F020303 | Generation of alpha-ketoglutarate

GO:0006103 map00020 R-HSA-71403
Function of mitochondria >> TCA >> generation of alpha-ketoglutarate

Compound Dose Time Species Model Method Action Result Positive criterion Reference
Metformin 5mM 30 minutes mouse; C57BL/6J isolated skeletal muscle mitochondria Meassurement of alpha-ketoglutarate concentration; compared with MCF10A affect Positive p < 0.05 172
Metformin 5mM 30 minutes mouse; C57BL/6J isolated skeletal muscle mitochondria Meassurement of alpha-ketoglutarate concentration; compared with MCF10A affect Positive p < 0.05 172
Metformin 0.5mM 24 hours human MCF10A Meassurement of alpha-ketoglutarate concentration; compared with MCF10A affect Positive p < 0.05 172
Metformin 0.5mM 24 hours human MCF7 Meassurement of alpha-ketoglutarate concentration; compared with MCF10A affect Positive p < 0.05 172