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Drug

D0003 | Acetaminophen

Molecular Formula C8H9NO2
Molecular Weight 151.16
Structure
State solid
Clearance Adults: 0.27 L/h/kg following a 15 mg/kg intravenous (IV) dose [FDA label]. Children: 0.34 L/h/kg following a 15 mg/kg intravenous (IV dose) [FDA label]. More clearance information for a variety of populations is available on the acetaminophen FDA label [FDA label].
Volume of distribution Volume of distribution is about 0.9L/kg. 10 to 20% of the drug is bound to red blood cells [A176357]. Acetaminophen appears to be widely distributed throughout most body tissues except in fat [FDA label].
Route of elimination Acetaminophen metabolites are mainly excreted in the urine. Less than 5% is excreted in the urine as free (unconjugated) acetaminophen and at least 90% of the administered dose is excreted within 24 hours [F4124].
Protein binding The binding of acetaminophen to plasma proteins is low (ranging from 10% to 25%), when given at therapeutic doses [FDA label].
Half life The half-life for adults is 2.5 h after an intravenous dose of 15 mg/kg [FDA label]. After an overdose, the half-life can range from 4 to 8 hours depending on the severity of injury to the liver, as it heavily metabolizes acetaminophen [A35815]. More information on half-life for neonates and other populations may be found on the acetaminophen FDA label [FDA label].
Absorption Acetaminophen has 88% oral bioavailability and reaches its highest plasma concentration 90 minutes after ingestion [A35815]. Peak blood levels of free acetaminophen are not reached until 3 hours after rectal administration of the suppository form of acetaminophen and the peak blood concentration is approximately 50% of the observed concentration after the ingestion of an equivalent oral dose (10-20 mcg/mL) [F4124]. The percentage of a systemically absorbed rectal dose of acetaminophen is inconsistent, demonstrated by major differences in the bioavailability of acetaminophen after a dose administered rectally. Higher rectal doses or an increased frequency of administration may be used to attain blood concentrations of acetaminophen similar to those attained after oral acetaminophen administration [FDA label].
Trade names Tylenol, Panadol
Description analgesic; antipyretic

