MITOTOX

Compound

D0221 | Deguelin

Molecular Formula	C23H22O6
Molecular Weight	394.4
Structure
Description	member of rotenoids; insecticide and piscicide; Complex I inhibitor; anticancer candidate drug

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
ELECTRON TRANSPORT CHAIN	4.2 nmol/mg		bovine	mitochondria	NADH–Q	decrease	IC50	95
GLUCOSE GALACTOSE IC50 RATIO	450			LUHMES (Lund human mesencephalic) cells	Glc–Gal–NeuriTox assay		EC25(NA) [Glc/Gal]	326

Target	Dose	Species	Model	Method	Action	Positive criterion	Reference
NADH:ubiquinone reductase	4.2 nmol/mg	bovine	mitochondria	NADH–Q	inhibitor	IC50	95
NADH:ubiquinone reductase							185
NADH:ubiquinone reductase	450		LUHMES (Lund human mesencephalic) cells	Glc–Gal–NeuriTox assay		EC25(NA) [Glc/Gal]	326

(-)-Deguelin	(-)-Deguelin, >98% (HPLC), powder	(-)-Deguelin, Mundulea sericea
(-)-cis-deguelin	(7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H,7aH-pyrano[2,3-c;6,5-f']dichromen-7-one	(7as,13as)-13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-3h-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7ah)-one
13,13aS-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-[1]benzopyrano[3,4-b]pyrano[2,3-h][1]benzopyran-7(7aS)-one	1702AH	3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS-cis)-	3H-[1]Benzopyrano[3,4-b]pyrano[2,3-h][1]benzopyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-	4CN-1289
522-17-8	ABP000411	ACN-053693
AKOS024456769	AS-56004	BCP9000596
BRD-K61401890-001-02-0	BRD-K61401890-001-03-8	BRD-K61401890-001-04-6
BSPBio_002583	C10417	CCG-39856
CCRIS 8104	CHEBI:4357	CHEMBL393417
CS-1802	DEGUELIN(-)	DTXSID10200231
Deguelin	Deguelin/	HMS1923A05
HMS3268E12	HY-13425	K5Z93K66IE
KBio2_001524	KBio2_004092	KBio2_006660
KBio3_002083	KBioGR_002434	KBioSS_001524
LMPK12060019	MFCD01740600	MLS006010295
NCGC00025288-01	NCGC00025288-02	NCGC00025288-03
ORDAZKGHSNRHTD-UXHICEINSA-N	Q5251862	SCHEMBL73183
SDCCGMLS-0066380.P001	SMR004701363	SPBio_000236
SPECTRUM201138	SR-01000597503	SR-01000597503-1
SR-01000597503-3	SR-01000597503-4	Spectrum2_000298
Spectrum3_001122	Spectrum4_001965	Spectrum5_001852
Spectrum_001044	Tocris-1770	UNII-K5Z93K66IE
ZINC3978987	s8132