Drug
D1071 | propylparaben
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 38.60±1.67 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 35.48 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | rat | hepatocytes | MMP assay | Negative | IC50 | 163 | ||
| MEMBRANE POTENTIAL | 162.8 µM | 30 mins | mouse | liver mitochondria | Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss) | decrease | EC20 | 36 |
| RESPIRATION | 63 µM | 60 mins | mouse | liver mitochondria | Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. | decrease | EC20 | 36 |
| RESPIRATION | 28.4 µM | 60 mins | mouse | liver mitochondria | Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. | decrease | EC20 | 36 |
| SWELLING | > 800 µM | 30 mins | mouse | liver mitochondria | swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling ) | increase | EC20 | 36 |
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| NADH:ubiquinone reductase | 63 µM | 60 mins | mouse | liver mitochondria | Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. | inhibit | EC20 | 36 |
| Succinate dehydrogenase | 28.4 µM | 60 mins | mouse | liver mitochondria | Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. | inhibit | EC20 | 36 |
| Cytochrome c | > 800 µM | 30 mins | mouse | liver mitochondria | Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline) | release | EC20 | 36 |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Warning |
Aggregated GHS information provided by 2750 companies from 24 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 802 of 2750 companies. For more detailed information, please visit ECHA C&L website Of the 22 notification(s) provided by 1948 of 2750 companies with hazard statement code(s): H315 (93.07%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (97.48%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (91.74%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard] |
P273, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) | ||
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | 85mg/kg (85mg/kg) | Drug Standards. Vol. 20, Pg. 89, 1952. | |
| mouse | LD50 | intravenous | 180mg/kg (180mg/kg) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956. | |
| mouse | LD50 | intraperitoneal | 490mg/kg (490mg/kg) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956. | |
| mouse | LD50 | oral | 3700mg/kg (3700mg/kg) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956. | |
| 36M | 4-10-00-00374 (Beilstein Handbook Reference) | 4-Arm PEG-OMs, 95%, average M.W. 20,000 |
| 4-Hydroxybenzoic acid propyl ester | 4-Hydroxybenzoic acid propylester | 4-Hydroxybenzoic acid, n-propyl ester |
| 4-Hydroxybenzoic acid, propyl ester | 4-Hydroxybenzoic acid-propyl ester | 4-Hydroxybenzoic acid-propyl ester 100 microg/mL in Acetonitrile |
| 4-hydroxybenzoic acid n-propyl ester | 85403-59-4 | 94-13-3 |
| A844839 | ACMC-209rqc | AI3-01341 |
| AK106260 | AKOS008948099 | ANW-40210 |
| Aseptoform P | BBL023754 | BDBM70190 |
| BIDD:ER0229 | BRN 1103245 | Bayer D 206 |
| Benzoic acid, 4-hydroxy-, propyl ester | Benzoic acid, p-hydroxy-, propyl ester | Betacide P |
| Betacine P | Bonomold OP | CAS-94-13-3 |
| CHEBI:32063 | CHEMBL194014 | CS-0018518 |
| CTK3I9857 | Caswell No. 714 | Certified Reference Material |
| Chemacide pk | Chemocide pk | Chemoside PK |
| D01422 | DB14177 | DS-3427 |
| DSSTox_CID_2527 | DSSTox_GSID_22527 | DSSTox_RID_76614 |
| DTXSID4022527 | E216 | EC 202-307-7 |
| EINECS 202-307-7 | EPA Pesticide Chemical Code 061203 | FEMA No. 2951 |
| FEMA Number 2951 | FT-0618698 | HMS2268K21 |
| HSDB 203 | HY-N2026 | InChI=1/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H; |
| K713 | KS-00000GZK | KSC489Q5P |
| LS-1958 | Lexgard P | MCULE-6661199693 |
| MFCD00002354 | MLS002152934 | MLS002222346 |
| MLS006011654 | N-Propyl p-hydroxybenzoate | N-Propylparaben |
| NCGC00090965-01 | NCGC00090965-02 | NCGC00090965-03 |
| NCGC00090965-04 | NCGC00090965-05 | NCGC00090965-06 |
| NSC 23515 | NSC-23515 | NSC-8511 |
| NSC23515 | NSC8511 | Nipagin P |
| Nipasol | Nipasol M | Nipasol P |
| Nipazol | P1955 | PROPYL PARA HYDROXY BENZOATE |
| PROPYLPARABEN | Paraben | Parasept |
| Paseptol | Preserval P | Propagin |
| Propyl 4-hydroxybenzoate | Propyl 4-hydroxybenzoate, 99+% | Propyl 4-hydroxybenzoate, >=99% |
| Propyl 4-hydroxybenzoate, BioXtra | Propyl 4-hydroxybenzoate, SAJ first grade, >=98.0% | Propyl 4-hydroxybenzoate, Vetec(TM) reagent grade, 98% |
| Propyl 4-hydroxybenzoate, p.a., 99.0-100.5% | Propyl 4-hydroxybenzoate, tested according to Ph.Eur. | Propyl Butex |
| Propyl Chemosept | Propyl Parahydroxybenzoate 0.01 mg/ml in Methanol | Propyl Parahydroxybenzoate 1.0 mg/ml in Methanol |
| Propyl Parasept | Propyl aseptoform | Propyl chemsept |
| Propyl p-hydroxybenzoate | Propyl paraben | Propyl parahydroxybenzoate |
| Propyl parahydroxybenzoate (JP17) | Propyl parahydroxybenzoate (TN) | Propyl parahydroxybenzoate, European Pharmacopoeia (EP) Reference Standard |
| Propyl-4-Hydroxybenzoate,(S) | Propyl-4-hydroxybenzoate | Propyl-paraben |
| Propylester kyseliny p-hydroxybenzoove | Propylester kyseliny p-hydroxybenzoove [Czech] | Propylis parahydroxybenzoas |
| Propylparaben (NF) | Propylparaben [USAN:NF] | Propylparaben [USAN] |
| Propylparaben, Pharmaceutical Secondary Standard | Propylparaben, USAN | Propylparaben, United States Pharmacopeia (USP) Reference Standard |
| Propylparaben, certified reference material, TraceCERT(R) | Propylparasept | Protaben P |
| Pulvis conservans | Pulvis conservans (VAN) | Q-201635 |
| Q511627 | QELSKZZBTMNZEB-UHFFFAOYSA-N | RTR-029455 |
| SBB015060 | SCHEMBL977 | SMR000112070 |
| ST075003 | ST24049048 | STL294815 |
| Solbrol P | T8305 | TR-029455 |
| TRA0042844 | Tegosept P | Tox21_111048 |
| Tox21_400012 | UNII-AZF98361GV component QELSKZZBTMNZEB-UHFFFAOYSA-N | UNII-Z8IX2SC1OH |
| WLN: QR DVO3 | Z8IX2SC1OH | ZINC1586788 |
| cid_7175 | component of Heb-Cort MC (Salt/Mix) | n-PROPYL-p-HYDROXYBENZOATE |
| n-Propyl 4-hydroxybenzoate | n-propyl paraben | n-propyl-p-hydroxy-benzoate |
| p-Hydroxybenzoic acid n-propyl ester | p-Hydroxybenzoic acid propyl ester | p-Hydroxybenzoic acid, propyl ester |
| p-Hydroxybenzoic propyl ester | p-Hydroxypropyl benzoate | p-Oxybenzoesaeurepropylester |
| p-Oxybenzoesaurepropylester | p-Oxybenzoesaurepropylester [German] | propyl 4-oxidanylbenzoate |
| propyl para-hydroxybenzoate | s5405 |