N

N02BE71 Paracetamol, combinations with psycholeptics


[N02BE] Anilides


[N02B] OTHER ANALGESICS AND ANTIPYRETICS


[N02] ANALGESICS


[N] Nervous system

N02BE51 Paracetamol, combinations excl. psycholeptics


[N02BE] Anilides


[N02B] OTHER ANALGESICS AND ANTIPYRETICS


[N02] ANALGESICS


[N] Nervous system

N02BE01 Paracetamol


[N02BE] Anilides


[N02B] OTHER ANALGESICS AND ANTIPYRETICS


[N02] ANALGESICS


[N] Nervous system

N02AJ17 Oxycodone and paracetamol


[N02AJ] Opioids in combination with non-opioid analgesics


[N02A] OPIOIDS


[N02] ANALGESICS


[N] Nervous system

N02AJ13 Tramadol and paracetamol


[N02AJ] Opioids in combination with non-opioid analgesics


[N02A] OPIOIDS


[N02] ANALGESICS


[N] Nervous system

N02AJ06 Codeine and paracetamol


[N02AJ] Opioids in combination with non-opioid analgesics


[N02A] OPIOIDS


[N02] ANALGESICS


[N] Nervous system

N02AJ01 Dihydrocodeine and paracetamol


[N02AJ] Opioids in combination with non-opioid analgesics


[N02A] OPIOIDS


[N02] ANALGESICS


[N] Nervous system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL > 200 µM 30 mins mouse liver mitochondria Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss) decrease EC20 36
RESPIRATION 348.5 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease EC20 36
RESPIRATION > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease EC20 36
ELECTRON TRANSPORT CHAIN decrease 35
ELECTRON TRANSPORT CHAIN decrease 35
MITOCHONDRIAL FATTY ACID BETA OXIDATION affect 227
MITOCHONDRIAL FATTY ACID BETA OXIDATION >400μM >400 mice Lean mice vs Ob/ob mice Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform EC20 227
GSSH/GHS RATIO 300 mg/kg 1 hour rat; Fischer (F344) in vivo GSH level measurement Negative p < 0.05 1
GSSH/GHS RATIO 1 g/kg 1 hour mice; C57Bl/6 in vivo GSH level measurement Negative p < 0.05 1
GSSH/GHS RATIO 300 mg/kg 3 hours rat; Fischer (F344) in vivo GSH level measurement Negative p < 0.05 1
GSSH/GHS RATIO 1 g/kg 3 hours mice; C57Bl/6 in vivo GSH level measurement Negative p < 0.05 1
GSSH/GHS RATIO 300 mg/kg 6 hours rat; Fischer (F344) in vivo GSH level measurement Negative p < 0.05 1
GSSH/GHS RATIO 1 g/kg 6 hours mice; C57Bl/6 in vivo GSH level measurement increase p < 0.05 1
GSSH/GHS RATIO 300 mg/kg 12 hours rat; Fischer (F344) in vivo GSH level measurement Negative p < 0.05 1
GSSH/GHS RATIO 1 g/kg 12 hours mice; C57Bl/6 in vivo GSH level measurement increase p < 0.05 1
GSSH/GHS RATIO 300 mg/kg 24 hours rat; Fischer (F344) in vivo GSH level measurement Negative p < 0.05 1
GSSH/GHS RATIO 1 g/kg 24 hours mice; C57Bl/6 in vivo GSH level measurement increase p < 0.05 1
SWELLING > 200 µM 30 mins mouse liver mitochondria swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling ) increase EC20 36
OXIDATIVE STRESS increase 35
OXIDATIVE STRESS 243
OXIDATIVE STRESS 258
LIVER-SPECIFIC OXIDATIVE STRESS 300 mg/kg 1 hour mice; C57Bl/6 in vivo ALT activity measurement Negative p < 0.05 1
LIVER-SPECIFIC OXIDATIVE STRESS 1 g/kg 1 hour rat; Fischer (F344) in vivo ALT activity measurement Negative p < 0.05 1
LIVER-SPECIFIC OXIDATIVE STRESS 300 mg/kg 3 hours mice; C57Bl/6 in vivo ALT activity measurement increase p < 0.05 1
LIVER-SPECIFIC OXIDATIVE STRESS 1 g/kg 3 hours rat; Fischer (F344) in vivo ALT activity measurement Negative p < 0.05 1
LIVER-SPECIFIC OXIDATIVE STRESS 300 mg/kg 6 hours mice; C57Bl/6 in vivo ALT activity measurement increase p < 0.05 1
LIVER-SPECIFIC OXIDATIVE STRESS 1 g/kg 6 hours rat; Fischer (F344) in vivo ALT activity measurement Negative p < 0.05 1
LIVER-SPECIFIC OXIDATIVE STRESS 300 mg/kg 24 hours mice; C57Bl/6 in vivo ALT activity measurement increase p < 0.05 1
LIVER-SPECIFIC OXIDATIVE STRESS 1 g/kg 24 hours rat; Fischer (F344) in vivo ALT activity measurement Negative p < 0.05 1
LIVER-SPECIFIC OXIDATIVE STRESS 1 g/kg 24 hours rat; Fischer (F344) in vivo ALT activity measurement Negative p < 0.05 1
LIVER-SPECIFIC OXIDATIVE STRESS 1.5 g/kg 24 hours rat; Fischer (F344) in vivo ALT activity measurement increase p < 0.05 1
LIVER-SPECIFIC OXIDATIVE STRESS 1 g/kg 24 hours rat; Sprague–Dawley in vivo ALT activity measurement Negative p < 0.05 1
LIVER-SPECIFIC OXIDATIVE STRESS 2 g/kg 24 hours rat; Sprague–Dawley in vivo ALT activity measurement Negative p < 0.05 1

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase inhibitor 35
NADH:ubiquinone reductase 348.5 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. inhibit EC20 36
Succinate dehydrogenase inhibitor 35
Succinate dehydrogenase > 400 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. inhibit EC20 36
Cytochrome c > 400 µM 30 mins mouse liver mitochondria Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline) release EC20 36

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 320 companies from 46 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 5 of 320 companies. For more detailed information, please visit ECHA C&L website


Of the 44 notification(s) provided by 315 of 320 companies with hazard statement code(s):


H302 (99.05%): Harmful if swallowed [Warning Acute toxicity, oral]


H315 (40.32%): Causes skin irritation [Warning Skin corrosion/irritation]


H317 (19.37%): May cause an allergic skin reaction [Warning Sensitization, Skin]


H319 (40%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H412 (50.48%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H315: Causes skin irritation [Warning Skin corrosion/irritation]


H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]


 P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]


H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]


H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]


