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Compound

D0284 | N,N'-dicyclohexylcarbodiimide

Molecular Formula C13H22N2
Molecular Weight 206.33
Structure
Description lipid-soluble carbodiimides; inhibit ATP synthase; Carboxyl Group Modifiers; classical carboxyl reagent

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 0.30±0.20 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 0.02 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL rat hepatocytes MMP assay Negative IC50 163
ELECTRON TRANSPORT CHAIN 0.2 μg of inhibitor/mg protein S. cerevisiae SMP-ATPase affect IC50 170
ELECTRON TRANSPORT CHAIN 1-5 μg of inhibitor/mg protein T. pyriformis SMP-ATPase affect IC50 170
ELECTRON TRANSPORT CHAIN 200 μMa in less than 5 min and at ∼40 μMa in 30 min R. rubrum F1-ATPase affect 170
ELECTRON TRANSPORT CHAIN 1.9 μg/mg protein C. fasciculata SMP-ATPase affect IC50 170
ELECTRON TRANSPORT CHAIN 1 mol DCCD/mol F1 EF1-ATPase affect 95% inhibition 170
ELECTRON TRANSPORT CHAIN 30 μM membrane-bound EF0F1-ATPase affect maximal 70-80% inhibition 170
ELECTRON TRANSPORT CHAIN 5 μM C. thermoaceticum membrane-bound F0F1-ATPase affect 47% inhibition 170
ELECTRON TRANSPORT CHAIN 2 mol inhibitor bound/mol F1 bovine heart MF1-ATPase affect 97% inhibition 170
ELECTRON TRANSPORT CHAIN 1 mol inhibitor/mol F0 bovine heart SMP-ATPase affect maximal inhibition 170
ELECTRON TRANSPORT CHAIN 2 mol inhibitor/mol F0 bovine heart H+-translocation affect maximal inhibition 170
ELECTRON TRANSPORT CHAIN 1 mol inhibitor/mol F0 E. coli membrane H+-translocation affect maximal inhibition 170
ELECTRON TRANSPORT CHAIN affect 170
ELECTRON TRANSPORT CHAIN 0.1 mM NADH–Q-1 decrease IC50 129

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase 0.1 mM NADH–Q-1 inhibitor IC50 129
Fo subunits 0.2 μg of inhibitor/mg protein S. cerevisiae SMP-ATPase inhibitor IC50 170
Fo subunits 1-5 μg of inhibitor/mg protein T. pyriformis SMP-ATPase inhibitor IC50 170
Fo subunits 200 μMa in less than 5 min and at ∼40 μMa in 30 min R. rubrum F1-ATPase inhibitor 170
Fo subunits 1.9 μg/mg protein C. fasciculata SMP-ATPase inhibitor IC50 170
Fo subunits 1 mol DCCD/mol F1 EF1-ATPase inhibitor 95% inhibition 170
Fo subunits 30 μM membrane-bound EF0F1-ATPase inhibitor maximal 70-80% inhibition 170
Fo subunits 5 μM C. thermoaceticum membrane-bound F0F1-ATPase inhibitor 47% inhibition 170
Fo subunits 2 mol inhibitor bound/mol F1 bovine heart MF1-ATPase inhibitor 97% inhibition 170
Fo subunits 1 mol inhibitor/mol F0 bovine heart SMP-ATPase inhibitor maximal inhibition 170
Fo subunits 2 mol inhibitor/mol F0 bovine heart H+-translocation inhibitor maximal inhibition 170
Fo subunits 1 mol inhibitor/mol F0 E. coli membrane H+-translocation inhibitor maximal inhibition 170
F1 subunits inhibitor 170

Pictogram Signal Statements Precautionary Statement Codes
Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H311: Toxic in contact with skin [Danger Acute toxicity, dermal]


H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]


 P261, P264, P270, P272, P280, P301+P312, P302+P352, P305+P351+P338, P310, P312, P321, P322, P330, P333+P313, P361, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

Aggregated GHS information provided by 398 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


H311 (100%): Toxic in contact with skin [Danger Acute toxicity, dermal]


H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]


H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]


H400 (11.31%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410 (11.31%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310, P312, P321, P322, P330, P333+P313, P361, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H311: Toxic in contact with skin [Danger Acute toxicity, dermal]


H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]


 P261, P264, P270, P272, P280, P301+P312, P302+P352, P305+P351+P338, P310, P312, P321, P322, P330, P333+P313, P361, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H315: Causes skin irritation [Warning Skin corrosion/irritation]


H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]


H330: Fatal if inhaled [Danger Acute toxicity, inhalation]


H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]


