Compound

D0223 | Pentachlorophenol

Molecular Formula C6HCl5O
Molecular Weight 266.3
Structure
Description uncoupler

Toxicity Dose Time Species Model Method Action Positive criterion Reference
UNCOUPLING 253
MEMBRANE POTENTIAL 3.09±0.60 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 8.9 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 4.17±0.75 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]


H311: Toxic in contact with skin [Danger Acute toxicity, dermal]


H315: Causes skin irritation [Warning Skin corrosion/irritation]


H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H330: Fatal if inhaled [Danger Acute toxicity, inhalation]


H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


H351: Suspected of causing cancer [Warning Carcinogenicity]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P201, P202, P260, P261, P264, P270, P271, P273, P280, P281, P284, P301+P310, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

Aggregated GHS information provided by 21 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H300 (38.1%): Fatal if swallowed [Danger Acute toxicity, oral]


H301 (61.9%): Toxic if swallowed [Danger Acute toxicity, oral]


H310 (38.1%): Fatal in contact with skin [Danger Acute toxicity, dermal]


H311 (61.9%): Toxic in contact with skin [Danger Acute toxicity, dermal]


H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]


H335 (61.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]


H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410 (61.9%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


H413 (38.1%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P201, P202, P260, P261, P262, P264, P270, P271, P273, P280, P281, P284, P301+P310, P302+P350, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]


H311: Toxic in contact with skin [Danger Acute toxicity, dermal]


H315: Causes skin irritation [Warning Skin corrosion/irritation]


H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H330: Fatal if inhaled [Danger Acute toxicity, inhalation]


H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


H351: Suspected of causing cancer [Warning Carcinogenicity]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P201, P202, P260, P261, P264, P270, P271, P273, P280, P281, P284, P301+P310, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]


H310: Fatal in contact with skin [Danger Acute toxicity, dermal]


H315: Causes skin irritation [Warning Skin corrosion/irritation]


H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


H351: Suspected of causing cancer [Warning Carcinogenicity]


H360: May damage fertility or the unborn child [Danger Reproductive toxicity]


H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]


H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


P201, P202, P260, P261, P262, P264, P270, P271, P280, P281, P301+P310, P302+P350, P302+P352, P304+P340, P305+P351+P338, P307+P311, P308+P313, P310, P312, P314, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P273, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rabbit LDLo subcutaneous 100mg/kg (100mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 104, 1942.
mouse LD50 intraperitoneal 32mg/kg (32mg/kg) Archives of Toxicology. Vol. 40, Pg. 63, 1978.
duck LD50 oral 380mg/kg (380mg/kg) Down to Earth. Vol. 35, Pg. 25, 1979.
rat LD50 skin 96mg/kg (96mg/kg) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 13(9), Pg. 58, 1969.
