Function of mitochondria >> Respiration >> uncoupled respiration

Related Drugs/Compounds

Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
Perhexiline	200 μM	5 minutes preincubation	mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	193
Metformin	0.5 mM	24 hours	human	MCF7	Meassurement of non-mitochondrial respiration	increase	Positive	p < 0.05	172
Metformin	5 mM	24 hours	human	MCF7	Meassurement of non-mitochondrial respiration	increase	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	human	MCF7	Meassurement of coupled respiration; Meassurement of uncoupled respiration; cells grown in glucose	increase	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	human	MCF7	Meassurement of coupled respiration; Meassurement of uncoupled respiration; cells grown in galactose	increase	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	mouse	NMuMG	Meassurement of coupled respiration; Meassurement of uncoupled respiration	increase	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	human	MCF10A	Meassurement of coupled respiration; Meassurement of uncoupled respiration	increase	Positive	p < 0.05	172