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Drug

D0149 | Bisphenol A

Molecular Formula C15H16O2
Molecular Weight 228.29
Structure
State solid

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 13.97±6.29 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 15.85 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 37.65±3.06 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Danger

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]


H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


H360F: May damage fertility [Danger Reproductive toxicity]


 P201, P202, P261, P271, P272, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P321, P333+P313, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

Aggregated GHS information provided by 2569 companies from 49 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 1 of 2569 companies. For more detailed information, please visit ECHA C&L website


Of the 48 notification(s) provided by 2568 of 2569 companies with hazard statement code(s):


H317 (99.92%): May cause an allergic skin reaction [Warning Sensitization, Skin]


H318 (99.92%): Causes serious eye damage [Danger Serious eye damage/eye irritation]


H335 (99.34%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


H360 (17.45%): May damage fertility or the unborn child [Danger Reproductive toxicity]


H361 (82.48%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


H411 (20.4%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P201, P202, P261, P271, P272, P273, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P321, P333+P313, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]


H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


H361f: Suspected of damaging fertility [Warning Reproductive toxicity]


 P201, P202, P261, P271, P272, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P321, P333+P313, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]


H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]


H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


 P201, P202, P261, P271, P272, P273, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P321, P333+P313, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]


H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure


Narcotic effects]


H360: May damage fertility or the unborn child [Danger Reproductive toxicity]


H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]


H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]


H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


 P201, P202, P260, P261, P264, P270, P271, P272, P273, P280, P281, P302+P352, P304+P340, P305+P351+P338, P307+P311, P308+P313, P310, P312, P314, P321, P333+P313, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H303: May be harmful if swallowed [Warning Acute toxicity, oral]


H313: May be harmful in contact with skin [Acute toxicity, dermal]


H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]


H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure


Narcotic effects]


H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]