H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


 P201, P202, P260, P264, P270, P281, P307+P311, P308+P313, P309+P311, P314, P321, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
child TDLo oral 801mg/kg (801mg/kg) Pediatrics. Vol. 61, Pg. 68, 1978.
mouse LD50 subcutaneous 310mg/kg (310mg/kg) Human Toxicology. Vol. 3, Pg. 13S, 1984.
rat LC50 inhalation 100mg/m3/4H (100mg/m3) National Technical Information Service. Vol. OTS0538278,
mammal (species unspecified) LD50 oral > 5gm/kg (5000mg/kg) National Technical Information Service. Vol. OTS0538278,
child LDLo oral 140mg/kg/7D-I (140mg/kg) Medical Journal of Australia. Vol. 171, Pg. 472, 1999.
mammal (species unspecified) LDLo oral 512mg/kg (512mg/kg) United States Patent Document. Vol. #4035499,
mouse LD50 oral 338mg/kg (338mg/kg) Toxicology and Applied Pharmacology. Vol. 19, Pg. 20, 1971.
human LDLo oral 143mg/kg (143mg/kg) behavioral: general anesthetic British Medical Journal. Vol. 282, Pg. 199, 1981.
man LDLo oral 143mg/kg/24H- (143mg/kg) American Journal of Medicine. Vol. 74, Pg. 349, 1983.
mouse LD50 intraperitoneal 367mg/kg (367mg/kg) behavioral: analgesia Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 520, 1965.
child LDLo oral 50mg/kg (50mg/kg) American Journal of Emergency Medicine. Vol. 6, Pg. 510, 1988.
child TDLo oral 591mg/kg/2D-I (591mg/kg) Clinical Pediatrics Vol. 33, Pg. 42, 1994.
man TDLo oral 714mg/kg (714mg/kg) cardiac: ekg changes not diagnostic of above Postgraduate Medical Journal. Vol. 69, Pg. 52, 1993.
rat LD50 intraperitoneal 1205mg/kg (1205mg/kg) Studi Sassaresi, Sezione 2. Vol. 57, Pg. 561, 1979.
man TDLo oral 9286ug/kg (9.286mg/kg) Allergy. Vol. 50(Suppl,
women LDLo oral 400mg/kg (400mg/kg) Journal of Toxicology, Clinical Toxicology. Vol. 35, Pg. 325, 1997.
child LDLo oral 360mg/kg/2D (360mg/kg) Journal of Pediatrics. Vol. 92, Pg. 832, 1978.
women TDLo oral 325mg/kg (325mg/kg) Postgraduate Medical Journal. Vol. 68, Pg. 116, 1992.
women TDLo oral 13mg/kg (13mg/kg) behavioral: excitement Allergy. Vol. 50(Suppl,
dog LDLo intravenous 826mg/kg (826mg/kg) behavioral: analgesia Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.
pig LDLo intravenous 1gm/kg (1000mg/kg) Veterinary and Human Toxicology. Vol. 30, Pg. 324, 1988.
women TDLo oral 4962ug/kg (4.962mg/kg) Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 223, 1991.
guinea pig LD50 oral 2620mg/kg (2620mg/kg) Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958.
man LDLo oral 714mg/kg (714mg/kg) liver: other changes Human Toxicology. Vol. 1, Pg. 25, 1981.
women LDLo oral 260mg/kg (260mg/kg) JAMA, Journal of the American Medical Association. Vol. 236, Pg. 1874, 1976.
rat LD50 oral 1944mg/kg (1944mg/kg) United States Patent Document. Vol. #4636513,
frog LDLo subcutaneous 50mg/kg (50mg/kg) Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 33, Pg. 216, 1894.
dog LDLo oral 2gm/kg (2000mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 24, Pg. 602, 1993.
infant TDLo oral 1440mg/kg/6D (1440mg/kg) American Journal of Diseases of Children. Vol. 137, Pg. 386, 1983.
mammal (species unspecified) LD50 unreported 891mg/kg (891mg/kg) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(6), Pg. 22, 1983.
women LDLo oral 650mg/kg (650mg/kg) American Journal of Emergency Medicine. Vol. 6, Pg. 511, 1988.
mammal (species unspecified) LD50 skin > 2gm/kg (2000mg/kg) National Technical Information Service. Vol. OTS0538278,
women TDLo oral 490mg/kg (490mg/kg) Southern Medical Journal. Vol. 71, Pg. 906, 1978.
human LDLo oral 357mg/kg (357mg/kg) Lancet. Vol. 1, Pg. 66, 1973.

