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Drug

D1140 | triclosan

Molecular Formula C12H7Cl3O2
Molecular Weight 289.5
Structure
State solid
Route of elimination In one study, after in vivo topical application of a 64.5mM alcoholic solution of [(3)H]triclosan to rat skin, 12% radioactivity was recovered in the faeces, 8% in the carcass 1% in the urine, 30% in the stratum corneum and 26% was rinsed from the skin surface at 24 hours after application. [PMID: 10722890]
Half life The terminal plasma half life of triclosan is 21 h (Sandborgh-Englund et al., 2006).
Absorption A study conducted in 2000 demonstrated that low amounts of triclosan can be absorbed through skin and can enter the bloodstream. [PMID: 10722890] Triclosan is rapidly absorbed and distributed in the human body (Sandborgh-Englund et al., 2006). Maximum concentrations are reached within three hours after oral intake. However, the metabolism and excretion of the compound is fast.
Description antibacterial and antifungal agent present in some consumer products; aromatic ether

D

D09AA06 Triclosan


[D09AA] Medicated dressings with antiinfectives


[D09A] MEDICATED DRESSINGS


[D09] MEDICATED DRESSINGS


[D] Dermatological drugs

D08AE04 Triclosan


[D08AE] Phenol and derivatives


[D08A] ANTISEPTICS AND DISINFECTANTS


[D08] ANTISEPTICS AND DISINFECTANTS


[D] Dermatological drugs

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 1.50±0.88 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 6.15 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 15.17±13.52 rat hepatocytes MMP assay decrease IC50 163
BASAL RESPIRATION 0.5 µM zebrafish XFe24 Extracellular Flux Analyzer decrease 85
MAXIMAL RESPIRATION 1 µM zebrafish XFe24 Extracellular Flux Analyzer Negative 85
MAXIMAL RESPIRATION 30 μM zebrafish XFe24 Extracellular Flux Analyzer decrease 89
ATP TURNOVER 0.5 µM zebrafish XFe24 Extracellular Flux Analyzer decrease 85
ATP TURNOVER 30 μM zebrafish XFe24 Extracellular Flux Analyzer decrease 89
SPARE/ RESPIRATORY CAPACITY 30 μM zebrafish XFe24 Extracellular Flux Analyzer increase 89
PROTON LEAK 0.5 µM zebrafish XFe24 Extracellular Flux Analyzer decrease 85
PROTON LEAK 1 µM zebrafish XFe24 Extracellular Flux Analyzer Negative 85

Pictogram Signal Statements Precautionary Statement Codes
Warning

H315: Causes skin irritation [Warning Skin corrosion/irritation]


H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


 P264, P273, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

Aggregated GHS information provided by 1081 companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H315 (99.81%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (99.81%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H400 (95.93%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410 (99.81%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P264, P273, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H315: Causes skin irritation [Warning Skin corrosion/irritation]


H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H331: Toxic if inhaled [Danger Acute toxicity, inhalation]


H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


 P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P311, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

H315: Causes skin irritation [Warning Skin corrosion/irritation]


H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


 P261, P264, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rabbit LD50 skin 9300mg/kg (9300mg/kg) Industrial Medicine and Surgery. Vol. 38, Pg. 64, 1969.
mouse LD50 oral 4530mg/kg (4530mg/kg) "Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J.L. Halos, 1968-70Vol. 6, Pg. 245, 1968/1970.
mouse LD50 subcutaneous 3800mg/kg (3800mg/kg) Yakkyoku. Pharmacy. Vol. 28, Pg. 985, 1977.
rat LD50 intraperitoneal 89mg/kg (89mg/kg) Yakkyoku. Pharmacy. Vol. 28, Pg. 985, 1977.
rat LD50 oral 3700mg/kg (3700mg/kg) "Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J.L. Halos, 1968-70Vol. 6, Pg. 245, 1968/1970.
mouse LD50 intraperitoneal 84mg/kg (84mg/kg) Yakkyoku. Pharmacy. Vol. 28, Pg. 985, 1977.
rat LD50 intravenous 29mg/kg (29mg/kg) Industrial Medicine and Surgery. Vol. 38, Pg. 64, 1969.
rat LD50 subcutaneous 3900mg/kg (3900mg/kg) Yakkyoku. Pharmacy. Vol. 28, Pg. 985, 1977.


