D0223 | Pentachlorophenol
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| UNCOUPLING | 253 | |||||||
| MEMBRANE POTENTIAL | 3.09±0.60 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 8.9 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 4.17±0.75 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
    |
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H311: Toxic in contact with skin [Danger Acute toxicity, dermal] H315: Causes skin irritation [Warning Skin corrosion/irritation] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] H330: Fatal if inhaled [Danger Acute toxicity, inhalation] H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H351: Suspected of causing cancer [Warning Carcinogenicity] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P201, P202, P260, P261, P264, P270, P271, P273, P280, P281, P284, P301+P310, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
Aggregated GHS information provided by 21 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H300 (38.1%): Fatal if swallowed [Danger Acute toxicity, oral] H301 (61.9%): Toxic if swallowed [Danger Acute toxicity, oral] H310 (38.1%): Fatal in contact with skin [Danger Acute toxicity, dermal] H311 (61.9%): Toxic in contact with skin [Danger Acute toxicity, dermal] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation] H335 (61.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H351 (100%): Suspected of causing cancer [Warning Carcinogenicity] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (61.9%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] H413 (38.1%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P201, P202, P260, P261, P262, P264, P270, P271, P273, P280, P281, P284, P301+P310, P302+P350, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H311: Toxic in contact with skin [Danger Acute toxicity, dermal] H315: Causes skin irritation [Warning Skin corrosion/irritation] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] H330: Fatal if inhaled [Danger Acute toxicity, inhalation] H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H351: Suspected of causing cancer [Warning Carcinogenicity] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P201, P202, P260, P261, P264, P270, P271, P273, P280, P281, P284, P301+P310, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H310: Fatal in contact with skin [Danger Acute toxicity, dermal] H315: Causes skin irritation [Warning Skin corrosion/irritation] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H351: Suspected of causing cancer [Warning Carcinogenicity] H360: May damage fertility or the unborn child [Danger Reproductive toxicity] H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] |
P201, P202, P260, P261, P262, P264, P270, P271, P280, P281, P301+P310, P302+P350, P302+P352, P304+P340, P305+P351+P338, P307+P311, P308+P313, P310, P312, P314, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Warning |
H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P273, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| rabbit | LDLo | subcutaneous | 100mg/kg (100mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 104, 1942. | |
| mouse | LD50 | intraperitoneal | 32mg/kg (32mg/kg) | Archives of Toxicology. Vol. 40, Pg. 63, 1978. | |
| duck | LD50 | oral | 380mg/kg (380mg/kg) | Down to Earth. Vol. 35, Pg. 25, 1979. | |
| rat | LD50 | skin | 96mg/kg (96mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 13(9), Pg. 58, 1969. | |
| mouse | LD50 | oral | 197mg/kg (197mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 106, 1982. | |
| guinea pig | LDLo | oral | 250mg/kg (250mg/kg) | Meditsinskii Zhurnal Uzbekistana. Vol. (9), Pg. 29, 1959. | |
| mouse | LD50 | intraperitoneal | 63700ug/kg (63.7mg/kg) | Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. Vol. 5, Pg. 119, 1956. | |
| rabbit | LD50 | oral | 328mg/kg (328mg/kg) | Meditsinskii Zhurnal Uzbekistana. Vol. (9), Pg. 29, 1959. | |
| guinea pig | LDLo | intratracheal | 120mg/kg (120mg/kg) | Meditsinskii Zhurnal Uzbekistana. Vol. (9), Pg. 29, 1959. | |
