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Drug

D0366 | Mebendazole

Molecular Formula C16H13N3O3
Molecular Weight 295.29
Structure
State solid
Route of elimination In man, approximately 2% of administered mebendazole is excreted in urine and the remainder in the feces as unchanged drug or a primary metabolite.
Protein binding 90-95%
Half life 2.5 to 5.5 hours (range 2.5 to 9 hours) in patients with normal hepatic function. Approximately 35 hours in patients with impaired hepatic function (cholestasis).
Absorption Poorly absorbed (approximately 5 to 10%) from gastrointestinal tract. Fatty food increases absorption.

P

P02CA51 Mebendazole, combinations


[P02CA] Benzimidazole derivatives


[P02C] ANTINEMATODAL AGENTS


[P02] ANTHELMINTICS


[P] Antiparasitic products, insecticides and repellents

P02CA01 Mebendazole


[P02CA] Benzimidazole derivatives


[P02C] ANTINEMATODAL AGENTS


[P02] ANTHELMINTICS


[P] Antiparasitic products, insecticides and repellents

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 2.45±0.34 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 2.34 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL rat hepatocytes MMP assay Negative IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 73 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H302 (98.63%): Harmful if swallowed [Warning Acute toxicity, oral]


H400 (13.7%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P264, P270, P273, P301+P312, P330, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
domestic animals - goat/sheep LD50 oral > 80mg/kg (80mg/kg) United States Patent Document. Vol. #3657267,
chicken LD50 unreported > 40mg/kg (40mg/kg) United States Patent Document. Vol. #3657267,
cat LD50 oral > 640mg/kg (640mg/kg) Toxicology and Applied Pharmacology. Vol. 24, Pg. 371, 1973.
rat LD50 oral 714mg/kg (714mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 735, 1988.
mouse LD50 intraperitoneal 712mg/kg (712mg/kg) Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. Vol. 48(4), Pg. 29, 1979.
rat LD50 intramuscular 350mg/kg (350mg/kg) Drugs in Japan Vol. -, Pg. 1207, 1990.
guinea pig LD50 oral > 1280mg/kg (1280mg/kg) Toxicology and Applied Pharmacology. Vol. 24, Pg. 371, 1973.
dog LD intramuscular > 2gm/kg (2000mg/kg) Drugs in Japan Vol. -, Pg. 1207, 1990.
dog LD50 oral 1280mg/kg (1280mg/kg) Drugs in Japan Vol. -, Pg. 1207, 1990.
rabbit LD50 oral > 640mg/kg (640mg/kg) Toxicology and Applied Pharmacology. Vol. 24, Pg. 371, 1973.
mouse LD50 oral 620mg/kg (620mg/kg) Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. Vol. 47(6), Pg. 48, 1978.

