Drug
D0355 | Hexachlorophene
D
D08AE01 Hexachlorophene
[D08AE] Phenol and derivatives
[D08A] ANTISEPTICS AND DISINFECTANTS
[D08] ANTISEPTICS AND DISINFECTANTS
[D] Dermatological drugs
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| UNCOUPLING | increase | 42 | ||||||
| MEMBRANE POTENTIAL | 0.70±0.46 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 0.63 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 1.00±0.74 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| GLUCOSE GALACTOSE IC50 RATIO | 1.6 | LUHMES (Lund human mesencephalic) cells | Glc–Gal–NeuriTox assay | Negative | EC25(NA) [Glc/Gal] | 326 | ||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
  |
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H311: Toxic in contact with skin [Danger Acute toxicity, dermal] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P264, P270, P273, P280, P301+P310, P302+P352, P312, P321, P322, P330, P361, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
Aggregated GHS information provided by 207 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] H311 (100%): Toxic in contact with skin [Danger Acute toxicity, dermal] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P273, P280, P301+P310, P302+P352, P312, P321, P322, P330, P361, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
 |
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H311: Toxic in contact with skin [Danger Acute toxicity, dermal] H361d: Suspected of damaging the unborn child [Warning Reproductive toxicity] H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P201, P202, P260, P264, P270, P273, P280, P281, P301+P310, P302+P352, P307+P311, P308+P313, P312, P314, P321, P322, P330, P361, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] |
P201, P202, P260, P264, P270, P281, P301+P310, P307+P311, P308+P313, P314, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| child | LDLo | oral | 250mg/kg (250mg/kg) | Medical Journal of Australia. Vol. 1, Pg. 737, 1963. | |
| rabbit | LD50 | oral | 40690ug/kg (40.69mg/kg) | Teratology, The International Journal of Abnormal Development. Vol. 20, Pg. 413, 1979. | |
| rat | LD50 | skin | 1840mg/kg (1840mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 47(10), Pg. 26, 1982. | |
| infant | TDLo | oral | 257mg/kg/7D-I (257mg/kg) | American Journal of Diseases of Children. Vol. 111, Pg. 333, 1966. | |
| mouse | LD50 | intraperitoneal | 20mg/kg (20mg/kg) | Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe A: Medizinische Mikrobiologie und Parasitologie. Vol. 234, Pg. 110, 1976. | |
| dog | LDLo | intravenous | 5mg/kg (5mg/kg) | Surgery. Vol. 24, Pg. 542, 1948. | |
| rabbit | LD50 | intravenous | 8500ug/kg (8.5mg/kg) | Journal of the Society of Cosmetic Chemists. Vol. 20, Pg. 173, 1969. | |
| guinea pig | LDLo | intraperitoneal | 25mg/kg (25mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 163, Pg. 210, 1966. | |
| women | TDLo | oral | 600mg/kg (600mg/kg) | JAMA, Journal of the American Medical Association. Vol. 181, Pg. 587, 1962. | |
| guinea pig | LD50 | skin | 1100mg/kg (1100mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 47(10), Pg. 26, 1982. | |
| rat | LD50 | intravenous | 7500ug/kg (7.5mg/kg) | Toxicology and Applied Pharmacology. Vol. 25, Pg. 332, 1973. | |
| mouse | LD50 | skin | 270mg/kg (270mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 47(10), Pg. 26, 1982. | |
| rat | LD50 | subcutaneous | 7650ug/kg (7.65mg/kg) | Industrial Medicine and Surgery. Vol. 38, Pg. 64, 1969. | |
