Compound

D0862 | cyhalothrin

Molecular Formula C23H19ClF3NO3
Molecular Weight 449.8
Structure

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 33.62±5.79 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL human HepG2 MMP assay Negative IC50 163
MEMBRANE POTENTIAL 33.80±9.96 rat hepatocytes MMP assay decrease IC50 163
ELECTRON TRANSPORT CHAIN 0.6 μM NADH–DQ decrease IC50 110

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase 0.6 μM NADH–DQ inhibitor IC50 110

Pictogram Signal Statements Precautionary Statement Codes
Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]


H312: Harmful in contact with skin [Warning Acute toxicity, dermal]


H330: Fatal if inhaled [Danger Acute toxicity, inhalation]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P260, P264, P270, P271, P273, P280, P284, P301+P310, P302+P352, P304+P340, P310, P312, P320, P321, P322, P330, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H301 (97.5%): Toxic if swallowed [Danger Acute toxicity, oral]


H315 (95%): Causes skin irritation [Warning Skin corrosion/irritation]


H317 (95%): May cause an allergic skin reaction [Warning Sensitization, Skin]


H319 (97.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H330 (97.5%): Fatal if inhaled [Danger Acute toxicity, inhalation]


H400 (97.5%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410 (97.5%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P310, P302+P352, P304+P340, P305+P351+P338, P310, P320, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

Aggregated GHS information provided by 251 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]


H311 (77.29%): Toxic in contact with skin [Danger Acute toxicity, dermal]


H312 (22.71%): Harmful in contact with skin [Warning Acute toxicity, dermal]


H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]


H400 (84.86%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P260, P264, P270, P271, P273, P280, P284, P301+P310, P302+P352, P304+P340, P310, P312, P320, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

Aggregated GHS information provided by 227 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]


H311 (15.86%): Toxic in contact with skin [Danger Acute toxicity, dermal]


H312 (84.14%): Harmful in contact with skin [Warning Acute toxicity, dermal]


H319 (15.42%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]


H370 (15.42%): Causes damage to organs [Danger Specific target organ toxicity, single exposure]


H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P260, P264, P270, P271, P273, P280, P284, P301+P310, P302+P352, P304+P340, P305+P351+P338, P307+P311, P310, P312, P320, P321, P322, P330, P337+P313, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]


H312: Harmful in contact with skin [Warning Acute toxicity, dermal]


H330: Fatal if inhaled [Danger Acute toxicity, inhalation]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P260, P264, P270, P271, P273, P280, P284, P301+P310, P302+P352, P304+P340, P310, P312, P320, P321, P322, P330, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]


H311: Toxic in contact with skin [Danger Acute toxicity, dermal]


H320: Causes eye irritation [Warning Serious eye damage/eye irritation]


H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]


H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P260, P261, P264, P270, P271, P273, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P307+P311, P312, P314, P321, P322, P330, P337+P313, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rat LD50 intravenous 1951ug/kg (1.951mg/kg) Pesticide Biochemistry and Physiology. Vol. 30, Pg. 79, 1988.
rat LD50 oral 56mg/kg (56mg/kg) Pesticide Manual. Vol. 9, Pg. 203, 1991.
rat LD50 skin 632mg/kg (632mg/kg) Pesticide Manual. Vol. 9, Pg. 203, 1991.
mammal (species unspecified) LC50 inhalation 60mg/m3/4H (60mg/m3) Pesticide Manual. Vol. 9, Pg. 203, 1991.
duck LD50 oral > 3950mg/kg (3950mg/kg) Farm Chemicals Handbook. Vol. -, Pg. C175, 1991.


  • (1alpha,3alpha(Z))-(+-)-Cyano-(3-phenoxyphenyl)methyl 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate (RS)-alpha-Cyano-3-phenoxybenzyl (Z)-(1RS,3RS)-(2-chloro-3,3,3- trifluoropropenyl)-2,2-dimethylcyclopropanecarboxylate (RS)-alpha-Cyano-3-phenoxybenzyl (Z)-(1RS,3RS)-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarboxylate
    (Z)-cyano(3-phenoxyphenyl)methyl 3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate .alpha-cyano-3-phenoxybenzyl 3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2- dimethyl cyclopropanecarboxylate 085C858
    3-(2-Chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcycloproanecarboxylic acid cyano(3-phenoxyphenyl)methyl ester 3-(2-Chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid cyan(3-phenoxyphenyl)methyl ester 3-(2-Chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid cyano(3-phenoxyphenyl)methyl ester
    3-[(Z)-2-Chloro-3,3,3-trifluoro-1-propenyl]-2,2-dimethylcyclopropanecarboxylic acid alpha-cyano-3-phenoxybenzyl ester 527-EP2274983A1 527-EP2275422A1
    527-EP2280009A1 527-EP2292608A1 527-EP2308857A1
    527-EP2308858A1 527-EP2311816A1 527-EP2311817A1
    527-EP2314583A1 538-EP2308857A1 68085-85-8
    91465-08-6 AS-15902 C10983
    CHEBI:4035 CHEMBL2105498 CYHALOTHRIN
    Coopertix [veterinary] (TN) Cyano(3-phenoxyphenyl)methyl 3-(2-chloro-3,3,3-trifluoro-1-propen-1-yl)-2,2-dimethylcyclopropanecarboxylate; Cyclopropanecarboxylic acid, 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl-, cyano(3-phenoxyphenyl)methyl ester
    Cyhalothrin (BAN) Cyhalothrin [BAN] Cyhalothrin [BSI:ISO]
    Cyhalothrin solution, 100 mug/mL in acetonitrile, PESTANAL(R), analytical standard Cyhalothrin, analytical standard Cyhalothrine
    Cyhalothrine [ISO-French] D07762 DTXSID6023997
    EINECS 268-450-2 EPA Pesticide Chemical Code 128867 Grenade
    HSDB 6791 ICI 146814 Ici-pp 563
    NCGC00248527-01 PP 563 PP-563
    Q421593 SB18909 SCHEMBL23923
    Saber Scimitar W-111325
    ZXQYGBMAQZUVMI-UNOMPAQXSA-N [cyano-(3-phenoxyphenyl)methyl] 3-[(Z)-2-chloro-3,3,3-trifluoro-prop-1-enyl]-2,2-dimethyl-cyclopropanecarboxylate alpha-Cyano-3-phenoxybenzyl 3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate
    alpha-Cyhalothrin cyano(3-phenoxyphenyl)methyl 3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylate lambda-Cyhalothrin

    CAS Number 68085-85-8, 91465-08-6
    PubChem Compound 5281873
    KEGG Compound ID C10983
    KEGG Drug D07762
    ChEBI 4035