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Drug

D0106 | Risperidone

Molecular Formula C23H27FN4O2
Molecular Weight 410.5
Structure
State solid
Clearance Risperidone is cleared by the kidneys. Clearance is decreased in the elderly and those with renal creatinine clearance of 15 mL/min to 59 mL/min, which decreases clearance by 60% [L1214].
Volume of distribution 1 to 2 L/kg
Route of elimination Risperidone is extensively metabolized in the liver. In healthy elderly subjects, renal clearance of both risperidone and 9-hydroxyrisperidone was decreased, and elimination half-lives are prolonged compared to young healthy subjects [A31772, L1214].
Protein binding Risperidone, ~88% bound in human plasma; 9-hydroxyrisperidone, ~77% bound in human plasma [A31772].
Half life 3 hours in extensive metabolizers [A31772] Up to 20 hours in poor metabolizers [A31772]
Absorption Well absorbed. The absolute oral bioavailability of risperidone is 70% (CV=25%). The relative oral bioavailability of risperidone from a tablet is 94% (CV=10%) when compared to a solution.

N

N05AX08 Risperidone


[N05AX] Other antipsychotics


[N05A] ANTIPSYCHOTICS


[N05] PSYCHOLEPTICS


[N] Nervous system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTRON TRANSPORT CHAIN rat isolated liver mitochondria decrease 23

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase rat isolated liver mitochondria inhibitor 23

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 142 companies from 17 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H301 (99.3%): Toxic if swallowed [Danger Acute toxicity, oral]


H331 (12.68%): Toxic if inhaled [Danger Acute toxicity, inhalation]


H351 (12.68%): Suspected of causing cancer [Warning Carcinogenicity]


H411 (19.01%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P201, P202, P261, P264, P270, P271, P273, P281, P301+P310, P304+P340, P308+P313, P311, P321, P330, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

  • Abnormal behaviour

  • Anxiety

  • Autism

  • Bipolar disorder

  • Breast cancer

  • Carcinogenicity

  • Delusion

  • Dementia

  • Dementia Alzheimer's type

  • Dementia with Lewy bodies

  • Diabetes mellitus

  • Distractibility

  • Hallucination

  • Hostility

  • Irritability

  • Liver disorder

  • Mental disability

  • Mental disorder

  • Mental retardation

  • Nephropathy

  • Parkinson's disease

  • Parkinsonism

  • Pituitary tumour

  • Poverty of speech

  • Pressure of speech

  • Psychotic disorder

  • Renal failure

  • Renal impairment

  • Schizoaffective disorder

  • Social avoidant behaviour

  • Suspiciousness

  • Tachyphrenia

  • Ataxia (0.01)

  • Viral infection (0.02)