| guinea pig | LDLo | skin | 266mg/kg (266mg/kg) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 125, 1959. | |
| rabbit | LDLo | subcutaneous | 70mg/kg (70mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 104, 1942. | |
| man | LDLo | oral | 401mg/kg (401mg/kg) | Ecotoxicology and Environmental Safety. Vol. 1, Pg. 343, 1977. | |
| rat | LD50 | subcutaneous | 66mg/kg (66mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 104, 1942. | |
| frog | LD50 | unreported | 36mg/kg (36mg/kg) | Phytiatrie-Phytopharmacie. Vol. 1, Pg. 3, 1953. | |
| rabbit | LDLo | oral | 70mg/kg (70mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 104, 1942. | |
| rabbit | LDLo | skin | 250mg/kg (250mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 104, 1942. | |
| rat | LC50 | inhalation | 355mg/m3 (355mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 13(9), Pg. 58, 1969. | |
| rabbit | LDLo | intravenous | 22mg/kg (22mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 104, 1942. | |
| dog | LDLo | subcutaneous | 135mg/kg (135mg/kg) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 125, 1959. | |
| mouse | LDLo | intratracheal | 164mg/kg (164mg/kg) | Meditsinskii Zhurnal Uzbekistana. Vol. (9), Pg. 29, 1959. | |
| rabbit | LDLo | intraperitoneal | 50mg/kg (50mg/kg) | Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 239, 1941. | |
| rabbit | LDLo | skin | 40mg/kg (40mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 104, 1942. | |
| gerbil | LD50 | oral | 294mg/kg (294mg/kg) | Archives of Toxicology. Vol. 40, Pg. 63, 1978. | |
| rat | LD50 | oral | 27mg/kg (27mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 104, 1942. | |
| guinea pig | LC50 | inhalation | 341mg/m3/2H (341mg/m3) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 106, 1982. | |
| dog | LD50 | unreported | 70mg/kg (70mg/kg) | Phytiatrie-Phytopharmacie. Vol. 1, Pg. 3, 1953. | |
| mouse | LD50 | oral | 36mg/kg (36mg/kg) | Archives of Toxicology. Vol. 40, Pg. 63, 1978. | |
| mouse | LC50 | inhalation | 225mg/m3 (225mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 13(9), Pg. 58, 1969. | |
| mouse | LD50 | skin | 124mg/kg (124mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 106, 1982. | |
| rat | LDLo | intratracheal | 146mg/kg (146mg/kg) | Meditsinskii Zhurnal Uzbekistana. Vol. (9), Pg. 29, 1959. | |
| rat | LD50 | oral | 126mg/kg (126mg/kg) | Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. Vol. 13, Pg. 8, 1979. | |
| rat | LD50 | intraperitoneal | 56mg/kg (56mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 13, Pg. 20, 1958. | |
| dog | LDLo | subcutaneous | 135mg/kg (135mg/kg) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 123, 1959. | |
| hamster | LD50 | oral | 168mg/kg (168mg/kg) | Toxicology and Applied Pharmacology. Vol. 48, Pg. A192, 1979. | |
| mouse | LDLo | subcutaneous | 56mg/kg (56mg/kg) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 125, 1959. | |
| guinea pig | LD50 | unreported | 100mg/kg (100mg/kg) | Phytiatrie-Phytopharmacie. Vol. 1, Pg. 3, 1953. | |
| rabbit | LDLo | intraperitoneal | 135mg/kg (135mg/kg) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 123, 1959. | |
| mouse | LC50 | inhalation | 240mg/m3/2H (240mg/m3) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 106, 1982. | |
| 1-Hydroxy-2,3,4,5,6-pentachlorobenzene | 1-Hydroxy-2,4,5,6-pentachlorobenzene | 1-Hydroxypentachlorobenzene |
| 1y4z | 2, 3,4,5,6-Pentachlorophenol | 2,3,4,5,6-Pentachloro-Phenol |
| 2,3,4,5,6-Pentachlorophenol | 2,3,4,5,6-Pentachlorophenol (ACD/Name 4.0) | 2,3,4,5,6-Pentachlorophenol (Dowicide EC-7) |
| 2,3,4,5,6-Pentachlorophenol, technical grade | 2,4,5,6-Pentachlorophenol | 2646-EP2298313A1 |
| 33410-EP2275404A1 | 33410-EP2305662A1 | 33410-EP2311815A1 |
| 3998AC | 4rpn | 87-86-5 |
| AC-11105 | AD 73 | AI3-00134 |
| AKOS001075639 | Acutox | BDBM92749 |
| BIDD:ER0651 | BRD-K50711164-001-02-4 | BRD-K50711164-001-07-3 |
| BRN 1285380 | BSPBio_002433 | C02575 |
| CAS-87-86-5 | CCG-39355 | CCRIS 1663 |
| CHEBI:17642 | CHEMBL75967 | CM 613 |
| CP 1309 | Caswell No. 641 | Chem-Penta |
