D0537 | citrate

Molecular Formula C6H8O7
Molecular Weight 192.12


A09AB04 Citric acid

[A09AB] Acid preparations



[A] Alimentary tract and metabolism

Toxicity Dose Time Species Model Method Action Positive criterion Reference
OPENING OF PERMEABILITY TRANSITION PORE (PTP) > 100 µM 1 hour Human HepG2 High-content screening assay Negative MEC 306
MEMBRANE POTENTIAL > 100 µM 1 hour Human HepG2 High-content screening assay Negative MEC 306
TCA affect 79
ROS PRODUCTION > 100 µM 1 hour Human HepG2 High-content screening assay Negative MEC 306

Target Dose Time Species Model Method Action Positive criterion Reference
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial competitive inhibitor 79
Reactive oxygen species > 100 µM 1 hour Human HepG2 High-content screening assay Negative MEC 306

Pictogram Signal Statements Precautionary Statement Codes

Aggregated GHS information provided by 4645 companies from 29 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria by 467 of 4645 companies. For more detailed information, please visit ECHA C&L website

Of the 28 notification(s) provided by 4178 of 4645 companies with hazard statement code(s):

H315 (10.15%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (90.07%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362; (The corresponding statement to each P-code can be found at the GHS Classification page.)

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure

Respiratory tract irritation]

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rabbit LDLo oral 7gm/kg (7000mg/kg) Industrial and Engineering Chemistry. Vol. 15, Pg. 628, 1923.
mouse LD50 intravenous 42mg/kg (42mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
mouse LD50 oral 5040mg/kg (5040mg/kg) Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 25, 1971.
rabbit LD50 intravenous 330mg/kg (330mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
mouse LD50 intraperitoneal 903mg/kg (903mg/kg) Toxicology. Vol. 62, Pg. 203, 1990.
mouse LD50 subcutaneous 2700mg/kg (2700mg/kg) Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 25, 1971.
rat LD50 intraperitoneal 290mg/kg (290mg/kg) Toksikologicheskii Vestnik. Vol. (5), Pg. 9, 1994.
rat LD50 oral 3gm/kg (3000mg/kg) Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 561, 1992.
rat LD50 subcutaneous 5500mg/kg (5500mg/kg) Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 25, 1971.

