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T080 Source: Uniprot

enzyme familyPyruvate dehydrogenase kinase (PDK)
Transferase Kinase
Full Name Pyruvate dehydrogenase kinase
Subcellular Location Mitochondrion matrix
EC numbers 2.7.11.2

Compound Dose Time Species Model Method Result Positive criterion Reference
AZD7545 Positive 256
VER-246608 Positive 256
JX06 Positive 256
radicicol Positive 256
Oxythiamine Positive 249
Dichloroacetate Positive IC50 255
2-chloroproprionate Positive 255
Nov3r Positive 255
Pfz3 Positive 255
AZD7545 Positive IC50 255
radicicol Positive 255
Dicoumarol 19.42 μM ovarian cancer cell line SKOV3 Positive IC50 256

T080001. [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)
T080002. [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)
T080003. [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)
T080004. [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4)

F020401. glycolysis
F0202. Pyruvate metabolism