mouse LD50 oral 197mg/kg (197mg/kg) "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 106, 1982.
guinea pig LDLo oral 250mg/kg (250mg/kg) Meditsinskii Zhurnal Uzbekistana. Vol. (9), Pg. 29, 1959.
mouse LD50 intraperitoneal 63700ug/kg (63.7mg/kg) Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. Vol. 5, Pg. 119, 1956.
rabbit LD50 oral 328mg/kg (328mg/kg) Meditsinskii Zhurnal Uzbekistana. Vol. (9), Pg. 29, 1959.
guinea pig LDLo intratracheal 120mg/kg (120mg/kg) Meditsinskii Zhurnal Uzbekistana. Vol. (9), Pg. 29, 1959.
guinea pig LDLo skin 266mg/kg (266mg/kg) "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 125, 1959.
rabbit LDLo subcutaneous 70mg/kg (70mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 104, 1942.
man LDLo oral 401mg/kg (401mg/kg) Ecotoxicology and Environmental Safety. Vol. 1, Pg. 343, 1977.
rat LD50 subcutaneous 66mg/kg (66mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 104, 1942.
frog LD50 unreported 36mg/kg (36mg/kg) Phytiatrie-Phytopharmacie. Vol. 1, Pg. 3, 1953.
rabbit LDLo oral 70mg/kg (70mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 104, 1942.
rabbit LDLo skin 250mg/kg (250mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 104, 1942.
rat LC50 inhalation 355mg/m3 (355mg/m3) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 13(9), Pg. 58, 1969.
rabbit LDLo intravenous 22mg/kg (22mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 104, 1942.
dog LDLo subcutaneous 135mg/kg (135mg/kg) "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 125, 1959.
mouse LDLo intratracheal 164mg/kg (164mg/kg) Meditsinskii Zhurnal Uzbekistana. Vol. (9), Pg. 29, 1959.
rabbit LDLo intraperitoneal 50mg/kg (50mg/kg) Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 239, 1941.
rabbit LDLo skin 40mg/kg (40mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 104, 1942.
gerbil LD50 oral 294mg/kg (294mg/kg) Archives of Toxicology. Vol. 40, Pg. 63, 1978.
rat LD50 oral 27mg/kg (27mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 104, 1942.
guinea pig LC50 inhalation 341mg/m3/2H (341mg/m3) "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 106, 1982.
dog LD50 unreported 70mg/kg (70mg/kg) Phytiatrie-Phytopharmacie. Vol. 1, Pg. 3, 1953.
mouse LD50 oral 36mg/kg (36mg/kg) Archives of Toxicology. Vol. 40, Pg. 63, 1978.
mouse LC50 inhalation 225mg/m3 (225mg/m3) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 13(9), Pg. 58, 1969.
mouse LD50 skin 124mg/kg (124mg/kg) "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 106, 1982.
rat LDLo intratracheal 146mg/kg (146mg/kg) Meditsinskii Zhurnal Uzbekistana. Vol. (9), Pg. 29, 1959.
rat LD50 oral 126mg/kg (126mg/kg) Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. Vol. 13, Pg. 8, 1979.
rat LD50 intraperitoneal 56mg/kg (56mg/kg) British Journal of Pharmacology and Chemotherapy. Vol. 13, Pg. 20, 1958.
dog LDLo subcutaneous 135mg/kg (135mg/kg) "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 123, 1959.
hamster LD50 oral 168mg/kg (168mg/kg) Toxicology and Applied Pharmacology. Vol. 48, Pg. A192, 1979.
mouse LDLo subcutaneous 56mg/kg (56mg/kg) "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 125, 1959.
guinea pig LD50 unreported 100mg/kg (100mg/kg) Phytiatrie-Phytopharmacie. Vol. 1, Pg. 3, 1953.
rabbit LDLo intraperitoneal 135mg/kg (135mg/kg) "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 123, 1959.
mouse LC50 inhalation 240mg/m3/2H (240mg/m3) "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 106, 1982.