  • Arthritis

  • Back pain

  • Body temperature increased

  • Cough

  • Discomfort

  • Dysmenorrhoea

  • Dyspepsia

  • Glucose-6-phosphate dehydrogenase deficiency

  • Gout

  • Headache

  • Influenza

  • Insomnia

  • Migraine

  • Musculoskeletal discomfort

  • Myalgia

  • Nasal congestion

  • Neuralgia

  • Oropharyngeal discomfort

  • Oropharyngeal pain

  • Osteoarthritis

  • Poor quality sleep

  • Renal failure

  • Rheumatic disorder

  • Rhinitis

  • Rhinorrhoea

  • Sinusitis

  • Tension headache

  • Toothache

  • Ulcer

  • Abdominal distension (0.02)

  • Post procedural haemorrhage (0.02)

  • Alveolitis

  • Anaemia

  • Body temperature increased

  • Constipation

  • Dizziness

  • Headache

  • Injection site pain

  • Injection site reaction

  • Insomnia

  • Mental disorder

  • Nausea

  • Nervous system disorder

  • Pruritus

  • Vomiting

    • 103-90-2 222 AF 362O9ITL9D
    4 inverted exclamation marka-Hydroxyacetanilide 4'-Hydroxyacetanilide 4-(Acetylamino)phenol
    4-(N-Acetylamino)phenol 4-13-00-01091 (Beilstein Handbook Reference) 4-Acetamidophenol
    4-Acetamidophenol 4-Acetamidophenol, 98% 4-Acetamino phenol
    4-Acetaminophenol 4-Hydroxyacetanilide 4-Hydroxyanilid kyseliny octove
    4-Hydroxyanilid kyseliny octove [Czech] 4-acetamido phenol 4-acetamido-phenol
    4-acetominophenol 4-acetylaminophenol 6473-EP1441224A2
    6473-EP2270008A1 6473-EP2272832A1 6473-EP2275420A1
    6473-EP2277565A2 6473-EP2277566A2 6473-EP2277567A1
    6473-EP2277568A2 6473-EP2277569A2 6473-EP2277570A2
    6473-EP2277861A1 6473-EP2277865A1 6473-EP2277875A2
    6473-EP2280008A2 6473-EP2281559A1 6473-EP2281819A1
    6473-EP2281823A2 6473-EP2292280A1 6473-EP2292617A1
    6473-EP2292619A1 6473-EP2298764A1 6473-EP2298765A1
    6473-EP2305219A1 6473-EP2305654A1 6473-EP2305659A1
    6473-EP2308510A1 6473-EP2308872A1 6473-EP2311818A1
    6473-EP2314585A1 6473-EP2314590A1 6473-EP2316829A1
    6473-EP2371811A2 72238-EP2305640A2 72238-EP2308867A2
    72238-EP2308870A2 91399-EP2277876A1 91399-EP2284149A1
    91399-EP2292614A1 91399-EP2305636A1 A-Per
    A.F. Anacin AB00051905 AB00051905-09
    AB00051905_10 AB1009347 AC-23969
    ACMC-20989w ACT06727 AKOS000121004
    ANEXSIA 10/660 ANW-14994 APAP
    APAP APAP, Paracetamol Abenol
    Abensanil Abrol Abrolet
    Acamol Accu-Tap Acenol
    Acenol (pharmaceutical) Acertol Aceta Elixir
    Aceta Tablets Acetaco Acetagesic
    Acetalgin Acetamide, N-(4-hydroxyphenyl)- Acetamide, N-(p-hydroxyphenyl)-
    Acetaminofen Acetaminophen (4-hydroxyacetanilide) Acetaminophen (JP17/USP)
    Acetaminophen 650 Acetaminophen Uniserts Acetaminophen [USP:JAN]
    Acetaminophen [USP] Acetaminophen solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material Acetaminophen solution, drug standard, 1.0 mg/mL in methanol
    Acetaminophen, BioXtra, >=99.0% Acetaminophen, Pharmaceutical Secondary Standard Acetaminophen, United States Pharmacopeia (USP) Reference Standard
    Acetaminophen, analytical standard Acetaminophen, meets USP testing specifications, 98.0-102.0%, powder Acetamol
    Acetanilide, 4'-hydroxy- Acetavance Acetofen
    Acetominophen Actamin Actamin Extra
    Actamin Super Actifed Plus Actifed Plus (Salt/Mix)