 P260, P261, P264, P270, P271, P272, P280, P284, P301+P312, P302+P352, P304+P340, P305+P351+P338, P309+P311, P310, P320, P321, P330, P332+P313, P333+P313, P362, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • 0T1427205E 1, 3-dicyclohexylcarbodiimide 1,3- dicyclohexylcarbodiimide
    1,3-Dicyclohexylcarbodiimide 1,3-di-cyclohexyl carbodiimide 1,3-dicyclo hexyl carbodiimide
    1,3-dicyclo-hexylcarbodiimide 1,3-dicyclohexyl carbo-diimide 1,3-dicyclohexyl carbodiimide
    1,3-dicyclohexyl- carbodiimide 1,3-dicyclohexyl-1,3-diazapropa-1,2-diene 1,3-dicyclohexyl-carbodiimide
    1,3-dicyclohexylcarbo-diimide 1,3-dicyclohexylcarbodiimid 1,3-dicyclohexylcarbodimide
    1,3-dicylcohexylcarbodiimide 1,3dicyclohexylcarbodiimide 1,N'-dicyclohexylcarbodimide
    1.3-dicyclohexylcarbodiimide 1.3-dicyclohexylcarbodimide 4-12-00-00072 (Beilstein Handbook Reference)
    538-75-0 538D750 AB1002886
    ACMC-1ASTJ ACT09818 AI3-08191
    AK-43977 AKOS000120067 AM83818
    ANW-31872 BB0294814 BBL012208
    BB_SC-06630 BDBM129231 BP-13398
    BRN 0610662 Bis(cyclohexyl)carbodiimide C-24241
    CARBODIIMIDE,DICYCLOHEXYL CAS-538-75-0 CC-31780
    CCRIS 9266 CHEBI:53090 CHEMBL162598
    CS-W020097 CTK1G9383 Carbodicyclohexylimide
    Carbodiimide, dicyclohexyl- Cyclohexaamine, N,N'-methanetetraylbis- Cyclohexaamine, N,N'-methanetetraylbis- (9CI)
    Cyclohexanamine, N,N'-methanetetraylbis- Cyclohexanamine,N'-methanetetraylbis- D0436
    D0437 DB-002694 DCC
    DCC, 1.0 M in methylene chloride DCC, 99% DCC, puriss., >=99.0% (GC)
    DCCD DCCI DICYCLOHEXYLCARBODIIMIDE
    DSSTox_CID_3817 DSSTox_GSID_23817 DSSTox_RID_77197
    DTXSID1023817 Dicyclimide;1,3-dicyclohexylcarbodiimide;N,N-Dicyclohexylcarbodiimide;N,N'-Methanediylidenedicyclohexanamine Dicyclohexyicarbodiimide
    Dicyclohexyl carbo diimide Dicyclohexyl-Carbodiimide Dicyclohexyl-carboxydilmide
    Dicyclohexylcarbodiimide solution, 60 wt. % in xylenes Dicylcohexylcarbodiimide Dicylcohexylcarbodimide
    EC 208-704-1 EINECS 208-704-1 Epitope ID:114067
    F0001-1397 FT-0629452 HSDB 8049
    InChI=1/C13H22N2/c1-3-7-12(8-4-1)14-11-15-13-9-5-2-6-10-13/h12-13H,1-10H KS-000002OK KSC269G8H
    LS-200 MCULE-5242025177 MFCD00011659
    Methanediimine, N,N'-dicyclohexyl- N, N'-dicyclohexyl carbodiimide N, N'-dicyclohexylcarbodiimide
    N, N'-dicyclohexylcarbodimide N, N'dicyclohexylcarbodimide N,N'- dicyclohexyl carbodiimide
    N,N'-DICYCLOHEXYL-CARBODIIMIDE N,N'-Dicyclohexyl carbodimide N,N'-Dicyclohexylcarbodiimide
    N,N'-Dicyclohexylcarbodiimide (DCC) N,N'-Dicyclohexylcarbodiimide, 1M solution in dichloromethane, AcroSeal(R) N,N'-Dicyclohexylcarbodiimide, 99%
    N,N'-Methanetetraylbiscyclohexaamine N,N'-Methanetetraylbiscyclohexanamine N,N'-dicyclo hexyl carbodiimide
    N,N'-dicyclo hexylcarbodiimide N,N'-dicyclo-hexylcarbodiimide N,N'-dicyclohexylcarbodimide
    N,N'-dicyclohexylmethanediimine N,N'-dicylcohexylcarbodiimide N,N'-methanediylidene-dicyclohexanamine
    N,N'dicyclohexylcarbodiimide N,N,-dichyclohexyl-carbodiimide N,N-dicyclohexylcarbodiimide(DCC)
    N-((cyclohexylimino)methylene) cyclohexanamine N-((cyclohexylimino)methylene)cyclohexanamine N-(N-cyclohexylcarboximidoyl)cyclohexanamine
    N.N' - dicyclohexylcarbodiimide NCGC00091497-01 NCGC00091497-02
    NCGC00091497-03 NCGC00091497-04 NCGC00257167-01
    NCGC00260545-01 NSC 30022 NSC-30022
    NSC-53373 NSC-57182 NSC30022
    NSC53373 NSC57182 PubChem12523
    Q-200966 Q306565 QOSSAOTZNIDXMA-UHFFFAOYSA-N
    RTR-019040 SBB059225 SC-11254
    SCHEMBL303 ST2407331 ST50825552
    STL089892 Tox21_203000 Tox21_303237
    UNII-0T1427205E US8815951, N/A US8815951, dicyclohexylcarbodiimide
    ZINC8585900 ZX-AT019822 dicyciohexylcarbodiimide
    dicyclo-hexylcarbodiimide dicyclohe-xylcarbodiimide dicyclohexyl carbodiimide
    dicyclohexyl carbodimide dicyclohexylcarbo-diimide dicyclohexylcarbod iimide
    dicyclohexylcarbodi-imide dicyclohexylcarbodiimid dicyclohexylcarbodimide
    dicyclohexylmethanediimine dicylohexyl-carbodiimide dicylohexylcarbodiimide
    n,n' dicyclohexyl carbodiimide n,n'-dicyclohexyl carbodiimide n,n'-dicyclohexylcarbodiimid
    n,n'-dicylohexylcarbodiimide n,n'-methanediylidenedicyclohexanamine n,n-dichyclohexylcarbodiimide
    n,n-dicychohexylcarbodiimide n,n-dicyclohexyl carbodiimide n,n-dicyclohexylcarbodiimide
    n.n'-dicyclohexylcarbodiimide

    CAS Number 143900-43-0, 538-75-0
    PubChem Compound 10868
    ChEBI 53090
    ChemSpider 10408
    Wikipedia N,N'-Dicyclohexylcarbodiimide