F020605 | Phospholipid metabolism

Compound Dose Time Species Model Method Action Result Positive criterion Reference
Troglitazone 10 ┬ÁM ZDF fa/fa rat vs ZDF lean rat isolated mitochondria Oxidation of mitochondrial phospholipids was measured by HPLC analysis. Peak area ratio (235/206 nm) shows relative peroxidative phospholipid content. Peak areas at 206 nm and 235 nm analyze non-peroxidative and peroxidative phospholipid. peroxidation Positive significantly different from ZDF lean rats (p < 0.05) 225