| rat | LD50 | intraperitoneal | 22mg/kg (22mg/kg) | Toxicology and Applied Pharmacology. Vol. 24, Pg. 239, 1973. | |
| mouse | LD50 | subcutaneous | 46mg/kg (46mg/kg) | Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. Vol. 16, Pg. 13, 1961. | |
| guinea pig | LD50 | oral | 60mg/kg (60mg/kg) | Drugs in Japan Vol. 6, Pg. 742, 1982. | |
| dog | LDLo | oral | 40mg/kg (40mg/kg) | Veterinarski Arhiv. Veterinary Archives. Vol. 35, Pg. 35, 1965. | |
| rat | LC50 | inhalation | 340mg/m3 (340mg/m3) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 49(8), Pg. 25, 1984. | |
| rat | LD50 | oral | 56mg/kg (56mg/kg) | Toxicology and Applied Pharmacology. Vol. 25, Pg. 332, 1973. | |
| domestic animals - goat/sheep | LD50 | oral | 30mg/kg (30mg/kg) | Annals of the New York Academy of Sciences. Vol. 320, Pg. 426, 1979. | |
| mouse | LD50 | oral | 67mg/kg (67mg/kg) | Chinese Medical Journal Vol. 82, Pg. 691, 1963. | |
| mouse | LC50 | inhalation | 290mg/m3 (290mg/m3) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 49(8), Pg. 25, 1984. | |
| 0895AC | 2,2',3,3',5,5'-Hexachloro-6,6'-dihydroxydiphenylmethane | 2,2'-Dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane |
| 2,2'-Dihydroxy-3,5,6,3',5',6'-hexachlorodiphenylmethane | 2,2'-Methylene bis(3,4,6-trichlorophenol) | 2,2'-Methylenebis(3,4,6-trichlorophenol) |
| 2,2'-Methylenebis[3,4,6-trichlorophenol] | 2,2'-methanediylbis(3,4,6-trichlorophenol) | 2,2-Methylenebis(3,4,6-Trichlorophenol) |
| 2,3',5,5',6,6'-hexachlorodiphenylmethane | 2,3,3',5,5'-Hexachloro-6,6'-dihydroxydiphenylmethane | 2,4,6-trichlorophenol] |
| 2,5,6,3',5',6'-hexachlorodiphenylmethane | 2,5,6-trichlorophenol) | 3,3',5,5',6,6'-Hexachloro-2,2'-dihydroxydiphenylmethane |
| 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxy-phenyl)methyl]phenol | 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol | 3,4,6-trichloro-2-[(3,5,6-trichloro-2-hydroxyphenyl)methyl]phenol |
| 6,6'-Methylenebis(2,4,5-trichlorophenol) | 6,6-Methylenebis(2,4,5-trichlorophenol) | 70-30-4 |
| AB00052010_17 | ACGUYXCXAPNIKK-UHFFFAOYSA-N | AI3-02372 |
| AKOS005449243 | API0002904 | AS-10068 |
| AT 7 | AT-7 | Acigena |
| Almederm | Armohex | At-17 |
| B & b Flea Kontroller for Dogs Only | B 32 | B 32 (VAN) |
| B32 | BDBM31712 | BIDD:ER0608 |
| BIDD:GT0722 | BP-30177 | BRD-K99792991-001-02-6 |
| BRD-K99792991-001-18-2 | BRN 2064407 | BSPBio_002100 |
| Bilevon | Bis(2,3,5-tric hloro-6-hydroxyphenyl)methane | Bis(2,3,5-trichloro-6-hydroxyphenyl)methane |
| Bis(2-hydroxy-3,5,6-trichlorophenyl)methane | Bis(2-hydroxy-3,6-trichlorophenyl)methane | Bis(3,5,6-trichloro-2-hydroxyphenyl)-methane |
| Bis(3,5,6-trichloro-2-hydroxyphenyl)methane | Bis(3,6-trichloro-2-hydroxyphenyl)methane | Bis-(2-hydroxy-3,5,6-trichlorophenyl)methane |
| Bis-2,3,5-trichlor-6-hydroxyfenylmethan | Bis-2,3,5-trichloro-6-hydroxyfenylmethan | Bis-2,3,5-trichloro-6-hydroxyfenylmethan [Czech] |
| Bis-2,5-trichlor-6-hydroxyfenylmethan | Bis[3,4,6-trichlorophenol], 2,2'-methylene- | Bivelon |
| Blockade Anti Bacterial Finish | Brevity Blue Liquid Bacteriostatic Scouring Cream | Brevity Blue Liquid Sanitizing Scouring Cream |
| C08039 | C13H6Cl6O2 | CAS-70-30-4 |
| CCG-39768 | CCRIS 331 | CHEBI:5693 |
| CHEMBL496 | CPD000058356 | CS-3866 |
| CTK9A1850 | Caswell No. 566 | Compound G-11 |
| Cotofilm | D00859 | DB00756 |
| DSSTox_CID_690 | DSSTox_GSID_20690 | DSSTox_RID_75738 |
| DTXSID6020690 | Dermadex | Distodin |
| DivK1c_000630 | EINECS 200-733-8 | EPA Pesticide Chemical Code 044901 |
| Eleven | En-Viron D Concentrated Phenolic Disinfectant | Enditch Pet Shampoo |
