F021202 | NADPH metabolism

Compound Dose Time Species Model Method Action Result Positive criterion Reference
Nimesulide 1 mM rat; Sprague-Dawley Crl:CD (SD) BR lung microsomes measurement of NADPH oxidation increase Positive p < 0.05 11
Diclofenac 50 ╬╝mol/L 10 minutes rat liver mitochondria Measurement of Mitochondrial NADPH; incubated in the presence of Ca2+ increase Positive p < 0.01 6