Compound
D0537 | citrate
A
A09AB04 Citric acid
[A09AB] Acid preparations
[A09A] DIGESTIVES, INCL. ENZYMES
[A09] DIGESTIVES, INCL. ENZYMES
[A] Alimentary tract and metabolism
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| OPENING OF PERMEABILITY TRANSITION PORE (PTP) | > 100 µM | 1 hour | Human | HepG2 | High-content screening assay | Negative | MEC | 306 |
| MEMBRANE POTENTIAL | > 100 µM | 1 hour | Human | HepG2 | High-content screening assay | Negative | MEC | 306 |
| TCA | affect | 79 | ||||||
| ROS PRODUCTION | > 100 µM | 1 hour | Human | HepG2 | High-content screening assay | Negative | MEC | 306 |
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | competitive inhibitor | 79 | ||||||
| Reactive oxygen species | > 100 µM | 1 hour | Human | HepG2 | High-content screening assay | Negative | MEC | 306 |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Warning |
Aggregated GHS information provided by 4645 companies from 29 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 467 of 4645 companies. For more detailed information, please visit ECHA C&L website Of the 28 notification(s) provided by 4178 of 4645 companies with hazard statement code(s): H315 (10.15%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (90.07%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Warning |
H315: Causes skin irritation [Warning Skin corrosion/irritation] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] |
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| rabbit | LDLo | oral | 7gm/kg (7000mg/kg) | Industrial and Engineering Chemistry. Vol. 15, Pg. 628, 1923. | |
| mouse | LD50 | intravenous | 42mg/kg (42mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948. | |
| mouse | LD50 | oral | 5040mg/kg (5040mg/kg) | Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 25, 1971. | |
| rabbit | LD50 | intravenous | 330mg/kg (330mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948. | |
| mouse | LD50 | intraperitoneal | 903mg/kg (903mg/kg) | Toxicology. Vol. 62, Pg. 203, 1990. | |
| mouse | LD50 | subcutaneous | 2700mg/kg (2700mg/kg) | Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 25, 1971. | |
| rat | LD50 | intraperitoneal | 290mg/kg (290mg/kg) | Toksikologicheskii Vestnik. Vol. (5), Pg. 9, 1994. | |
| rat | LD50 | oral | 3gm/kg (3000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 561, 1992. | |
| rat | LD50 | subcutaneous | 5500mg/kg (5500mg/kg) | Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 25, 1971. | |
| .beta.-Hydroxytricarballylic acid | 1,2,3-PROPANETRICARBOXYLIC ACID,2-HYDROXY (CITRIC ACID) | 1,2,3-Propanetricarboxylic acid, 2-hydroxy- |