    Actimol Chewable Tablets Actimol Children's Suspension Actimol Infants' Suspension
    Actimol Junior Strength Caplets Afebrin Afebryl
    Aferadol Algesidal Algina
    Algomol Algotropyl Alpiny
    Alpinyl Alvedon Amadil
    Aminofen Aminofen Max Anacin-3
    Anacin-3 Extra Strength Anadin dla dzieci Anaflon
    Analter Anapap Andox
    Anelix Anexsia Anexsia (Salt/Mix)
    Anhiba Anti-Algos Antidol
    Anuphen Apacet Apacet Capsules
    Apacet Elixir Apacet Extra Strength Caplets Apacet Extra Strength Tablets
    Apacet Regular Strength Tablets Apadon Apamid
    Apamide Apitrelal Apo-Acetaminophen
    Arfen Arthralgen Asetam
    Asomal Aspac Aspirin Free Anacin Maximum Strength Caplets
    Aspirin Free Anacin Maximum Strength Gel Caplets Aspirin Free Anacin Maximum Strength Tablets Aspirin-Free Anacin
    Aspirin-Free Anacin (Salt/Mix) Aspirin-Free Excedrin Caplets Asplin
    Atasol Atasol Caplets Atasol Drops
    Atasol Forte Caplets Atasol Forte Tablets Atasol Oral Solution
    Atasol Tablets Atralidon BBL005229
    BCP0726000305 BCP23431 BCP9000225
    BCPP000441 BDBM26197 BIDD:GT0005
    BPBio1_001007 BRD-K41524689-001-08-6 BSPBio_000915
    BSPBio_001786 Babikan Bacetamol
    Banesin Bayer Select Allergy-Sinus Bayer Select Allergy-Sinus (Salt/Mix)
    Bayer Select Head Cold Bayer Select Head Cold (Salt/Mix) Bayer Select Headache Pain
    Bayer Select Maximum Strength Headache Pain Relief Formula Bayer Select Menstrual Multi-Symptom Bayer Select Menstrual Multi-Symptom (Salt/Mix)
    Bayer Select Sinus Pain Relief Bayer Select Sinus Pain Relief (Salt/Mix) Ben-u-ron
    Benmyo Bickie-mol Biocetamol
    C06804 CAS-103-90-2 CCG-38901
    CCRIS 3 CHEBI:46195 CHEMBL112
    CS-2819 CTK3J2516 Cadafen
    Calapol Calmanticold Calonal
    Calpol Calpol infant Capital
    Capital with Codeine Captin Causalon
    Cefalex Certified Reference Material Cetadol
    Children's Acetaminophen Elixir Drops Children's Acetaminophen Elixir Solution Children's Acetaminophen Oral Solution
    Children's Tylenol Chewable Citramon P Claradol Codeine
    Claratal Clixodyne Cod-Acamol Forte
    Codabrol Codalgin Codapane
    Codicet Codisal Codisal Forte
    Codoliprane Codral Pain Relief Cofamol
    Conacetol Contac Cough & Sore Throat Formula Contac Cough & Sore Throat Formula (Salt/Mix)
    Contra-Schmerz P Coricidin (Salt/Mix) Coricidin D
    Coricidin D (Salt/Mix) Coricidin Sinus Coricidin Sinus (Salt/Mix)
    Cosutone Croix Blanche Cuponol
    Curadon Curpol Custodial
    D oliprane D00217 DB00316
    DDS-06A DSSTox_CID_6 DSSTox_GSID_20006
    DSSTox_RID_75318 DTXSID2020006 Dafalgan
    Dafalgan Codeine Daga Dapa X-S
    Daphalgan Darocet Darvocet
    Darvocet-N (Salt/Mix) Datril Datril Extra-Strength
    Daygrip Demilets Demilets (Salt/Mix)
    Deminofen Democyl Demogripal
    Desfebre Dhamol Dial-A-Gesic
    Dial-alpha-gesic Dimindol Dirox
    Disprol DivK1c_000660 Dol-Stop
    Dolcor Dolefin Dolegrippin
    Dolgesic Doliprane Dolko
    Dolofugin Doloreduct Dolorfug
    Dolorol Forte Dolorstop Dolotec
    Dolprone Dorocoff Dresan
    Dristan Cold No Drowsiness Dristancito Drixoral Cold & Flu
    Drixoral Cold & Flu (Salt/Mix) Drixoral Sinus Drixoral Sinus (Salt/Mix)
    Duaneo Dularin Duorol
    Duracetamol Durapan Dymadon
    Dymadon Co Dymadon Forte Dypap
