F021214 | NADH level

Compound Dose Time Species Model Method Action Result Positive criterion Reference
Gentamicin 300 μg/ml 1hr postnatal day 6 (P6±1d) FVB mice basal turn outer hair cells ( low-frequency processing OHCs) from intact cochlear (organ of Corti) explants scanning confocal microscope (NADH autofluorescence); T1 imaging buffer contained 5 mM glucose. T2 imaging buffer contained 10 mM glucose, 3 mM glutamate and 2 mM pyruvate. decrease Positive 312