| 1,2,3-Propanetricarboxylic acid, 2-hydroxy- (9CI) | 1,2,3-Tricarboxy-2-hydroxypropane | 1,3-Propanetricarboxylic acid, 2-hydroxy- |
| 10024-66-5 | 111855-EP2295439A1 | 111855-EP2298761A1 |
| 1185-57-5 | 119851-23-9 | 120156-45-8 |
| 1466-EP2269610A2 | 1466-EP2269986A1 | 1466-EP2269988A2 |
| 1466-EP2269989A1 | 1466-EP2269990A1 | 1466-EP2270002A1 |
| 1466-EP2270003A1 | 1466-EP2270006A1 | 1466-EP2270008A1 |
| 1466-EP2270011A1 | 1466-EP2270017A1 | 1466-EP2270505A1 |
| 1466-EP2272516A2 | 1466-EP2272537A2 | 1466-EP2272817A1 |
| 1466-EP2272822A1 | 1466-EP2272825A2 | 1466-EP2272827A1 |
| 1466-EP2272832A1 | 1466-EP2272834A1 | 1466-EP2272841A1 |
| 1466-EP2272843A1 | 1466-EP2275102A1 | 1466-EP2275105A1 |
| 1466-EP2275401A1 | 1466-EP2275403A1 | 1466-EP2275404A1 |
| 1466-EP2275410A1 | 1466-EP2275411A2 | 1466-EP2275412A1 |
| 1466-EP2275413A1 | 1466-EP2275414A1 | 1466-EP2277507A1 |
| 1466-EP2277848A1 | 1466-EP2277858A1 | 1466-EP2277866A1 |
| 1466-EP2277867A2 | 1466-EP2280000A1 | 1466-EP2280001A1 |
| 1466-EP2280003A2 | 1466-EP2280004A1 | 1466-EP2280009A1 |
| 1466-EP2280010A2 | 1466-EP2280012A2 | 1466-EP2280020A1 |
| 1466-EP2280021A1 | 1466-EP2281559A1 | 1466-EP2281563A1 |
| 1466-EP2281813A1 | 1466-EP2281816A1 | 1466-EP2281817A1 |
| 1466-EP2281818A1 | 1466-EP2281819A1 | 1466-EP2281820A2 |
| 1466-EP2281823A2 | 1466-EP2284149A1 | 1466-EP2284160A1 |
| 1466-EP2284169A1 | 1466-EP2284178A2 | 1466-EP2284179A2 |
| 1466-EP2286795A1 | 1466-EP2286811A1 | 1466-EP2287153A1 |
| 1466-EP2287155A1 | 1466-EP2287156A1 | 1466-EP2287160A1 |
| 1466-EP2287161A1 | 1466-EP2287162A1 | 1466-EP2287165A2 |
| 1466-EP2287166A2 | 1466-EP2287167A1 | 1466-EP2289509A2 |
| 1466-EP2289510A1 | 1466-EP2289518A1 | 1466-EP2289876A1 |
| 1466-EP2289879A1 | 1466-EP2289883A1 | 1466-EP2289887A2 |
| 1466-EP2289888A2 | 1466-EP2289890A1 | 1466-EP2289893A1 |
| 1466-EP2292227A2 | 1466-EP2292228A1 | 1466-EP2292231A1 |
| 1466-EP2292233A2 | 1466-EP2292234A1 | 1466-EP2292592A1 |
| 1466-EP2292593A2 | 1466-EP2292611A1 | 1466-EP2292612A2 |
| 1466-EP2292615A1 | 1466-EP2292617A1 | 1466-EP2292619A1 |
| 1466-EP2292620A2 | 1466-EP2292621A1 | 1466-EP2292622A1 |
| 1466-EP2292628A2 | 1466-EP2295053A1 | 1466-EP2295401A2 |
| 1466-EP2295402A2 | 1466-EP2295406A1 | 1466-EP2295407A1 |
| 1466-EP2295408A1 | 1466-EP2295410A1 | 1466-EP2295412A1 |
| 1466-EP2295413A1 | 1466-EP2295414A1 | 1466-EP2295415A1 |
| 1466-EP2295416A2 | 1466-EP2295418A1 | 1466-EP2295424A1 |
| 1466-EP2295426A1 | 1466-EP2295427A1 | 1466-EP2295432A1 |
| 1466-EP2295433A2 | 1466-EP2295437A1 | 1466-EP2298731A1 |
| 1466-EP2298734A2 | 1466-EP2298735A1 | 1466-EP2298736A1 |
| 1466-EP2298742A1 | 1466-EP2298744A2 | 1466-EP2298746A1 |
| 1466-EP2298747A1 | 1466-EP2298748A2 | 1466-EP2298750A1 |