  • Ascariasis

  • Diarrhoea

  • Enterobiasis

  • Hookworm infection

  • Trichuriasis

    • (5-Benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester (5-Benzoyl-1H-benzimidazol-2-yl)carbamic acid methyl ester (5-benzoyl-1(3)H-benzoimidazol-2-yl)-carbamic acid methyl ester;
    2-Benzimidazolecarbamic acid, 5-benzoyl-, methyl ester 2-Benzimidazolecarbamic acid, 5-benzoyl-, methyl ester (8CI) 31431-39-7
    431M397 5-Benzoyl-2-benzimidazolecarbamic acid methyl ester 5-Benzoyl-2-benzimidazolecarbamic acid methyl ester
    5-Benzoyl-2-benzimidazolecarbamic acid, methyl ester 5-benzoyl-1H-benzimidazol-2-yl carbamic acid methyl ester 81G6I5V05I
    A820852 AB00052203 AB00052203-09
    AB00052203_10 AB1009303 AC-12064
    AG-205/04588045 AK-97348 AKOS000539066
    AKOS015896232 ANW-54402 AS-12272
    BBL008298 BDBM50180753 BIDD:GT0087
    BPBio1_000257 BRD-K77987382-001-01-7 BRD-K77987382-001-06-6
    BRD-K77987382-001-08-2 BSPBio_000233 BSPBio_003178
    Bantenol Besantin CAS-31431-39-7
    CBDivE_010559 CCG-39628 CCRIS 4479
    CHEBI:6704 CHEMBL685 CPD000036734
    CS-3974 CTK6J2930 CTK8B6803
    Cambridge id 5250893 Carbamic acid, (5-benzoyl-1H-benzimidazol-2-yl)-, methyl ester Carbamic acid, (5-benzoyl-1H-benzimidazol-2-yl)-, methyl ester (9CI)
    Carbamic acid, N-(5-benzoylbenzimidazol-2-yl)-, methyl ester D00368 DB00643
    DSSTox_CID_20682 DSSTox_GSID_40682 DSSTox_RID_79538
    DTXSID4040682 DivK1c_000751 EBD12117
    EINECS 250-635-4 EN300-50844 Emverm
    Equivurm Plus Equivurmp Plus FT-0628179
    FT-0628180 HMS1536H11 HMS1568L15
    HMS1921F03 HMS2090B03 HMS2092B15
    HMS2095L15 HMS3259B11 HMS3604N11
    HMS3712L15 HMS502F13 HSDB 3232
    HY-17595 IDI1_000751 KBio1_000751
    KBio2_001778 KBio2_004346 KBio2_006914
    KBio3_002398 KBioGR_000712 KBioSS_001778
    KS-00000F1I LS-48951 Lomper
    M2273 MBDZ MCULE-4133611535
    MFCD00057872 MLS000028491 MLS006011879
    MMV003152 Mebatreat Mebendazol
    Mebendazol Mebendazol [INN-Spanish] Mebendazole (JAN/USP/INN)
    Mebendazole Polymorph C, United States Pharmacopeia (USP) Reference Standard Mebendazole [USAN:INN:BAN:JAN] Mebendazole [USAN:USP:INN:BAN:JAN]
    Mebendazole for system suitability, European Pharmacopoeia (EP) Reference Standard Mebendazole, European Pharmacopoeia (EP) Reference Standard Mebendazole, United States Pharmacopeia (USP) Reference Standard
    Mebendazole, VETRANAL(TM), analytical standard Mebendazole, analytical standard, >=98% (HPLC) Mebendazole,(S)
    Mebendazolum Mebendazolum [INN-Latin] Mebenoazole
    Mebenvet Mebex Mebutar
    Methyl (5-benzoyl-1H-benzo[d]imidazol-2-yl)carbamate Methyl (6-benzoyl-1H-benzimidazol-2-yl)carbamate Methyl 5-benzoyl benzimidazole-2-carbamate
    Methyl 5-benzoyl-2-benzimidazolecarbamate Methyl 5-benzoyl-2-benzimidazolylcarbamate Methyl 6-benzoyl-1H-benzimidazol-2-ylcarbamate
    Methyl N-(5-benzoyl-1H-benzimidazol-2-yl)carbamate Methyl N-(5-benzoyl-1Hbenzimidazol-2-yl)carbamate Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate
    Methyl [5-(Benzoyl)benzimidazol-2-yl]carbamate N-(6-benzoyl-1H-benzimidazol-2-yl)carbamic acid methyl ester N-(Benzoyl-5, benzimidazolyl)-2, carbamate de methyle
    N-(Benzoyl-5, benzimidazolyl)-2, carbamate de methyle [French] N-2 (5-Benzoyl-benzimidazole) carbamate de methyle N-2 (5-Benzoyl-benzimidazole) carbamate de methyle [French]
    NC00639 NCGC00016806-01 NCGC00016806-02
    NCGC00016806-03 NCGC00016806-04 NCGC00016806-05
    NCGC00016806-06 NCGC00016806-07 NCGC00016806-08
    NCGC00016806-09 NCGC00016806-10 NCGC00016806-12
    NCGC00016806-13 NCGC00021698-03 NCGC00021698-04
    NCGC00021698-05 NCGC00021698-06 NCGC00021698-07
    NE41992 NINDS_000751 NSC 184849
    NSC-184849 NSC-757838 NSC184849
    NSC757838 Noverme OPXLLQIJSORQAM-UHFFFAOYSA-N
    Oprea1_278237 Oprea1_768530 Ovitelmin
    Pantelmin Pharmakon1600-01501110 Prestwick0_000217
    Prestwick1_000217 Prestwick2_000217 Prestwick3_000217
    Prestwick_310 Probes1_000013 Probes2_000149
    Q422194 R 17,635 R 17635
    R-17635 R17635 RTR-013370
    SAM002548959 SAM002589942 SBB057003
    SBI-0051641.P002 SCHEMBL15860 SMR000036734
    SPBio_001442 SPBio_002154 SPECTRUM1501110
    SR-01000003109 SR-01000003109-2 SR-01000003109-3
    ST011967 ST24047541 STK093862
    Spectrum2_001401 Spectrum3_001439 Spectrum4_000416
    Spectrum5_001381 Spectrum_001298 Sufil
    TR-013370 Telmin TimTec1_000869
    Tox21_110620 Tox21_110620_1 UNII-81G6I5V05I
    Vermicidin Vermirax Vermox
    Vermox (TN) Verpanyl Versid
    W-106901 W-6804 Z234895185
    ZINC121541 mebendazole methoxy-N-[5-(phenylcarbonyl)benzimidazol-2-yl]carboxamide
    methoxy-N-[6-(phenylcarbonyl)benzimidazol-2-yl]carboxamide methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate methyl 5-benzoyl-1H-benzo[d]imidazol-2-ylcarbamate
    methyl N-(5-benzoyl-1H-1,3-benzimidazol-2-yl)carbamate methyl N-(6-benzoyl-1H-1,3-benzodiazol-2-yl)carbamate methyl N-[6-(phenylcarbonyl)-1H-benzimidazol-2-yl]carbamate
    methyl [5-(phenylcarbonyl)-1H-benzimidazol-2-yl]carbamate s4610

    DrugBank Name Mebendazole
    DrugBank DB00643
    CAS Number 31431-39-7
    PubChem Compound 4030
    KEGG Compound ID x
    KEGG Drug D00368
    PubChem.Substance 46508807
    ChEBI 6704
    PharmGKB PA164776669
    ChemSpider 3890
    BindingDB 50180753.0
    TTD DAP000950
    Wikipedia Mebendazole
    DPD 2434