    EBD5728 EC 203-157-5 EINECS 203-157-5
    Ecosetol Elixodyne Empracet
    Empracet (Salt/Mix) Endecon Endecon (Salt/Mix)
    Enelfa Eneril Epitope ID:117710
    Eu-Med Excedrin Caplets Excedrin Extra Strength Caplets
    Excipain Exdol Exdol Strong
    F3096-1731 F48B493F-B1FD-410C-AA0A-F40EC71A0689 FT-0658035
    Fanalgic Farmadol Febranine
    Febrectal Febrectol Febrex
    Febricet Febridol Febrilix
    Febrin Febrinol Febro-Gesic
    Febrolin Fendon Fensum
    Fepanil Fever All Feverall Junior Strength
    Feverall Sprinkle Caps Junior Strength Fevor Finimal
    Finiweh Flexsure Fluparmol
    Fortalidon P Freka-cetamol GTPL5239
    Gattaphen T Gelocatil Geluprane
    Genapap Children's Elixir Genapap Children's Tablets Genapap Extra Strength Caplets
    Genapap Extra Strength Tablets Genapap Regular Strength Tablets Genebs Extra Strength Caplets
    Genebs Regular Strength Tablets Genebs X-Tra Geralgine-P
    Gripin Bebe Grippostad Gynospasmine
    H865 HMS1570N17 HMS1920A03
    HMS2091G03 HMS2097N17 HMS2269G20
    HMS3268A10 HMS3412D16 HMS3676D16
    HMS3714N17 HMS502A22 HSDB 3001
    HY-66005 Hedex Helon N
    Homoolan Hy-Phen Hy-Phen (Salt/Mix)
    IDI1_000660 INFANTS' FEVERALL IV-APAP
    Ildamol InChI=1/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10 Inalgex
    Infadrops Influbene N Injectapap
    Intensin Intensin (Salt/Mix) J-001064
    J-514275 Janupap Jin Gang
    Junior Disprol KBio1_000660 KBio2_000356
    KBio2_002924 KBio2_005492 KBio3_001286
    KBioGR_000560 KBioSS_000356 KS-000002NN
    KSC492K1N Kataprin Kinder Finimal
    Korum Kratofin simplex L024125
    LS-32 Labamol Lekadol
    Lemgrip Lemsip Lestemp
    Liqiprine Liquagesic Liquigesic Co
    Liquiprin (Salt/Mix) Liquiprin Children's Elixir Liquiprin Infants" Drops
    Lonarid Lonarid Mono Lupocet
    Lyteca Lyteca Syrup MCULE-3844920617
    MFCD00002328 MLS001146925 MLS001331684
    MLS002154041 Magnidol Malex N
    Malgis Malidens Maxadol
    Medinol Paediatric Medocodene Melabon Infantil
    Mexalen Midol PM Night Time Formula Midol PM Night Time Formula (Salt/Mix)
    Midol Regular Strength Midol Regular Strength (Salt/Mix) Midol Teen Formula
    Midol Teen Formula (Salt/Mix) Migraleve Yellow Minafen
    Minoset Miralgin Momentum
    Mono Praecimed Multin N-(4-Hydroxyphenyl)acetamide
    N-(4-Hydroxyphenyl)acetamide (Tylenol) N-(4-Hydroxyphenyl)acetanilide N-(4-hydroxyfenyl)ethanamid
    N-(4-hydroxyphenyl)-acetamide N-(4-hydroxyphenyl)ethanamide N-Acetyl-4-aminophenol
    N-Acetyl-4-aminophenol N-Acetyl-p-aminophenol N-acetyl para aminophenol
    N-acetyl-4-hydroxyaniline; N-acetyl-para-aminophenol NCGC00016361-01
    NCGC00016361-02 NCGC00016361-03 NCGC00016361-04
    NCGC00016361-05 NCGC00016361-06 NCGC00016361-07
    NCGC00016361-08 NCGC00016361-09 NCGC00016361-10
    NCGC00016361-12 NCGC00016361-13 NCGC00025267-01
    NCGC00025267-02 NCGC00025267-03 NCGC00025267-04
    NCGC00025267-05 NCGC00253912-01 NCGC00259479-01
    NCI-C55801 NEBS NINDS_000660
    NSC 109028 NSC 3991 NSC-109028
    NSC-3991 NSC-755853 NSC109028
    NSC3991 NSC755853 Naldegesic
    Naldegesic (Salt/Mix) Napafen Naprinol
    Nealgyl Neo-Fepramol NeoCitran
    Neodol Neodolito Neopap
    Neotrend Neuridon New Cortal for Children
    NilnOcen Nina No-Febril
