F0202 | Pyruvate metabolism
| Compound | Dose | Time | Species | Model | Method | Action | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Ciprofloxacin | Increase | Positive | 307 | ||||||
| Metformin | 0.5mM | 24 hours | human | MCF7 | Meassurement of lactate + pyruvate concentration; compared with MCF10A | increase | Positive | p < 0.05 | 172 |
| Metformin | 5.0mM | 24 hours | human | MCF7 | Meassurement of lactate + pyruvate concentration; compared with MCF10A | increase | Positive | p < 0.05 | 172 |
| Metformin | 5mM | 30 minutes | mouse; C57BL/6J | isolated skeletal muscle mitochondria | Meassurement of lactate concentration | increase | Positive | p < 0.05 | 172 |