  • Abdominal discomfort

  • Abdominal pain

  • Abdominal pain upper

  • Acne

  • Aggression

  • Agitation

  • Akathisia

  • Alanine aminotransferase increased

  • Altered state of consciousness

  • Amenorrhoea

  • Anaemia

  • Angiopathy

  • Anxiety

  • Apathy

  • Arrhythmia

  • Arthralgia

  • Aspartate aminotransferase increased

  • Asthenia

  • Automatism

  • Back pain

  • Balance disorder

  • Blood creatine phosphokinase increased

  • Blood prolactin increased

  • Body temperature increased

  • Bone pain

  • Bradykinesia

  • Breast disorder

  • Cardiac disorder

  • Cardiovascular disorder

  • Cellulitis

  • Cerebrovascular accident

  • Chest discomfort

  • Chest pain

  • Confusional state

  • Conjunctivitis

  • Connective tissue disorder

  • Constipation

  • Cough

  • Dandruff

  • Decreased appetite

  • Depressed level of consciousness

  • Dermatitis

  • Diarrhoea

  • Disturbance in attention

  • Disturbance in sexual arousal

  • Dizziness

  • Dizziness postural

  • Drooling

  • Dry mouth

  • Dry skin

  • Dysarthria

  • Dyskinesia

  • Dyspepsia

  • Dysphagia

  • Dyspnoea

  • Ear pain

  • Ejaculation failure

  • Enuresis

  • Epistaxis

  • Erectile dysfunction

  • Erythema

  • Extrapyramidal disorder

  • Eye disorder

  • Fatigue

  • Feeling abnormal

  • Flat affect

  • Gait disturbance

  • Galactorrhoea

  • Gastrointestinal disorder

  • Gastrointestinal pain

  • Gynaecomastia

  • Headache

  • Hyperkeratosis

  • Hyperkinesia

  • Hypersensitivity

  • Hypersomnia

  • Hypertension

  • Hypertonia

  • Hypoaesthesia

  • Hypokinesia

  • Hypotension

  • Immune system disorder

  • Increased appetite

  • Infection

  • Infestation

  • Influenza

  • Insomnia

  • Joint stiffness

  • Joint swelling

  • Laryngeal pain

  • Lethargy

  • Libido decreased

  • Loss of consciousness

  • Malnutrition

  • Mania

  • Mediastinal disorder

  • Menstrual disorder

  • Mental disability

  • Mental disorder

  • Middle insomnia

  • Muscle contractions involuntary

  • Muscle rigidity

  • Muscle twitching

  • Musculoskeletal discomfort

  • Myalgia

  • Nasal congestion

  • Nasopharyngitis

  • Nausea

  • Neck pain

  • Nervous system disorder

  • Nervousness

  • Neuropathy peripheral

  • Oculogyric crisis

  • Oedema

  • Oedema peripheral

  • Orthostatic hypotension

  • Osteoarthritis

  • Pain

  • Pain in extremity

  • Palpitations

  • Parkinsonism

  • Pharyngitis

  • Pneumonia

  • Pollakiuria

  • Posture abnormal

  • Pruritus

  • Psychotic disorder

  • Pulmonary congestion

  • Rash

  • Respiratory tract congestion

  • Respiratory tract infection

  • Rhinitis

  • Rhinorrhoea

  • Salivary hypersecretion

  • Seborrhoeic dermatitis

  • Shock

  • Sinus congestion

  • Sinusitis

  • Skin disorder

  • Sluggishness

  • Somnolence

  • Suicide attempt

  • Syncope

  • Tachycardia

  • Tardive dyskinesia

  • Tension

  • Thirst

  • Tooth disorder

  • Toothache

  • Transient ischaemic attack

  • Tremor

  • Upper respiratory tract infection

  • Urethral disorder

  • Urinary incontinence

  • Urinary tract disorder

  • Urinary tract infection

  • Vision blurred

  • Visual acuity reduced

  • Visual impairment

  • Vomiting

  • Weight decreased

  • Weight increased

    • (risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one 1026102-43-1 106266-06-2
    2-(2-(4-(benzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-7,8,9,9a-tetrahydro-1H-pyrido[1,2-a]pyrimidin-4(6H)-one 2-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-6,7,8,8a-tetrahydro-5H-naphthalen-1-one 3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)ethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one
    3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one 3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one 3-Ethyl-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one(Risperidone Impurity)
    3-[2-[-4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 3-[2-[4(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 3-[2-[4(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl4H-pyrido[1,2-a]pyrimidin-4-one
    3-[2-[4-(6 fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-me thyl-4H-pyrido[1,2-a]pyrimidin-4-one 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperi-dino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one
    3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one 3-[2-[4-(6-fluoro- 1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl4H-pyrido[1,2-a]pyrimidin-4-one 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidiny]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
    3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-A]pyrimidin-4-one 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
    3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)-1-piperidinyl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)-1-piperidyl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
