive 307
Ganciclovir Interfere Positive 307
Zalcitabine Interfere Positive 307
Saquinavir Interfere Positive 307
tetracyclines decrease Positive 307
Ciprofloxacin decrease Positive 307
Ciprofloxacin decrease Positive 307
Ciprofloxacin Increase Positive 307
Cisplatin decrease Positive 307
Cyclophosphamide decrease Positive 307
Clozapine decrease Positive 307
sertraline rat brain mitochondria decrease Positive 307
Fluoxetine rat brain mitochondria decrease Positive 307
sertraline rat liver mitochondria decrease Positive 307
Fluoxetine rat liver mitochondria decrease Positive 307
sertraline decrease Positive 307
Fluoxetine decrease Positive 307
Flufenamic Acid 2.9 ± 0.3 rat isolated rat liver mitochondria State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) inhibit Positive UC50 (nmol/mg mitochondrial protein) 40
Tolfenamic Acid 3.4 ± 0.6 rat isolated rat liver mitochondria State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) inhibit Positive UC50 (nmol/mg mitochondrial protein) 40
Mefenamic acid 17.9 ± 2.2 rat isolated rat liver mitochondria State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) inhibit Positive UC50 (nmol/mg mitochondrial protein) 40
Meloxicam 22.8 ± 2.8 rat isolated rat liver mitochondria State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) inhibit Positive UC50 (nmol/mg mitochondrial protein) 40
Sudoxicam 37.4 ± 3.0 rat isolated rat liver mitochondria State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) inhibit Positive UC50 (nmol/mg mitochondrial protein) 40
Piroxicam 69.0 ± 7.2 rat isolated rat liver mitochondria State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) inhibit Positive UC50 (nmol/mg mitochondrial protein) 40
Diflunisal 6.7 ± 1.3 rat isolated rat liver mitochondria State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) inhibit Positive UC50 (nmol/mg mitochondrial protein) 40
Diclofenac 56.3 ± 4.9 rat isolated rat liver mitochondria State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) inhibit Positive UC50 (nmol/mg mitochondrial protein) 40
Sulindac > 100 rat isolated rat liver mitochondria State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) inhibit Positive UC50 (nmol/mg mitochondrial protein) 40
Sulindac sulfide 25.7 ± 4.5 rat isolated rat liver mitochondria State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) inhibit Positive UC50 (nmol/mg mitochondrial protein) 40
Nimesulide 2.6 ± 0.2 rat isolated rat liver mitochondria State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) inhibit Positive UC50 (nmol/mg mitochondrial protein) 40
Sulindac sulfide 39.8 ± 2.9 rat isolated rat liver mitochondria State 3 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) inhibit Positive IC50 (nmol/mg mitochondrial protein) 40
Flufenamic Acid 146 24hr rat hepatocytes LipidTox, for neutral lipid accumulation, to evaluate lipid content. accumulation Positive AC50 (μM) 40
Tolfenamic Acid 83.1 24hr rat hepatocytes LipidTox, for neutral lipid accumulation, to evaluate lipid content. accumulation Positive AC50 (μM) 40
Mefenamic acid 161 24hr rat hepatocytes LipidTox, for neutral lipid accumulation, to evaluate lipid content. accumulation Positive AC50 (μM) 40
Meloxicam > 500 24hr rat hepatocytes LipidTox, for neutral lipid accumulation, to evaluate lipid content. accumulation Positive AC50 (μM) 40
Sudoxicam > 500 24hr rat hepatocytes LipidTox, for neutral lipid accumulation, to evaluate lipid content. accumulation Positive AC50 (μM) 40
Piroxicam 728 24hr rat hepatocytes LipidTox, for neutral lipid accumulation, to evaluate lipid content. accumulation Positive AC50 (μM) 40
Diflunisal 68 24hr rat hepatocytes LipidTox, for neutral lipid accumulation, to evaluate lipid content. accumulation Positive AC50 (μM) 40
Diclofenac 122 24hr rat hepatocytes LipidTox, for neutral lipid accumulation, to evaluate lipid content. accumulation Positive AC50 (μM) 40
Sulindac sulfide 78 24hr rat hepatocytes LipidTox, for neutral lipid accumulation, to evaluate lipid content. accumulation Positive AC50 (μM) 40
Nimesulide 29 24hr rat hepatocytes LipidTox, for neutral lipid accumulation, to evaluate lipid content. accumulation Positive AC50 (μM) 40
Flufenamic Acid 79 24hr rat hepatocytes glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342 Positive AC50 (μM) 40