  • .beta.-Hydroxytricarballylic acid 1,2,3-PROPANETRICARBOXYLIC ACID,2-HYDROXY (CITRIC ACID) 1,2,3-Propanetricarboxylic acid, 2-hydroxy-
    1,2,3-Propanetricarboxylic acid, 2-hydroxy- (9CI) 1,2,3-Tricarboxy-2-hydroxypropane 1,3-Propanetricarboxylic acid, 2-hydroxy-
    10024-66-5 111855-EP2295439A1 111855-EP2298761A1
    1185-57-5 119851-23-9 120156-45-8
    1466-EP2269610A2 1466-EP2269986A1 1466-EP2269988A2
    1466-EP2269989A1 1466-EP2269990A1 1466-EP2270002A1
    1466-EP2270003A1 1466-EP2270006A1 1466-EP2270008A1
    1466-EP2270011A1 1466-EP2270017A1 1466-EP2270505A1
    1466-EP2272516A2 1466-EP2272537A2 1466-EP2272817A1
    1466-EP2272822A1 1466-EP2272825A2 1466-EP2272827A1
    1466-EP2272832A1 1466-EP2272834A1 1466-EP2272841A1
    1466-EP2272843A1 1466-EP2275102A1 1466-EP2275105A1
    1466-EP2275401A1 1466-EP2275403A1 1466-EP2275404A1
    1466-EP2275410A1 1466-EP2275411A2 1466-EP2275412A1
    1466-EP2275413A1 1466-EP2275414A1 1466-EP2277507A1
    1466-EP2277848A1 1466-EP2277858A1 1466-EP2277866A1
    1466-EP2277867A2 1466-EP2280000A1 1466-EP2280001A1
    1466-EP2280003A2 1466-EP2280004A1 1466-EP2280009A1
    1466-EP2280010A2 1466-EP2280012A2 1466-EP2280020A1
    1466-EP2280021A1 1466-EP2281559A1 1466-EP2281563A1
    1466-EP2281813A1 1466-EP2281816A1 1466-EP2281817A1
    1466-EP2281818A1 1466-EP2281819A1 1466-EP2281820A2
    1466-EP2281823A2 1466-EP2284149A1 1466-EP2284160A1
    1466-EP2284169A1 1466-EP2284178A2 1466-EP2284179A2
    1466-EP2286795A1 1466-EP2286811A1 1466-EP2287153A1
    1466-EP2287155A1 1466-EP2287156A1 1466-EP2287160A1
    1466-EP2287161A1 1466-EP2287162A1 1466-EP2287165A2
    1466-EP2287166A2 1466-EP2287167A1 1466-EP2289509A2
    1466-EP2289510A1 1466-EP2289518A1 1466-EP2289876A1
    1466-EP2289879A1 1466-EP2289883A1 1466-EP2289887A2
    1466-EP2289888A2 1466-EP2289890A1 1466-EP2289893A1
    1466-EP2292227A2 1466-EP2292228A1 1466-EP2292231A1
    1466-EP2292233A2 1466-EP2292234A1 1466-EP2292592A1
    1466-EP2292593A2 1466-EP2292611A1 1466-EP2292612A2
    1466-EP2292615A1 1466-EP2292617A1 1466-EP2292619A1
    1466-EP2292620A2 1466-EP2292621A1 1466-EP2292622A1
    1466-EP2292628A2 1466-EP2295053A1 1466-EP2295401A2
    1466-EP2295402A2 1466-EP2295406A1 1466-EP2295407A1
    1466-EP2295408A1 1466-EP2295410A1 1466-EP2295412A1
    1466-EP2295413A1 1466-EP2295414A1 1466-EP2295415A1
    1466-EP2295416A2 1466-EP2295418A1 1466-EP2295424A1
    1466-EP2295426A1 1466-EP2295427A1 1466-EP2295432A1
    1466-EP2295433A2 1466-EP2295437A1 1466-EP2298731A1
    1466-EP2298734A2 1466-EP2298735A1 1466-EP2298736A1
    1466-EP2298742A1 1466-EP2298744A2 1466-EP2298746A1
    1466-EP2298747A1 1466-EP2298748A2 1466-EP2298750A1
    1466-EP2298751A2 1466-EP2298754A1 1466-EP2298755A1
    1466-EP2298757A2 1466-EP2298758A1 1466-EP2298759A1
    1466-EP2298767A1 1466-EP2298768A1 1466-EP2298772A1
    1466-EP2298775A1 1466-EP2298776A1 1466-EP2298778A1
    1466-EP2298779A1 1466-EP2301536A1 1466-EP2301538A1
    1466-EP2301544A1 1466-EP2301922A1 1466-EP2301923A1
    1466-EP2301925A1 1466-EP2301928A1 1466-EP2301929A1
    1466-EP2301930A1 1466-EP2301931A1 1466-EP2301933A1
    1466-EP2301934A1 1466-EP2301935A1 1466-EP2301936A1
    1466-EP2301937A1 1466-EP2301939A1 1466-EP2301940A1
    1466-EP2301941A1 1466-EP2305219A1 1466-EP2305248A1
    1466-EP2305250A1 1466-EP2305257A1 1466-EP2305633A1
    1466-EP2305636A1 1466-EP2305641A1 1466-EP2305646A1