    Nobedon Nodolex Noral
    Ofirmev Oltyl Oralgan
    Oraphen-PD Ornex Severe Cold Formula (Salt/Mix) Ortensan
    Oxycocet PCM Paracetamol Lichtenstein Paceco
    Pacemo Pacemol Pacet
    Pacimol Paedialgon Paedol
    Painex Paldesic Pamol
    Panacete Panadeine Panadeine Co
    Panadiene Panado-Co Panado-Co Caplets
    Panadol Panadol Extra Strength Panadol Junior Strength Caplets
    Panadol Maximum Strength Caplets Panadol Maximum Strength Tablets Panale ve
    Panaleve Panamax Panasorb
    Panasorbe Panets Panex
    Panodil Panofen Pantalgin
    Para-Suppo Para-Tabs Paracemol
    Paracenol Paracet Paracetamol
    Paracetamol (Acetaminophen) 1.0 mg/ml in Methanol Paracetamol (INN) Paracetamol 100 microg/mL in Methanol
    Paracetamol AL Paracetamol Antipanin P Paracetamol BC
    Paracetamol Basics Paracetamol DC Paracetamol Dr. Schmidgall
    Paracetamol Fecofar Paracetamol Genericon Paracetamol Hanseler
    Paracetamol Harkley Paracetamol Heumann Paracetamol Hexal
    Paracetamol Italfarmaco Paracetamol Nycomed Paracetamol PB
    Paracetamol Raffo Paracetamol Ratiopharm Paracetamol Rosch
    Paracetamol Saar Paracetamol SmithKline Beecham Paracetamol Stada
    Paracetamol Winthrop Paracetamol [INN:BAN] Paracetamol for equipment qualification, EuropePharmacopoeia (EP) Reference Standard
    Paracetamol von ct Paracetamol, British Pharmacopoeia (BP) Reference Standard Paracetamol, European Pharmacopoeia (EP) Reference Standard
    Paracetamol;Tylenol Paracetamole Paracetamolo
    Paracetamolo [Italian] Paracetamolum Paracetamolum [INN-Latin]
    Paracetanol Paracetol Paracin
    Paracod Paracodol Parador
    Paradrops Parakapton Parake
    Paralen Paralief Paralink
    Paralyoc Paramol Paramolan
    Paranox Parapan Parasedol
    Parasin Paraspen Parcetol
    Parelan Parmol Parogal
    Paroma Pasolind Pasolind N
    Pe-Tam Pediapirin Pediatrix
    Pedric Percocet-5 Percocet-Demi
    Percogesic with Codeine Perdolan Mono Perfalgan
    Pharmakon1600-01500101 Phenaphen Caplets Phenaphen W/Codeine
    Phendon Phenipirin Phenol, p-acetamido-
    Phogoglandin Pinex Piramin
    Pirinasol Plicet Polmofen
    Predimol Predualito Prestwick0_000868
    Prestwick1_000868 Prestwick2_000868 Prestwick3_000868
    Prestwick_13 Prodol Prompt
    Prontina Propacet Propacet (Salt/Mix)
    Proxyphene/Acetamine PubChem17726 Puernol
    Pulmofen Pyregesic-C Pyrigesic
    Pyrinazine Pyromed Q57055
    Quiet World Quiet World (Salt/Mix) RTR-000905
    RZVAJINKPMORJF-UHFFFAOYSA-N Redutemp Reliv
    Remedol Resfenol Resprin
    Rhinex D-Lay Tablets Rivalgyl Robigesic
    Robitussin Night Relief Robitussin Night Relief (Salt/Mix) Rockamol Plus
    Rounox Roxicet 5/500 RubieMol
    Rubophen Rupemol SBB043758
    SBI-0051269.P003 SC-19146 SCHEMBL19474893
    SCHEMBL3480 SGCUT00014 SK-Apap
    SMR000112065 SOM SPBio_000010
    SPBio_002836 SPECTRUM1500101 SR-01000597517
    SR-01000597517-1 SR-01000597517-2 SR-01000597517-4
    ST24028862 ST45179777 STL140694
    STR00901 Salzone Sanicet
    Sanicopyrine Scanol Scentalgyl
    Scherzatabletten Rezeptur 534 Schmerzex Sedalito
    Semolacin Servigesic Seskamol
    Setakop Setamol Setol
    Sifenol Sinaspril Sine-Aid, Maximum Strength (Salt/Mix)
    Sine-Off Sinus Medicine Caplets Sine-Off Sinus Medicine Caplets (Salt/Mix) Sinedol
