T181 Source: Uniprot

proteinGlycerol-3-phosphate dehydrogenase, mitochondrial (mGDH)
Oxidoreductase Transporter
Full Name Glycerol-3-phosphate dehydrogenase, mitochondrial
Protein Names Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC 1.1.5.3) (mitohondrial glycerophosphate dehydrogenase gene) (mGDH) (mtGPD)
Subcellular Location Mitochondrion
EC numbers 1.1.5.3
Uniprot Accession P43304
Uniprot Name GPDM_HUMAN
Gene symbol GPD2
Gene Name Glycerol-3-phosphate dehydrogenase 2
Ensembl ENSG00000115159

Compound Dose Time Species Model Method Result Positive criterion Reference
lovastatin C2C12 myoblasts Positive 180
Simvastatin C2C12 myoblasts Positive 180
Indomethacin Positive 162
Doxorubicin Positive 162
Diazoxide Positive 162
Diazoxide Homogenates of isolated pancreatic islets; homogenates of whole pancreas, liver, heart, or skeletal muscle The activity of the rnitochondrial glycerol phosphate dehydrogenase was assayed with a timed assay using iodonitrotetrazolium violet as an electron acceptor and in a continuous spectrophotometric assay using dichloroindophenol as an electron acceptor. acceptor. Glycerol phosphate oxidation by islet intact mitochondria was estimated from the tritiated water released from [2- 3H]glycerol phosphate Positive 187
glyceraldehyde 3-phosphate 2.5mM Positive 162
dihydroxyacetone phosphate Positive 162
glyceraldehyde 3-phosphate 2.5mM Positive 162
dihydroxyacetone phosphate Positive 162
1h-benzimidazol-5-amine-2-4-aminophenyl ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-(Dimethylamino)-1,3-benzothiazol-6-ol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)amino]phenol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
7,8-Dihydroxy-4-methylcoumarin ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4-Amino-2-(5-ethyl-benzooxazol-2-yl)-phenol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
(4-Methoxyphenyl)-[2-(p-anisidino)ethyl]amine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
3,3'-Diamino-4,4'-dihydroxydiphenyl Sulfone ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-(4-Hydroxy-1H-indol-3-yl)acetamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2,5-Bis(2-phenylacetamido)terephthalic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2,6-Dimethyl-5,12-dihydroindolo[3,2-d][1,3]benzodiazepine;hydrochloride ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
N-(4-{[(4,6-Dimethyl-2-pyrimidinyl)amino]sulfonyl}phenyl)-2,4-dimethoxybenzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
N'-(4-Methoxybenzyl)-N,N-dimethylbenzene-1,3-diamine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4-(1,2,3,4-Tetrahydro-benzo[a]phenanthridin-5-yl)-benzene-1,2-diol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
N-Benzyl-4-methoxyaniline ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
Methyl 2-amino-4-ethyl-5-methylthiophene-3-carboxylate ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
N-(4-(4-Methyl-1-piperazinyl)phenyl)-9-acridinamine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4-Chloro-N-(2-hydroxyphenyl)benzenesulfonamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
N-(4-Hydroxyphenyl)furan-2-carboxamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
(Z)-2-Cyano-3-(3-ethoxy-4-hydroxyphenyl)prop-2-enamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
(3-Bromo-4-hydroxyphenyl)[(4-chlorophenyl)sulfonyl]amine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-Chloro-6-methylindolo[1,2-c]quinazolin-12-amine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4-(2,3-Dihydro-1H-benzo[f]cyclopenta[c]quinolin-4-yl)benzene-1,2-diol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
(5E)-5-(4-Hydroxybenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
8-Chloro-2,2-dimethyl-2,3-dihydro-1H-phenothiazin-4(10H)-one ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-[(3,4-Dimethylphenyl)sulfonyl]benzene-1,4-diol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4-([4-(1H-Benzimidazol-2-yl)phenyl]amino)-4-oxobutanoic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
Ethyl 2-ethoxy-5-hydroxy-1H-indole-3-carboxylate ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4-(1,2,3,4-Tetrahydrobenzo[a]phenanthridin-5-yl)benzene-1,3-diol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
N-(Cyclohexylmethyl)-4-methoxyaniline ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
N-(Furan-2-ylmethyl)-1,3-benzodioxol-5-amine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
5-Nitro-2-phenyl-1H-indole ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
8-Chloro-2,3-dihydro-1H-phenothiazin-4(10H)-one ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
N-(4-Bromophenyl)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-[2-(2-Aminophenyl)vinyl]-5,7-dimethylquinolin-8-ol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4,6-Dimethyl-2-phenyl-2H-pyrazolo[3,4-b]pyridin-3-ol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4-Methoxy-2-[(4-piperidylpiperidyl)methyl]phenol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
N-(5-Isopropyl-1,3,4-thiadiazol-2-yl)-3-nitrobenzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-Amino-6-ethyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