    1466-EP2305651A1 1466-EP2305652A2 1466-EP2305653A1
    1466-EP2305655A2 1466-EP2305657A2 1466-EP2305659A1
    1466-EP2305663A1 1466-EP2305664A1 1466-EP2305666A1
    1466-EP2305668A1 1466-EP2305672A1 1466-EP2305673A1
    1466-EP2305674A1 1466-EP2305675A1 1466-EP2305682A1
    1466-EP2305683A1 1466-EP2305684A1 1466-EP2305687A1
    1466-EP2305808A1 1466-EP2308479A2 1466-EP2308492A1
    1466-EP2308510A1 1466-EP2308562A2 1466-EP2308812A2
    1466-EP2308828A2 1466-EP2308838A1 1466-EP2308839A1
    1466-EP2308849A1 1466-EP2308850A1 1466-EP2308851A1
    1466-EP2308854A1 1466-EP2308857A1 1466-EP2308861A1
    1466-EP2308869A1 1466-EP2308871A1 1466-EP2308872A1
    1466-EP2308873A1 1466-EP2308875A1 1466-EP2308877A1
    1466-EP2308879A1 1466-EP2311455A1 1466-EP2311494A1
    1466-EP2311807A1 1466-EP2311808A1 1466-EP2311809A1
    1466-EP2311810A1 1466-EP2311811A1 1466-EP2311814A1
    1466-EP2311818A1 1466-EP2311820A1 1466-EP2311821A1
    1466-EP2311822A1 1466-EP2311823A1 1466-EP2311824A1
    1466-EP2311827A1 1466-EP2311829A1 1466-EP2311830A1
    1466-EP2311831A1 1466-EP2311834A1 1466-EP2311837A1
    1466-EP2311839A1 1466-EP2311840A1 1466-EP2311842A2
    1466-EP2311850A1 1466-EP2314574A1 1466-EP2314575A1
    1466-EP2314576A1 1466-EP2314577A1 1466-EP2314584A1
    1466-EP2314585A1 1466-EP2314586A1 1466-EP2314587A1
    1466-EP2314589A1 1466-EP2314593A1 1466-EP2316457A1
    1466-EP2316458A1 1466-EP2316459A1 1466-EP2316470A2
    1466-EP2316824A1 1466-EP2316825A1 1466-EP2316826A1
    1466-EP2316827A1 1466-EP2316828A1 1466-EP2316829A1
    1466-EP2316831A1 1466-EP2316832A1 1466-EP2316833A1
    1466-EP2316834A1 1466-EP2316835A1 1466-EP2316836A1
    1466-EP2316837A1 1466-EP2316974A1 1466-EP2371799A1
    1466-EP2371802A1 1466-EP2371811A2 1466-EP2371814A1
    1466-EP2372017A1 1466-EP2374454A1 1466-EP2374526A1
    1466-EP2374780A1 1466-EP2374781A1 1466-EP2374790A1
    1466-EP2374895A1 1466-EP2377510A1 1466-EP2377848A1
    1466-EP2380568A1 1i2s 1o4l
    1rq2 1y4a 2-Hydroxy-1,2,3-propane tricarboxylic acid
    2-Hydroxy-1,2,3-propanenetricarboxylic acid 2-Hydroxy-1,3-propanetricarboxylic acid 2-Hydroxypropanetricarboxylic acid
    2-Hydroxytricarballylic acid 2-hydroxy-1,2,3-propanetricarboxyic acid 2-hydroxy-1,2,3-propanetricarboxylate
    2-hydroxy-1,2,3-propanetricarboxylic 2-hydroxy-1,2,3-propanetricarboxylic acid 2-hydroxypropane-1,2,3-tricarboxylic acid
    2bo4 2c4v 2fw6
    2fwp 3-Carboxy-3-hydroxypentane-1,5-dioate 3-Carboxy-3-hydroxypentane-1,5-dioic acid
    4-03-00-01272 (Beilstein Handbook Reference) 4aci 4nrm
    4o61 4to8 5077-53-2
    77-92-9 8F5D336A-442D-434A-9FB0-E400FF74E343 AB1002470
    ACMC-209pcr AE-562/40806920 AI3-06286
    AK116143 AKOS000119911 ANW-37129
    ANW-44011 Aciletten Anhydrous citrate
    Anhydrous citric acid Anhydrous citric acid (JP17) B7297
    BBL002530 BDBM14672 BP-31028
    BRN 0782061 BSPBio_003240 C00158
    C1949 C6H8O7 CAS-77-92-9
    CCRIS 3292 CHEBI:30769 CHEMBL1261
    Caswell No. 221C Certified Reference Material Chemfill
    Citraclean Citraclean (Salt/Mix) Citralite
    Citrate Ion Citrate standard for IC, 1000 mg/L, analytical standard Citretten
    Citric Acid (Anhydrous) Citric Acid (Industrial Grade) Citric Acid, Aqueous Solution (Food Grade)
    Citric Acid, anhydrous granular, A.C.S. Citric Acid, anhydrous powder, A.C.S. Citric Acid, anhydrous, USP
    Citric Acid,(S) Citric acid (8CI) Citric acid 50% solution in water
