Drug

D1015 | nifuroxazide

Molecular Formula C12H9N3O5
Molecular Weight 275.22
Structure

A

A07AX03 Nifuroxazide


[A07AX] Other intestinal antiinfectives


[A07A] INTESTINAL ANTIINFECTIVES


[A07] ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS


[A] Alimentary tract and metabolism


Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 1.57±0.30 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 2.34 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 6.71±1.54 rat hepatocytes MMP assay decrease IC50 163
MEMBRANE POTENTIAL 388.2 µM 30 mins mouse liver mitochondria Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss) decrease EC20 36
RESPIRATION 61.5 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease EC20 36
RESPIRATION 3.7 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease EC20 36
SWELLING > 400 µM 30 mins mouse liver mitochondria swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling ) increase EC20 36

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase 61.5 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. inhibit EC20 36
Succinate dehydrogenase 3.7 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. inhibit EC20 36
Cytochrome c > 400 µM 30 mins mouse liver mitochondria Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline) release EC20 36

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 6 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 4 of 6 companies. For more detailed information, please visit ECHA C&L website


Of the 2 notification(s) provided by 2 of 6 companies with hazard statement code(s):


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]


H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
mouse LD50 intraperitoneal 1gm/kg (1000mg/kg) Journal of Pharmacy and Pharmacology. Vol. 16, Pg. 663, 1964.
mouse LDLo oral 6gm/kg (6000mg/kg) Annales Pharmaceutiques Francaises. Vol. 21, Pg. 287, 1963.


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    4-Hydroxy-N'-(5-nitrofurfuryliden)benzhydrazid 4-hydroxy-N'-[(1E)-(5-nitro-2-furyl)methylene]benzohydrazide 4-hydroxy-N'-[(E)-(5-nitrofuran-2-yl)methylidene]benzohydrazide
    4-hydroxy-N-[(E)-(5-nitro-2-furanyl)methylideneamino]benzamide 4-hydroxy-N-[(E)-(5-nitro-2-furyl)methyleneamino]benzamide 4-hydroxy-N-[(E)-(5-nitrofuran-2-yl)methylidene]benzenecarbohydrazonic acid
    4-hydroxy-N-[(E)-(5-nitrofuran-2-yl)methylideneamino]benzamide 965-52-6 965N526
    A845610 AB00513861 AB00513861_02
    AB00513861_03 AC-8713 AKOS000483758
    ARONIS016368 AS-13310 BDBM50396177
    BENZOIC ACID, p-HYDROXY-, (5-NITROFURFURYLIDENE)HYDRAZIDE BIM-0014420.P001 BPBio1_000693
    BRD-K68188368-001-03-7 BRN 1352180 BSPBio_000629
    Benzoic acid, 4-hydroxy-, ((5-nitro-2-furanyl)methylene)hydrazide Benzoic acid, 4-hydroxy-, 2-[(5-nitro-2-furanyl)methylene]hydrazide Benzoic acid, 4-hydroxy-, [(1E)-(5-nitro-2-furanyl)methylene]hydrazide;
    C12H9N3O5 CCG-213989 CCRIS 5490
    CHEBI:135136 CHEBI:94556 CHEMBL244888
    CS-4918 D07111 DB13855
    Diarlidan Diaryl Dicoferin
    EINECS 213-522-0 Ercefurol Ercefuryl
    H868 HMS1569P11 HMS2096P11
    HMS3713P11 HY-B1436 LS-37645
    MLS000069620 N-[(E)-(5-nitrofuran-2-yl)methylideneamino]-4-oxidanyl-benzamide NSC-759261
    NSC759261 Nifuroxazid Nifuroxazida
    Nifuroxazida [INN-Spanish] Nifuroxazide Nifuroxazide (INN)
    Nifuroxazide [INN:BAN:DCF] Nifuroxazide [INN:DCF] Nifuroxazide, European Pharmacopoeia (EP) Reference Standard
    Nifuroxazide, VETRANAL(TM), analytical standard Nifuroxazide-d4 Nifuroxazidum
    Nifuroxazidum [INN-Latin] Opera_ID_40 PM5LI0P38J
    Pharmakon1600-01505788 Prestwick2_000555 Prestwick3_000555
    Prestwick_874 R.C. 27-109 RC 27109
    RC-27109 SBI-0014420.P002 SC-16466
    SCHEMBL14608895 SCHEMBL542542 SCHEMBL543480
    SJ000287313 SMR000058185 STK091243
    STL454990 TX-017860 UNII-PM5LI0P38J
    W-100139 YCWSUKQGVSGXJO-NTUHNPAUSA-N ZINC7997719
    p-Hydroxybenzoic acid (5-nitrofurfurylidene)hydrazide p-Hydroxybenzoic acid 5-nitrofurfurylidene hydrazide s4182

    DrugBank Name nifuroxazide
    DrugBank DB13855
    CAS Number 1188487-83-3, 965-52-6
    PubChem Compound 5337997
    KEGG Drug D07111
    ChEBI 135136