    Sinmol Sinubid (Salt/Mix) Snaplets-FR
    Spalt N Spalt fur die nacht Spectrum2_000085
    Spectrum3_000283 Spectrum4_000140 Spectrum5_000736
    Spectrum_000016 St Joseph Aspirin-Free St Joseph Aspirin-Free for Children
    St. Joseph Cold Tablets for Children St. Joseph Cold Tablets for Children (Salt/Mix) St. Joseph Fever Reducer
    Stanback Stopain Sudafed Severe Cold Formula
    Sudafed Severe Cold Formula (Salt/Mix) Sudafed Sinus Sudafed Sinus (Salt/Mix)
    Sunetheton Supac (Salt/Mix) Supadol mono
    Supofen Suppap Suppap-120
    Suppap-325 Suppap-650 Supramol-M
    TR-000905 TRA0127672 TYL
    Tabalgin Tachiprina Talacen (Salt/Mix)
    Tapanol Extra Strength Caplets Tapanol Extra Strength Tablets Tapar
    Tavist Allergy/Sinus/Headache Tazamol Temlo
    Tempanal Tempra Tempra Caplets
    Tempra Chewable Tablets Tempra D.S Tempra Drops
    Tempra Syrup Termacet Termalgin
    Termalgine Termofren TheraFlu (Salt/Mix)
    Theraflu Tiffy Titralgan
    Tocris-1706 Tox21_110397 Tox21_110397_1
    Tox21_201930 Tox21_300100 Toximer P
    Tralgon Treupel N Treupel mon
    Treuphadol Triaminic Sore Throat Formula Triaminic Sore Throat Formula (Salt/Mix)
    Tricoton Tussapap Ty lenol
    Tylenol Tylenol (TN) Tylenol (caplet)
    Tylenol (geltab) Tylenol 8-Hour Tylenol Allergy Sinus
    Tylenol Allergy Sinus (Salt/Mix) Tylenol Arthritis Extended Relief Tylenol Caplets
    Tylenol Children's Chewable Tablets Tylenol Children's Elixir Tylenol Children's Suspension Liquid
    Tylenol Drops Tylenol Elixir Tylenol Extra Strength Adult Liquid Pain Reliever
    Tylenol Extra Strength Caplets Tylenol Extra Strength Gelcaps Tylenol Extra Strength Tablets
    Tylenol Gelcaps Tylenol Infants Drops Tylenol Infants" Suspension Drops
    Tylenol Junior Strength Caplets Tylenol Junior Strength Chewable Tablets Tylenol Regular Strength Caplets
    Tylenol Regular Strength Tablets Tylenol Tablets Tylex
    Tylex CD Tylol Tylox (Salt/Mix)
    Tymol UNII-362O9ITL9D Upsanol
    Utragin Valadol Valgesic
    Valorin Valorin Extra Veralgina
    Vermidon Verpol Viclor Richet
    Vicodin Vicodin (Salt/Mix) Vips
    Viruflu Vivimed Volpan
    WLN: QR DMV1 Wygesic Wygesic (Salt/Mix)
    ZINC13550868 Zatinol Zolben
    Zydone (Salt/Mix) acetaminophen acetaminophene
    acetaminophenol acetominophene alpha-Per
    component of Dialog component of Dilone component of Endecon
    component of Hycomine Compound component of Percocet component of Percogesic
    component of Phenaphen n-acetyl-4-hydroxyaniline p-(Acetylamino)phenol
    p-Acetamidophenol p-Acetaminophenol p-Acetoaminophen
    p-Acetylaminophenol p-Hydroxyacetanilide p-Hydroxyphenolacetamide
    p-hydroxy-acetanilid p-hydroxyacetoanilide para-acetylaminophenol
    paracetamol (acetaminophen) phenol derivative, 11 to_000023

    DrugBank Name Acetaminophen
    DrugBank DB00316
    CAS Number 103-90-2, 147630-09-9, 1693-37-4, 24424-99-5, 39465-00-4, 64315-36-2, 8055-08-1
    PubChem Compound 1983
    KEGG Compound ID C06804
    KEGG Drug D00217
    PubChem.Substance 46506142
    ChEBI 46195
    PharmGKB PA448015
    ChemSpider 1906
    BindingDB 26197.0
    TTD DAP001436
    Wikipedia Acetaminophen
    HET TYL
    DPD 270

    1. Hinson et al. (2004)