Drug

D1385 | Dyclonine

Molecular Formula C18H27NO2
Molecular Weight 289.4
Structure
State solid
Half life Approximately 30 to 60 minutes.
Absorption Readily absorbed through mucous membranes into the systemic circulation. The rate of absorption is influenced by the vascularity or rate of blood flow at the site of application, the total dosage (concentration and volume) administered, and the duration of exposure. Absorption from mucous membranes of the throat or respiratory tract may be especially rapid.
Trade names Sucrets
Description oral anaesthetic

N

R

R02AD04 Dyclonine


[R02AD] Anesthetics, local


[R02A] THROAT PREPARATIONS


[R02] THROAT PREPARATIONS


[R] Respiratory system


N01BX02 Dyclonine


[N01BX] Other local anesthetics


[N01B] ANESTHETICS, LOCAL


[N01] ANESTHETICS


[N] Nervous system


Toxicity Dose Time Species Model Method Action Positive criterion Reference
OXYGEN CONSUMPTION RATE (OCR) mouse neuron Oxygen consumption rate (OCR) or extracellular acidification rate (ECAR) measurements from permeabilized neurons and isolated brain mitochondria were performed using the XF96 Extracellular Flux analyzer (Seahorse Bioscience). increase 269
ELONGATION mouse neuron Mitochondrial morphology and neurite area measurements induce 269

Organism Test type Route Dose (normalized dose) Effect Source
dog LDLo oral 40mg/kg (40mg/kg) Toxicology and Applied Pharmacology. Vol. 2, Pg. 616, 1960.
rat LD50 intraperitoneal 33mg/kg (33mg/kg) Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 708, 1958.
rat LD50 subcutaneous 201mg/kg (201mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 413, 1955.
mouse LD50 intraperitoneal 52mg/kg (52mg/kg) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 410, 1962.
rabbit LD50 oral 240mg/kg (240mg/kg) behavioral: ataxia Toxicology and Applied Pharmacology. Vol. 2, Pg. 616, 1960.
mouse LD50 intravenous 20mg/kg (20mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 419, 1955.
dog LD50 intravenous 9500ug/kg (9.5mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 419, 1955.
mouse LDLo oral 100mg/kg (100mg/kg) Toxicology and Applied Pharmacology. Vol. 2, Pg. 616, 1960.
mouse LD50 subcutaneous 37mg/kg (37mg/kg) Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 708, 1958.


  • 078A24Q30O 1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone 1-(4-butoxyphenyl)-3-(piperidin-1-yl)propan-1-one
    1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one 1-(4-butoxyphenyl)-3-piperidylpropan-1-one 1-Propanone, 1-(4-butoxyphenyl)-3-(1-piperidinyl)-
    1-Propanone, 1-(4-butoxyphenyl)-3-(1-piperidinyl)- (9CI) 2-(1-piperidyl)ethyl p-butoxyphenyl ketone 3-Piperidino-4'-butoxypropiophenone
    4'-Butoxy-3-piperidinopropiophenone 4-butoxy-beta-piperidinopropiophenone 4-n-butoxy-beta-(1-piperidyl)propiophenone
    586-60-7 AB00053467 AB00053467_13
    AB00053467_14 AC-12286 AKOS000505031
    AMOT0928 API0009050 BPBio1_000120
    BRD-K72259270-003-05-8 BRD-K72259270-003-15-7 BRN 0224037
    BSPBio_000108 BSPBio_001940 C07881
    CAS-536-43-6 CHEBI:4724 CHEMBL1201217
    D07881 DB00645 DTXSID6047864
    Diclonina [INN-Spanish] DivK1c_000632 Dyclocaine
    Dyclocainum Dyclone (Salt/Mix) Dyclonin
    Dyclonine (INN) Dyclonine [INN:BAN] Dycloninum
    Dycloninum [INN-Latin] FT-0660914 GTPL7173
    IDI1_000632 KBio1_000632 KBio2_001496
    KBio2_004064 KBio2_006632 KBio3_001160
    KBioGR_001137 KBioSS_001496 LS-125084
    MCULE-1206604674 NCGC00016498-01 NCGC00016498-02
    NCGC00016498-03 NCGC00016498-04 NCGC00016498-05
    NINDS_000632 NS00010019 PROPIOPHENONE, 4'-BUTOXY-3-PIPERIDINO-
    Prestwick0_000264 Prestwick1_000264 Prestwick2_000264
    Prestwick3_000264 Q425386 S039
    SBI-0051358.P003 SCHEMBL25773 SPBio_001165
    SPBio_002327 ST095169 STK524544
    Spectrum2_001013 Spectrum3_000410 Spectrum4_000529
    Spectrum5_000951 Spectrum_001016 Tanaclone (Salt/Mix)
    UNII-078A24Q30O ZINC1530940 dyclonine
    dyclonine hydrochloride;Dyclonine;dyclonine

    DrugBank DB00645
    CAS Number 536-43-6, 586-60-7
    PubChem Compound 3180