| 1466-EP2298751A2 | 1466-EP2298754A1 | 1466-EP2298755A1 |
| 1466-EP2298757A2 | 1466-EP2298758A1 | 1466-EP2298759A1 |
| 1466-EP2298767A1 | 1466-EP2298768A1 | 1466-EP2298772A1 |
| 1466-EP2298775A1 | 1466-EP2298776A1 | 1466-EP2298778A1 |
| 1466-EP2298779A1 | 1466-EP2301536A1 | 1466-EP2301538A1 |
| 1466-EP2301544A1 | 1466-EP2301922A1 | 1466-EP2301923A1 |
| 1466-EP2301925A1 | 1466-EP2301928A1 | 1466-EP2301929A1 |
| 1466-EP2301930A1 | 1466-EP2301931A1 | 1466-EP2301933A1 |
| 1466-EP2301934A1 | 1466-EP2301935A1 | 1466-EP2301936A1 |
| 1466-EP2301937A1 | 1466-EP2301939A1 | 1466-EP2301940A1 |
| 1466-EP2301941A1 | 1466-EP2305219A1 | 1466-EP2305248A1 |
| 1466-EP2305250A1 | 1466-EP2305257A1 | 1466-EP2305633A1 |
| 1466-EP2305636A1 | 1466-EP2305641A1 | 1466-EP2305646A1 |
| 1466-EP2305651A1 | 1466-EP2305652A2 | 1466-EP2305653A1 |
| 1466-EP2305655A2 | 1466-EP2305657A2 | 1466-EP2305659A1 |
| 1466-EP2305663A1 | 1466-EP2305664A1 | 1466-EP2305666A1 |
| 1466-EP2305668A1 | 1466-EP2305672A1 | 1466-EP2305673A1 |
| 1466-EP2305674A1 | 1466-EP2305675A1 | 1466-EP2305682A1 |
| 1466-EP2305683A1 | 1466-EP2305684A1 | 1466-EP2305687A1 |
| 1466-EP2305808A1 | 1466-EP2308479A2 | 1466-EP2308492A1 |
| 1466-EP2308510A1 | 1466-EP2308562A2 | 1466-EP2308812A2 |
| 1466-EP2308828A2 | 1466-EP2308838A1 | 1466-EP2308839A1 |
| 1466-EP2308849A1 | 1466-EP2308850A1 | 1466-EP2308851A1 |
| 1466-EP2308854A1 | 1466-EP2308857A1 | 1466-EP2308861A1 |
| 1466-EP2308869A1 | 1466-EP2308871A1 | 1466-EP2308872A1 |
| 1466-EP2308873A1 | 1466-EP2308875A1 | 1466-EP2308877A1 |
| 1466-EP2308879A1 | 1466-EP2311455A1 | 1466-EP2311494A1 |
| 1466-EP2311807A1 | 1466-EP2311808A1 | 1466-EP2311809A1 |
| 1466-EP2311810A1 | 1466-EP2311811A1 | 1466-EP2311814A1 |
| 1466-EP2311818A1 | 1466-EP2311820A1 | 1466-EP2311821A1 |
| 1466-EP2311822A1 | 1466-EP2311823A1 | 1466-EP2311824A1 |
| 1466-EP2311827A1 | 1466-EP2311829A1 | 1466-EP2311830A1 |
| 1466-EP2311831A1 | 1466-EP2311834A1 | 1466-EP2311837A1 |
| 1466-EP2311839A1 | 1466-EP2311840A1 | 1466-EP2311842A2 |
| 1466-EP2311850A1 | 1466-EP2314574A1 | 1466-EP2314575A1 |
| 1466-EP2314576A1 | 1466-EP2314577A1 | 1466-EP2314584A1 |
| 1466-EP2314585A1 | 1466-EP2314586A1 | 1466-EP2314587A1 |
| 1466-EP2314589A1 | 1466-EP2314593A1 | 1466-EP2316457A1 |
| 1466-EP2316458A1 | 1466-EP2316459A1 | 1466-EP2316470A2 |
| 1466-EP2316824A1 | 1466-EP2316825A1 | 1466-EP2316826A1 |
| 1466-EP2316827A1 | 1466-EP2316828A1 | 1466-EP2316829A1 |
| 1466-EP2316831A1 | 1466-EP2316832A1 | 1466-EP2316833A1 |
| 1466-EP2316834A1 | 1466-EP2316835A1 | 1466-EP2316836A1 |
| 1466-EP2316837A1 | 1466-EP2316974A1 | 1466-EP2371799A1 |
| 1466-EP2371802A1 | 1466-EP2371811A2 | 1466-EP2371814A1 |
| 1466-EP2372017A1 | 1466-EP2374454A1 | 1466-EP2374526A1 |