(NE)-N-[[3-[[3-[(E)-hydroxyiminomethyl]-2,4,6-trimethylphenyl]methyl]-2,4,6-trimethylphenyl]methylidene]hydroxylamine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
N-(3-Fluorophenyl)-2,4,6-tri(propan-2-yl)benzenesulfonamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-(4-Hydroxy-3-methoxybenzylidene)-1H-indene-1,3(2H)-dione ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-Furancarboxamide, N-[[(4-methoxyphenyl)amino]thioxomethyl]- ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-Amino-N-quinolin-8-yl-benzenesulfonamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
(5Z)-5-[(4-Fluorophenyl)methylidene]-1-methyl-3-phenyl-1,3-diazinane-2,4,6-trione ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-[4-(1-Adamantyl)phenoxy]-N,N-diethylethanamine;hydrochloride ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
(2Z)-2-(Acetylamino)-N-(4-hydroxyphenyl)-3-phenylprop-2-enamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
(5E)-5-[(3-Bromo-4-methoxyphenyl)methylidene]-1-phenyl-2-sulfanylidene-1,3-diazinane-4,6-dione ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
[(3-{[(4-Bromophenyl)amino]carbonyl}phenyl)thio]acetic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-[(4-Chlorobenzyl)thio]-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
1-(5-Hydroxy-2-methyl-1-phenyl-1H-indol-3-yl)ethanone ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-[(4-Ethylpiperazin-1-yl)methyl]-4-methoxyphenol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4-(4-Fluorophenyl)-1,3,5-trimethyl-2,6-diphenylpiperidin-4-ol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
N-[(E)-1-[5-(4-Bromophenyl)furan-2-yl]-3-[3-(dimethylamino)propylamino]-3-oxoprop-1-en-2-yl]-4-methylbenzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
(2Z)-3-{N-[4-(4-Chlorophenyl)phenyl]carbamoyl}prop-2-enoic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4-[(E)-3-(4-Ethylpiperazin-1-yl)prop-1-enyl]-N,N-dimethylaniline ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
1,5-Dihydro-4,5-diphenyl-2H-imidazol-2-one ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-[(E)-2-(4-Chlorophenyl)ethenyl]-1-methyl-1H-benzimidazole ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4-[1-Azabicyclo[2.2.2]octan-3-ylidene-[4-(dimethylamino)phenyl]methyl]-N,N-dimethylaniline;hydrochloride ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4-Oxo-4-((4-(styryl)phenyl)amino)but-2-enoic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2,5-Dianilinoterephthalic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4-Methoxy-N-[4-(thiazol-2-ylsulfinamoyl)-phenyl]-benzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
3-[(3,4-Dimethylphenyl)sulfonyl]propanenitrile ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4-[4-(1,3-Benzoxazol-2-yl)anilino]-4-oxobutanoic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
1-(3-Chlorophenyl)-2,3,4,5,6,7,8,8a-octahydro-1H-isoquinolin-4a-ol;hydrochloride ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
6-Methyl-2-(1,2,2,2-tetrafluoroethyl)-1H-benzimidazole ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
Ethyl 6-amino-5-cyano-2-methyl-4-(2-nitrophenyl)-4H-pyran-3-carboxylate ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
N-(2,1,3-Benzoxadiazol-4-yl)-2,2,2-trifluoroacetamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4-Tert-butyl-N-(4-methylphenyl)benzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-Methoxy-4-(morpholin-4-ylmethyl)phenol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
Bis((1E)-2-phenylvinyl)phosphinic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
1-[2-(Allyloxy)benzyl]-4-benzylpiperidine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2,5-Diaminoterephthalic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
N-(1-Adamantylcarbonyl)-N'-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)thiourea ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-(Isobutylthio)succinic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
N-{4-[Acetyl(methyl)amino]phenyl}-4-biphenylcarboxamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
4-[(E)-3-(2-Ethylpiperidin-1-yl)prop-1-enyl]-N,N-dimethylaniline ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
3-(2-Chloro-phenyl)-2-(4-(2-oxo-2H-chromen-3-YL)-thiazol-2-YL)-acrylonitrile ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
Ethyl (7Z)-2-amino-7-(hydroxyimino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-Amino-4-(3,4-dichlorophenyl)thiazole ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
5-(2-Nitrobenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
3-(4-Bromo-2-thienyl)-2-cyano-2-propenethioamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
Benzyl [(6-amino-3,5-dicyano-4-ethylpyridin-2-yl)sulfanyl]acetate ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
N-{2-[(1,3-Diphenyl-1H-pyrazol-5-yl)amino]phenyl}benzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-Butyl-5-methylisophthalic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-Butylsulfanyl-6-methyl-9H-1,3,4,9-tetraaza-fluorene ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162
2-Phenyldipyrrolo[1,2-a:2',1'-c]pyrazine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production Positive 162