F050401 | H2O2 production

Compound Dose Time Species Model Method Action Result Positive criterion Reference
Manganese 15 mg/l in drinking water Swiss Albino mice increase Positive 242
Methylmercury 15 mg/l in drinking water Swiss albino mice Positive 242
Gentamicin 5mM 10min rat isolated rat liver (and kidney) mitochondria Mitochondrial ROS production can be measured using Amplex Red, a dye that fluoresces dependent on hydrogen peroxide (H2O2) levels. reduce Positive 316
glyceraldehyde 3-phosphate 2.5mM decrease Positive 162
dihydroxyacetone phosphate decrease Positive 162