    Citric acid [USAN:JAN] Citric acid anhydrous Citric acid anhydrous (JAN)
    Citric acid, 99% Citric acid, 99%, pure, anhydrous Citric acid, 99.5%, for analysis, anhydrous
    Citric acid, 99.6%, ACS reagent, anhydrous Citric acid, >=99.5%, FCC, FG Citric acid, ACS reagent, >=99.5%
    Citric acid, Anhydrous, Pharmaceutical Secondary Standard Citric acid, BioUltra, anhydrous, >=99.5% (T) Citric acid, LR, anhydrous, >=99%
    Citric acid, SAJ first grade, >=99.5% Citric acid, United States Pharmacopeia (USP) Reference Standard Citric acid, Vetec(TM) reagent grade, 99%
    Citric acid, analytical standard Citric acid, anhydrous Citric acid, anhydrous (USP)
    Citric acid, anhydrous [USP:JAN] Citric acid, anhydrous, European Pharmacopoeia (EP) Reference Standard Citric acid, anhydrous, cell culture tested, plant cell culture tested
    Citric acid, anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=99.5% Citric acid, certified reference material, TraceCERT(R) Citric acid, for molecular biology, anhydrous, Rnase and Protease free
    Citric acid, meets USP testing specifications, anhydrous Citric acid, meets analytical specification of Ph. Eur., BP, USP, E330, anhydrous, 99.5-100.5% (based on anhydrous substance) Citric acid, p.a., 99.5%
    Citric acid,anhydrous Citricacid Citro
    Citronensaeure D00037 DB04272
    DSSTox_CID_332 DSSTox_GSID_20332 DSSTox_RID_75520
    DTXSID3020332 E 330 E-330
    E330 EC 201-069-1 EINECS 201-069-1
    EPA Pesticide Chemical Code 021801 F 0001 (polycarboxylic acid) F2191-0222
    FEMA No. 2306 FEMA Number 2306 FT-0623957
    FT-0728530 GTPL2478 H3cit
    HMS1787N01 HMS2268B04 HOC(CH2COOH)2COOH
    HSDB 911 HY-N1428 Hydrocerol A
    InChI=1/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12; J-520099 K-Lyte
    K-Lyte (Salt/Mix) K-Lyte DS K-Lyte DS (Salt/Mix)
    K-Lyte/Cl (Salt/Mix) KBio3_002740 KRKNYBCHXYNGOX-UHFFFAOYSA-N
    KS-00000V8J KSC273E4P Kyselina 2-hydroxy-1,2,3-propantrikarbonova
    Kyselina 2-hydroxy-1,2,3-propantrikarbonova [Czech] Kyselina citronova Kyselina citronova [Czech]
    LS-3185 LS-96070 MCULE-7981253226
    MFCD00011669 MLS001066346 NCGC00090954-01
    NCGC00090954-02 NCGC00090954-03 NCGC00090954-04
    NCGC00090954-05 NCGC00254055-01 NCGC00259954-01
    NCI60_022579 NCIOpen2_004062 NCIOpen2_004502
    NCIStruc1_000057 NCIStruc2_000099 NE10694
    NSC 30279 NSC 626579 NSC-112226
    NSC-30279 NSC-626579 NSC-759606
    NSC30279 NSC626579 NSC759606
    Neodymium chloride citrate Neodymium citrate chloride Oprea1_502996
    Pharmakon1600-01300013 PubChem20283 Q159683
    RTR-020636 SBB008922 SBI-0206765.P001
    SC-43865 SMR000471840 ST50308093
    STK286098 STR12052 Spectrum3_001850
    Suby G T8019 TR-020636
    Tox21_113436 Tox21_202405 Tox21_300124
    UNII-XF417D3PSL Uralyt U Uro-trainer
    WLN: QV1XQVQ1VQ XF417D3PSL Z56754862
    ZINC895081 beta-Hydroxytricarballylate beta-Hydroxytricarballylic acid
    bmse000076 cid_311 citr
    citrate citric acid citric acid (Fragrance Grade)
    citric-acid s5761

    CAS Number 10024-66-5, 106168-20-1, 106809-03-4, 117148-05-7, 12262-73-6, 125139-08-4, 125139-09-5, 125139-13-1, 153301-06-5, 154618-13-0, 16922-05-7, 3458-72-8, 3522-50-7, 4596-23-0, 5077-53-2, 57-12-5, 5949-29-1, 6018-92-4, 6080-58-6, 77-92-9, 866-82-0
    PubChem Compound 311
    KEGG Compound ID C00158
    ChEBI 50744