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Drug

D0331 | Clofarabine

Molecular Formula C10H11ClFN5O3
Molecular Weight 303.68
Structure
State solid
Clearance * 28.8 L/h/m2 [Pediatric patients (2 - 19 years old) with relapsed or refractory acute lymphoblastic leukemia (ALL) or acute myelogenous leukemia (AML) receiving 52 mg/m2 dose]
Volume of distribution * 172 L/m2
Route of elimination Based on 24-hour urine collections in the pediatric studies, 49 - 60% of the dose is excreted in the urine unchanged.
Protein binding 47% bound to plasma proteins, predominantly to albumin.
Half life The terminal half-life is estimated to be 5.2 hours.
Trade names Clolar, Evoltra
Description synthetic purine nucleoside; antimetabolite antineoplastic agent

L

L01BB06 Clofarabine


[L01BB] Purine analogues


[L01B] ANTIMETABOLITES


[L01] ANTINEOPLASTIC AGENTS


[L] Antineoplastic and immunomodulating agents

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 284

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 46 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H300 (84.78%): Fatal if swallowed [Danger Acute toxicity, oral]


H341 (13.04%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]


H360 (13.04%): May damage fertility or the unborn child [Danger Reproductive toxicity]


H372 (13.04%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P201, P202, P260, P264, P270, P281, P301+P310, P308+P313, P314, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

  • Acute leukaemia

  • Acute lymphocytic leukaemia

  • Acute myeloid leukaemia

  • Anxiety (0.0012)

  • Asthenia (0.0014)

  • Body temperature increased (0.0019)

  • Dermatitis (0.0021)

  • Diarrhoea (0.002)

  • Fatigue (0.0014)

  • Flushing (0.0011)

  • Headache (0.0024)

  • Leukopenia (0.00877)

  • Lymphopenia (0.00823)

  • Mucosal inflammation (0.0011)

  • Neutropenia (0.00637)

  • Pruritus (0.002)

  • Rash (0.0021)

  • Tachycardia (0.0035)

  • Vomiting (0.0059)

  • Alanine aminotransferase increased

  • Anaemia

  • Aspartate aminotransferase increased

  • Blood bilirubin increased

  • Blood creatinine increased

  • Thrombocytopenia

    • (2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol (2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol (2R,3R,4S,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
    (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine 123318-82-1
    2-Chloro-9-(2-Deoxy-2-Fluoro-B -D-Arabinofuranosyl)-9h-Purin-6-Amine 2-Chloro-9-(2-deoxy-2-fluoro-?-D-arabinofuranosyl)-9H-purin-6-amine 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine
    2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine 2-Cl-2'-F-araA
    2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-adenine 318C821
    3S211048 5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol 762RDY0Y2H
    9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)- 9H-Purine-6-amine,2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)- AB00430247-03
    AB00430247-04 AB00430247_06 AC-274
    ACT05522 AKOS005063562 AKOS015919355
    API0002064 AS-12958 BCP0726000280
    BCP23422 BCP9000540 BDBM50247921
    BIFK0045 C-18934 C1-F-Ara-A
    C10H11ClFN5O3 CAFdA CAS-123318-82-1
    CC-25917 CFB CHEBI:681569
    CHEMBL1750 CS-0373 Cl-F-Ara-A
    Cl-F-araA Clofarabin Clofarabine
    Clofarabine (JAN/USAN/INN) Clofarabine [USAN:INN:BAN] Clofarabine [USAN]
    Clofarabine, >=98% (HPLC) Clofarabine,Clolar, Evoltra Clofarex
    Clolar Clolar (TN) D03546
    DB00631 DSSTox_CID_26437 DSSTox_GSID_46437
    DSSTox_RID_81613 DTXSID5046437 Evoltra
    FT-0082882 FT-0601617 GTPL6802
    HMS2090A07 HMS3413J15 HMS3677J15
    HY-A0005 KS-00000650 LS-126466
    MCULE-2276059681 MFCD00871077 MLS003915615
    NCGC00164553-01 NCGC00164553-02 PubChem19116
    Q5134875 SAR-393590 SB17339
    SC-22779 SCHEMBL9040 SMR002530055
    SR-01000930565 SR-01000930565-3 ST24046359
    SW218080-2 Tox21_112182 Tox21_112182_1
    UNII-762RDY0Y2H W-5182 WDDPHFBMKLOVOX-AYQXTPAHSA-N
    Z1557400138 ZINC3798247 clofarabina
    clofarabinum s1218

    DrugBank Name Clofarabine
    DrugBank DB00631
    CAS Number 123318-82-1
    PubChem Compound 119182
    KEGG Drug D03546
    PubChem.Substance 46504968
    ChEBI 681569
    PharmGKB PA164754863
    ChemSpider 106472
    TTD DAP000849
    Wikipedia Clofarabine
    HET CFB
    DPD 20504