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Compound

D1357 | Butein

Molecular Formula C15H12O5
Molecular Weight 272.25
Structure
Description a chalcone of the chalconoids; antioxidative; aldose reductase and advanced glycation endproducts inhibitor

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL > 200 µM 30 mins mouse liver mitochondria Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss) decrease EC20 36
RESPIRATION 29.6 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease EC20 36
RESPIRATION ND 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. Negative EC20 36
SWELLING > 200 µM 30 mins mouse liver mitochondria swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling ) increase EC20 36

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase 29.6 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. inhibit EC20 36
Succinate dehydrogenase ND 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. Negative EC20 36
Cytochrome c > 200 µM 30 mins mouse liver mitochondria Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline) release EC20 36


  • (2E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one (E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one (E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
    (E)-2',3,4,4'-terahydroxychalcone (E)-3-(3,4-Dihydroxy-phenyl)-1-(2,4-dihydroxy-phenyl)-propenone 1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one
    2 inverted exclamation mark ,3,4,4 inverted exclamation mark -tetrahydroxy Chalcone 2′,4′,3,4-Tetrahydroxychalcone 2',3,4,4'-Tetrahydroxychalcone
    2',3,4,4'-Tetrahydroxychalcone 2',4',3,4-Tetrahydroxychalcone 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-
    2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-, (2E)- 2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)- 21849-70-7
    3,4,2'',4''-tetrahydroxychalone 3,4,2',4'-Tetrahydroxychalcone 3,4,2',4'-Tetrahydroxychalone
    3-(3,4-Dihydroxy-phenyl)-1-(2,4-dihydroxy-phenyl)-propenone 487-52-5 4WVS5M0LGF
    ACM21849707 AKOS032948361 AS-35311
    Acrylophenone, 2',4'-dihydroxy-3-(3,4-dihydroxyphenyl)- B3803 BDBM50042949
    BRD-K17497770-001-01-0 Butein Butein, analytical standard
    Butein, solid C08578 CCG-208298
    CHEBI:3237 CHEBI:92312 CHEMBL128000
    CS-5675 Chalcone, 2',3,4,4'-tetrahydroxy- (7CI,8CI) EINECS 207-659-5
    HSCI1_000162 HY-16558 LMPK12120111
    LS-123867 LS-175098 NCGC00163519-01
    NS00018353 NSC-652892 NSC652892
    Q5002498 SCHEMBL139243 SR-05000002316
    SR-05000002316-2 ST50331397 SW219249-1
    UNII-4WVS5M0LGF W1236 ZINC12428433
    butein s8036

    CAS Number 21849-70-7, 487-52-5
    PubChem Compound 5281222