Tolfenamic Acid 105 24hr rat hepatocytes glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342 Positive AC50 (μM) 40
Mefenamic acid 148 24hr rat hepatocytes glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342 Positive AC50 (μM) 40
Meloxicam 316 24hr rat hepatocytes glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342 Positive AC50 (μM) 40
Sudoxicam 313 24hr rat hepatocytes glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342 Positive AC50 (μM) 40
Diflunisal 29 24hr rat hepatocytes glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342 Positive AC50 (μM) 40
Diclofenac 167 24hr rat hepatocytes glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342 Positive AC50 (μM) 40
Sulindac 896 24hr rat hepatocytes glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342 Positive AC50 (μM) 40
Sulindac sulfide 40 24hr rat hepatocytes glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342 Positive AC50 (μM) 40
Nimesulide 1 24hr rat hepatocytes glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342 Positive AC50 (μM) 40
Amiodarone 75.2 ± 12.9, 92.0 ± 5.5, 0.8, 95.1 ± 10.1 ,69.1 ± 24.1, 1.3 4hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
Amitriptyline 70.9 ± 16.8, 72.0 ± 5.3, 1, 68.1 ± 9.1, 67.0 ± 11.6, 1 4hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
Chlorpromazine 36.6 ± 19.4, 48.4 ± 11.9, 0.8, 17.3 ± 7.6, 25.3 ± 10.8, 0.7 4hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
Fluoxetine 63.4 ± 8.1, 43.1 ± 9.6 ,1.5, 58.0 ± 15.1, 63.3 ± 26.2, 0.9 4hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
Idarubicin 7.9 ± 3.3 , 4.2 ± 2.0, 1.9, 11.5 ± 5.7 ,6.2 ± 4.0, 1.9 4hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
imipramine 91.6 ± 18.2, 84.1 ± 10.3, 1.1, 71.4 ± 22.4, 90.3 ± 11.7, 0.8 4hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
mefloquine 2.9 ± 1.1, 2.3 ± 1.0, 1.4 ,3.4 ± 1.3, 3.6 ± 2.2, 1.2 4hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
Menadione 18.0 ± 7.2, 14.7 ± 7.9 ,1.2, 19.5 ± 8.3, 14.0 ± 8.7, 1.4 4hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
Nortriptyline 62.0 ± 18.7, 57.8 ± 28.3, 1.1, 65.3 ± 25.0, 49.2 ± 23.0, 1.3 4hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
paroxetine 37.5 ± 15.9, 36.9 ± 27.9, 1, 37.1 ± 11.3, 32.3 ± 17.8, 1.2 4hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
sertraline 30.7 ± 4.7, 24.7 ± 16.0, 1.2, 29.1 ± 12.0, 23.6 ± 19.2, 1.2 4hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
Tamoxifen 97.9 ± 28.0, 64.4 ± 11.4, 1.5, 75.2 ± 8.4, 43.9 ± 7.8, 1.7 4hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
Thioridazine 31.0 ± 5.9, 27.7 ± 19.8 ,1.4, 24.4 ± 5.7, 21.9 ± 18.0, 1.6 4hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
Flutamide 300.0 ± 0, 78.3 ± 24.8, 4.1, 266 ± 58.9 , 62.6 ± 27.3, 5 24hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
Nilutamide 250 ± 86.6, 44.0 ± 12.0 , 5.7 , 300.0 ± 0, 15.6 ± 9.9 , 19.2 24hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
Troglitazone 300.00 ± 0 , 1.4 ± 0.1, 219.8, 300.0 ± 0, 1.9 ± 0.1, 156.7 24hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
zoniporide 300.00 ± 0, 22.1 ± 14.3, 13.6, 300.0 ± 0, 21.6 ± 5.1, 13.9 24hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Positive glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
Antimycin A 5.9 (42.1nM/7.1nM) 24hr L6 ATP levels in high-glucose (25 mM) or galactose (10 mM) medium Positive glucose/galactose IC50 ratio 325
Antimycin A 10.7 (176.5nM/16.5nM) 24hr H9c2 ATP levels in high-glucose (25 mM) or galactose (10 mM) medium Positive glucose/galactose IC50 ratio 325
Antimycin A 17.7(58.1nM/3.3nM) 24hr HepG2 ATP levels in high-glucose (25 mM) or galactose (10 mM) medium Positive glucose/galactose IC50 ratio 325
1-Octylguanidine 4.3 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
3-NPA permeabilized LUHMES cells Assessment of the function of individual mitochondrial complexes using Agilent Seahorse XFe24 Positive EC25(NA) [Glc/Gal] 326
Antimycin A 12000 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
azoxystrobin 3.6 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
Berberine 7 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
Carboxin 3.1 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
Deguelin 450 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