| Esaclorofene | Esaclorofene [DCIT] | Exofene |
| FT-0626955 | Fascol | Fesia-sin |
| Fo stril | Fomac | Fostril |
| G-11 | G-Eleven | G-II |
| GERMA-MEDICA "MG" | Gamophen | Gamophene |
| Germa-Medica | HMS1920D07 | HMS2091J13 |
| HMS3259C19 | HMS3715P21 | HMS501P12 |
| HSDB 224 | HY-12637 | Hexa-Germ |
| Hexabalm | Hexachlorofen | Hexachlorofen [Czech] |
| Hexachlorophane | Hexachlorophen | Hexachlorophene (USP/INN) |
| Hexachlorophene 5000 microg/mL in Dichloromethane | Hexachlorophene 5000 microg/mL in Methanol | Hexachlorophene [INN] |
| Hexachlorophene [UN2875] [Poison] | Hexachlorophene [USP:INN:BAN] | Hexachlorophene, PESTANAL(R), analytical standard |
| Hexachlorophene, United States Pharmacopeia (USP) Reference Standard | Hexachlorophenone | Hexachlorophenum |
| Hexachlorophenum [INN-Latin] | Hexaclorofeno | Hexaclorofeno [INN-Spanish] |
| Hexafen | Hexaphene-LV | Hexascrub |
| Hexide | Hexophene | Hexosan |
| Hilo Cat Flea Powder | Hilo Flea Powder | IDI1_000630 |
| IWW5FV6NK2 | KBio1_000630 | KBio2_001347 |
| KBio2_003915 | KBio2_006483 | KBio3_001320 |
| KBioGR_001006 | KBioSS_001347 | KSC-19-051 |
| KSC-285-117-1 | KUC106447N | KUC112427N |
| LS-1597 | M0219 | MCULE-3028228047 |
| MFCD00002171 | MLS-0072923.0001 | MLS000028433 |
| MLS001148404 | MLS002152906 | Methane, bis(2,3,5-trichloro-6-hydroxyphenyl) |
| Methane, bis(2,3,5-trichloro-6-hydroxyphenyl)- | Methane,3,5-trichloro-6-hydroxyphenyl) | Methylenebis(3,4,6-trichlorophenol) |
| NC00512 | NCGC00091195-01 | NCGC00091195-02 |
| NCGC00091195-03 | NCGC00091195-04 | NCGC00091195-05 |
| NCGC00091195-06 | NCGC00091195-07 | NCGC00091195-08 |
| NCGC00256580-01 | NCGC00258902-01 | NCI-C02653 |
| NINDS_000630 | NSC 49115 | NSC-49115 |
| NSC-757055 | NSC-9887 | NSC49115 |
| NSC757055 | NSC9887 | Nabac |
| Nabac 25 ec | Neosept V | Opera_ID_504 |
| PRE-OP II | Pedigree Dog Shampoo Bar | Pharmakon1600-01500328 |
| Phenol, 2,2'-methylenebis(3,4,6-trichloro)- | Phenol, 2,2'-methylenebis(3,4,6-trichloro- | Phenol, 2,2'-methylenebis[3,4,6-trichloro- |
| Phenol,2'-methylenebis[3,4,6-trichloro- | Phenol,2'-methylenebis[3,5,6-trichloro- | Phiso-Scrub |
| Phisodan | Phisohex (TN) | Pre-Op |
| Q425362 | RCRA waste no. U132 | REGID_for_CID_3598 |
| Rcra waste number U132 | Ritosept | SAM002554903 |
| SBB058855 | SBI-0051403.P003 | SC-51022 |
| SCHEMBL15579 | SMR000058356 | SPBio_001210 |
| SPECTRUM1500328 | SR-01000721924 | SR-01000721924-2 |
| SR-01000721924-5 | SR-01000721924-6 | ST24029562 |
| ST50880633 | STK377478 | Scrubteam Surgical Spongebrush |
| Septi-Soft | Septisol | Septofen |
| Solu-Heks | Soy-dome | Spectrum2_001105 |
| Spectrum3_000450 | Spectrum4_000573 | Spectrum5_000792 |
| Spectrum_000867 | Staphene O | Ster-zac |
| Steral | Steraskin | Surgi-Cen |
| Surgi-Cin | Surofene | TR-023301 |
| TRICHLOROPHENE | Tersaseptic | Thera-Groom Pet Shampoo for Dogs for Veterinary Use Only |
| Tox21_111099 | Tox21_111099_1 | Tox21_201350 |
| Tox21_302741 | Trisophen | Turgex |
| UN 2875 | UN2875 | UNII-IWW5FV6NK2 |
| WLN: QR BG DG EG F1R BQ CG EG FG | ZINC1530968 | cid_3598 |
| hexachlorophene | pHisoHex | s4632 |
| DrugBank Name | Hexachlorophene |
| DrugBank | DB00756 |
| CAS Number | 139411-96-4, 3247-34-5, 70-30-4 |
| PubChem Compound | 3598 |
| KEGG Compound ID | C08039 |
| KEGG Drug | D00859 |
| PubChem.Substance | 46505858 |
| ChEBI | 5693 |
| PharmGKB | PA449871 |
| ChemSpider | 3472 |
| BindingDB | 31712.0 |
| TTD | DAP001050 |
| Wikipedia | Hexachlorophene |
| HET | H3P |
| DPD | 9751 |