H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


 P201, P202, P260, P261, P264, P270, P271, P272, P280, P281, P302+P352, P304+P340, P305+P351+P338, P307+P311, P308+P313, P310, P312, P314, P321, P333+P313, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • (1-methylethylidene)bis-Phenol .beta.,.beta.'-Bis(p-hydroxyphenyl)propane .beta.-Di-(p-hydroxyphenyl)propane
    .beta.-di-p-hydroxyphenylpropane 1,1'-(1-Methylethylidene)bisphenylol, 9CI 2, 2-Bis(4-hydroxyphenyl)propane
    2, 2-Bis(hydroxyphenyl)propane 2, 2-Di(4-phenylol)propane 2,2'-Bis(4-hydroxyphenyl)propane
    2,2-(4,4'-Dihydroxydiphenyl)propane 2,2-(4,4-Dihydroxydiphenyl)propane 2,2-Bis (4-hydroxyphenol) propane
    2,2-Bis(4'-hydroxyphenyl)propane 2,2-Bis(4,4'-hydroxyphenyl)propane 2,2-Bis(4-hydroxyphenyl)propane
    2,2-Bis(hydroxyphenyl)propane 2,2-Bis(p-hydroxyphenyl)propane 2,2-Bis-4'-hydroxyfenylpropan
    2,2-Bis-4'-hydroxyfenylpropan [Czech] 2,2-Di(4-hydroxyphenyl)propane 2,2-Di(4-phenylol)propane
    2,2-bis(4-hydroxyphenyl) propane 2,2-bis(p-hydroxyphenyl)-propane 2,2-bis-(4- hydroxyphenyl)-propane
    2,2-bis-(4-hydroxy phenyl)propane 2,2-bis-(4-hydroxyphenyl) propane 2,2-bis-(4-hydroxyphenyl)-propane
    2,2-bis-(p-hydroxyphenyl)-propane 2,2-bis[4-Hydroxyphenyl]propane 2,2-di(p-hydroxy-phenyl-)propane
    2,2-di-(4'-Hydroxyphenyl)-propane 2,4'-Dihydroxydiphenyl)propane 27100-33-0
    2OH 2e2r 2p7g
    4, 4'-Bisphenol A 4, 4'-Dihydroxydiphenyl-2,2-propane 4, 4'-Dihydroxydiphenyldimethylmethane
    4, 4'-Dihydroxydiphenylpropane 4,2-diphenylpropane 4,2-propane
    4,4' Isopropylidinediphenol 4,4'-(1-Methylethane-1,1-diyl)diphenol 4,4'-(1-Methylethylidene)bisphenol
    4,4'-(1-Methylethylidene)bisphenol homopolymer 4,4'-(1-Methylethylidene)bisphenol, 9CI 4,4'-(1-methylethylidene)bis-phenol
    4,4'-(propane-2,2-diyl)diphenol 4,4'-Bisphenol A 4,4'-Dihydroxdiphenylpropane
    4,4'-Dihydroxy-2,2-diphenylpropane 4,4'-Dihydroxydiphenyl-2,2-propane 4,4'-Dihydroxydiphenyldimethylmethane
    4,4'-Dihydroxydiphenylpropane 4,4'-Dimethylmethylenedi-Phenol 4,4'-Dimethylmethylenediphenol
    4,4'-ISOPROPYLIDENE-DIPHENOL 4,4'-ISOPROPYLIDENEDIPHENOL (BISPHENOL A) 4,4'-Isopropylidene diphenol
    4,4'-Isopropylidenebis[phenol] 4,4'-Isopropylidenebisphenol 4,4'-Isopropylidenedi-Phenol
    4,4'-Isopropylidenediphenol 4,4'-Isopropylidenediphenol B 4,4'-Isopropylidenediphenol, 8CI
    4,4'-Isopropylidenediphenol, 97% 4,4'-Isopropylidenediphenol, analytical standard 4,4'-bisphenol-A
    4,4'-dihydroxy diphenyl-2,2-propane 4,4'-propane-2,2-diyldiphenol 4,4-ISOPROPYLIDENEDIPHENOL
    4,4[-Isopropylidenediphenol 4-06-00-06717 (Beilstein Handbook Reference) 4-[1-(4-hydroxyphenyl)-1-methylethyl]phenol
    4-[1-(4-hydroxyphenyl)-isopropyl]phenol 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol 80-05-7
    A839823 ACMC-20977c AE-848/01247026
    AI3-04009 AKOS000119022 ANW-13606
    B0494 BBL010647 BDBM29608
    BIDD:ER0208 BIDD:PXR0120 BPA
    BPA 157 BRD-K41494493-001-04-7 BRN 1107700
    Biphenol A Bis Phenol A Bis(4-hydroxyphenyl) dimethylmethane
    Bis(4-hydroxyphenyl)dimethylmethane Bis(4-hydroxyphenyl)propane Bis(p-hydroxyphenyl)propane
    Bisferol A Bisferol A [Czech] Bisphenol
    Bisphenol A Bisphenol A (BPA) Bisphenol A - Polycarbonate Grade
    Bisphenol A, 97% Bisphenol A, >=99% Bisphenol A, United States Pharmacopeia (USP) Reference Standard
    Bisphenol A, certified reference material, TraceCERT(R) Bisphenol A. Bisphenol a(ring 13c12)
    Bisphenol-A C13624 CAS-80-05-7
    CCG-214370 CCRIS 95 CHEBI:33216
    CHEMBL418971 CS-B1737 CTK3E8098
    DB06973 DIAN DSSTox_CID_182
    DSSTox_GSID_20182 DSSTox_RID_75420 DTXSID7020182
    Diano Dimethyl bis(p-hydroxyphenyl)methane Dimethylbis(p-hydroxyphenyl)methane
    Dimethylmethylene-p,p'-diphenol Diphenylolpropane EC 201-245-8
    EINECS 201-245-8 F1284-0895 FT-0609178
    GTPL7865 HMS2866B07 HMS3749E11
    HSDB 513 IISBACLAFKSPIT-UHFFFAOYSA-N InChI=1/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H
    Ipognox 88 Isopropylidenebis(4-hydroxybenzene) KSC-7-199
    KSC448A9R KUC105370N LS-1788
    MCULE-1016303245 MFCD00002366 MLS001055461
    MLT3645I99 Millad HBPA NCGC00090952-01
    NCGC00090952-02 NCGC00090952-03 NCGC00090952-04
    NCGC00090952-05 NCGC00090952-06 NCGC00090952-07
    NCGC00090952-08 NCGC00090952-09 NCGC00260537-01
    NCI-C50635 NE10183 NSC 1767
    NSC-1767 NSC-17959 NSC1767
    NSC17959 Noname O169
    Oprea1_215541 Parabis A Phenol, (1-methylethylidene)bis-
    Phenol, 4,4'-(1-methylethylidene)bis- Phenol, 4,4'-(1-methylethylidene)bis-, homopolymer Phenol, 4,4'-dimethylmethylenedi-
    Phenol, 4,4'-isopropylidenedi- Phenol,4'-(1-methylethylidene)bis- Phenol,4'-dimethylmethylenedi-
    Phenol,4'-isopropylidenedi- Pluracol 245 Poly(Bisphenol A carbonate)
    Polycarbonate Propane, 2,2-bis(p-hydroxyphenyl)- Propane,2-bis(p-hydroxyphenyl)-
    PubChem22174 Q271980 RTR-025374
    Rikabanol SBB012432 SC-62333
    SCHEMBL15062 SMR000315090 SR-01000596928
    SR-01000596928-1 ST065685 ST24042488
    STK801675 TR-025374 Tox21_202992
    Tox21_400088 UNII-MLT3645I99 UPCMLD0ENAT5883875:001
    Ucar bisphenol A Ucar bisphenol HP VS-02603
    WLN: QR DX1&1&R DQ Z256709694 ZINC56434
    beta, beta'-Bis(p-hydroxyphenyl)propane beta,beta'-Bis(p-hydroxyphenyl)propane beta,beta-di-(p-hydroxyphenyl)propane
    beta-Di-(p-hydroxyphenyl)propane beta-di-p-hydroxyphenylpropane bis(4-hyd roxyphenyl) dimethylmethane
    bis(4-hydroxyphenyl)-propane bis-phenol A bis-phenol-a
    bisphenol A, disodium salt bisphenol A, sodium salt di-2,2-(4-Hydroxyphenyl)propane
    dimethyl bis(p-hydroxyphenyl)methane p, p'-Dihydroxydiphenyldimethylmethane p, p'-Dihydroxydiphenylpropane
    p, p'-Isopropylidenediphenol p,p'-Bisphenol A p,p'-Dihydroxydiphenyldimethylmethane
    p,p'-Dihydroxydiphenylpropane p,p'-Isopropylidenebisphenol p,p'-Isopropylidenediphenol

    DrugBank Name Bisphenol A
    DrugBank DB06973
    CAS Number 103598-77-2, 25068-38-6, 27100-33-0, 60112-98-3, 7417-21-2, 80-05-7, 96210-87-6
    PubChem Compound 6623
    KEGG Compound ID C13624
    PubChem.Substance 99443444
    ChEBI 33216
    ChemSpider 6371
    BindingDB 29608.0
    Wikipedia Bisphenol A
    HET 2OH

    1. Chan et al. (2017)
    2. Kaur et al., 2014