fenamidone 16 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
fenazaquin 450 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
Fenpyroximate 5600 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
Methyltriphenylphosphonium bromide 8.6 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
MPP 30 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
Nefazodone 10 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
Oligomycin 8.7 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
Phenformin 27 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
picoxystrobin 50µM permeabilized LUHMES cells Assessment of the function of individual mitochondrial complexes using Agilent Seahorse XFe24 Positive 326
pyraclostrobin 50µM permeabilized LUHMES cells Assessment of the function of individual mitochondrial complexes using Agilent Seahorse XFe24 Positive 326
Pyridaben 75000 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
Pyrimidifen 10000 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
Rotenone 51 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
Salinomycin 3.7 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
Sodium Azide 11 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
Cyanide 5.2 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
Tebufenpyrad 2700 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay Positive EC25(NA) [Glc/Gal] 326
Troglitazone 50 μM male CD-1 mice isolated liver mitochondria Assessment of mitochondrial Ca2+ efflux with arsenazo III at 675/685 nm. decrease Positive 331
Ciglitazone 50 μM male CD-1 mice isolated liver mitochondria Assessment of mitochondrial Ca2+ efflux with arsenazo III at 675/685 nm. decrease Positive 331
Troglitazone 10-50 μM ZDF fa/fa rat & ZDF lean rat isolated liver mitochondria OCR and measured using a fluorescent oxygen probe (Presens) decrease Positive significantly different from control (p < 0.05) 225
Pioglitazone 25-50 μM ZDF fa/fa rat & ZDF lean rat isolated liver mitochondria OCR and measured using a fluorescent oxygen probe (Presens) decrease Positive significantly different from control (p < 0.05) 225
Troglitazone 10 µM ZDF fa/fa rat vs ZDF lean rat isolated mitochondria Measurement of reduced/oxidized glutathione (GSH/GSSG): the reduced/oxidized glutathione (GSH/GSSG) concentration of the samples was determined from a standard curve using the enzymatic method and a Multiskan JX system. lower Positive significantly different from ZDF lean rats (p < 0.05). 225
Troglitazone 10 µM ZDF fa/fa rat vs ZDF lean rat isolated mitochondria Oxidation of mitochondrial phospholipids was measured by HPLC analysis. Peak area ratio (235/206 nm) shows relative peroxidative phospholipid content. Peak areas at 206 nm and 235 nm analyze non-peroxidative and peroxidative phospholipid. peroxidation Positive significantly different from ZDF lean rats (p < 0.05) 225
Troglitazone >25 µM 1 and 2 hr HepG2 cells Cellular ATP concentrations were measured with a ATP Bioluminescent Somatic Cell Assay Kit decrease Positive 332
TDGA 0.31 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition Positive IC50 (μM) 333
POCA 59.7 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition Positive IC50 (μM) 333
Etomoxir 2.76 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition Positive IC50 (μM) 333
DET 5.6 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition Positive IC50 (μM) 333
aminocarnitine 0.97 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition Positive IC50 (μM) 333
palmitoylaminocarnitine 0.11 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition Positive IC50 (μM) 333
ST1326 1.1 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition Positive IC50 (μM) 333
ST2425 0.21 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition Positive IC50 (μM) 333
Trimetazidine 47.1 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition Positive IC50 (μM) 333
Perhexiline 14.8 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition Positive IC50 (μM) 333
Amiodarone 16.6 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition Positive IC50 (μM) 333
Oxfenicine >100 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition Positive IC50 (μM) 333
oxfenicine metabolite 25.8 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition Positive IC50 (μM) 333