| 1466-EP2374780A1 | 1466-EP2374781A1 | 1466-EP2374790A1 |
| 1466-EP2374895A1 | 1466-EP2377510A1 | 1466-EP2377848A1 |
| 1466-EP2380568A1 | 1i2s | 1o4l |
| 1rq2 | 1y4a | 2-Hydroxy-1,2,3-propane tricarboxylic acid |
| 2-Hydroxy-1,2,3-propanenetricarboxylic acid | 2-Hydroxy-1,3-propanetricarboxylic acid | 2-Hydroxypropanetricarboxylic acid |
| 2-Hydroxytricarballylic acid | 2-hydroxy-1,2,3-propanetricarboxyic acid | 2-hydroxy-1,2,3-propanetricarboxylate |
| 2-hydroxy-1,2,3-propanetricarboxylic | 2-hydroxy-1,2,3-propanetricarboxylic acid | 2-hydroxypropane-1,2,3-tricarboxylic acid |
| 2bo4 | 2c4v | 2fw6 |
| 2fwp | 3-Carboxy-3-hydroxypentane-1,5-dioate | 3-Carboxy-3-hydroxypentane-1,5-dioic acid |
| 4-03-00-01272 (Beilstein Handbook Reference) | 4aci | 4nrm |
| 4o61 | 4to8 | 5077-53-2 |
| 77-92-9 | 8F5D336A-442D-434A-9FB0-E400FF74E343 | AB1002470 |
| ACMC-209pcr | AE-562/40806920 | AI3-06286 |
| AK116143 | AKOS000119911 | ANW-37129 |
| ANW-44011 | Aciletten | Anhydrous citrate |
| Anhydrous citric acid | Anhydrous citric acid (JP17) | B7297 |
| BBL002530 | BDBM14672 | BP-31028 |
| BRN 0782061 | BSPBio_003240 | C00158 |
| C1949 | C6H8O7 | CAS-77-92-9 |
| CCRIS 3292 | CHEBI:30769 | CHEMBL1261 |
| CITRATE ANION | CS-6965 | CTK1H3247 |
| Caswell No. 221C | Certified Reference Material | Chemfill |
| Citraclean | Citraclean (Salt/Mix) | Citralite |
| Citrate Ion | Citrate standard for IC, 1000 mg/L, analytical standard | Citretten |
| Citric Acid (Anhydrous) | Citric Acid (Industrial Grade) | Citric Acid, Aqueous Solution (Food Grade) |
| Citric Acid, anhydrous granular, A.C.S. | Citric Acid, anhydrous powder, A.C.S. | Citric Acid, anhydrous, USP |
| Citric Acid,(S) | Citric acid (8CI) | Citric acid 50% solution in water |
| Citric acid [USAN:JAN] | Citric acid anhydrous | Citric acid anhydrous (JAN) |
| Citric acid, 99% | Citric acid, 99%, pure, anhydrous | Citric acid, 99.5%, for analysis, anhydrous |
| Citric acid, 99.6%, ACS reagent, anhydrous | Citric acid, >=99.5%, FCC, FG | Citric acid, ACS reagent, >=99.5% |
| Citric acid, Anhydrous, Pharmaceutical Secondary Standard | Citric acid, BioUltra, anhydrous, >=99.5% (T) | Citric acid, LR, anhydrous, >=99% |
| Citric acid, SAJ first grade, >=99.5% | Citric acid, United States Pharmacopeia (USP) Reference Standard | Citric acid, Vetec(TM) reagent grade, 99% |
| Citric acid, analytical standard | Citric acid, anhydrous | Citric acid, anhydrous (USP) |
| Citric acid, anhydrous [USP:JAN] | Citric acid, anhydrous, European Pharmacopoeia (EP) Reference Standard | Citric acid, anhydrous, cell culture tested, plant cell culture tested |