| Chem-Tol | Chlon | Chlorophen |
| Chlorophenasic acid | D9BSU0SE4T | DSSTox_CID_1106 |
| DSSTox_GSID_21106 | DSSTox_RID_75945 | DTXSID7021106 |
| DivK1c_006610 | Dow pentachlorophenol DP-2 antimicrobial | Dowcide 7 |
| Dowicide 7 | Dowicide 7 Antimicrobial | Dowicide EC-7 |
| Dowicide G (Salt/Mix) | Dura Treet II | Dura-Treet |
| Durotox | EINECS 201-778-6 | EN300-18735 |
| EP 30 | EP 30 (pesticide) | EPA Pesticide Chemical Code 063001 |
| FT-0673580 | Forepen | Forpen-50 Wood Preservative |
| Fungifen | Glazd penta | Grundier arbezol |
| HMS2232I10 | HMS3373L22 | HSDB 894 |
| IZUPBVBPLAPZRR-UHFFFAOYSA-N | InChI=1/C6HCl5O/c7-1-2(8)4(10)6(12)5(11)3(1)9/h12 | KBio1_001554 |
| KBio2_002417 | KBio2_004985 | KBio2_007553 |
| KBio3_001933 | KBioGR_001153 | KBioSS_002423 |
| LS-14 | Lauxtol | Lauxtol A |
| Liroprem | MB 333 | MCULE-1979998413 |
| MLS001066359 | MLS002454435 | NCGC00091143-01 |
| NCGC00091143-02 | NCGC00091143-03 | NCGC00091143-04 |
| NCGC00091143-05 | NCGC00091143-06 | NCGC00091143-07 |
| NCGC00253977-01 | NCGC00259680-01 | NCI-C54933 |
| NCI-C55378 | NCI-C55389 | NCI-C56655 |
| NCI60_003902 | NSC 263497 | NSC-263497 |
| NSC263497 | NSC40792 | Ontrack WE Herbicide |
| Ortho Triox Liquid Vegetation Killer | Osmoplastic | Osmose Wood Preserving Compound |
| Oz-88 | P0033 | PCP (pesticide) |
| PENTA | PKhF | Penchlorol |
| Penta Concentrate | Penta ready | Penta wr |
| Penta-Kil | Pentachloorfenol | Pentachloorfenol (DUTCH) |
| Pentachloorfenol [Dutch] | Pentachlorofenol | Pentachlorophenate |
| Pentachlorophenol (PCP) | Pentachlorophenol 10 microg/mL in Acetonitrile | Pentachlorophenol 10 microg/mL in Cyclohexane |
| Pentachlorophenol 10 microg/mL in Methanol | Pentachlorophenol 100 microg/mL in Methanol | Pentachlorophenol 1000 microg/mL in Methanol |
| Pentachlorophenol [BSI:ISO] | Pentachlorophenol [Polychlorophenols and their sodium salts] | Pentachlorophenol [UN3155] [Poison] |
| Pentachlorophenol [UN3155] [Poison] | Pentachlorophenol pure | Pentachlorophenol solution, 100 mug/mL in methanol, PESTANAL(R), analytical standard |
| Pentachlorophenol solution, certified reference material, 500 mug/mL in methanol | Pentachlorophenol solution, certified reference material, 5000 mug/mL in methanol | Pentachlorophenol, 97% |
| Pentachlorophenol, analytical standard | Pentachlorophenol, dowicide ec-7 | Pentachlorophenol, dp-2 |
| Pentachlorophenol, purified | Pentachlorophenol, technical | Pentachlorphenol |
| Pentachlorphenol (GERMAN) | Pentachlorphenol [German] | Pentaclorofenolo |
| Pentaclorofenolo (ITALIAN) | Pentaclorofenolo [Italian] | Pentacon |
| Penton 70 | Penwar | Peratox |
| Perchlorophenol | Permacide | Permagard |
| Permasan | Permatox | Permatox DP-2 |
| Permatox penta | Permite | Phenol, 2,3,4,5,6-pentachloro- |
| Phenol, pentachloro- | Phenol, pentachloro-, pure | Pkhfn (Salt/Mix) |
| Pol Nu | Pol-NU | Pole topper fluid |
| Preventol P | Preventol PN (Salt/Mix) | Priltox |
| Q423922 | QTL1_000066 | RCRA waste no. U242 |
| Rcra waste number U242 | SCHEMBL1492 | SGCUT00104 |
| SMR000471858 | SPBio_001720 | SPECTRUM330056 |
| Santobrite | Santobrite (Salt/Mix) | Santophen |
| Santophen 20 | Satophen | Sinituho |
| SpecPlus_000514 | Spectrum2_001870 | Spectrum3_000847 |
| Spectrum4_000687 | Spectrum5_002010 | Spectrum_001893 |
| TR-027615 | TRANSGENIC LECM (PENTACHLOROPHENOL) (SEE ALSOPENTACHLOROPHENOL) | Term-i-trol |
| Thompson's wood fix | Tox21_202131 | Tox21_300023 |
| UN3155 | UNII-AZ1041M258 component IZUPBVBPLAPZRR-UHFFFAOYSA-N | UNII-D9BSU0SE4T |
| W-104003 | WLN: QR BG CG DG EG FG | Watershed Wood Preservative |
| Weed and Brush Killer | Witophen P | Woodtreat A |
| Z90121614 | ZINC1529471 | bmse000697 |
| cryptogil oil | lauxt ol | pentachloro-Phenol |
| pentachlorophenol | pentachlorophenol dp-2 | pentachlorophenol,penta,pcp,penchlorol,santophen 20 |
| to_000075 |
| CAS Number | 131-52-2, 6338-69-8, 73927-19-2, 87-86-5 |
| PubChem Compound | 992 |
| KEGG Compound ID | C02575 |
| ChEBI | 17642 |
| ChemSpider | 967 |
| Wikipedia | Pentachlorophenol |