  • 1nhg 2,4,4'-Trichloro-2'-hydroxy diphenyl ether 2,4,4'-Trichloro-2'-hydroxydiphenyl ether
    2,4,4'-trichloro-2'-hydroxydiphenylethe 2-(2,4-dichlorophenoxy)-5-chlorophenol 2-Hydroxy-2',4,4'-trichlorodiphenyl Ether
    2-[2,4-bis(chloranyl)phenoxy]-5-chloranyl-phenol 3380-34-5 380T345
    3p9t 4NM5039Y5X 4w9n
    5-CHLORO-2-(2,4-DICHLOROPHENOXY)PHENOL 5-Chloro-2-(2,4-dichloro-phenoxy)-phenol 5-Chloro-2-(2,4-dichlorophenoxy)phenol, 97%
    5-chloro-2-(2, 4-dichlorophenoxy)phenol 5-chloro-2-(2,4-di-chloro-phenoxy)-phenol 88032-08-0
    A821950 AB00698074_08 AC-10667
    AK-73001 AKOS015850380 ANW-42338
    API0004498 AX8020299 Aquasept
    BDBM8726 BII1002 BR-73001
    BRD-K41731458-001-04-5 BRD-K41731458-001-09-4 BRN 2057142
    C-18186 C12059 C12H7Cl3O2
    CAS-3380-34-5 CCG-213459 CCRIS 9253
    CH 3565 CH-3565 CH-3635
    CHEBI:164200 CHEMBL849 CPD000471847
    CS-4718 CTK3J8301 Caswell No. 186A
    Certified Reference Material; Cloxifenol Cloxifenolum
    D06226 DB08604 DNDI1246774
    DP 300 DP-300 DSSTox_CID_12498
    DSSTox_GSID_32498 DSSTox_RID_78958 DTXSID5032498
    EINECS 222-182-2 EPA Pesticide Chemical Code 054901 Epitope ID:119683
    Ether, 2'-hydroxy-2,4,4'-trichlorodiphenyl F2173-0825 FT-0609773
    GA5716 HMS2093L17 HMS2270M06
    HMS3259K19 HMS3715H11 HSDB 7194
    HY-B1119 Irgasan Irgasan
    Irgasan DP 30 Irgasan DP 300 Irgasan DP300
    Irgasan, >=97.0% (HPLC) J10025 KS-000009AG
    KS-5356 KSC498G0D LS-67854
    Lexol 300 M-6446 MCULE-2614621397
    MFCD00800992 MLS001066347 MLS001074876
    MLS001335937 MLS001335938 NC00516
    NCGC00159417-02 NCGC00159417-03 NCGC00159417-04
    NCGC00159417-05 NCGC00159417-06 NCGC00159417-07
    NCGC00159417-08 NSC-759151 NSC759151
    Neostrata Antibacterial Facial Cleanser Pharmakon1600-01505465 Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-
    Phenyl ether, 2'-hydroxy-2,4,4'-trichloro- PubChem9026 Q-201866
    Q408646 RTR-014090 S00100
    SAM002554907 SBB058565 SBI-0206807.P001
    SC-16588 SCHEMBL3269 SMR000471847
    SR-01000762974 SR-01000762974-2 SR-01000762974-3
    ST2411924 ST50826110 STL451034
    Sapoderm Sterzac Stri-Dex Cleansing Bar
    Stri-Dex Face Wash Stri-Dex cleansing bar (TN) TCCP
    TCL TR-014090 TRA0068104
    Tox21_111648 Tox21_111648_1 Tox21_400079
    Trichlorosan Triclosan Triclosan (USP/INN)
    Triclosan 10 microg/mL in Cyclohexane Triclosan 100 microg/mL in Methanol Triclosan USP
    Triclosan [USAN:BAN:INN] Triclosan [USAN:USP:INN:BAN] Triclosan, Antibiotic for Culture Media Use Only
    Triclosan, Pharmaceutical Secondary Standard Triclosan, United States Pharmacopeia (USP) Reference Standard Triclosan, certified reference material, TraceCERT(R)
    Triclosanum Triclosanum [INN-Latin] UNII-4NM5039Y5X
    XEFQLINVKFYRCS-UHFFFAOYSA-N ZINC2216 ZX-AFC000465
    s4541 triclosan

    DrugBank DB08604
    CAS Number 1020719-98-5, 3380-34-5, 88032-08-0
    PubChem Compound 5564
    KEGG Compound ID C12059
    KEGG Drug D06226
    ChEBI 164200