D0119 | Thioridazine

Molecular Formula C21H26N2S2
Molecular Weight 370.6
State solid
Protein binding 0.95
Half life 21-25 hours
Absorption 0.6
Trade names Mellaril , Melleril
Description phenothiazine antipsychotic


N05AC02 Thioridazine

[N05AC] Phenothiazines with piperidine structure



[N] Nervous system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTRON TRANSPORT CHAIN rat isolated liver mitochondria Negative 23
GLUCOSE GALACTOSE IC50 RATIO 31.0 ± 5.9, 27.7 ± 19.8 ,1.4, 24.4 ± 5.7, 21.9 ± 18.0, 1.6 4hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase rat isolated liver mitochondria Negative 23

Pictogram Signal Statements Precautionary Statement Codes

Aggregated GHS information provided by 195 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H302 (99.49%): Harmful if swallowed [Warning Acute toxicity, oral]

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (99.49%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P264, P270, P273, P301+P312, P330, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rat LD50 intravenous 71mg/kg (71mg/kg) "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
mouse LD50 intraperitoneal 100mg/kg (100mg/kg) National Technical Information Service. Vol. AD277-689,
women TDLo oral 864mg/kg/18D- (864mg/kg) Postgraduate Medical Journal. Vol. 60, Pg. 445, 1984.
rabbit LD50 oral 1100mg/kg (1100mg/kg) "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
mouse LD50 intravenous 33mg/kg (33mg/kg) Therapie. Vol. 14, Pg. 793, 1959.
mouse LD50 oral 360mg/kg (360mg/kg) "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
rabbit LD50 intravenous 26mg/kg (26mg/kg) "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
rat LD50 oral 1060mg/kg (1060mg/kg) Drugs in Japan Vol. 6, Pg. 458, 1982.
dog LD50 oral 160mg/kg (160mg/kg) "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.

  • (+-)-Thioridazine (.+/-.)-Thioridazine (Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine
    10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine
    10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine # 10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine (thioridazine) 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfanyl-phenothiazine
    10-[2-(1-methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10h-phenothiazine 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylthio)-10H-phenothiazine
    10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine 10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylthio)- 10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-
    10H-Phenothiazine, 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylthio- 1452-EP2272537A2 1452-EP2275420A1
    1452-EP2298776A1 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine 242T875
    3-Methylmercapto-N-(2'-(N-methyl-2-piperidyl)ethyl)phenothiazine 50-52-2 6960AB
    AB00053553 AB00053553-16 AB00053553_17
    AB00053553_18 AI3-51923 API0003283
    AX8153985 BCP19922 BDBM50002338
    BPBio1_000325 BPBio1_001175 BRD-A84481105-003-17-2
    BSPBio_000295 BSPBio_002030 Biomol-NT_000017
    C21H26N2S2 CAS-50-52-2 CCG-205326
    CHEBI:9566 CHEMBL479 D00373
    DB00679 DSSTox_CID_3656 DSSTox_GSID_23656
    DSSTox_RID_77130 DTXSID6023656 DivK1c_000066
    EINECS 200-044-2 GTPL100 HMS2090J04
    HSDB 3189 IDI1_000066 KBio1_000066
    KBio2_001546 KBio2_002308 KBio2_004114
    KBio2_004876 KBio2_006682 KBio2_007444
    KBio3_001530 KBio3_002788 KBioGR_000791
    KBioGR_002308 KBioSS_001546 KBioSS_002310
    Lopac0_001252 MCULE-7796139302 Mallorol
    Malloryl Meleril Mellaril
    Mellaril (*Hydrochloride*) Mellaril (Salt/Mix) Mellaril-S
    Mellaril-S (TN) Mellarit Mellerets
    Mellerette Melleretten Melleril
    Melleril (liquid) Melleryl NCGC00016059-03
    NCGC00016059-04 NCGC00016059-05 NCGC00016059-07
    NCGC00016059-08 NCGC00016059-09 NCGC00016059-10
    NCGC00016059-11 NCGC00016059-13 NCGC00016059-14
    NCGC00089809-02 NCGC00089809-03 NINDS_000066
    NS-835 NSC186060 Orsanil
    Phenothiazine, 10-((1-methyl-2-piperidyl)ethyl)-2-(methylthio)- Phenothiazine, 10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylthio)- Prestwick0_000078
    Prestwick1_000078 Prestwick2_000078 Prestwick3_000078
    Q58375 SBI-0051219.P004 SC-19270
    SCHEMBL12434241 SCHEMBL9566 SPBio_001483
    SPBio_002216 Sonapax Spectrum2_001332
    Spectrum3_000585 Spectrum4_000356 Spectrum5_001062
    Spectrum_001066 TP-21 Thioridazin
    Thioridazine (USP/INN) Thioridazine [USAN:INN:BAN] Thioridazine [USAN:USP:INN:BAN]
    Thioridazine prolongatum Thioridazine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material Thioridazine, prolongatum
    Thioridazinum Thioridazinum [INN-Latin] Thioxidazine
    Thiozine Tioridazina Tioridazina [INN-Spanish]
    Tox21_110294 Tox21_110294_1 cMAP_000015
    dl-Thioridazine thioridazine

    DrugBank Name Thioridazine
    DrugBank DB00679
    CAS Number 107388-89-6, 130-61-0, 50-52-2
    PubChem Compound 5452
    KEGG Drug D00373
    PubChem.Substance 46509070
    ChEBI 9566
    PharmGKB PA451666
    ChemSpider 5253
    BindingDB 50002338.0
    TTD DAP000476
    Wikipedia Thioridazine
    DPD 7962|7964

    1. Dykens et al. (2007)