    3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[2,1-b]pyrimidin-4-one 3-{2-[4-(6-FLUORO-BENZO[D]ISOXAZOL-3-YL)-PIPERIDIN-1-YL]-ETHYL}-2-METHYL-6,7,8,9-TETRAHYDRO-PYRIDO[1,2-A]PYRIMIDIN-4-ONE 3-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-ethyl}- 6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
    3-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl}-6,7,8,9-tetrahydro-2-methylpyrido[1,2-a]pyrimidin-4-one 3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone) 3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (risperidone)
    3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one(risperidone) 3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one 3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl}-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimid-in-4-one
    3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl}-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-4-one
    3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one 3-{2-[4-(6-fluorobenzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one 4767-EP2269990A1
    4767-EP2272537A2 4767-EP2272841A1 4767-EP2275420A1
    4767-EP2275423A1 4767-EP2280008A2 4767-EP2280010A2
    4767-EP2298731A1 4767-EP2298776A1 4767-EP2301936A1
    4767-EP2308867A2 4767-EP2308870A2 4767-EP2308875A1
    4767-EP2316836A1 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6 ,7,8,9-tetrahydro-2-methyl- 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-2-methyl-
    4H-Pyrido(1,2-a)pyrimidin-4-one, 6,7,8,9-tetrahydro-3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-2-methyl- 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benz-isoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl- 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-
    5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-methyl-1,3-dihydro-indol-2-one(Norastemizole) 66R062 A801409
    AB0004623 AB00514010 AB00514010-09
    AB00514010-11 AB00514010-12 AB00514010_13
    AB00514010_14 AC-1306 ACT04270
    AK172045 AKOS005577302 ANW-42874
    API0004081 Apexidone BCP08161
    BDBM50001885 BG0309 BIDD:GT0262
    BRD-K53857191-001-04-5 BRD-K53857191-001-10-2 BRN 4891881
    Belivon C-21900 C23H27FN4O2
    CAS-106266-06-2 CC-34268 CCG-100930
    CHEBI:8871 CHEMBL85 CPD000466323
    CR0023 CS-1619 Certified Reference Material
    D00426 DB00734 DSSTox_CID_25193
    DSSTox_GSID_45193 DSSTox_RID_80740 DTXSID8045193
    EU-0101074 FT-0631037 GTPL96
    HMS1571M19 HMS2051H07 HMS2089C22
    HMS2098M19 HMS2233O11 HMS3373M18
    HMS3393H07 HMS3657G13 HMS3715M19
    HSDB 7580 HY-11018 J-001555
    J10290 KS-00000760 KS-1106
    L000510 L6UH7ZF8HC LS-134196
    Lopac-R-118 MCULE-4027175053 MFCD00274576
    MLS000759429 MLS001165758 MLS001424081
    NC00180 NCGC00015883-01 NCGC00015883-02
    NCGC00015883-03 NCGC00015883-04 NCGC00015883-05
    NCGC00015883-06 NCGC00015883-07 NCGC00015883-08
    NCGC00015883-11 NCGC00094352-01 NCGC00094352-02
    NCGC00094352-03 NCGC00179257-01 NP-202
    NSC-759895 NSC759895 PB26023
    PYR332 Pharmakon1600-01506038 Prestwick0_001029
    Prestwick1_001029 Psychodal Q-4040
    Q412443 R 62 766 R 64 766
    R 64,766 R 64766 R-118
    R-64-766 R-64766 R0087
    R64766 RAPZEAPATHNIPO-UHFFFAOYSA-N RTR-001241
    Relday Rispen Risperdal
    Risperdal (TN) Risperdal Consta Risperdal M-Tab
    Risperidal Risperidal M-Tab Risperidona
    Risperidona [Spanish] Risperidone (JP17/USAN/INN) Risperidone (RIS)
    Risperidone (Risperdal) Risperidone 1.0 mg/ml in Methanol Risperidone [USAN:BAN:INN]
    Risperidone [USAN:USP:INN:BAN] Risperidone for system suitability, European Pharmacopoeia (EP) Reference Standard Risperidone solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material
    Risperidone(R 64 766) Risperidone(Risperdal) Risperidone, 99%
    Risperidone, >=98% (HPLC), powder Risperidone, British Pharmacopoeia (BP) Reference Standard Risperidone, European Pharmacopoeia (EP) Reference Standard
    Risperidone, Pharmaceutical Secondary Standard Risperidone, United States Pharmacopeia (USP) Reference Standard Risperidone, placebo
    Risperidone-ISM Risperidone??? Risperidonum
    Risperidonum [Latin] Risperin Rispolept
    Rispolin SAM001246595 SC-16313
    SCHEMBL27911 SMR000466323 SPBio_003078
    SR-01000075399 SR-01000075399-2 SR-01000075399-8
    STK646402 SW197348-4 Sequinan
    Spiron TR-001241 Tox21_110253
    Tox21_110253_1 UNII-L6UH7ZF8HC US8802672, Risperidone
    Z1522566617 ZINC538312 Zophrenal
    risperidone s1615

    DrugBank Name Risperidone
    DrugBank DB00734
    CAS Number 106266-06-2, 106266-09-5
    PubChem Compound 5073
    KEGG Drug D00426
    PubChem.Substance 46505850
    ChEBI 8871
    PharmGKB PA451257
    ChemSpider 4895
    BindingDB 50001885.0
    TTD DAP000003
    Wikipedia Risperidone
    HET 8NU
    DPD 723

    1. Chan et al. (2005)