| Citric acid, anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=99.5% | Citric acid, certified reference material, TraceCERT(R) | Citric acid, for molecular biology, anhydrous, Rnase and Protease free |
| Citric acid, meets USP testing specifications, anhydrous | Citric acid, meets analytical specification of Ph. Eur., BP, USP, E330, anhydrous, 99.5-100.5% (based on anhydrous substance) | Citric acid, p.a., 99.5% |
| Citric acid,anhydrous | Citricacid | Citro |
| Citronensaeure | D00037 | DB04272 |
| DSSTox_CID_332 | DSSTox_GSID_20332 | DSSTox_RID_75520 |
| DTXSID3020332 | E 330 | E-330 |
| E330 | EC 201-069-1 | EINECS 201-069-1 |
| EPA Pesticide Chemical Code 021801 | F 0001 (polycarboxylic acid) | F2191-0222 |
| FEMA No. 2306 | FEMA Number 2306 | FT-0623957 |
| FT-0728530 | GTPL2478 | H3cit |
| HMS1787N01 | HMS2268B04 | HOC(CH2COOH)2COOH |
| HSDB 911 | HY-N1428 | Hydrocerol A |
| INS NO.330 | INS-330 | IRRIGATING SOLUTION G IN PLASTIC CONTAINER |
| InChI=1/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12; | J-520099 | K-Lyte |
| K-Lyte (Salt/Mix) | K-Lyte DS | K-Lyte DS (Salt/Mix) |
| K-Lyte/Cl (Salt/Mix) | KBio3_002740 | KRKNYBCHXYNGOX-UHFFFAOYSA-N |
| KS-00000V8J | KSC273E4P | Kyselina 2-hydroxy-1,2,3-propantrikarbonova |
| Kyselina 2-hydroxy-1,2,3-propantrikarbonova [Czech] | Kyselina citronova | Kyselina citronova [Czech] |
| LS-3185 | LS-96070 | MCULE-7981253226 |
| MFCD00011669 | MLS001066346 | NCGC00090954-01 |
| NCGC00090954-02 | NCGC00090954-03 | NCGC00090954-04 |
| NCGC00090954-05 | NCGC00254055-01 | NCGC00259954-01 |
| NCI60_022579 | NCIOpen2_004062 | NCIOpen2_004502 |
| NCIStruc1_000057 | NCIStruc2_000099 | NE10694 |
| NSC 30279 | NSC 626579 | NSC-112226 |
| NSC-30279 | NSC-626579 | NSC-759606 |
| NSC30279 | NSC626579 | NSC759606 |
| Neodymium chloride citrate | Neodymium citrate chloride | Oprea1_502996 |
| Pharmakon1600-01300013 | PubChem20283 | Q159683 |
| RTR-020636 | SBB008922 | SBI-0206765.P001 |
| SC-43865 | SMR000471840 | ST50308093 |
| STK286098 | STR12052 | Spectrum3_001850 |
| Suby G | T8019 | TR-020636 |
| Tox21_113436 | Tox21_202405 | Tox21_300124 |
| UNII-XF417D3PSL | Uralyt U | Uro-trainer |
| WLN: QV1XQVQ1VQ | XF417D3PSL | Z56754862 |
| ZINC895081 | beta-Hydroxytricarballylate | beta-Hydroxytricarballylic acid |
| bmse000076 | cid_311 | citr |
| citrate | citric acid | citric acid (Fragrance Grade) |
| citric-acid | s5761 |
| CAS Number | 10024-66-5, 106168-20-1, 106809-03-4, 117148-05-7, 12262-73-6, 125139-08-4, 125139-09-5, 125139-13-1, 153301-06-5, 154618-13-0, 16922-05-7, 3458-72-8, 3522-50-7, 4596-23-0, 5077-53-2, 57-12-5, 5949-29-1, 6018-92-4, 6080-58-6, 77-92-9, 866-82-0 |
| PubChem Compound | 311 |
| KEGG Compound ID | C00158 |
| ChEBI | 50744 |