Compound
D0206 | MPP+
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| ELECTRON TRANSPORT CHAIN | 0.3 mM | NADH:O2 | decrease | IC50 | 114 | |||
| ELECTRON TRANSPORT CHAIN | 2–4 mM | NADH–Q | decrease | IC50 | 115 | |||
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| NADH:ubiquinone reductase | 0.3 mM | NADH:O2 | inhibitor | IC50 | 114 | |||
| NADH:ubiquinone reductase | 2–4 mM | NADH–Q | inhibitor | IC50 | 115 | |||
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | unreported | 27500ug/kg (27.5mg/kg) | "MPTP: A Neurotoxin Producing a Parkinsonian Syndrome, Papers Presented at a Symposium, Bethesda, MD, 1985," Markey, S.P., et al., eds., Orlando, FL, Academic Press, Inc., 1986Vol. -, Pg. 571, 1986. | |
| 1 Methyl 4 Phenylpyridinium | 1-METHYL-4-PHENYLPYRIDINIUM | 1-methyl-4-phenylpyridin-1-ium |
| 48134-75-4 | 5-20-07-00550 (Beilstein Handbook Reference) | BDBM81945 |
| BRN 1618932 | C11310 | CAS_39484 |
| CCRIS 2187 | CHEBI:641 | CHEMBL311617 |
| Cyperquat | Cyperquat [ANSI:ISO] | Cyperquat [ANSI] |
| DTXSID4058106 | GTPL4568 | LS-132763 |
| MPP+ | N-Methyl-4-phenylpyridine | N-Methyl-4-phenylpyridinium |
| N-Methyl-4-phenylpyridinium ion | NSC_39484 | Pyridinium, 1-methyl-4-phenyl- |
| Pyridinium, 1-methyl-4-phenyl- (9CI) | Q161645 | R865A5OY8J |
| SCHEMBL37321 | UNII-R865A5OY8J | ZINC967769 |