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Drug

D1391 | Cefixime

Molecular Formula C16H15N5O7S2
Molecular Weight 453.5
Structure
State solid
Protein binding 65% (concentration independent)
Half life 3-4 hours (may range up to 9 hours). In severe renal impairment (5 to 20 mL/min creatinine clearance), the half-life increased to an average of 11.5 hours.
Absorption About 40%-50% absorbed orally whether administered with or without food, however, time to maximal absorption is increased approximately 0.8 hours when administered with food.

J

J01DD08 Cefixime


[J01DD] Third-generation cephalosporins


[J01D] OTHER BETA-LACTAM ANTIBACTERIALS


[J01] ANTIBACTERIALS FOR SYSTEMIC USE


[J] Antiinfectives for systemic use

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL > 400 µM 30 mins mouse liver mitochondria Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss) decrease EC20 36
RESPIRATION 41.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease EC20 36
RESPIRATION 216.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease EC20 36
SWELLING > 400 µM 30 mins mouse liver mitochondria swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling ) increase EC20 36

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase 41.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. inhibit EC20 36
Succinate dehydrogenase 216.8 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. inhibit EC20 36
Cytochrome c > 400 µM 30 mins mouse liver mitochondria Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline) release EC20 36

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 56 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 1 of 56 companies. For more detailed information, please visit ECHA C&L website


Of the 5 notification(s) provided by 55 of 56 companies with hazard statement code(s):


H315 (23.64%): Causes skin irritation [Warning Skin corrosion/irritation]


H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]


H319 (23.64%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H334 (27.27%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]


H335 (23.64%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P261, P264, P271, P272, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rat LD50 oral > 10gm/kg (10000mg/kg) gastrointestinal: "hypermotility, diarrhea" Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 3509, 1986.
rat LD50 subcutaneous > 10gm/kg (10000mg/kg) behavioral: somnolence (general depressed activity) Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 3509, 1986.
rat LD50 intravenous 6990mg/kg (6990mg/kg) Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 3509, 1986.
mouse LD50 oral > 10gm/kg (10000mg/kg) gastrointestinal: "hypermotility, diarrhea" Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 3509, 1986.
dog LD50 oral > 600mg/kg (600mg/kg) gastrointestinal: "hypermotility, diarrhea" Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 3509, 1986.
dog LD50 intravenous > 3200mg/kg (3200mg/kg) Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 3509, 1986.
mouse LD50 intravenous 4420mg/kg (4420mg/kg) Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 3509, 1986.
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg) behavioral: somnolence (general depressed activity) Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 3509, 1986.


  • DrugBank DB00671
    CAS Number 108691-83-4, 79350-37-1
    PubChem Compound 5362065