  • 1-Hydroxy-2,3,4,5,6-pentachlorobenzene 1-Hydroxy-2,4,5,6-pentachlorobenzene 1-Hydroxypentachlorobenzene
    1y4z 2, 3,4,5,6-Pentachlorophenol 2,3,4,5,6-Pentachloro-Phenol
    2,3,4,5,6-Pentachlorophenol 2,3,4,5,6-Pentachlorophenol (ACD/Name 4.0) 2,3,4,5,6-Pentachlorophenol (Dowicide EC-7)
    2,3,4,5,6-Pentachlorophenol, technical grade 2,4,5,6-Pentachlorophenol 2646-EP2298313A1
    33410-EP2275404A1 33410-EP2305662A1 33410-EP2311815A1
    3998AC 4rpn 87-86-5
    AC-11105 AD 73 AI3-00134
    AKOS001075639 Acutox BDBM92749
    BIDD:ER0651 BRD-K50711164-001-02-4 BRD-K50711164-001-07-3
    BRN 1285380 BSPBio_002433 C02575
    CAS-87-86-5 CCG-39355 CCRIS 1663
    CHEBI:17642 CHEMBL75967 CM 613
    CP 1309 Caswell No. 641 Chem-Penta
    Chem-Tol Chlon Chlorophen
    Chlorophenasic acid D9BSU0SE4T DSSTox_CID_1106
    DSSTox_GSID_21106 DSSTox_RID_75945 DTXSID7021106
    DivK1c_006610 Dow pentachlorophenol DP-2 antimicrobial Dowcide 7
    Dowicide 7 Dowicide 7 Antimicrobial Dowicide EC-7
    Dowicide G (Salt/Mix) Dura Treet II Dura-Treet
    Durotox EINECS 201-778-6 EN300-18735
    EP 30 EP 30 (pesticide) EPA Pesticide Chemical Code 063001
    FT-0673580 Forepen Forpen-50 Wood Preservative
    Fungifen Glazd penta Grundier arbezol
    HMS2232I10 HMS3373L22 HSDB 894
    IZUPBVBPLAPZRR-UHFFFAOYSA-N InChI=1/C6HCl5O/c7-1-2(8)4(10)6(12)5(11)3(1)9/h12 KBio1_001554
    KBio2_002417 KBio2_004985 KBio2_007553
    KBio3_001933 KBioGR_001153 KBioSS_002423
    LS-14 Lauxtol Lauxtol A
    Liroprem MB 333 MCULE-1979998413
    MLS001066359 MLS002454435 NCGC00091143-01
    NCGC00091143-02 NCGC00091143-03 NCGC00091143-04
    NCGC00091143-05 NCGC00091143-06 NCGC00091143-07
    NCGC00253977-01 NCGC00259680-01 NCI-C54933
    NCI-C55378 NCI-C55389 NCI-C56655
    NCI60_003902 NSC 263497 NSC-263497
    NSC263497 NSC40792 Ontrack WE Herbicide
    Ortho Triox Liquid Vegetation Killer Osmoplastic Osmose Wood Preserving Compound
    Oz-88 P0033 PCP (pesticide)
    PENTA PKhF Penchlorol
    Penta Concentrate Penta ready Penta wr
    Penta-Kil Pentachloorfenol Pentachloorfenol (DUTCH)
    Pentachloorfenol [Dutch] Pentachlorofenol Pentachlorophenate
    Pentachlorophenol (PCP) Pentachlorophenol 10 microg/mL in Acetonitrile Pentachlorophenol 10 microg/mL in Cyclohexane
    Pentachlorophenol 10 microg/mL in Methanol Pentachlorophenol 100 microg/mL in Methanol Pentachlorophenol 1000 microg/mL in Methanol
    Pentachlorophenol [BSI:ISO] Pentachlorophenol [Polychlorophenols and their sodium salts] Pentachlorophenol [UN3155] [Poison]
    Pentachlorophenol [UN3155] [Poison] Pentachlorophenol pure Pentachlorophenol solution, 100 mug/mL in methanol, PESTANAL(R), analytical standard
    Pentachlorophenol solution, certified reference material, 500 mug/mL in methanol Pentachlorophenol solution, certified reference material, 5000 mug/mL in methanol Pentachlorophenol, 97%
    Pentachlorophenol, analytical standard Pentachlorophenol, dowicide ec-7 Pentachlorophenol, dp-2
    Pentachlorophenol, purified Pentachlorophenol, technical Pentachlorphenol
    Pentachlorphenol (GERMAN) Pentachlorphenol [German] Pentaclorofenolo
    Pentaclorofenolo (ITALIAN) Pentaclorofenolo [Italian] Pentacon
    Penton 70 Penwar Peratox
    Perchlorophenol Permacide Permagard
    Permasan Permatox Permatox DP-2
    Permatox penta Permite Phenol, 2,3,4,5,6-pentachloro-
    Phenol, pentachloro- Phenol, pentachloro-, pure Pkhfn (Salt/Mix)
    Pol Nu Pol-NU Pole topper fluid
    Preventol P Preventol PN (Salt/Mix) Priltox
    Q423922 QTL1_000066 RCRA waste no. U242
    Rcra waste number U242 SCHEMBL1492 SGCUT00104
    SMR000471858 SPBio_001720 SPECTRUM330056
    Santobrite Santobrite (Salt/Mix) Santophen
    Santophen 20 Satophen Sinituho
    SpecPlus_000514 Spectrum2_001870 Spectrum3_000847
    Spectrum4_000687 Spectrum5_002010 Spectrum_001893
    TR-027615 TRANSGENIC LECM (PENTACHLOROPHENOL) (SEE ALSOPENTACHLOROPHENOL) Term-i-trol
    Thompson's wood fix Tox21_202131 Tox21_300023
    UN3155 UNII-AZ1041M258 component IZUPBVBPLAPZRR-UHFFFAOYSA-N UNII-D9BSU0SE4T
    W-104003 WLN: QR BG CG DG EG FG Watershed Wood Preservative
    Weed and Brush Killer Witophen P Woodtreat A
    Z90121614 ZINC1529471 bmse000697
    cryptogil oil lauxt ol pentachloro-Phenol
    pentachlorophenol pentachlorophenol dp-2 pentachlorophenol,penta,pcp,penchlorol,santophen 20
    to_000075

    CAS Number 131-52-2, 6338-69-8, 73927-19-2, 87-86-5
    PubChem Compound 992
    KEGG Compound ID C02575
    ChEBI 17642
    ChemSpider 967
    Wikipedia Pentachlorophenol