RO-25-0187 1.5 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition Positive IC50 (μM) 333
TDGA <0.05/0.04 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition Positive IC50 (μM) 333
POCA 10.4/95.9 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition Positive IC50 (μM) 333
Etomoxir 0.29/0.34 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition Positive IC50 (μM) 333
DET 1.8/4.4 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition Positive IC50 (μM) 333
aminocarnitine −/− human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition Positive IC50 (μM) 333
palmitoylaminocarnitine 2.8/0.27 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition Positive IC50 (μM) 333
ST1326 4.0/0.98 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition Positive IC50 (μM) 333
ST2425 0.73/0.03 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition Positive IC50 (μM) 333
Trimetazidine 20.5/>100 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition Positive IC50 (μM) 333
Perhexiline 22.4/21.4 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition Positive IC50 (μM) 333
Amiodarone 28.5/>100 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition Positive IC50 (μM) 333
Oxfenicine >100/>100 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition Positive IC50 (μM) 333
oxfenicine metabolite 33.3/>100 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition Positive IC50 (μM) 333
RO-25-0187 25.5/>100 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition Positive IC50 (μM) 333
Cadmium 4 4hr HPNE cell (human pancreatic Nestin-expressing cells) Mitochondrial toxicity: exposure to various concentrations of CdCl2 in the presence of 25 mM glucose or 10 mM galactose, followed by MTT assay increase Positive IC50_glucose/IC50_galactose 334

F0201. respiration
F0202. Pyruvate metabolism
F0203. TCA
F0204. glucose metabolism
F0205. Pentose phosphate pathway
F0206. lipid metabolism
F0207. metabolism of amino acid
F0208. glycogen metabolism
F0209. protein scaffolding
F0210. protein quality control
F0211. transport
F0212. metabolism of cofactors and vitamins
F0213. Thiol compounds metabolism
F0214. Iron homeostasis
F0215. Phospholipid metabolism
F0216. glyoxylate metabolim
F0218. creatine metabolism
F0219. Lipoic acid metabolism
F0220. nucleotide metabolism
F0221. glutathione metabolism
F0222. sulfur compound metabolism
F0223. Urea cycle
F0224. fructose metabolism
F020101. Respiratory states
F020102. mitochondrial parameters
F020103. electron transport chain
F020104. uncoupled respiration
F020105. DNP-uncoupled respiration
F02010101. state 1 respiration
F02010102. state 2 respiration
F02010103. state 3 respiration
F02010104. state 4 respiration
F02010105. state 5 respiration
F02010106. state 3u respiration
F02010201. respiratory control ratio (RCR)
F02010202. oxygen consumption rate (OCR)
F02010203. basal respiration
F02010204. maximal respiration
F02010205. ATP turnover
F02010206. spare/ respiratory capacity
F02010207. proton leak
F02010208. non-mitochondrial respiration
F02010209. P/O ratio ( ADP/O)
F020201. generation of lactate
F020202. lactate to pyruvate ratio
F020301. generation of citrate
F020302. generation of isocitrate
F020303. generation of alpha-ketoglutarate
F020304. generation of succinate
F020401. glycolysis
F020402. Gluconeogenesis
F020403. glucose galactose IC50 ratio
F02040101. ECAR
F02040102. glucose consumption
F02040103. lactate production
F020601. Fatty acid metabolism
F020602. Ketone body metabolism
F020603. lipid peroxidation
F020604. steroid metabolism
F020605. phospholipid metabolism
F02060101. mitochondrial fatty acid beta oxidation
F02060102. fatty acyl-CoA biosynthesis
F02060103. carnitine shuttle
F02060104. carnitine biosynthesis
F02060105. fatty acid biosynthetic
F02060106. acetyl-CoA biosynthesis
F02060201. Synthesis of ketone body
F02060202. Catabolism of ketone body
F020701. Alanine metabolism
F020702. Arginine metabolism
F020703. Asparagine metabolism
F020704. Aspartate metabolism
F020705. Cysteine metabolism
F020706. Glutamine metabolism
F020707. Glutamate metabolism
F020708. Glycine metabolism
F020709. Histidine metabolism
F020710. Isoleucine metabolism
F020711. Leucine metabolism
F020712. Lysine metabolism
F020713. Methionine metabolism
