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Compound

D0567 | tentoxin

Molecular Formula C22H30N4O4
Molecular Weight 414.5
Structure
Description natural cyclic tetrapeptide; potential natural herbicide; phytotoxic

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTRON TRANSPORT CHAIN ∼0.6 mol/mol spinach CF1-ATPase affect IC50 170
ELECTRON TRANSPORT CHAIN 50 nM spinach CF1(-ɛ)-ATPase affect IC50 170
ELECTRON TRANSPORT CHAIN 0.4-0.6 μM lettuce chloroplasts, photophosphorylation affect IC50 170
ELECTRON TRANSPORT CHAIN 10 nM spinach CF1(-ɛ)-ATPase affect Ki 170
ELECTRON TRANSPORT CHAIN 30-60 μM TF1-ATPase affect Ki 170
ELECTRON TRANSPORT CHAIN 8-10 nM spinach CF1(-ɛ)-ATPase affect Kd 170

Target Dose Time Species Model Method Action Positive criterion Reference
F1 subunits ∼0.6 mol/mol spinach CF1-ATPase inhibitor IC50 170
F1 subunits 50 nM spinach CF1(-ɛ)-ATPase inhibitor IC50 170
F1 subunits 0.4-0.6 μM lettuce chloroplasts, photophosphorylation inhibitor IC50 170
F1 subunits 10 nM spinach CF1(-ɛ)-ATPase inhibitor Ki 170
F1 subunits 30-60 μM TF1-ATPase inhibitor Ki 170
F1 subunits 8-10 nM spinach CF1(-ɛ)-ATPase inhibitor Kd 170


  • (3S,6S,12Z)-1,6,7-trimethyl-3-(2-methylpropyl)-12-(phenylmethylidene)-1,4,7,10-tetraazacyclododecane-2,5,8,11-tetrone (3S,6S,12Z)-12-benzylidene-1,6,7-trimethyl-3-(2-methylpropyl)-1,4,7,10-tetrazacyclododecane-2,5,8,11-tetrone (3S,6S,12Z)-12-benzylidene-3-isobutyl-1,6,7-trimethyl-1,4,7,10-tetrazacyclododecane-2,5,8,11-tetrone;
    28540-82-1 AC1NQY3N C08441
    CCRIS 8423 CHEBI:9439 Cyclo(N-methyl-L-alanyl-L-leucyl-alpha,beta-didehydro-N-methylphenylalanylglycyl), (Z)-
    Cycloleucyl-N-methylalanylglycyl-N-methyl dehydrophenylalanine DTXSID70893264 FW4EQ02E0Z
    LS-188550 Q7700913 SCHEMBL2266662
    SureCN2266662 Tentoxin from Alternaria tenuis, Naturally occurring phytotoxic cyclic tetrapeptide Tentoxin, analytical standard
    UNII-FW4EQ02E0Z ZINC100230999 cyclo(l-leucyl-N-methyl(z)-dehydrophenylalanyl-glycyl-N-methyl-l-alanyl)
    tentoxin

    CAS Number 28540-82-1
    PubChem Compound 5281143
    KEGG Compound ID C08441
    ChEBI 9439