F020714. Phenylalanine metabolism
F020715. Proline metabolism
F020716. Serine metabolism
F020717. Threonine metabolism
F020718. Tryptophan metabolism
F020719. Tyrosine metabolism
F020720. Valine metabolism
F020721. selenocysteine metabolism
F021001. mitochondrial ubiquitination
F021101. metabolite transport
F021102. mitochondrial protein transport
F021103. mitochondrial ion transport
F02110102. malate asparatate shuttle
F02110103. s,n-glycerophosphate shuttle
F02110104. transport of glutamate
F02110105. transport of dicarboxylate
F02110106. transport of 2-oxoglutarate
F02110107. carnitine shuttle
F02110108. transport of tricarboxylate
F02110109. transport of ornithine/citrulline
F02110110. transport of deoxynucleotide
F02110111. transport of L-aspartic acid
F02110112. transport of pyruvate
F02110113. transport of monocarboxylate
F02110114. transport of citrate
F02110115. transport of glucose
F02110116. transport of fatty acid
F02110301. transport of calcium
F02110302. accumulation of calcium
F02110303. transport of sodium
F02110304. transport of potassium
F02110305. potassium release
F02110306. accumulation of potassium
F02110307. transport of proton
F02110308. transport of phosphate
F02110309. accumulation of phosphate
F02110310. transport of chlorine
F02110311. transport of anion
F02110312. bicarbonate transport
F021201. ATP synthesis
F021202. NADPH metabolism
F021203. ATP level
F021204. ATP hydrolysis
F021205. Heme synthesis
F021206. CoA synthesis
F021207. Ubiquinone synthesis
F021208. Cobalamin (Cbl, vitamin B12) metabolism
F021209. folate (vitamin B9) metabolism
F021210. calciferol (Vitamin D) metabolism
F021211. biotin (vitamin B7) metabolism
F021212. Thiamine (vitamin B1) metabolism
F021213. Riboflavin (vitamin B2) metabolism
F021214. NADH level
F021215. energy charge
F021216. ATP/ADP ratio
F021401. ferritin depletion
F021501. Phosphatidylethanolamine biosynthesis
F022001. Pyrimidine nucleotide biosynthesis
F022002. Pyridine nucleotide biosynthesis
F022101. GSH content
F022102. GSSH/GHS ratio
F022401. Fructose biosynthesis

T001. NADH:ubiquinone reductase
T001060. quinone
T001061. semiquinone
T001062. quinol
T001063. flavin mononucleotide
T001064. iron-sulfur clusters
T002. Succinate dehydrogenase
T002007. Quinone pocket
T002008. Succinate pocket
T002009. Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
T004. Quinol--cytochrome-c reductase
T004001. Cytochrome b
T004012. Qo site (Qp site or ubiquinol oxidation site)
T004013. Qi site (Qn site or quinone reduction site)
T005. Cytochrome c oxidase
T016. oxygen
T018. copper
T019. ATP synthase
T019002. Fo subunits
T019003. F1 subunits
T019003003. ATP synthase subunit alpha, mitochondrial
T019003004. ATP synthase subunit beta, mitochondrial
T019004. ATP synthase subunit O, mitochondrial
T019011. ATP synthase subunit a
T020. ATP
T021. carnitine palmitoyltransferases I
T022. Carnitine O-palmitoyltransferase 2, mitochondrial, EC 2.3.1.21
T026. 3-ketoacyl-CoA thiolase, mitochondrial
T027. Long-chain-fatty-acid--CoA ligase
T027001. Long-chain-fatty-acid--CoA ligase 1
T028. Short-chain specific acyl-CoA dehydrogenase, mitochondrial
T029. Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
T030. Long-chain specific acyl-CoA dehydrogenase, mitochondrial
T032. Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
T034. Medium-chain acyl-CoA ligase ACSF2, mitochondrial
T047. Acetyl-CoA carboxylase 2
T056. Isovaleryl-CoA dehydrogenase, mitochondrial
T067. Hexokinase-1
T072. Glyceraldehyde-3-phosphate dehydrogenase
T077. lactate
T080. Pyruvate dehydrogenase kinase
T084. Mitochondrial pyruvate carrier 1
T091. Citrate synthase, mitochondrial
T092. Aconitate hydratase, mitochondrial
T101. Malate:quinone oxidoreductase
T106. citrate
T107. isocitrate
T108. alpha-ketoglutarate
T109. succinate
T181. Glycerol-3-phosphate dehydrogenase, mitochondrial
T195. Mitochondrial pyruvate carrier
T205. mCU (mitochondrial calcium uniporter)
T206. mitochondrial Na/Ca2+ exchanger
T208. mitochondrial KATP chanel (mtKATP)
T211. Potassium voltage-gated channel subfamily A member 5
T212. hERG
T213. potassium
T214. Phosphate carrier protein, mitochondrial
T227. Thiol compounds
T408. Cytochrome c
T417. 5'-AMP-activated protein kinase catalytic subunit alpha-2
T432. Calcium uptake protein 1, mitochondrial